Michael Rosenfeld

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
    Michael G Rosenfeld
    Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Genes Dev 20:1405-28. 2006
  2. pmc Evidence for vestibular regulation of autonomic functions in a mouse genetic model
    Dean M Murakami
    Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95619 8519, USA
    Proc Natl Acad Sci U S A 99:17078-82. 2002
  3. pmc Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis
    J S Dasen
    Howard Hughes Medical Institute, School and Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    Genes Dev 15:3193-207. 2001
  4. ncbi request reprint Hedgehog signaling is required for pituitary gland development
    M Treier
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, CMMW, Room 345, La Jolla, CA 92093 0648, USA
    Development 128:377-86. 2001
  5. ncbi request reprint Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
    C R Lin
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 401:279-82. 1999
  6. pmc Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators
    T M Sugihara
    Division of Endocrinology and Metabolism, Department and School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 95:15418-23. 1998
  7. ncbi request reprint Pitx2 determines left-right asymmetry of internal organs in vertebrates
    A K Ryan
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 394:545-51. 1998
  8. pmc P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1
    I Bach
    Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Proc Natl Acad Sci U S A 92:2720-4. 1995
  9. ncbi request reprint Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid
    E E Turner
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego
    Neuron 12:205-18. 1994
  10. ncbi request reprint Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types
    J S Dasen
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla 92093 0648, USA
    Cell 97:587-98. 1999

Research Grants

  1. Genomic and Epigenetic Approaches to Cardiovascular Development and Disease
    Michael G Rosenfeld; Fiscal Year: 2011
  2. Genome-wide location analysis of neuronal genes
    Michael Rosenfeld; Fiscal Year: 2007
  3. BRAIN SPECIFIC REGULATORY FACTORS
    Michael Rosenfeld; Fiscal Year: 2007
  4. MOLECULAR MECHANISMS OF AORTIC AND PULMONARY DEFECTS
    Michael Rosenfeld; Fiscal Year: 2004
  5. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael Rosenfeld; Fiscal Year: 2005
  6. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael G Rosenfeld; Fiscal Year: 2010
  7. Repressors in Prostate Cancer
    Michael G Rosenfeld; Fiscal Year: 2011
  8. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael G Rosenfeld; Fiscal Year: 2010
  9. Genomic Approaches to Cardiovascular Development
    Michael Rosenfeld; Fiscal Year: 2009
  10. HORMONAL AND CAMP REGULATION OF PROTEIN SYNTHESIS
    Michael Rosenfeld; Fiscal Year: 1990

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
    Michael G Rosenfeld
    Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Genes Dev 20:1405-28. 2006
    ..This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events...
  2. pmc Evidence for vestibular regulation of autonomic functions in a mouse genetic model
    Dean M Murakami
    Section of Neurobiology, Physiology, and Behavior, University of California, Davis, CA 95619 8519, USA
    Proc Natl Acad Sci U S A 99:17078-82. 2002
    ....
  3. pmc Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis
    J S Dasen
    Howard Hughes Medical Institute, School and Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    Genes Dev 15:3193-207. 2001
    ....
  4. ncbi request reprint Hedgehog signaling is required for pituitary gland development
    M Treier
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, CMMW, Room 345, La Jolla, CA 92093 0648, USA
    Development 128:377-86. 2001
    ..Thus, SHH appears to exert effects on both proliferation and cell-type determination in pituitary gland development...
  5. ncbi request reprint Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
    C R Lin
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 401:279-82. 1999
    ..Thus, Pitx2 is a transcription factor that encodes 'leftness' of the lung...
  6. pmc Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators
    T M Sugihara
    Division of Endocrinology and Metabolism, Department and School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 95:15418-23. 1998
    ....
  7. ncbi request reprint Pitx2 determines left-right asymmetry of internal organs in vertebrates
    A K Ryan
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 394:545-51. 1998
    ..Changes in Pitx2 expression are evident in mouse mutants with laterality defects. Thus, Pitx2 seems to serve as a critical downstream transcription target that mediates left-right asymmetry in vertebrates...
  8. pmc P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1
    I Bach
    Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Proc Natl Acad Sci U S A 92:2720-4. 1995
    ..The LIM domain of P-Lim specifically interacts with the Pit-1 POU domain and is required for synergistic interactions with Pit-1, but not for basal transcriptional activation events...
  9. ncbi request reprint Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid
    E E Turner
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego
    Neuron 12:205-18. 1994
    ..Our analysis suggests that in the CNS Brn-3.2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes...
  10. ncbi request reprint Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types
    J S Dasen
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla 92093 0648, USA
    Cell 97:587-98. 1999
    ....
  11. ncbi request reprint RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Nat Genet 22:394-9. 1999
    ..We conclude that Rlim is a novel corepressor that recruits histone deacetylase-containing complexes to the LIM domain...
  12. ncbi request reprint Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
    L Erkman
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Nature 381:603-6. 1996
    ..Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia...
  13. ncbi request reprint Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism
    M W Sornson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA
    Nature 384:327-33. 1996
    ..These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis...
  14. pmc Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs
    M R Gerrero
    Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, University of California, San Diego
    Proc Natl Acad Sci U S A 90:10841-5. 1993
    ..Brn-3.0, Brn-3.1, and the Drosophila tI-POU share an N-terminal region of homology, referred to as the "POU-IV box," which is similar to a conserved functional domain in the c-myc gene family...
  15. ncbi request reprint A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system
    L Erkman
    Howard Hughes Medical Institute and, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 28:779-92. 2000
    ..elegans homolog, UNC-115. Our findings provide insights into a Brn-3.2-directed hierarchical program linking signaling events to cytoskeletal changes required for axon pathfinding...
  16. pmc Multistep signaling requirements for pituitary organogenesis in vivo
    M Treier
    Howard Hughes Medical Institute, University of California, San Diego, School and Department of Medicine, La Jolla, California 92093 0648 USA
    Genes Dev 12:1691-704. 1998
    ....
  17. ncbi request reprint A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland
    Y Jiang
    Department of Medicine, Howard Hughes Medical Institute, La Jolla, California, USA
    J Biol Chem 271:10723-30. 1996
    ..Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs...
  18. pmc P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development
    D P Szeto
    Biomedical Sciences Graduate Program, Howard Hughes Medical Institute, University of California, San Diego 92093 0648, USA
    Proc Natl Acad Sci U S A 93:7706-10. 1996
    ..Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs...
  19. ncbi request reprint The hypothalamic-pituitary axis: co-development of two organs
    M Treier
    Howard Hughes Medical Institute, University of California at San Diego, Department and School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Curr Opin Cell Biol 8:833-43. 1996
    ..Recent data from gene-targeting experiments in mice further imply that the execution of this program is dependent on inductive signals originating in the floor of the diencephalon...
  20. ncbi request reprint A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Genes Dev 11:1370-80. 1997
    ..Our results link LIM homeodomain proteins and members of the Otx class of transcription factors in gene activation events during embryogenesis via the actions of specific cofactors...
  21. ncbi request reprint Signal-specific co-activator domain requirements for Pit-1 activation
    L Xu
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0648, USA
    Nature 395:301-6. 1998
    ..These data show that there is a switch in specific requirements for histone acetyltransferases and CBP domains in mediating the effects of different signal-transduction pathways on specific DNA-bound transcription factors...
  22. ncbi request reprint Combinatorial codes in signaling and synergy: lessons from pituitary development
    J S Dasen
    Howard Hughes Medical Institute Cellular and Molecular Medicine University of California San Diego, Department and School of Medicine La Jolla, California, 92093 0648, USA
    Curr Opin Genet Dev 9:566-74. 1999
    ....
  23. ncbi request reprint The Ames dwarf gene is required for Pit-1 gene activation
    B Andersen
    Howard Hughes Medical Institute, School and Department of Medicine, University of California, San Diego, La Jolla 92093 0648, USA
    Dev Biol 172:495-503. 1995
    ..This suggests that the df gene is required for activation of the Pit-1 gene and provides evidence for a hierarchy of tissue-specific factors required for cellular commitment in the anterior pituitary gland...
  24. ncbi request reprint Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth
    C Lin
    Eukaryotic Regulatory Biology Program, University of California, San Diego
    Nature 360:765-8. 1992
    ..The pituitary hypoplasia in these mice thus appears to be due, at least in part, to the absence of GRF receptor, which is in turn due to the absence of functional Pit-1...
  25. doi request reprint Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation
    R Gherzi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Cell Death Differ 17:975-83. 2010
    ..Upon Akt2-phosphorylation, the complex Pitx2/HuR/Ccnd1 mRNA dissociates and Ccnd1 mRNA is destabilized. These events contribute to the switch of C2C12 cells from a proliferating to a differentiating phenotype...
  26. ncbi request reprint Regulation of neuronal traits by a novel transcriptional complex
    N Ballas
    Howard Hughes Medical Institute, State University of New York, Stony Brook, 11794, USA
    Neuron 31:353-65. 2001
    ..Collectively, these studies define a novel HDAC complex that is recruited by the C-terminal repressor domain of REST to actively repress genes essential to the neuronal phenotype...
  27. ncbi request reprint Signaling and transcriptional mechanisms in pituitary development
    J S Dasen
    Howard Hughes Medical Institute, Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0648, USA
    Annu Rev Neurosci 24:327-55. 2001
    ....
  28. pmc Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell
    B Andersen
    Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648
    Proc Natl Acad Sci U S A 90:11084-8. 1993
    ..These data suggest that the Sprm-1 gene encodes a DNA-binding protein that may exert a regulatory function in meiotic events that are required for terminal differentiation of the male germ cell...
  29. ncbi request reprint POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease
    B Andersen
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Endocr Rev 22:2-35. 2001
    ....
  30. ncbi request reprint Signaling mechanisms in pituitary morphogenesis and cell fate determination
    J S Dasen
    Howard Hughes Medical Institute, Cellular and Molecular Medicine, University of California, San Diego, CA, USA
    Curr Opin Cell Biol 11:669-77. 1999
    ....
  31. ncbi request reprint Body's left side
    C Kioussi
    Howard Hughes Medical Institute, Cellular and Molecular Medicine, University of California San Diego, School and Department of Medicine, La Jolla 92093 0648, USA
    Cell Mol Biol (Noisy-le-grand) 45:517-22. 1999
    ..While the precise mechanisms by which genetically linked factors exert their effects still remains incompletely defined, an outline of those events can be deduced...
  32. ncbi request reprint Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta
    M Wegner
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648
    Science 256:370-3. 1992
    ..Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta...
  33. ncbi request reprint Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification
    K M Scully
    Howard Hughes Medical Institute, Department of Endocrinology and Metabolism, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Science 290:1127-31. 2000
    ....
  34. pmc Tbx19, a tissue-selective regulator of POMC gene expression
    J Liu
    Howard Hughes Medical Institute, School and Department of Medicine, University of California at San Diego, 9500 Gilman Drive, Cellular and Molecular Medicine West, Room 345, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 98:8674-9. 2001
    ..It is suggested that Tbx19, depending on the presence of synergizing transcription factors, can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters...
  35. ncbi request reprint Pitx genes during cardiovascular development
    C Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093, USA
    Cold Spring Harb Symp Quant Biol 67:81-7. 2002
  36. pmc Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
    C Kioussi
    Howard Hughes Medical Institute, University of California San Diego, School, Department of Medicine, 9500 Gilman Drive, Cellular and Molecular Medicine Room 345, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 96:14378-82. 1999
    ..We suggest that the transient dorsal expression of Pax6 is essential for establishing a sharp boundary between dorsal and ventral cell types, based on the inhibition of Shh ventral signals...
  37. ncbi request reprint Mutations in PROP1 cause familial combined pituitary hormone deficiency
    W Wu
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0648, USA
    Nat Genet 18:147-9. 1998
    ..Our results identify a major cause of CPHD in humans and suggest a direct or indirect role for PROP1 in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes...
  38. ncbi request reprint RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
    V C Yu
    Eukaryotic Regulatory Biology Program, University of California, San Diego
    Cell 67:1251-66. 1991
    ....
  39. ncbi request reprint Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression
    S M Lipkin
    Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093 0648
    Genes Dev 7:1674-87. 1993
    ....
  40. ncbi request reprint Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors
    P Li
    Howard Hughes Medical Institute, University of California, School of Medicine, San Diego
    Genes Dev 7:2483-96. 1993
    ..Similar mechanisms may underlie differential flexibility in spacing and orientation for diverse families of transcription factors...
  41. ncbi request reprint Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
    C P Chang
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648
    Neuron 11:1187-95. 1993
    ..Alternative splicing events generate a second, relatively abundant gene product expressed in a distinct ontogenic pattern. These findings serve to identify the receptor for an important neuropeptide...
  42. pmc Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression
    J M Mathis
    Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093 0648
    EMBO J 11:2551-61. 1992
    ....
  43. ncbi request reprint Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
    R J McEvilly
    Howard Hughes Medical Institute, University of California, San Diego, USA
    Nature 384:574-7. 1996
    ..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations...
  44. ncbi request reprint The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers
    G E DiMattia
    Howard Hughes Medical Institute, Department and School of Medicine, University of California at San Diego, La Jolla 92093 0648, USA
    Dev Biol 182:180-90. 1997
    ....
  45. ncbi request reprint A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
    T Heinzel
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 387:43-8. 1997
    ....
  46. ncbi request reprint Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope
    S C Lin
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648
    Development 120:515-22. 1994
    ..These data suggest that different molecular mechanisms, based on the actions of distinct transcription factors, can serve to independently generate a specific cell phenotype during mammalian organogenesis...
  47. ncbi request reprint Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis
    B Andersen
    Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, University of California School of Medicine, San Diego, La Jolla 92093
    Science 260:78-82. 1993
    ..The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development...
  48. ncbi request reprint TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins
    D W Drolet
    Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093 0648
    Genes Dev 5:1739-53. 1991
    ..These data are consistent with a role for a member of a new class of bZIP transcription factors in activating gene expression in the developing thyrotroph...
  49. pmc Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
    J Llopis
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 97:4363-8. 2000
    ..These findings suggest that ligand-dependent transcriptional activities of the RAR and ER require concurrent or sequential recruitment of SRC-1 and PBP-containing coactivator complexes...
  50. ncbi request reprint Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..Both respond with increased edema formation in response to thermal exposure, however, indicating that in contrast to its central role in anxiety, the peripheral role of Crhr2 in vascular permeability is independent of gender...
  51. ncbi request reprint Molecular basis of the little mouse phenotype and implications for cell type-specific growth
    S C Lin
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093 0648
    Nature 364:208-13. 1993
    ..This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs...
  52. pmc Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0
    X He
    Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093 0648
    Mol Cell Biol 11:1739-44. 1991
    ..In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB...
  53. ncbi request reprint Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2
    M D Schonemann
    Eukaryotic Regulatory Biology Program, Howard Hughes Medical Institute, University of California, San Diego, USA
    Genes Dev 9:3122-35. 1995
    ....
  54. ncbi request reprint A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
    ....
  55. ncbi request reprint The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
    J Torchia
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 387:677-84. 1997
    ..p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways...
  56. ncbi request reprint Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation
    B Andersen
    Department of Medicine, University of California, San Diego, La Jolla 92037 0648, USA
    Genes Dev 11:1873-84. 1997
    ..Therefore, at least two POU domain genes, Skn-1a/i and Tst-1, serve both distinct and overlapping functions to regulate differentiation of epidermal keratinocytes during normal development and wound healing...
  57. ncbi request reprint Transcription factor-specific requirements for coactivators and their acetyltransferase functions
    E Korzus
    Howard Hughes Medical Institute, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Science 279:703-7. 1998
    ....
  58. ncbi request reprint Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors
    D M Simmons
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, La Jolla 92093 0613
    Genes Dev 4:695-711. 1990
    ....
  59. ncbi request reprint Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration
    J R Bermingham
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Genes Dev 10:1751-62. 1996
    ..In addition, aberrant differentiation and migration of specific neurons in Tst-1/Oct-6/SCIP mutant homozygotes is associated with a fatal breathing defect, providing a model for investigating the regulation of pulmonary homeostasis...
  60. ncbi request reprint Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1
    S Li
    Department of Chemistry, University of California, San Diego, La Jolla 92093
    Nature 347:528-33. 1990
    ..The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis...
  61. pmc Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
    R M Lavinsky
    Howard Hughes Medical Institute, Department and School of Medicine, University of California at San Diego, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 95:2920-5. 1998
    ..Our data suggest that N-CoR- and SMRT-containing complexes act as rate-limiting components in the actions of specific nuclear receptors, and that their actions are regulated by multiple signal transduction pathways...
  62. ncbi request reprint Combinatorial roles of the nuclear receptor corepressor in transcription and development
    K Jepsen
    Howard Hughes Medical Institute, Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 102:753-63. 2000
    ..Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems...
  63. ncbi request reprint A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene
    S J Rhodes
    Eukaryotic Regulatory Biology Program, University of California, San Diego
    Genes Dev 7:913-32. 1993
    ....
  64. ncbi request reprint A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
    H A Ingraham
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093
    Cell 55:519-29. 1988
    ..The structure of Pit-1 and its recognition elements suggests that metazoan tissue phenotype is controlled by a family of transcription factors that bind to related cis-active elements and contain several highly conserved domains...
  65. pmc Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
    Ivan Garcia-Bassets
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:505-18. 2007
    ..These events link an inhibitory methylation component of the histone code to a broadly used strategy that circumvents pathological constitutive gene induction by physiologically regulated transcription factors...
  66. pmc Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters
    Young Soo Kwon
    Department of Cellular and Molecular Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093 0651, USA
    Proc Natl Acad Sci U S A 104:4852-7. 2007
    ..This study demonstrates the power of the ChIP-DSL technology in revealing regulatory gene expression programs that have been previously invisible in the human genome...
  67. pmc Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma
    Serena Ghisletti
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 25:57-70. 2007
    ..These studies define parallel but functionally distinct pathways that are utilized by PPARgamma and LXRs to differentially regulate complex programs of gene expression that control immunity and homeostasis...
  68. pmc Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis
    Xiaoyan Zhu
    Howard Hughes Medical Institute, Department and School of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 20:2739-53. 2006
    ....
  69. ncbi request reprint Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system
    Kevin T Bush
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, and Urological Diseases Research Center, Department of Urology, Children s Hospital, Boston, MA 02115, USA
    Dev Biol 298:571-84. 2006
    ....
  70. ncbi request reprint A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription
    Bong Gun Ju
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0648, USA
    Science 312:1798-802. 2006
    ..Our data mechanistically link DNA topoisomerase IIbeta-dependent dsDNA breaks and the components of the DNA damage and repair machinery in regulated gene transcription...
  71. pmc TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
    Valentina Perissi
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 29:755-66. 2008
    ..Thus, our data reveal a strategy of dual-factor repression checkpoints, in which dedicated exchange factors serve as sensors for signal-specific dismissal of distinct corepressors, with specificity imposed by upstream signaling pathways...
  72. ncbi request reprint Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression
    Kazuhito Toyo-oka
    Department of Pediatrics, University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA
    Cancer Res 66:5565-73. 2006
    ..These results reveal an important role for Mnt in pregnancy-associated mammary gland development and suggest that mammary gland tumorigenesis in the absence of Mnt is analogous to that caused by Myc deregulation...
  73. ncbi request reprint Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination
    Lorin E Olson
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 125:593-605. 2006
    ....
  74. ncbi request reprint Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance
    Zhiyong Wang
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell Metab 3:111-22. 2006
    ..They exhibit increased basal metabolic rates and heightened levels of physical activity. Therefore, p/CIP and SRC-1 play critical roles in energy balance by controlling both energy intake and energy expenditure...
  75. pmc Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Cell 122:707-21. 2005
    ..These findings reveal combinatorial control of homeostasis and immune responses by nuclear receptors and suggest new approaches for treatment of inflammatory diseases...
  76. pmc Expression of nestin-green fluorescent protein transgene marks oval cells in the adult liver
    Anatoli S Gleiberman
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0648, USA
    Dev Dyn 234:413-21. 2005
    ..Our results suggest that nestin-GFP cells in the liver correspond to a specialized cell type whose primary function may be to serve as a reserve for adult liver epithelial cell types...
  77. pmc A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 437:759-63. 2005
    ..This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-kappaB target genes that regulate immunity and homeostasis...
  78. ncbi request reprint Controlling nuclear receptors: the circular logic of cofactor cycles
    Valentina Perissi
    Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Mol Cell Biol 6:542-54. 2005
    ....
  79. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..Our findings demonstrate that beta-catenin signaling regulates proliferation and survival of cardiac progenitors...
  80. doi request reprint Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
    Juhee Jeong
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Development 135:2905-16. 2008
    ..We propose a new model for Dlx-mediated mammalian jaw patterning...
  81. doi request reprint Epigenetic regulation of stem cell fate
    Victoria V Lunyak
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
    Hum Mol Genet 17:R28-36. 2008
    ..In this review, we discuss the impact of the epigenetic research on our understanding of stem cell biology...
  82. pmc Genetic approaches identify adult pituitary stem cells
    Anatoli S Gleiberman
    Howard Hughes Medical Institute, Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 105:6332-7. 2008
    ..These parallel but distinct lineages of differentiated cells in the gland may help the maturing organism adapt to changes in the metabolic regulatory landscape...
  83. pmc Cooperative regulation in development by SMRT and FOXP1
    Kristen Jepsen
    Department of Medicine, Howard Hughes Medical Institute, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA
    Genes Dev 22:740-5. 2008
    ..Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor...
  84. pmc Atbf1 is required for the Pit1 gene early activation
    Yingchuan Qi
    Howard Hughes Medical Institute and Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:2481-6. 2008
    ..A transcription factor belonging to the "giant, multiple-homeodomain and zinc finger family," Atbf1, serves as a novel pituitary regulator for one of the two required enhancers as shown by genetic and in vitro analysis...
  85. pmc Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
    Wenlai Zhou
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 29:69-80. 2008
    ..We suggest that distinct H2A ubiquitinases, each recruited based on interactions with different corepressor complexes, contribute to distinct transcriptional repression programs...
  86. pmc Signaling and epigenetic regulation of pituitary development
    Xiaoyan Zhu
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Curr Opin Cell Biol 19:605-11. 2007
    ..Epigenetic studies of the transcriptional events in terminal differentiation process have provided insights into the functions of non-coding RNA and developmentally regulated chromatin organization...
  87. ncbi request reprint SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
    Kristen Jepsen
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 450:415-9. 2007
    ....
  88. ncbi request reprint Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2
    Wenlai Zhou
    Howard Hughes Medical Institute and Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Nat Genet 39:1225-34. 2007
    ..Thus, we propose that transcriptional readout mediated at least in part by a Wnt11 --> ATF/CREB --> TGFbeta2 pathway is critical in regulating morphogenesis in response to noncanonical Wnt signaling...
  89. pmc A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
    Ping Zhu
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 27:609-21. 2007
    ....
  90. ncbi request reprint Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis
    Victoria V Lunyak
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 317:248-51. 2007
    ..These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation...
  91. ncbi request reprint Molecular physiology of pituitary development: signaling and transcriptional networks
    Xiaoyan Zhu
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Physiol Rev 87:933-63. 2007
    ....
  92. pmc Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis
    Ran Xiao
    Department of Surgery Urology, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Mol Cell Biol 27:5393-402. 2007
    ..These findings reveal the involvement of SC35 in specific pathways in regulating cell proliferation and genomic stability during mammalian organogenesis and suggest its potential function in tumorigenesis...
  93. ncbi request reprint Opposing LSD1 complexes function in developmental gene activation and repression programmes
    Jianxun Wang
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 446:882-7. 2007
    ..These findings suggest that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs...
  94. ncbi request reprint No rest for REST: REST/NRSF regulation of neurogenesis
    Victoria V Lunyak
    Cell 121:499-501. 2005
    ..This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors...
  95. pmc Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
    Sung Hee Baek
    Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 100:3245-50. 2003
    ....
  96. ncbi request reprint Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
    Chrissa Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 111:673-85. 2002
    ....
  97. ncbi request reprint Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve
    John R Bermingham
    McLaughlin Research Institute, Great Falls, Montana 59405, USA
    J Neurosci 22:10217-31. 2002
    ..Our results suggest that pou3f1 functions to activate gene expression in the differentiation of myelinating Schwann cells...
  98. ncbi request reprint Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase
    Vivek Kumar
    Department of Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 10:857-69. 2002
    ..Together, our data suggest that CtBP is an NAD(+)-regulated component of critical complexes for specific repression events in cells...
  99. ncbi request reprint N-CoR controls differentiation of neural stem cells into astrocytes
    Ola Hermanson
    Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 419:934-9. 2002
    ..We propose that repression by N-CoR, modulated by opposing enzymatic activities, is a critical mechanism in neural stem cells that underlies the inhibition of glial differentiation...
  100. ncbi request reprint Corepressor-dependent silencing of chromosomal regions encoding neuronal genes
    Victoria V Lunyak
    Howard Hughes Medical Institute HHMI, Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 298:1747-52. 2002
    ....
  101. ncbi request reprint REST repression of neuronal genes requires components of the hSWI.SNF complex
    Elena Battaglioli
    Department of Neurobiology and Behavior, Howard Hughes Medical Institute, State University of New York, Stony Brook, NY 11794, USA
    J Biol Chem 277:41038-45. 2002
    ..Together, our data suggest that ATP-dependent chromatin remodeling, as well as histone deacetylation, is needed for REST-mediated repression...

Research Grants66

  1. Genomic and Epigenetic Approaches to Cardiovascular Development and Disease
    Michael G Rosenfeld; Fiscal Year: 2011
    ....
  2. Genome-wide location analysis of neuronal genes
    Michael Rosenfeld; Fiscal Year: 2007
    ..We believe that with validation of these approaches, technologies developed here will be of widespread utility in neuroscience, particularly in studies of development and neurodegenerative disease. ..
  3. BRAIN SPECIFIC REGULATORY FACTORS
    Michael Rosenfeld; Fiscal Year: 2007
    ..These studies will provide insights into the molecular mechanisms underlying control of gene transcription that are required for maintaining the neural stem cell state and for establishing specific neuronal phenotypes. ..
  4. MOLECULAR MECHANISMS OF AORTIC AND PULMONARY DEFECTS
    Michael Rosenfeld; Fiscal Year: 2004
    ..The possible role of environmental and regulatory factors in the animal model can therefore be studied, based on the modulation or alteration of these pathways. ..
  5. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael Rosenfeld; Fiscal Year: 2005
    ..abstract_text> ..
  6. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael G Rosenfeld; Fiscal Year: 2010
    ....
  7. Repressors in Prostate Cancer
    Michael G Rosenfeld; Fiscal Year: 2011
    ..Together, understanding these unexpected specific regulatory strategies should provide a series of leads for new therapeutic approaches to clinical resistance in prostate cancer. ..
  8. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael G Rosenfeld; Fiscal Year: 2010
    ....
  9. Genomic Approaches to Cardiovascular Development
    Michael Rosenfeld; Fiscal Year: 2009
    ..These studies are likely to have direct implications for several human cardiovascular defects and diseases. ..
  10. HORMONAL AND CAMP REGULATION OF PROTEIN SYNTHESIS
    Michael Rosenfeld; Fiscal Year: 1990
    ....
  11. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael Rosenfeld; Fiscal Year: 2000
    ..Current experiments that explore the role of the novel transcription factors in early pituitary development will be completed. ..
  12. HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSION
    Michael Rosenfeld; Fiscal Year: 1993
    ..These studies should provide insights into the complex interactions of regulatory factors that control development and homeostatic characteristics of specific cell types within an endocrine organ...
  13. BRAIN SPECIFIC REGULATORY FACTORS
    Michael Rosenfeld; Fiscal Year: 2004
    ....
  14. Repressors in Prostate Cancer
    Michael Rosenfeld; Fiscal Year: 2006
    ..The major research methods used for both Specific Aims will involve molecular biological, cell biological, biochemical, and genetic approaches. ..