Robert Rosenfield

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Adolescent anovulation: maturational mechanisms and implications
    Robert L Rosenfield
    MD, University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue MC 5053, Chicago, Illinois 60637
    J Clin Endocrinol Metab 98:3572-83. 2013
  2. pmc Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test
    Robert L Rosenfield
    MD, University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue MC 5053, Chicago, Illinois 60637
    J Clin Endocrinol Metab 98:1591-601. 2013
  3. pmc Comparison of detection of normal puberty in boys by a hormonal sleep test and a gonadotropin-releasing hormone agonist test
    Robert L Rosenfield
    University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue MC 5053, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 97:4596-604. 2012
  4. pmc Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries
    Robert L Rosenfield
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Fertil Steril 98:242-9. 2012
  5. pmc Overcoming burdens in the regulation of clinical research in children. Proceedings of a consensus conference, in historical context
    Robert J Levine
    The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Pediatr Endocrinol 2011:19. 2011
  6. ncbi Hirsutism and the variable response of the pilosebaceous unit to androgen
    Robert L Rosenfield
    Department of Pediatrics, The University of Chicago Children s Hospital, Section of Pediatric Endocrinology, The University of Chicago, Chicago, Illinois 60637 1470, USA
    J Investig Dermatol Symp Proc 10:205-8. 2005
  7. ncbi Clinical review: Identifying children at risk for polycystic ovary syndrome
    Robert L Rosenfield
    The University of Chicago Pritzker School of Medicine, Department of Pediatrics, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 92:787-96. 2007
  8. ncbi Does a primary acceleration of LH pulse frequency underlie an association between central precocious puberty and polycystic ovary syndrome? Commentary on Escobar ME et al: Acceleration of LH pulse frequency in adolescent girls with a history of central pr
    Robert L Rosenfield
    Department of Pediatrics, Section of Pediatric Endocrinology, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Horm Res 68:286-7. 2007
  9. doi Improving balance in regulatory oversight of research in children and adolescents: a clinical investigator's perspective
    Robert L Rosenfield
    University of Chicago Comer Children s Hospital, Section of Pediatric Endocrinology, 5841 S Maryland Avenue M C 5053, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1135:287-95. 2008
  10. doi What every physician should know about polycystic ovary syndrome
    Robert L Rosenfield
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637 1470, USA
    Dermatol Ther 21:354-61. 2008

Research Grants

  1. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
  2. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
  3. Pediatric Endocrinology Research Training Grant
    Robert Rosenfield; Fiscal Year: 2007
  4. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1991
  5. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980

Collaborators

Detail Information

Publications39

  1. pmc Adolescent anovulation: maturational mechanisms and implications
    Robert L Rosenfield
    MD, University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue MC 5053, Chicago, Illinois 60637
    J Clin Endocrinol Metab 98:3572-83. 2013
    ..Research is needed on the mechanisms and prognosis of adolescent anovulation. ..
  2. pmc Comparison of detection of normal puberty in girls by a hormonal sleep test and a gonadotropin-releasing hormone agonist test
    Robert L Rosenfield
    MD, University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue MC 5053, Chicago, Illinois 60637
    J Clin Endocrinol Metab 98:1591-601. 2013
    ..Inconsistencies between clinical and hormonal staging may arise from peripubertal cyclicity of neuroendocrine function and from excess adiposity...
  3. pmc Comparison of detection of normal puberty in boys by a hormonal sleep test and a gonadotropin-releasing hormone agonist test
    Robert L Rosenfield
    University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue MC 5053, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 97:4596-604. 2012
    ..The magnitude of sleep-related gonadotropin rise required to activate pubertal gonadal function is not established...
  4. pmc Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries
    Robert L Rosenfield
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Fertil Steril 98:242-9. 2012
    ..To determine the relationship of antimüllerian hormone (AMH) levels to polycystic ovaries and ovarian androgenic function...
  5. pmc Overcoming burdens in the regulation of clinical research in children. Proceedings of a consensus conference, in historical context
    Robert J Levine
    The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Int J Pediatr Endocrinol 2011:19. 2011
    ..abstract:..
  6. ncbi Hirsutism and the variable response of the pilosebaceous unit to androgen
    Robert L Rosenfield
    Department of Pediatrics, The University of Chicago Children s Hospital, Section of Pediatric Endocrinology, The University of Chicago, Chicago, Illinois 60637 1470, USA
    J Investig Dermatol Symp Proc 10:205-8. 2005
    ..Improved treatment of hirsutism awaits improved understanding of the nature of the interaction between androgens and other determinants of hair follicle biology...
  7. ncbi Clinical review: Identifying children at risk for polycystic ovary syndrome
    Robert L Rosenfield
    The University of Chicago Pritzker School of Medicine, Department of Pediatrics, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 92:787-96. 2007
    ..Polygenic influences appear to account for about 70% of the variance in pathogenesis. In view of this evidence for congenital contributions to the syndrome, childhood manifestations may be expected...
  8. ncbi Does a primary acceleration of LH pulse frequency underlie an association between central precocious puberty and polycystic ovary syndrome? Commentary on Escobar ME et al: Acceleration of LH pulse frequency in adolescent girls with a history of central pr
    Robert L Rosenfield
    Department of Pediatrics, Section of Pediatric Endocrinology, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Horm Res 68:286-7. 2007
  9. doi Improving balance in regulatory oversight of research in children and adolescents: a clinical investigator's perspective
    Robert L Rosenfield
    University of Chicago Comer Children s Hospital, Section of Pediatric Endocrinology, 5841 S Maryland Avenue M C 5053, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1135:287-95. 2008
    ..Suggestions are made for improving the balance between the need for research in children and adolescents and its regulation...
  10. doi What every physician should know about polycystic ovary syndrome
    Robert L Rosenfield
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637 1470, USA
    Dermatol Ther 21:354-61. 2008
    ....
  11. doi Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index
    Robert L Rosenfield
    Department of aPediatrics, University of Chicago, Chicago, IL, USA
    Pediatrics 123:84-8. 2009
    ..We compared attainment of stage 2 breasts, stage 3 (sexual) pubic hair, and menarche in the Third National Health and Nutrition Examination Survey sample of children with normal BMI with those with excessive BMI (> or =85th percentile)...
  12. pmc Evidence that obesity and androgens have independent and opposing effects on gonadotropin production from puberty to maturity
    Robert L Rosenfield
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Brain Res 1364:186-97. 2010
    ..The data are compatible with the possibility that excess adiposity may paradoxically subtly suppress hypothalamic-pituitary-gonadal function in early puberty although it is known to contribute to the early onset of puberty...
  13. pmc Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test
    Robert L Rosenfield
    Department of Pediatrics and Medicine, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Hum Reprod 26:3138-46. 2011
    ..The objective of this study was to determine the source of androgen excess in the one-third of PCOS patients who atypically lack this type of ovarian dysfunction (PCOS-A)...
  14. ncbi Clinical practice. Hirsutism
    Robert L Rosenfield
    Department of Pediatrics and Medicine, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    N Engl J Med 353:2578-88. 2005
  15. ncbi Diagnosis of the polycystic ovary syndrome in adolescence: comparison of adolescent and adult hyperandrogenism
    R L Rosenfield
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, IL, USA
    J Pediatr Endocrinol Metab 13:1285-9. 2000
    ..For example, we are unable to diagnose ovarian dysfunction before puberty or in early puberty, and the relationship of "physiologic adolescent anovulation" to PCOS remains to be defined...
  16. ncbi Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome
    Robert L Rosenfield
    The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 90:6424-30. 2005
    ..Optimizing pubertal estrogen replacement in girls with Turner syndrome is important...
  17. ncbi Polycystic ovary syndrome and insulin-resistant hyperinsulinemia
    R L Rosenfield
    Section of Pediatric Endocrinology, Pritzker School of Medicine, The University of Chicago, IL 60637 1470, USA
    J Am Acad Dermatol 45:S95-104. 2001
    ..Treatment of PCOS with antidiabetic insulin-lowering agents may improve ovarian function and androgen levels; it remains to be determined whether it will benefit the pilosebaceous unit manifestations of the disorder...
  18. ncbi Peroxisome proliferator-activated receptors and skin development
    R L Rosenfield
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, Ill, USA
    Horm Res 54:269-74. 2000
    ..In addition, they may play roles in keratinocyte growth and differentiation and the inhibition of skin inflammation by diverse mechanisms not necessarily related to fat metabolism...
  19. ncbi Sebaceous epithelial cell differentiation requires cyclic adenosine monophosphate generation
    Robert L Rosenfield
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Illinois 60634 1470, USA
    In Vitro Cell Dev Biol Anim 38:54-7. 2002
    ..These data suggest ligand-dependent, complex interactions between cAMP and the other signal transduction pathways involved in sebocyte growth and development...
  20. pmc Asymptomatic volunteers with a polycystic ovary are a functionally distinct but heterogeneous population
    Monica Mortensen
    Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 94:1579-86. 2009
    ..Our objective was to determine the ovarian function of asymptomatic volunteers with a polycystic ovary (V-PCO)...
  21. ncbi Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene
    Kenan Qin
    Departments of Pediatrics and Medicine, The University of Chicago, Chicago, IL 60637, USA
    Biochim Biophys Acta 1728:115-25. 2005
    ..These results indicate that members of the Sp family of transcription factors play an important role in regulating constitutive and stimulated expression of the HSD17B5 gene in H295R cells...
  22. ncbi GnRH agonist stimulation of the pituitary-gonadal axis in children: age and sex differences in circulating inhibin-B and activin-A
    Daniel D Elsholz
    Department of Pediatrics, Division of Endocrinology, University of Michigan, Ann Arbor, MI 48109 0646, USA
    Hum Reprod 19:2748-58. 2004
    ..Inhibin-B decreases and activin increases FSH secretion in adults. We investigated whether an FSH-inhibin/activin feedback loop exists before or during puberty...
  23. ncbi Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome
    Elizabeth E Littlejohn
    University of Chicago, Pritzker School of Medicine, Department of Pediatrics, Section of Pediatric Endocrinology, 5841 S Maryland Avenue, IL 60637, USA
    J Pediatr Endocrinol Metab 20:41-51. 2007
    ..We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS)...
  24. ncbi The role of LH and FSH in ovarian androgen secretion and ovarian follicular development: clinical studies in a patient with isolated FSH deficiency and multicystic ovaries
    Randall B Barnes
    Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA
    Hum Reprod 17:88-91. 2002
    ..We also found that follicular development was present in the absence of FSH. These antral follicles had apparently developed normally, since estradiol and inhibin B increased promptly after FSH administration...
  25. pmc Characterization of functionally typical and atypical types of polycystic ovary syndrome
    Jennifer Hirshfeld-Cytron
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 94:1587-94. 2009
    ..The typical polycystic ovary syndrome (PCOS) phenotype includes 17-hydroxyprogesterone (17OHP) hyperresponsiveness to GnRH agonist (GnRHag) testing. Functionally atypical PCOS lacks this feature...
  26. pmc Blunted sleep-related luteinizing hormone rise in healthy premenarcheal pubertal girls with elevated body mass index
    Brian Bordini
    Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 94:1168-75. 2009
    ..Our objective was to determine whether excessive adiposity is associated with alteration of the normal hormonal changes of early pubertal girls...
  27. pmc Identification of a functional polymorphism of the human type 5 17beta-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome
    Kenan Qin
    Department of Pediatrics, Section of Pediatric Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 91:270-6. 2006
    ..Type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD5) appears to be the major testosterone-forming 17beta-HSD isoenzyme in females...
  28. ncbi Functional significance of polycystic-size ovaries in healthy adolescents
    Monica Mortensen
    Section of Pediatric Endocrinology, University of Chicago Comer Children s Hospital, 5841 South Maryland Avenue M C 5053, Chicago, IL 60637, USA
    J Clin Endocrinol Metab 91:3786-90. 2006
    ..The relevance of adult polycystic ovary criteria to adolescence is unclear...
  29. pmc Polycystic ovary syndrome in adolescence
    Colleen Buggs
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Endocrinol Metab Clin North Am 34:677-705, x. 2005
    ..This article reviews the definition, clinical features, diagnosis, and treatment of PCOS...
  30. ncbi Relationship of adolescent polycystic ovary syndrome to parental metabolic syndrome
    Natasha I Leibel
    University of Chicago Comer Children s Hospital, Section of Pediatric Endocrinology, 5841 South Maryland Avenue M C 5053, Chicago, IL 60637, USA
    J Clin Endocrinol Metab 91:1275-83. 2006
    ..We determined the relationship of metabolic syndrome (MBS) to polycystic ovary syndrome (PCOS)...
  31. ncbi A workshop on pubertal hormone replacement options in the United States
    Stephanie Drobac
    Department of Pediatrics, University of Chicago, IL, USA
    J Pediatr Endocrinol Metab 19:55-64. 2006
    ..The optimal pubertal hormone replacement therapy in females and males is unclear...
  32. pmc KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women
    Xiaofei Du
    Section of Pediatric Endocrinology, 5839 South Maryland Avenue, MC 5053, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 94:2594-601. 2009
    ..We present evidence for KLF15 as a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene (HSD17B5) and its potential role in the pathogenesis of hyperandrogenism...
  33. ncbi Oestrogens and puberty
    Laura C Alonso
    Department of Medicine, Section of Endocrinology, The University of Chicago Hospitals, 5841 S Maryland Avenue, MC 1027, Chicago, IL 60637 1470, USA
    Best Pract Res Clin Endocrinol Metab 16:13-30. 2002
    ..Girls deficient in oestrogen should receive replacement in physiological doses. Aromatase inhibitors and anti-oestrogens may prove to be useful therapeutic tools in some types of abnormal puberty...
  34. ncbi Molecular genetic and endocrine mechanisms of hair growth
    Laura C Alonso
    The Rockefeller University, New York, NY, USA
    Horm Res 60:1-13. 2003
    ..Advances in research on the interaction of hormone target genes with the biological processes involved in hair morphogenesis and cycling can be expected to improve management of hirsutism and alopecia...
  35. ncbi Perspectives on the endocrine society clinical practice guideline for the evaluation and treatment of women with hirsutism
    Robert L Rosenfield
    Endokrynol Pol 59:254-5. 2008
  36. ncbi The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women
    Robert L Rosenfield
    J Clin Endocrinol Metab 88:6115; author reply 6115-6. 2003
  37. ncbi Serum cortisol and 17-hydroxyprogesterone concentrations in children with classic congenital adrenal hyperplasia
    Robert L Rosenfield
    J Clin Endocrinol Metab 87:2993; author reply 2993. 2002
  38. ncbi KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans
    Balasubramanian Bhagavath
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Hum Reprod 13:165-70. 2007
    ..7%). All four mutations were in anosmic/hyposmic men making the prevalence 4/63 (6.3%) in this group of patients. No mutations were found in the 29 female patients. KAL1 mutations are an uncommon cause of Kallmann syndrome...
  39. doi Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline
    Kathryn A Martin
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1105-20. 2008
    ..Our objective was to develop clinical practice guidelines for the evaluation and treatment of hirsutism in premenopausal women...

Research Grants31

  1. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ....
  2. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
  3. Pediatric Endocrinology Research Training Grant
    Robert Rosenfield; Fiscal Year: 2007
    ..abstract_text> ..
  4. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1991
    ..Human sexual hairs and fibroblasts, rat vibrissae, and rat preputial glands will be studied using tissue and organ culture. Androgen metabolism and androgen receptor sites will be studied in these cultured PSA cells...
  5. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 1980
    ..The hypothesis that LH is insensitive to modest decrements of plasma testosterone will be tested by acutely lowering plasma testosterone levels in normal volunteers with aminoglutethimide...