Research Topics
| Margaret RosenfeldSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosisM Rosenfeld
University of Washington, Seattle, Washington
Pediatr Pulmonol 28:321-8. 1999..These findings may have implications for study design and interpretation as well as clinical management of young children with CF...- Effect of choice of reference equation on analysis of pulmonary function in cystic fibrosis patientsM Rosenfeld
Division of Pulmonary Medicine and Cystic Fibrosis Research Center, Children s Hospital and Regional Medical Center, 4800 Sandpoint Way, Seattle, WA 98105
Pediatr Pulmonol 31:227-37. 2001..CF physicians should be aware of the impact of choice of reference equation in both clinical care and research... - Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosisM Rosenfeld
Cystic Fibrosis Research Center, Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
Pediatr Pulmonol 32:356-66. 2001..Our findings provide a foundation for future studies of early intervention in CF lung disease, including antimicrobial and anti-inflammatory therapy... - Overview of published evidence on outcomes with early diagnosis from large US observational studiesMargaret Rosenfeld
Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98105, USA
J Pediatr 147:S11-4. 2005..Taken together, these observational studies provide indirect evidence that diagnosis by means of newborn screening may improve the pulmonary health and survival of patients with CF... 
Early anti-pseudomonal acquisition in young patients with cystic fibrosis: rationale and design of the EPIC clinical trial and observational study'Miriam M Treggiari
Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
Contemp Clin Trials 30:256-68. 2009..Risk factors for and clinical impact of early Pa infection in young CF patients are less well understood...- Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosisNicole Mayer-Hamblett
Department of Pediatrics, University of Washington, Seattle, Washington Seattle Children s Hospital, Seattle, Washington, USA
Pediatr Pulmonol 47:125-34. 2012..The risk of pulmonary exacerbation following Pseudomonas aeruginosa (Pa) acquisition in children with cystic fibrosis (CF) is unknown... 
Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohortMargaret Rosenfeld
Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, Washington, USA
Pediatr Pulmonol 45:934-44. 2010..The EPIC Observational Study is an ongoing prospective cohort study investigating risk factors for and clinical outcomes associated with early Pseudomonas aeruginosa (Pa) acquisition in young children with cystic fibrosis (CF)...- Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosisScott D Sagel
Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, Aurora, CO 80045, USA
J Pediatr 154:183-8. 2009..To assess the effects of Pseudomonas aeruginosa and Staphylococcus aureus infection on lower airway inflammation and clinical status in young children with cystic fibrosis (CF)... - Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohortMargaret Rosenfeld
Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, WA 98105, USA
J Cyst Fibros 11:446-53. 2012..We aimed to identify such risk factors in order to inform prevention strategies and identify high-risk populations... - Revision surgeries are associated with significant increased risk of subsequent cerebrospinal fluid shunt infectionTamara D Simon
Department of Pediatrics, University of Washington Seattle Children s Hospital, Seattle, WA, USA
Pediatr Infect Dis J 31:551-6. 2012..The object of this study was to determine whether cerebrospinal fluid (CSF) shunt revision(s) are associated with increased risk of CSF shunt infection, after adjusting for baseline factors that contribute to infection risk... - Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosisRonald L Gibson
Department of Pediatrics, Children s Hospital and Regional Medical Center University of Washington, Seattle, Washington 98105 0371, USA
Am J Respir Crit Care Med 167:841-9. 2003..We conclude that 28 days of tobramycin solution for inhalation of 300 mg twice daily is safe and effective for significant reduction of lower airway Pa density in young children with cystic fibrosis... - Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trialMargaret Rosenfeld
Division of Pulmonary Medicine, Seattle Children s Hospital, Seattle, Washington 98105, USA
JAMA 307:2269-77. 2012..Inhaled hypertonic saline is recommended as therapy for patients 6 years or older with cystic fibrosis (CF), but its efficacy has never been evaluated in patients younger than 6 years with CF... - Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosisDon B Sanders
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Pediatr Pulmonol 46:393-400. 2011..The purpose of this study was to determine the association between the frequency of pulmonary exacerbations and subsequent forced expiratory volume in 1 sec (FEV(1) ) decline in adults and children with CF... - Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis careMargaret Rosenfeld
Division of Pulmonary Medicine, Seattle Children s Hospital, Seattle, WA 98105, USA
J Cyst Fibros 11:456-7. 2012..To describe the prevalence of the CF pathogens Pseudomonas aeruginosa, Staphylococcus aureus and Haemophilus influenzae in OP cultures from healthy children... - Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbationDon B Sanders
Department of Pediatrics, American Family Children s Hospital, 600 Highland Avenue, Madison, WI 53792 9988, USA
Am J Respir Crit Care Med 182:627-32. 2010..Patients with cystic fibrosis periodically experience pulmonary exacerbations. Previous studies have noted that some patients' lung function (FEV(1)) does not improve with treatment... - Association of intraventricular hemorrhage secondary to prematurity with cerebrospinal fluid shunt surgery in the first year following initial shunt placementTamara D Simon
Department of Pediatrics, University of Washington Seattle Children s Hospital, Seattle, Washington, USA
J Neurosurg Pediatr 9:54-63. 2012..The object of this study was to identify baseline factors at the time of initial CSF shunt placement that are independently associated with subsequent surgery... - Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortalityNicole Mayer-Hamblett
Department of Pediatrics, University of Washington, Seattle, Washington 98105 0371, USA
Am J Respir Crit Care Med 166:1550-5. 2002..Better clinical predictors of short-term mortality among patients with CF are needed... - Lung function from infancy to preschool in a cohort of children with cystic fibrosisLyndia C Brumback
Dept of Biostatistics, University of Washington, Children s Hospital Research Institute, Seattle, WA 98195 7232, USA
Eur Respir J 41:60-6. 2013..5), FEF(25-75%) and forced vital capacity). Recent P. aeruginosa infection and cough are associated with lower lung function in children with CF. Significant inter-individual variability in lung function remains to be explained... - Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosisJulia Emerson
Division of Pulmonary Medicine, Department of Pediatrics, University of Washington, Seattle, USA
Pediatr Pulmonol 34:91-100. 2002..These findings confirm reports from previous smaller studies of outcomes among young children with CF, and highlight the potential to decrease the morbidity and mortality of young patients with CF through early intervention... - Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and managementMargaret Rosenfeld
Department of Pediatrics, University of Washington, Seattle, USA
Curr Opin Pulm Med 9:492-7. 2003..There is a critical need for further investigation of the clinical outcomes associated with early intervention, the long-term safety profile, and the optimal drug regimen... - Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpointsStephanie D Davis
Department of Pediatrics, North Carolina Children s Hospital, University of North Carolina at Chapel Hill, USA
Am J Respir Crit Care Med 182:1387-97. 2010..The conducting of clinical trials in infants with cystic fibrosis (CF) has been hindered by lack of sensitive outcome measures... - Cystic fibrosis pulmonary exacerbationsThomas Ferkol
Department of Pediatrics, Cell Biology and Physiology, Washington University School of Medicine, St. Louis Children's Hospital, 660 South Euclid Avenue, St. Louis, MO 63110, USA
J Pediatr 148:259-64. 2006 - Sputum tobramycin concentrations in cystic fibrosis patients with repeated administration of inhaled tobramycinJennifer Ruddy
1 Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, WA 98105
J Aerosol Med Pulm Drug Deliv 26:69-75. 2013..Peak bioactive concentrations, although lower than peak total concentrations, were still generally well within the bactericidal range. Sputum induction as a method for determining airway drug concentrations appears safe and feasible... - Improved survival among young patients with cystic fibrosisMichal Kulich
Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
J Pediatr 142:631-6. 2003..To investigate age-specific trends in survival among US patients with cystic fibrosis between 1985 and 1999 and to assess whether survival in female patients with cystic fibrosis has improved relative to survival in male patients... - Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safetyMargaret Rosenfeld
Department of Pediatrics, University of Washington School of Medicine, Seattle Children s Hospital, 4800 Sandpoint Way NE, Seattle, WA 98105, USA
Pediatr Pulmonol 46:666-71. 2011..Prior to undertaking a clinical trial of HS efficacy in young children with CF, tolerability, adherence, and safety must be established... - Reproducibility of spirometry during cystic fibrosis pulmonary exacerbationsDon B Sanders
Pediatric Pulmonary Division, Department of Pediatrics, Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington 98105, USA
Pediatr Pulmonol 43:1142-6. 2008..To compare the within day variation of spirometry between hospital admission, discharge, and outpatient follow up among children with cystic fibrosis (CF) hospitalized for a pulmonary exacerbation... - Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomesDavid L Veenstra
Institute for Public Health Genetics, Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Genet Med 9:695-704. 2007..Although the A1555G variant is very rare, it seems to confer a high risk of severe hearing loss in patients exposed to aminoglycosides... - Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosisMiriam M Treggiari
Department of Anesthesiology, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington 98104, USA
Pediatr Pulmonol 42:751-6. 2007.... - Update on cystic fibrosis epidemiologyChristopher H Goss
Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
Curr Opin Pulm Med 10:510-4. 2004..This review is not meant to be comprehensive, but highlights selected studies, many of which have particular relevance to the growing number of older CF patients... - Endpoints for clinical trials in young children with cystic fibrosisStephanie D Davis
Division of Pulmonology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Proc Am Thorac Soc 4:418-30. 2007..Further development of these outcomes measures will enable clinical trials in the youngest CF population with the objective of improving long-term prognosis... - The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge studyJason S Debley
Department of Pediatrics, Division of Pulmonary Medicine, University of Washington, Seattle, Washington 98105, USA
J Pediatr 147:233-8. 2005..To determine the prevalence of ibuprofen-sensitive asthma in school-aged children with mild or moderate persistent asthma... - An overview of endpoints for cystic fibrosis clinical trials: one size does not fit allMargaret Rosenfeld
Division of Pulmonary Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
Proc Am Thorac Soc 4:299-301. 2007..Finally, choosing appropriate endpoints for specific indications will be discussed... - Treatment and microbiology of repeated cerebrospinal fluid shunt infections in childrenTeresa J Tuan
Department of Pediatrics, University of California at San Francisco, San Francisco, CA, USA
Pediatr Infect Dis J 30:731-5. 2011..A small group of children have second and even more cerebrospinal fluid (CSF) shunt infections (SIs). We sought to describe the treatment approaches used for, and the microbiology of, repeated SIs... - Disease-specific reference equations for lung function in patients with cystic fibrosisMichal Kulich
Department of Probability and Mathematical Statistics, Charles University, Prague, Czech Republic
Am J Respir Crit Care Med 172:885-91. 2005..There are limitations to comparing the lung function of a patient with CF to that of healthy control subjects, and potential advantages to comparing it to that of other patients with CF... - Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysisScott D Grosse
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Pediatr 149:362-6. 2006..To estimate the population impact of child mortality as a result of cystic fibrosis (CF) potentially preventable by newborn screening... - Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programsScott D Grosse
Office of the Director, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia 30333, USA
MMWR Recomm Rep 53:1-36. 2004..States should consider the magnitude of benefits and costs and the need to minimize risks through careful planning and implementation, including ongoing collection and evaluation of outcome data... - Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery systemDavid E Geller
The Nemours Children s Clinic, 83 W Columbia St, Orlando, FL 32806 1101, USA
Chest 123:28-36. 2003..Second, we wanted to ascertain which AeroDose-delivered tobramycin dose is equivalent to the standard 300-mg dose administered with the PARI LC PLUS... - Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop reportAnne Marie Comeau
New England Newborn Screening Program and Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Pediatrics 119:e495-518. 2007....