Research Topics
| Philip J RosenfeldSummaryAffiliation: University of Miami Country: USA Publications
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Publications
Photodynamic therapy with verteporfin in ocular histoplasmosis: uncontrolled, open-label 2-year studyPhilip J Rosenfeld
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, FL 33136, USA
Ophthalmology 111:1725-33. 2004....
Ranibizumab for neovascular age-related macular degenerationPhilip J Rosenfeld
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
N Engl J Med 355:1419-31. 2006..Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration...
Ranibizumab: Phase III clinical trial resultsPhilip J Rosenfeld
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
Ophthalmol Clin North Am 19:361-72. 2006..At that time, the major dilemma facing most retina specialists will be whether to use intravitreal ranibizumab or intravitreal bevacizumab, the low cost alternative, for the treatment of neovascular AMD...
Tolerability and efficacy of multiple escalating doses of ranibizumab (Lucentis) for neovascular age-related macular degenerationPhilip J Rosenfeld
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida 33136, USA
Ophthalmology 113:623.e1. 2006....
Verteporfin therapy of subfoveal occult choroidal neovascularization in AMD using delayed light application: one-year results of the VALIO StudyPhilip J Rosenfeld
Bascom Palmer Eye Institute, Miami, FL, USA
Am J Ophthalmol 144:970-972. 2007..To compare photodynamic therapy (PDT) with verteporfin (Visudyne; Novartis Pharma AG, Basel, Switzerland) using either standard or delayed light application...
Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degenerationPhilip J Rosenfeld
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
Ophthalmology 112:1048-53. 2005..To investigate the maximum tolerated dose of ranibizumab administered as a single intravitreal injection...
Characteristics of patients losing vision after 2 years of monthly dosing in the phase III ranibizumab clinical trialsPhilip J Rosenfeld
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmology 118:523-30. 2011..To investigate the cause of visual acuity (VA) loss in patients with neovascular age-related macular degeneration (AMD) receiving monthly ranibizumab injections in the pivotal ranibizumab phase III trials...
Cataract surgery in ranibizumab-treated patients with neovascular age-related macular degeneration from the phase 3 ANCHOR and MARINA trialsPhilip J Rosenfeld
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Am J Ophthalmol 152:793-8. 2011....
A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO StudyGeeta A Lalwani
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Am J Ophthalmol 148:43-58.e1. 2009....
Short-term safety and efficacy of intravitreal bevacizumab (Avastin) for neovascular age-related macular degenerationRyan M Rich
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33136, USA
Retina 26:495-511. 2006..While the long-term safety and efficacy of intravitreal bevacizumab remain unknown, these short-term results suggest that intravitreal bevacizumab may be the most cost effective therapy for the treatment of neovascular ARMD...
Long-term safety and efficacy of intravitreal bevacizumab (Avastin) for the management of central retinal vein occlusionNinel Z Gregori
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th St, Miami, FL 33136, USA
Retina 28:1325-37. 2008..To evaluate the long-term safety and efficacy of intravitreal bevacizumab injections (Avastin, Genentech Inc., San Francisco, CA) for the treatment of macular edema secondary to central retinal vein occlusions...
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: twenty-four-week results of an uncontrolled open-label clinical studyAndrew A Moshfeghi
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmology 113:2002.e1-12. 2006....
Safety and efficacy of intravitreal bevacizumab (avastin) for the management of branch and hemiretinal vein occlusionNinel Z Gregori
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Retina 29:913-25. 2009..To evaluate the safety and efficacy of intravitreal bevacizumab (Avastin, Genentech) for the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO) and hemiretinal vein occlusion (HRVO)...
One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusionNinel Z Gregori
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Retina 26:889-95. 2006..CONCLUSION: IVTA can substantially improve vision in some patients, but most patients have stable visual acuity compared with baseline at 1 year despite repeated injections...
Endophthalmitis after intravitreal vascular [corrected] endothelial growth factor antagonists: a six-year experience at a university referral centerAndrew A Moshfeghi
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33418, USA
Retina 31:662-8. 2011....
Quantitative imaging of retinal pigment epithelial detachments using spectral-domain optical coherence tomographyFernando M Penha
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Florida, USA
Am J Ophthalmol 153:515-23. 2012....
Comparison of intravitreal bevacizumab followed by ranibizumab for the treatment of neovascular age-related macular degenerationKimberly E Stepien
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Retina 29:1067-73. 2009..To compare outcomes after switching from intravitreal bevacizumab (Avastin) to ranibizumab (Lucentis) in patients with neovascular age-related macular degeneration (AMD)...
Spectral domain optical coherence tomographic imaging of geographic atrophyBrandon J Lujan
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmic Surg Lasers Imaging 40:96-101. 2009..To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF)...
Spectral domain optical coherence tomography imaging of drusen in nonexudative age-related macular degenerationGiovanni Gregori
Bascom Palmer Eye Institute, Miami, FL, USA
Ophthalmology 118:1373-9. 2011..To measure drusen area and volume in eyes with nonexudative age-related macular degeneration (AMD) using spectral domain optical coherence tomography imaging (SD-OCT)...
Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye)Michael W Stewart
Department of Ophthalmology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
Retina 32:434-57. 2012..Pharmacokinetic modeling was performed to determine if more frequent dosing with anti-VEGF drugs could be theoretically beneficial...
Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusionPhilip J Rosenfeld
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida, USA
Ophthalmic Surg Lasers Imaging 36:336-9. 2005..The improvements were maintained for at least 4 weeks. Intravitreal injections of bevacizumab may provide another treatment option for patients with macular edema from vein occlusions...
Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degenerationPhilip J Rosenfeld
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida, USA
Ophthalmic Surg Lasers Imaging 36:331-5. 2005..An intravitreal injection of bevacizumab may provide an effective, safe, and inexpensive option for patients with age-related macular degeneration who are losing vision secondary to macular neovascularization...
Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomographyZohar Yehoshua
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmology 118:2434-41. 2011..To characterize the natural history of drusen using spectral-domain optical coherence tomography (SD-OCT) imaging of eyes from patients with nonexudative age-related macular degeneration (AMD)...
Imaging serpiginous choroidopathy with spectral domain optical coherence tomographyOmar S Punjabi
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
Ophthalmic Surg Lasers Imaging 39:S95-8. 2008..The researchers concluded that SD-OCT is a useful tool to study disease morphology and follow-up of chronic serpiginous choroiditis...
Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomographyZohar Yehoshua
Bascom Palmer Eye Institute, Department of Ophthalmology, Universityof Miami Miller School of Medicine, Miami, Florida, USA
Ophthalmology 118:679-86. 2011..To determine the area and enlargement rate (ER) of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) using the spectral domain optical coherence tomography (SD-OCT) fundus image...
Antiangiogenic therapy in neovascular age-related macular degenerationRichard C Lin
Bascom Palmer Eye Institute, University of Miami School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA
Int Ophthalmol Clin 47:117-37. 2007
Registration of OCT fundus images with color fundus photographs based on blood vessel ridgesYing Li
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Opt Express 19:7-16. 2011..The average root mean square errors for the affine model are 31 µm (normal) and 59 µm (eyes with disease). The proposed algorithm can be easily adapted to registration for other modality retinal images...
Spectral domain optical coherence tomography characteristics of cuticular drusenTheodore Leng
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Retina 29:988-93. 2009..To evaluate the appearance of cuticular drusen with spectral domain optical coherence tomography...
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical studyStephan Michels
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
Ophthalmology 112:1035-47. 2005..Although these preliminary results are promising, a randomized controlled clinical trial is necessary before concluding that systemic bevacizumab therapy is safe and effective for patients with neovascular AMD...
Bevacizumab (avastin) therapy for idiopathic macular telangiectasia type IIJaclyn L Kovach
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
Retina 29:27-32. 2009....
Verteporfin photodynamic therapy of choroidal neovascularization secondary to ocular toxoplasmosisRobert Wirthlin
Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33101, USA
Arch Ophthalmol 124:741-3. 2006
Strategies for following dry age-related macular degenerationZohar Yehoshua
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Fla 33136, USA
Ophthalmic Res 48:6-10. 2012....
Automatic montage of SD-OCT data setsYing Li
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Opt Express 19:26239-48. 2011..The results for 3 normal eyes and 3 eyes with retinal degeneration are analyzed, showing registration errors of 1.5±0.3 and 2.0±0.8 pixels respectively...
Avastin doesn't blind people, people blind peopleSerafin Gonzalez
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Am J Ophthalmol 153:196-203.e1. 2012..To review the appropriate preparation of bevacizumab for intravitreal injection by compounding pharmacies with specific recommendations designed to prevent microbial contamination...
Calibration of fundus images using spectral domain optical coherence tomographyBrandon J Lujan
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Ophthalmic Surg Lasers Imaging 39:S15-20. 2008..However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image...
Intravitreal triamcinolone acetonide for idiopathic cystoid macular edemaIngrid U Scott
Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA
Am J Ophthalmol 136:737-9. 2003..To report intravitreal triamcinolone acetonide for idiopathic cystoid macular edema (ICME)...
Spectral domain optical coherence tomography imaging of dry age-related macular degenerationZohar Yehoshua
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th St, Miami, FL 33136, USA
Ophthalmic Surg Lasers Imaging 41:S6-S14. 2010..This unique feature of spectral domain optical coherence tomography makes it the ideal imaging modality for clinical trials designed to assess new drugs for the treatment of dry AMD...
Novel method for analyzing snellen visual acuity measurementsNinel Z Gregori
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Retina 30:1046-50. 2010..A more intuitive approach is presented here which uses the conversion of Snellen visual acuity fractions to Early Treatment Diabetic Retinopathy Study (ETDRS) letter scores for statistical manipulations...
Geometric deformable model driven by CoCRFs: application to optical coherence tomographyGabriel Tsechpenakis
Dept of Electrical and Computer Engineering, University of Miami, USA
Med Image Comput Comput Assist Interv 11:883-91. 2008..We apply our method to Optical Coherence Tomography fundus images for the segmentation of geographic atrophies in dry age-related macular degeneration of the human eye...
Current Clinical Trials in Dry AMD and the Definition of Appropriate Clinical Outcome MeasuresZohar Yehoshua
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Semin Ophthalmol 26:167-80. 2011..Studies have identified genetic predispositions for dry AMD associated with complement dysfunction. Consequently, complement-based therapeutic treatment modalities are promising...
Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration: three-year results of an open-label extension of 2 randomized clinical trials--TAP Report no. 5Mark S Blumenkranz
Arch Ophthalmol 120:1307-14. 2002..Caution appears warranted in the absence of comparison with an untreated group during the extension and since not all patients in the TAP Investigation participated in the TAP Extension...
New treatments for age-related macular degenerationPhilip J Rosenfeld
Lancet 370:1479; author reply 1480. 2007
Effect of lesion size, visual acuity, and lesion composition on visual acuity change with and without verteporfin therapy for choroidal neovascularization secondary to age-related macular degeneration: TAP and VIP report no. 1Keven J Blinder
Am J Ophthalmol 136:407-18. 2003....
Medical consequences of stopping anticoagulant therapy before intraocular surgery or intravitreal injectionsSteve Charles
Retina 27:813-5. 2007
Acute severe visual acuity decrease after photodynamic therapy with verteporfin: case reports from randomized clinical trials-TAP and VIP report no. 3Jennifer J Arnold
Am J Ophthalmol 137:683-96. 2004..When considering verteporfin therapy, patients should be warned of the possibility of this serious adverse event...
Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin in the ocular histoplasmosis syndrome: one-year results of an uncontrolled, prospective case seriesDavid A Saperstein
Ophthalmology 109:1499-505. 2002..Two-year data from this study will provide important, additional information on the safety and effect of verteporfin therapy for the treatment of subfoveal CNV secondary to OHS...
Intravitreal avastin: the low cost alternative to lucentis?Philip J Rosenfeld
Am J Ophthalmol 142:141-3. 2006
Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: meta-analysis of 2-year safety results in three randomized clinical trials: Treatment Of Age-Related Macular Degeneration With Photodynamic Therapy and VertMohammad Azab
Retina 24:1-12. 2004..This detailed safety profile of verteporfin therapy clarifies the adverse reaction information in the current verteporfin product prescription information...
An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degenerationAnne E Fung
Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
Am J Ophthalmol 143:566-83. 2007..To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD)...
Verteporfin therapy for CNV secondary to OHSDavid A Saperstein
Ophthalmology 113:2371.e1-3. 2006
Verteporfin therapy of subfoveal minimally classic choroidal neovascularization in age-related macular degeneration: 2-year results of a randomized clinical trialMohammad Azab
Arch Ophthalmol 123:448-57. 2005....
Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration: four-year results of an open-label extension of 2 randomized clinical trials: TAP Report No. 7Neil M Bressler
Arch Ophthalmol 123:1283-5. 2005
Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose studyJeffrey S Heier
Ophthalmic Consultants of Boston, Boston, Massachusetts 02114, USA
Ophthalmology 113:642.e1-4. 2006..CONCLUSIONS: Repeated intravitreal injections of ranibizumab had a good safety profile and were associated with improved VA and decreased leakage from choroidal neovascularization in subjects with neovascular AMD...
Promising new treatments for neovascular age-related macular degenerationStephan Michels
Klinik für Augenheilkunde und Optometrie, Medizinische Universität Wien, Wahringer Gurtel 18 20, Allgemeines Krankenhaus 8i, 1090 Wien Vienna, Austria
Expert Opin Investig Drugs 15:779-93. 2006..This review provides an overview on angiogenic mechanisms, potential antiangiogenic treatment strategies and different antiangiogenic drugs with special focus on neovascular AMD...
Verteporfin in Photodynamic Therapy: report no. 5Francesco Bandello
Ophthalmology 111:2144. 2004
Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regionsDaniel E Weeks
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
Am J Hum Genet 75:174-89. 2004..The OSAs generate the interesting hypothesis that the effect of smoking on the risk of ARM is accentuated by a gene in the 10q26 region--a region implicated by four other studies...
