Eben L Rosenthal

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Reconstruction of scalp defects with the radial forearm free flap
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Alabama, USA
    Head Neck Oncol 4:21. 2012
  2. pmc Closure of post-laryngectomy pharyngocutaneous fistulae
    Isaac A Bohannon
    University of Washington, Puget Sound Veterans Administration Health System Department of Otolaryngology Head and Neck Surgery 1660 S Columbian Way, Mail Stop S 112OTO, Seattle, WA, 98108, USA
    Head Neck Oncol 3:29. 2011
  3. pmc Matrix metalloproteases in head and neck cancer
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology, BDB Suite 563, 1530 3rd Avenue South, Birmingham, AL 35294 0012, USA
    Head Neck 28:639-48. 2006
  4. ncbi request reprint Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Cancer Res 3:195-202. 2005
  5. ncbi request reprint Simplifying head and neck microvascular reconstruction
    Eben Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, 1501 5th Avenue South, Birmingham, AL 35249, USA
    Head Neck 26:930-6. 2004
  6. ncbi request reprint Extracellular matrix metalloprotease inducer stimulates fibroblast-mediated tumor growth in vivo
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 116:1086-92. 2006
  7. ncbi request reprint The mucosal invasion model: a novel in vitro model for evaluating the invasive behavior of mucocutaneous malignancies
    E L Rosenthal
    Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, 1501 Fifth Ave S, Birmingham, AL 35233, USA
    Arch Otolaryngol Head Neck Surg 127:1467-70. 2001
  8. ncbi request reprint Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma
    Eben L Rosenthal
    Division of Otolarynology Head and Neck Surgery, Comprehensive Cancer Center, University of Alabama at Birmingham, 35249, USA
    Laryngoscope 113:1406-10. 2003
  9. ncbi request reprint Duplicate publications in the otolaryngology literature
    Eben L Rosenthal
    Department of Surgery, University of Alabama at Birmingham, 35249, USA
    Laryngoscope 113:772-4. 2003
  10. ncbi request reprint Use of fluorescent labeled anti-epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts
    Eben L Rosenthal
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Mol Cancer Ther 6:1230-8. 2007

Research Grants

  1. CD147 as a Novel Target in Head and Neck Cancer
    Eben L Rosenthal; Fiscal Year: 2010
  2. Role of Fibroblast-Derived MT1-MMP in Oral Cancer
    Eben Rosenthal; Fiscal Year: 2006
  3. Tumor Stromal Interactions in Head and Neck Cancer
    Eben Rosenthal; Fiscal Year: 2007

Collaborators

Detail Information

Publications86

  1. pmc Reconstruction of scalp defects with the radial forearm free flap
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Alabama, USA
    Head Neck Oncol 4:21. 2012
    ..This study evaluates various microvascular free flap reconstructions in this patient population, including the rarely utilized radial forearm free flap...
  2. pmc Closure of post-laryngectomy pharyngocutaneous fistulae
    Isaac A Bohannon
    University of Washington, Puget Sound Veterans Administration Health System Department of Otolaryngology Head and Neck Surgery 1660 S Columbian Way, Mail Stop S 112OTO, Seattle, WA, 98108, USA
    Head Neck Oncol 3:29. 2011
    ..Closure of salvage laryngectomy defects with vascularized tissue remains controversial...
  3. pmc Matrix metalloproteases in head and neck cancer
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology, BDB Suite 563, 1530 3rd Avenue South, Birmingham, AL 35294 0012, USA
    Head Neck 28:639-48. 2006
    ..This accumulated data provide evidence for development of selective MT1-MMP inhibitors as therapy in HNSCC...
  4. ncbi request reprint Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Cancer Res 3:195-202. 2005
    ..These results suggest that fibroblast-derived MMPs but not those from tumor cells are important for in vitro collagenolysis and that this process is promoted by tumor cell-expressed EMMPRIN...
  5. ncbi request reprint Simplifying head and neck microvascular reconstruction
    Eben Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, 1501 5th Avenue South, Birmingham, AL 35249, USA
    Head Neck 26:930-6. 2004
    ..Free-tissue transfer has become the preferred method of head and neck reconstruction but is a technique that is considered to use excessive hospital resources...
  6. ncbi request reprint Extracellular matrix metalloprotease inducer stimulates fibroblast-mediated tumor growth in vivo
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 116:1086-92. 2006
    ..We hypothesize that fibroblasts are stimulated by EMMPRIN to create a microenvironment favorable to tumor growth...
  7. ncbi request reprint The mucosal invasion model: a novel in vitro model for evaluating the invasive behavior of mucocutaneous malignancies
    E L Rosenthal
    Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, 1501 Fifth Ave S, Birmingham, AL 35233, USA
    Arch Otolaryngol Head Neck Surg 127:1467-70. 2001
    ..A new acellular extracellular matrix, porcine submucosal matrix (PSM), is thought to accurately recapitulate the submucosal matrix. A novel in vitro model using PSM to assess mucocutaneous tumor cell invasion was studied...
  8. ncbi request reprint Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma
    Eben L Rosenthal
    Division of Otolarynology Head and Neck Surgery, Comprehensive Cancer Center, University of Alabama at Birmingham, 35249, USA
    Laryngoscope 113:1406-10. 2003
    ..We hypothesize that EMMPRIN is overexpressed in laryngeal cancer...
  9. ncbi request reprint Duplicate publications in the otolaryngology literature
    Eben L Rosenthal
    Department of Surgery, University of Alabama at Birmingham, 35249, USA
    Laryngoscope 113:772-4. 2003
    ..A duplicate publication duplicates other published work by the same author(s). The purpose of the study was to define the extent of this problem within the otolaryngology literature...
  10. ncbi request reprint Use of fluorescent labeled anti-epidermal growth factor receptor antibody to image head and neck squamous cell carcinoma xenografts
    Eben L Rosenthal
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Mol Cancer Ther 6:1230-8. 2007
    ..These results show the feasibility of using fluorescently labeled anti-EGFR antibody to detect human tumors in the surgical setting...
  11. doi request reprint Use of recombinant bone morphogenetic protein 2 in free flap reconstruction for osteonecrosis of the mandible
    Larissa Sweeny
    National Institutes of Health Research Fellow, Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    J Oral Maxillofac Surg 70:1991-6. 2012
    ..The purpose of this study is to determine whether the addition of rhBMP-2 at the union of vascularized bone and native bone improves surgical outcomes in patients with osteonecrosis of the mandible...
  12. pmc Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer
    J Robert Newman
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, USA
    Arch Otolaryngol Head Neck Surg 134:1218-24. 2008
    ..Tumor cell-derived EMMPRIN is highly overexpressed in HNSCC and is thought to be induced by surrounding fibroblasts to stimulate matrix metalloproteases, which modulate tumor cell invasion, growth, and angiogenesis...
  13. doi request reprint Assessment and incidence of salivary leak following laryngectomy
    Hilliary N White
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Laryngoscope 122:1796-9. 2012
    ..To determine the incidence and risk factors of pharyngocutaneous fistula formation in patients undergoing either primary or salvage laryngectomies and evaluate the role of barium esophagram in these patients...
  14. pmc Free flap reconstruction of lateral mandibular defects: indications and outcomes
    Nichole R Dean
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Otolaryngol Head Neck Surg 146:547-52. 2012
    ..To compare outcomes following osteocutaneous radial forearm and fibula free flap reconstruction of lateral mandibular defects...
  15. doi request reprint Incidence and outcomes of stricture formation postlaryngectomy
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Otolaryngol Head Neck Surg 146:395-402. 2012
    ..Postlaryngectomy stricture formation and dysphagia negatively affect quality of life and result in nutritional compromise. Understanding risk factors and successful treatment strategies may improve treatment outcomes...
  16. doi request reprint Primary versus delayed tracheoesophageal puncture for laryngopharyngectomy with free flap reconstruction
    Catherine F Sinclair
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 121:1436-40. 2011
    ..To determine whether postoperative complication rates and speech outcomes differ between patients undergoing primary versus secondary tracheoesophageal puncture following total laryngectomy with free flap reconstruction...
  17. doi request reprint Management of the N0 neck in recurrent laryngeal squamous cell carcinoma
    Isaac A Bohannon
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Laryngoscope 120:58-61. 2010
    ..To evaluate the utility of neck dissections in patients undergoing salvage laryngectomy with a clinically negative neck...
  18. doi request reprint Robotic-assisted surgery for primary or recurrent oropharyngeal carcinoma
    Nichole R Dean
    Department of Surgery, University of Alabama at Birmingham, USA
    Arch Otolaryngol Head Neck Surg 136:380-4. 2010
    ..To determine the feasibility of robotic-assisted salvage surgery for oropharyngeal cancer...
  19. pmc (18)F-FDG PET/CT imaging detects therapy efficacy of anti-EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts
    Nemil Shah
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Imaging Biol 14:237-44. 2012
    ....
  20. doi request reprint Patient-perceived and objective functional outcomes following transoral robotic surgery for early oropharyngeal carcinoma
    Catherine F Sinclair
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, 1530 Third Ave S, Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 137:1112-6. 2011
    ..To evaluate changes in patient-perceived swallowing function over time following transoral robotic surgery (TORS) for primary T1 and T2 oropharyngeal squamous cell carcinomas...
  21. pmc Stereomicroscopic fluorescence imaging of head and neck cancer xenografts targeting CD147
    J Robert Newman
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Cancer Biol Ther 7:1063-70. 2008
    ..To demonstrate that systemically administered fluorescently labeled anti-CD147 antibody can detect head and neck squamous cell carcinoma xenografts in vivo...
  22. pmc Optical imaging predicts tumor response to anti-EGFR therapy
    Emily E Helman
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biol Ther 10:166-71. 2010
    ..Tumors from cell lines that showed low internalized signal in vitro responded best to treatment with cetuximab. This preclinical model may aid in determining which cancer patients are best suited for cetuximab therapy...
  23. doi request reprint Functional outcomes of fibula and osteocutaneous forearm free flap reconstruction for segmental mandibular defects
    Frank W Virgin
    Department of Surgery, Division of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Laryngoscope 120:663-7. 2010
    ..To demonstrate that the osteocutaneous radial forearm free flap provides equivalent functional outcomes and improved morbidity compared to the fibular free flap in mandibular reconstruction...
  24. ncbi request reprint In vivo detection of head and neck cancer orthotopic xenografts by immunofluorescence
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Laryngoscope 116:1636-41. 2006
    ..To determine whether Cy5.5-labeled antiepidermal growth factor (EGFR) antibody could be used to detect head and neck squamous cell carcinoma (HNSCC) xenografts in vivo...
  25. ncbi request reprint Expression of proteolytic enzymes in head and neck cancer-associated fibroblasts
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Arch Otolaryngol Head Neck Surg 130:943-7. 2004
    ..To elucidate tumor-stromal interactions during tumor invasion by assessing the expression of proteolytic enzymes by carcinoma-associated fibroblasts (CAFs) in vivo using complementary DNA (cDNA) array analysis...
  26. doi request reprint Use of panitumumab-IRDye800 to image cutaneous head and neck cancer in mice
    C Hope Heath
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Otolaryngol Head Neck Surg 148:982-90. 2013
    ..To assess the feasibility of panitumumab in real-time fluorescent imaging and histologic processing of cutaneous squamous cell carcinoma (cSCC) in mice...
  27. pmc Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo
    Wenyue Zhang
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Cancer 6:52. 2006
    ....
  28. doi request reprint Functional outcomes following secondary free flap reconstruction of the head and neck
    Tim A Iseli
    Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Laryngoscope 119:856-60. 2009
    ..To evaluate head and neck patients undergoing secondary (delayed) free flap reconstructions...
  29. doi request reprint Functional outcomes after transoral robotic surgery for head and neck cancer
    Tim A Iseli
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Otolaryngol Head Neck Surg 141:166-71. 2009
    ..To evaluate functional outcomes following transoral robotic surgery for head and neck cancer...
  30. doi request reprint Fluorescent labeled anti-EGFR antibody for identification of regional and distant metastasis in a preclinical xenograft model
    John P Gleysteen
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 30:782-9. 2008
    ..Detection of regional and distant metastatic disease has significant implications for patient management. Fluorescent imaging may be a useful technique for metastasis detection and removal...
  31. ncbi request reprint Fluorescently labeled cetuximab to evaluate head and neck cancer response to treatment
    John P Gleysteen
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Biol Ther 6:1181-5. 2007
    ..Combining the therapeutic and diagnostic properties of targeted antibodies may improve clinical assessment of disease with limited added toxicity during treatment...
  32. ncbi request reprint Sensitivity and specificity of fluorescent immunoguided neoplasm detection in head and neck cancer xenografts
    Brian D Kulbersh
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 133:511-5. 2007
    ....
  33. pmc Disruption of the AKT pathway inhibits metastasis in an orthotopic model of head and neck squamous cell carcinoma
    Joseph A Knowles
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Laryngoscope 121:2359-65. 2011
    ..The objective of this study is to examine the role AKT inhibition may play in treatment of HNSCC...
  34. doi request reprint Utility of CT surveillance for primary site recurrence of squamous cell carcinoma of the head and neck
    Brian P Sullivan
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 33:1547-50. 2011
    ..The literature directly comparing the utility of clinical examination (CE) to that of CT in detecting recurrence of squamous cell carcinoma (SCC) for primary site recurrences is lacking...
  35. ncbi request reprint Assessment of indocyanine green-labeled cetuximab to detect xenografted head and neck cancer cell lines
    Kirk P Withrow
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Otolaryngol Head Neck Surg 137:729-34. 2007
    ..The aim of this study is to determine the efficacy of indocyanine green (ICG) conjugated to antiepidermal growth factor receptor antibody (cetuximab) to image head and neck cancer...
  36. pmc Outcomes of salvage surgery with free flap reconstruction for recurrent oral and oropharyngeal cancer
    John P Kostrzewa
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 120:267-72. 2010
    ..To evaluate outcomes of salvage surgery with free flap reconstruction for recurrent squamous cell carcinoma of the oropharynx and oral cavity with increased use of chemoradiotherapy...
  37. doi request reprint Postoperative reirradiation for mucosal head and neck squamous cell carcinomas
    Tim A Iseli
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 135:1158-64. 2009
    ..To compare toxic effects and functional outcomes of reirradiation with and without salvage surgery for nonnasopharyngeal mucosal head and neck squamous cell carcinoma...
  38. doi request reprint Robot-assisted surgery for upper aerodigestive tract neoplasms
    Bridget A Boudreaux
    Division of Otolaryngology, BDB 563, 1530 Third Ave S, Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 135:397-401. 2009
    ..To assess the feasibility and safety of performing robot-assisted resections of head and neck tumors, and to predict which variables lead to successful robot-assisted resection and better functional outcome...
  39. pmc EMMPRIN expression is required for response to bevacizumab therapy in HNSCC xenografts
    J Robert Newman
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, BDB Suit 563, 1808 7th Avenue South, Birmingham, AL 358294 0012, USA
    Cancer Lett 274:313-8. 2009
    ..By demonstrating effectiveness of bevacizumab therapy in tumors that express EMMPRIN, but not in tumors with silenced EMMPRIN expression, this study suggests that EMMPRIN may serve as a biomarker for response to bevacizumab treatment...
  40. doi request reprint Evolution of a paradigm for free tissue transfer reconstruction of lateral temporal bone defects
    Eben L Rosenthal
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 30:589-94. 2008
    ..Multiple pedicled flaps have been used to reconstruct these defects. Free flaps have been shown to provide the best tissue for these reconstructions. We review our experience and present an algorithm for their reconstruction...
  41. pmc Phase 1 study of erlotinib plus radiation therapy in patients with advanced cutaneous squamous cell carcinoma
    C Hope Heath
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Int J Radiat Oncol Biol Phys 85:1275-81. 2013
    ..To assess the toxicity profile of erlotinib therapy combined with postoperative adjuvant radiation therapy in patients with advanced cutaneous squamous cell carcinoma...
  42. pmc CD147 expression in advanced cutaneous squamous cell carcinoma
    Larissa Sweeny
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, AL 35233, USA
    J Cutan Pathol 39:603-9. 2012
    ..Our purpose was to evaluate the expression patterns of CD147 and related monocarboxylate transporters (MCT1, MCT4) to determine their correlation with survival...
  43. pmc Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Otolaryngol Head Neck Surg 145:956-60. 2011
    ..There is limited published evidence regarding the efficacy of these devices. The authors investigated the sensitivity and specificity of these modalities compared with standard examination...
  44. doi request reprint Outcomes following temporal bone resection
    Nichole R Dean
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Laryngoscope 120:1516-22. 2010
    ..To evaluate survival outcomes in patients undergoing temporal bone resection...
  45. doi request reprint Method for removing hypopharyngeal salivary bypass tubes
    Alexandra E Kejner
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 121:1478-9. 2011
    ..To describe a novel method for the removal of the salivary bypass tube (SBT) that precludes the need for extraction under general anesthesia...
  46. pmc Evaluation of tyrosine receptor kinases in the interactions of head and neck squamous cell carcinoma cells and fibroblasts
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Oral Oncol 48:1242-9. 2012
    ..In this article, we investigated the role of several receptor tyrosine kinases (RTKs) in the interactions between HNSCC cells and supporting cells (fibroblasts)...
  47. pmc EGFR expression in advanced head and neck cutaneous squamous cell carcinoma
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 34:681-6. 2012
    ..The significance of epidermal growth factor receptor (EGFR) expression in advanced cutaneous squamous cell carcinoma (SCC) of the head and neck remains poorly understood...
  48. doi request reprint Anti-EMMPRIN antibody treatment of head and neck squamous cell carcinoma in an ex-vivo model
    Nichole Renae Dean
    Department of Surgery, University of Alabama at Birmingham, USA
    Anticancer Drugs 21:861-7. 2010
    ..This study shows the potential of anti-EMMPRIN to inhibit proliferation and promote apoptosis and suggests its future role in the targeted treatment of head and neck carcinoma...
  49. doi request reprint Transoral robotic-assisted surgery for head and neck squamous cell carcinoma: one- and 2-year survival analysis
    Hilliary N White
    Division of Otolaryngology, Department of Surgery, University of Alabama School of Medicine, BDB Ste 563, 1530 Third Ave S, Birmingham, AL 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 136:1248-52. 2010
    ..to report 2-year survival outcomes for head and neck squamous cell carcinoma using transoral robotic-assisted resection...
  50. ncbi request reprint Use of negative-pressure dressings to manage a difficult surgical neck wound
    Satya Shreenivas
    Division of Otolaryngology, Department of Surgery, University of Alabama at Birmingham 35249, USA
    Ear Nose Throat J 85:390-1. 2006
    ..The wound had failed to heal properly after 2 weeks of conservative management. Following application of the negative-pressure dressings, the wound granulated quickly and healed well by secondary intention...
  51. doi request reprint Zygomatic-maxillary buttress reconstruction of midface defects with the osteocutaneous radial forearm free flap
    Patricio Andrades
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 30:1295-302. 2008
    ..The purpose of this study was to evaluate morbidity, functional, and aesthetic outcomes in midface zygomatic-maxillary buttress reconstruction using the osteocutaneous radial forearm free flap (OCRFFF)...
  52. doi request reprint CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma
    Larissa Sweeny
    Department of Surgery, University of Alabama, Division of Otolaryngology Head and Neck Surgery, Birmingham, Alabama, USA
    Exp Cell Res 318:1788-98. 2012
    ..In vitro, knockdown of CD147 or AGR2 decreased cellular proliferation, migration and invasion. In vivo, knockdown of CD147 or AGR2 expression decreased primary tumor growth as well as regional and distant metastasis...
  53. pmc Inhibition of fibroblasts reduced head and neck cancer growth by targeting fibroblast growth factor receptor
    Larissa Sweeny
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Laryngoscope 122:1539-44. 2012
    ..We further investigated these relationships by suppressing stromal cell growth through the inhibition of fibroblast growth factor receptor (FGFR)...
  54. doi request reprint Assessment of donor site morbidity for free radial forearm osteocutaneous flaps
    Catherine F Sinclair
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Microsurgery 32:255-60. 2012
    ....
  55. pmc Extracelluar matrix metalloproteinase as a novel target for pancreatic cancer therapy
    Hyunki Kim
    Department of Radiology, University of Alabama at Birmingham, USA
    Anticancer Drugs 22:864-74. 2011
    ..049). These data show the high potential of anti-EMMPRIN therapy for pancreatic cancer and support its clinical translation...
  56. doi request reprint Fistula analysis after radial forearm free flap reconstruction of hypopharyngeal defects
    Patricio Andrades
    Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Alabama in Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 118:1157-63. 2008
    ..To evaluate risk factors and management options for fistula formation after hypopharyngeal reconstruction using the radial forearm free flap reconstruction...
  57. ncbi request reprint Use of negative pressure dressings in head and neck reconstruction
    Eben L Rosenthal
    Division of Otolaryngology, Department of Surgery at The University of Alabama at Birmingham, BDB Suite 563, 1530 3rd Avenue South, Birmingham, AL 35294 0012, USA
    Head Neck 27:970-5. 2005
    ..Head and neck microvascular surgery commonly requires management of complex wounds of the upper aerodigestive tract and donor sites. Negative pressure dressings have been reported to promote healing in compromised wounds...
  58. ncbi request reprint Free tissue transfer to manage salvage laryngectomy defects after organ preservation failure
    Kirk P Withrow
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 117:781-4. 2007
    ..We hypothesize that even when sufficient mucosa is present to close the defect primarily, introduction of vascularized tissue to close the defect may improve outcomes...
  59. pmc In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts
    Joni B Skipper
    Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
    ORL J Otorhinolaryngol Relat Spec 71:1-5. 2009
    ..To assess the effect of combining a synthetic matrix metalloprotease inhibitor and chemoradiation therapy on tumor growth in a murine model of head and neck squamous-cell carcinoma (SCC)...
  60. pmc Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer
    Nichole R Dean
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Cancer Res 15:4058-65. 2009
    ..Because molecular therapy is considered more effective when delivered with conventional cytotoxic agents, anti-EMMPRIN therapy was assessed alone and in combination with external beam radiation...
  61. pmc Increased likelihood of long-term gastrostomy tube dependence in head and neck cancer survivors without partners
    J Scott Magnuson
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Head Neck 35:420-5. 2013
    ..We evaluated factors associated with long-term dependence on percutaneous endoscopic gastrostomy (PEG) tubes...
  62. pmc Molecular targeting of ultrasonographic contrast agent for detection of head and neck squamous cell carcinoma
    Joseph A Knowles
    Department of Surgery, University of Alabama at Birmingham, 35294 0012, USA
    Arch Otolaryngol Head Neck Surg 138:662-8. 2012
    ..We hypothesize that conjugation of microbubble contrast agent to tumor-specific antibodies may improve US detection of head and neck squamous cell carcinoma (HNSCC)...
  63. doi request reprint Functional and survival outcomes in patients undergoing total glossectomy compared with total laryngoglossectomy
    Catherine F Sinclair
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Otolaryngol Head Neck Surg 145:755-8. 2011
    ..To compare functional and survival outcomes for patients undergoing total glossectomy (TG) or total glossectomy plus laryngectomy (TGL) for advanced squamous cell carcinoma (SCC) of the tongue...
  64. ncbi request reprint Promotion of acellular dermal matrix resolution in vitro by matrix metalloproteinase-2
    Jonathan P Lindman
    Division of Otolaryngology, Department of Surgery, and Department of Biostatistics, University of Alabama at Birmingham, 35294 0012, USA
    Arch Facial Plast Surg 8:208-12. 2006
    ..To determine whether acellular human dermis is degraded by matrix metalloproteinases (MMPs), a large class of matrix-degrading enzymes...
  65. pmc Use of panitumumab-IRDye800 to image microscopic head and neck cancer in an orthotopic surgical model
    C Hope Heath
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
    Ann Surg Oncol 19:3879-87. 2012
    ..This study sought to determine if this imaging system was capable of detecting micrometastatic head and neck squamous cell carcinoma (HNSCC) in preclinical models...
  66. pmc Outcomes of recurrent head and neck cutaneous squamous cell carcinoma
    Nichole R Dean
    Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, The University of Alabama at Birmingham, Volker Hall G082, 1670 University Boulevard, Birmingham, AL 35233, USA
    J Skin Cancer 2011:972497. 2011
    ..001). Adjuvant postoperative radiotherapy did not improve overall survival (P = .42). Overall survival was poor for patients with advanced recurrent cSCC despite the combined treatment with surgery and radiotherapy...
  67. ncbi request reprint Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study
    Christopher F Baranano
    UAB Division of Otolaryngology Head and Neck Surgery, 1808 7th Ave S, Birmingham, AL 35294 0012, USA
    Ear Nose Throat J 90:584-90. 2011
    ..16 mm/day. We conclude that the DTS is effective in increasing the mandibular range of motion at a rate of change that is maximized during initial treatment...
  68. pmc Fibroblast growth factor receptor mediates fibroblast-dependent growth in EMMPRIN-depleted head and neck cancer tumor cells
    Zhiyong Liu
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, USA
    Mol Cancer Res 9:1008-17. 2011
    ..Taken together, these results suggest that EMMPRIN acquired during tumor progression promotes fibroblast-independent tumor growth...
  69. doi request reprint Reconstruction of periauricular and temporal bone defects
    Tim A Iseli
    Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Alabama School of Medicine, BDB 563, 1530 3rd Avenue South, Birmingham, AL 35294 0012, USA
    Facial Plast Surg Clin North Am 17:253-62. 2009
    ..Although free flap reconstruction provides rapid wound healing, local and regional flaps are alternatives for patients unable to tolerate prolonged anesthesia and for use after recurrence or complications...
  70. pmc Barriers to early detection and treatment of head and neck squamous cell carcinoma in African American men
    William R Carroll
    Division of Otolaryngology, University of Alabama, Birmingham, Alabama, USA
    Head Neck 31:1557-62. 2009
    ..One apparent cause is an advanced stage of presentation in African Americans. This study was designed to identify barriers to early treatment among African American men...
  71. doi request reprint Current strategies in reconstruction of maxillectomy defects
    Patricio Andrades
    Division of Plastic and Maxillofacial Surgery, Department of Surgery, University of Chile Clinical Hospital and Hospital del Trabajador de Santiago, Santiago, Chile
    Arch Otolaryngol Head Neck Surg 137:806-12. 2011
    ..To outline a contemporary review of defect classification and reconstructive options...
  72. doi request reprint All-cause mortality after tracheostomy at a tertiary care hospital over a 10-month period
    Alexandra E Kejner
    University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    Otolaryngol Head Neck Surg 146:918-22. 2012
    ..To evaluate perioperative mortality after tracheostomy in intensive care unit (ICU) patients undergoing routine tracheostomy over a 10-month period...
  73. ncbi request reprint Validation of ultrasonography to evaluate murine orthotopic oral cavity tumors
    John C Pezold
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35223, USA
    ORL J Otorhinolaryngol Relat Spec 68:159-63. 2006
    ..High-resolution ultrasound was evaluated as a noninvasive method to monitor tumor size in vivo...
  74. doi request reprint Fluorescent detection of rat parathyroid glands via 5-aminolevulinic acid
    Scott A Asher
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Laryngoscope 118:1014-8. 2008
    ..We sought to determine whether 5-aminolevulinic acid (5-ALA) could produce parathyroid gland fluorescence to improve their detection in a preclinical model...
  75. ncbi request reprint Targeting of a conditionally replicative adenovirus agent to human squamous cell carcinomas of the head and neck
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Oncol 31:1213-22. 2007
    ..As an added benefit, the activity of the CXCR4 promoter was low in human liver as described previously. Based on these data, the CRAd-CXCR4.F5/3 is a promising novel CRAd agent for SCCHN targeting with low host toxicity...
  76. ncbi request reprint Free flap complications: when is enough, enough?
    Eben L Rosenthal
    Department of Surgery Division of Otolaryngology Head and Neck Surgery University of Alabama at Birmingham, Birmingham, Alabama, USA
    Curr Opin Otolaryngol Head Neck Surg 11:236-9. 2003
    ....
  77. ncbi request reprint Expandable tracheal stenting for benign disease: worth the complications?
    Robert L Eller
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Alabama School of Medicine, Birmingham, Alabama, USA
    Ann Otol Rhinol Laryngol 115:247-52. 2006
    ..To characterize the limitations of self-expandable stents in the management of benign tracheal stenosis, we performed a retrospective review at a tertiary care medical center...
  78. ncbi request reprint Pretreatment, preoperative swallowing exercises may improve dysphagia quality of life
    Brian Daniel Kulbersh
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Laryngoscope 116:883-6. 2006
    ..Traditional dysphagia management strategies focus on post-treatment therapy. This study evaluated the utility of pretreatment swallowing exercises in improving post-treatment swallowing quality of life (QOL)...
  79. ncbi request reprint Breast cancer cells with inhibition of p38alpha have decreased MMP-9 activity and exhibit decreased bone metastasis in mice
    Catalina Suarez-Cuervo
    Department of Medicine, Division of Hematology Oncology, University of Alabama at Birmingham, USA
    Clin Exp Metastasis 21:525-33. 2004
    ..In conclusion, inhibition of the p38alpha pathway results in decreased MMP-9 activity, impaired uPA expression and decreased motility, all of which may contribute to the decreased formation of bone metastasis...
  80. ncbi request reprint A comparison of negative-pressure dressings versus Bolster and splinting of the radial forearm donor site
    D Macy Vidrine
    Department of Surgery, Division of Otolaryngology at the University of Alabama at Birmingham, 35294, USA
    Otolaryngol Head Neck Surg 133:403-6. 2005
    ..Negative-pressure dressings (NPDs) have been reported to improve split-thickness skin graft survival in some settings; we assessed whether NPDs could improve skin graft results in radial forearm donor sites...
  81. ncbi request reprint Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck
    William R Carroll
    Division of Otolaryngology Head and Neck Surgery, University of Alabama at Birmingham, 35233, USA
    Arch Otolaryngol Head Neck Surg 129:771-4. 2003
    ..This prospective clinical trial compared short-course and long-course clindamycin prophylaxis for wound infection in patients with head and neck cancer undergoing free-flap reconstruction...
  82. ncbi request reprint Influence of social support on health-related quality of life outcomes in head and neck cancer
    Lucy Hynds Karnell
    Department of Otolaryngology Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Head Neck 29:143-6. 2007
    ..Evidence that social support influences health-related quality of life (HRQOL) in oncologic patients could be particularly important for head and neck cancer because this disease can affect speech, eating, and facial aesthetics...
  83. ncbi request reprint The ulnar fasciocutaneous free flap in head and neck reconstruction
    Mark K Wax
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland 97201, USA
    Laryngoscope 112:2155-60. 2002
    ..This tissue gets its vascular supply from the ulnar artery. The purpose of the report was to describe the authors' experience with the ulnar fasciocutaneous free flap in head and neck reconstruction...
  84. ncbi request reprint Pulmonary atelectasis after reconstruction with a rectus abdominis free tissue transfer
    Mark K Wax
    Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Mail Code PV 01, Portland, OR 97201, USA
    Arch Otolaryngol Head Neck Surg 128:249-52. 2002
    ..Harvesting the flap results in abdominal wall pain and postoperative splinting that may contribute to an increased development of atelectasis. To our knowledge, this issue has not been previously examined...
  85. ncbi request reprint The role of free tissue transfer in the reconstruction of massive neglected skin cancers of the head and neck
    Mark K Wax
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland 97201, USA
    Arch Facial Plast Surg 5:479-82. 2003
    ..Reconstruction requires massive composite soft tissue replacement. We presented our experience with, to our knowledge, the largest series reported to date...
  86. ncbi request reprint Persistent posttreatment depressive symptoms in patients with head and neck cancer
    Lucy Hynds Karnell
    Department of Otolaryngology Head and Neck Surgery, Rm 21010 PFP, 200 Hawkins Drive, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Head Neck 28:453-61. 2006
    ..This study examined the prevalence and risk factors of persistent (versus short-term) depressive symptoms in patients with head and neck cancer...

Research Grants4

  1. CD147 as a Novel Target in Head and Neck Cancer
    Eben L Rosenthal; Fiscal Year: 2010
    ..Furthermore, novel molecular mechanisms by which CD147 acts to promote the malignant phenotype in vitro and in vivo will be investigated. ..
  2. Role of Fibroblast-Derived MT1-MMP in Oral Cancer
    Eben Rosenthal; Fiscal Year: 2006
    ..abstract_text> ..
  3. Tumor Stromal Interactions in Head and Neck Cancer
    Eben Rosenthal; Fiscal Year: 2007
    ....