- Treating human autoimmunity: current practice and future prospectsMichael D Rosenblum
Department of Dermatology, University of California, San Francisco, San Francisco, CA 94115, USA
Sci Transl Med 4:125sr1. 2012..This review discusses these advances as well as the challenges that must be overcome to target these therapies to patients suffering from autoimmune disease while avoiding the pitfalls of general immunosuppression...
- Response to self antigen imprints regulatory memory in tissuesMichael D Rosenblum
Department of Dermatology, University of California San Francisco, San Francisco, California 94115, USA
Nature 480:538-42. 2011..These findings provide a framework for understanding how T(reg) cells respond when exposed to self antigen in peripheral tissues and offer mechanistic insight into how tissues regulate autoimmunity...
- Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissuesIris K Gratz
Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA
J Immunol 190:4483-7. 2013..Conversely, IL-7 is essential for maintaining mTregs in skin in the steady state. These results elucidate the fundamental biology of mTregs and show that IL-7 plays an important role in their survival in skin...
- Opposing functions of IL-2 and IL-7 in the regulation of immune responsesShoshana D Katzman
Department of Pathology, University of California San Francisco, San Francisco, CA 94143 0511, USA
Cytokine 56:116-21. 2011..Here we discuss the opposing functions of two members of the common receptor gamma chain (γc) cytokines, IL-2 and IL-7 in the generation and regulation of immune responses in vivo...