T H Rosenquist

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint The expression of the NR1-subunit of the NMDA receptor during mouse and early chicken development
    Gregory D Bennett
    Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, 985805 UNMC, Omaha, NE 68198 5805, USA
    Reprod Toxicol 22:536-41. 2006
  2. doi request reprint Folate, homocysteine and the cardiac neural crest
    Thomas H Rosenquist
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Dev Dyn 242:201-18. 2013
  3. ncbi request reprint N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities
    T H Rosenquist
    University of Nebraska Medical Center, Omaha, Nebraska 68198 6395, USA
    FASEB J 13:1523-31. 1999
  4. ncbi request reprint Genes, folate and homocysteine in embryonic development
    T H Rosenquist
    Department of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha 68198 6395, USA
    Proc Nutr Soc 60:53-61. 2001
  5. ncbi request reprint Another key role for the cardiac neural crest in heart development
    Thomas H Rosenquist
    Univ of Nebraska Medical Center, 987878 Nebraska Medical Center, Omaha, NE 68198 7878, USA
    Am J Physiol Heart Circ Physiol 292:H1225-6. 2007
  6. ncbi request reprint Microarray analysis of homocysteine-responsive genes in cardiac neural crest cells in vitro
    T H Rosenquist
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 7878, USA
    Dev Dyn 236:1044-54. 2007
  7. ncbi request reprint Failure of homocysteine to induce neural tube defects in a mouse model
    Gregory D Bennett
    Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Birth Defects Res B Dev Reprod Toxicol 77:89-94. 2006
  8. doi request reprint Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation
    Janee Gelineau-van Waes
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5455, USA
    Birth Defects Res A Clin Mol Teratol 82:494-507. 2008
  9. ncbi request reprint Effect of elevated homocysteine on cardiac neural crest migration in vitro
    Philip R Brauer
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Dev Dyn 224:222-30. 2002
  10. pmc The N-methyl-d-aspartate receptor in heart development: a gene knockdown model using siRNA
    Octavian V Lie
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, United States
    Reprod Toxicol 29:32-41. 2010

Research Grants

  1. HOMOCYSTEINE AND CONGENITAL HEART DEFECTS
    Thomas Rosenquist; Fiscal Year: 2003

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The expression of the NR1-subunit of the NMDA receptor during mouse and early chicken development
    Gregory D Bennett
    Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, 985805 UNMC, Omaha, NE 68198 5805, USA
    Reprod Toxicol 22:536-41. 2006
    ..5-15.5 and continued to increase in its expression until term. Therefore, these experiments suggest that homocysteine-induced defects may be mediated via the NMDA receptor...
  2. doi request reprint Folate, homocysteine and the cardiac neural crest
    Thomas H Rosenquist
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Dev Dyn 242:201-18. 2013
    ..It is proposed that well-focused advances in folate-CNC research could lead to development of strategies, in addition to PFS, to facilitate normal CNC and heart development, and thereby further reduce CHD...
  3. ncbi request reprint N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities
    T H Rosenquist
    University of Nebraska Medical Center, Omaha, Nebraska 68198 6395, USA
    FASEB J 13:1523-31. 1999
    ..One potentially important consequence of this putative mechanism is that homocysteine may interact synergistically with other NMDAR antagonists to enhance its effect on development...
  4. ncbi request reprint Genes, folate and homocysteine in embryonic development
    T H Rosenquist
    Department of Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha 68198 6395, USA
    Proc Nutr Soc 60:53-61. 2001
    ....
  5. ncbi request reprint Another key role for the cardiac neural crest in heart development
    Thomas H Rosenquist
    Univ of Nebraska Medical Center, 987878 Nebraska Medical Center, Omaha, NE 68198 7878, USA
    Am J Physiol Heart Circ Physiol 292:H1225-6. 2007
  6. ncbi request reprint Microarray analysis of homocysteine-responsive genes in cardiac neural crest cells in vitro
    T H Rosenquist
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 7878, USA
    Dev Dyn 236:1044-54. 2007
    ..Although the genes identified in this experiment were consistent with prior observations of the effect of homocysteine upon neural crest cell function, none had been identified previously as response to homocysteine in adult cells...
  7. ncbi request reprint Failure of homocysteine to induce neural tube defects in a mouse model
    Gregory D Bennett
    Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Birth Defects Res B Dev Reprod Toxicol 77:89-94. 2006
    ..In an effort to develop a murine model of homocysteine-induced neural tube defects, several inbred mouse strains were treated with homocysteine or the NMDA inhibitor MK801 and the fetuses examined for any induced-NTD...
  8. doi request reprint Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation
    Janee Gelineau-van Waes
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5455, USA
    Birth Defects Res A Clin Mol Teratol 82:494-507. 2008
    ..In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation...
  9. ncbi request reprint Effect of elevated homocysteine on cardiac neural crest migration in vitro
    Philip R Brauer
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Dev Dyn 224:222-30. 2002
    ..Perturbation of this receptor may be related to some of the teratogenic effects observed with elevated Hcys...
  10. pmc The N-methyl-d-aspartate receptor in heart development: a gene knockdown model using siRNA
    Octavian V Lie
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, United States
    Reprod Toxicol 29:32-41. 2010
    ..These results indicate that the CNC may function normally in the absence of functional NMDAR, and that NMDAR antagonists may have a complex impact upon the CNC that transcends impairment of a single receptor type...
  11. doi request reprint High-affinity folate receptor in cardiac neural crest migration: a gene knockdown model using siRNA
    Thomas H Rosenquist
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198 5805, USA
    Dev Dyn 239:1136-44. 2010
    ..In summary, a brief reduction in the expression of Folr1 during a critical stage of NC development had long-term consequences for the development of the PAA and outflow tract...
  12. ncbi request reprint Dextromethorphan and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model
    V J Andaloro
    Department of Pharmacology, College of Medicine, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Pediatr Res 43:1-7. 1998
    ..Because dextromethorphan is a widely used nonprescription antitussive, its strong teratogeneticity using this model is particularly noteworthy...
  13. ncbi request reprint Homocysteine inhibits extra-embryonic vascular development in the avian embryo
    Kimberly S Latacha
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, 987878 Nebraska Medical Center, Omaha, NE 68198 7878, USA
    Dev Dyn 234:323-31. 2005
    ..These results suggest that homocysteine may impair the development of the extra-embryonic vasculature by reducing the expression of VEGF...
  14. ncbi request reprint Nutrient effects upon embryogenesis: folate, vitamin A and iodine
    Thomas H Rosenquist
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Nestle Nutr Workshop Ser Pediatr Program 55:29-40; discussion 40-8. 2005
  15. ncbi request reprint Partial cloning and sequencing of chick fibrillin-1 cDNA
    G Zhou
    Munroe Center for Human Genetics, University of Nebraska Medical Center, Omaha 68198 5430, USA
    In Vitro Cell Dev Biol Anim 36:19-25. 2000
    ..Antisense and sense riboprobes were synthesized and used in in situ hybridization in stage 14 chick embryos and high levels of FBN1 transcripts were observed in the heart...
  16. ncbi request reprint Importance of folate-homocysteine homeostasis during early embryonic development
    Shveta Taparia
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    Clin Chem Lab Med 45:1717-27. 2007
    ..Herein, we propose how homocysteinylation of the folate receptor may contribute to generation of these autoantibodies against the folate receptor...
  17. ncbi request reprint Gene-nutrient interactions: importance of folic acid and vitamin B12 during early embryogenesis
    Richard H Finnell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Food Nutr Bull 29:S86-98; discussion S99-100. 2008
    ..While not exhaustive, our goal was to provide an overview of important gene-nutrient interactions, focusing on folic acid and vitamin B12, to serve as a framework for understanding the multiple roles they play in early embryogenesis...
  18. ncbi request reprint Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis
    Richard H Finnell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Toxicol Appl Pharmacol 198:75-85. 2004
    ..Although not exhaustive, our goal was to provide an overview of important gene-nutrient interactions and a framework for their investigation...
  19. ncbi request reprint Maternal periconceptional vitamins: interactions with selected factors and congenital anomalies?
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Epidemiology 13:625-30. 2002
    ..We hypothesized that effects of congenital anomalies associated with maternal fever, cigarette smoking or alcohol use would be modified by intake of vitamins...
  20. ncbi request reprint Molecular basis of environmentally induced birth defects
    Richard H Finnell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Annu Rev Pharmacol Toxicol 42:181-208. 2002
    ..Understanding these signaling pathways may lead to the development of safer pharmaceutical compounds and a reduction in the number of infants born with preventable birth defects...

Research Grants12

  1. HOMOCYSTEINE AND CONGENITAL HEART DEFECTS
    Thomas Rosenquist; Fiscal Year: 2003
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