Jody Rosenblatt

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway
    Yapeng Gu
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 193:667-76. 2011
  2. pmc P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
    Gloria Slattum
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 186:693-702. 2009
  3. pmc Programmed cell death: a new way worms get rid of unwanted cells
    Jody Rosenblatt
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Curr Biol 22:R844-6. 2012
  4. doi request reprint Mitosis: moesin and the importance of being round
    Jody Rosenblatt
    University of Utah, Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    Curr Biol 18:R292-3. 2008
  5. doi request reprint Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
    George T Eisenhoffer
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA
    Nature 484:546-9. 2012
  6. pmc Bringing balance by force: live cell extrusion controls epithelial cell numbers
    George T Eisenhoffer
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA
    Trends Cell Biol 23:185-92. 2013
  7. pmc The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium
    Thomas W Marshall
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Mol Biol Cell 22:3962-70. 2011
  8. pmc New emerging roles for epithelial cell extrusion
    Yapeng Gu
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, United States
    Curr Opin Cell Biol 24:865-70. 2012
  9. doi request reprint Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P
    Gloria Slattum
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Curr Biol 24:19-28. 2014
  10. doi request reprint Apoptotic regulation of epithelial cellular extrusion
    DANIEL ANDRADE
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, 84112, USA
    Apoptosis 16:491-501. 2011

Collaborators

Detail Information

Publications12

  1. pmc Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway
    Yapeng Gu
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 193:667-76. 2011
    ..Because live cells can also be extruded, we predict that this S1P pathway may also be important for driving delamination of stem cells during differentiation or invasion of cancer cells...
  2. pmc P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
    Gloria Slattum
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 186:693-702. 2009
    ..Extrusion polarity has important implications for tumors where apoptosis is blocked but extrusion is not, as basal extrusion could enable these cells to initiate metastasis...
  3. pmc Programmed cell death: a new way worms get rid of unwanted cells
    Jody Rosenblatt
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Curr Biol 22:R844-6. 2012
    ..Yet, cells still die in mutants that disrupt this pathway. A recent study shows that this death occurs by cell shedding...
  4. doi request reprint Mitosis: moesin and the importance of being round
    Jody Rosenblatt
    University of Utah, Department of Oncological Sciences, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    Curr Biol 18:R292-3. 2008
    ..Ezrin/radixin/moesin proteins link the actin cytoskeleton to the plasma membrane. Two new reports have found that moesin phosphorylation is essential for mitotic cell rounding and identify a new role for cell rounding in spindle assembly...
  5. doi request reprint Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
    George T Eisenhoffer
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, Utah 84112, USA
    Nature 484:546-9. 2012
    ..These results suggest that live cell extrusion could be a tumour-suppressive mechanism that prevents the accumulation of excess epithelial cells...
  6. pmc Bringing balance by force: live cell extrusion controls epithelial cell numbers
    George T Eisenhoffer
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA
    Trends Cell Biol 23:185-92. 2013
    ..Factors that alter this response to cell crowding may lead to barrier function diseases or promote hyperplasia and cancer...
  7. pmc The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium
    Thomas W Marshall
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Mol Biol Cell 22:3962-70. 2011
    ..APC disruptions that are common in colon and breast cancer may promote basal extrusion of tumor cells, which could enable their exit and subsequent migration...
  8. pmc New emerging roles for epithelial cell extrusion
    Yapeng Gu
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, United States
    Curr Opin Cell Biol 24:865-70. 2012
    ..Here, we review recent advances in new processes that require cell extrusion and the signaling pathways controlling it...
  9. doi request reprint Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P
    Gloria Slattum
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Curr Biol 24:19-28. 2014
    ..As most cells extrude apically, they are typically eliminated through the lumen; however, cells with upregulated survival signals that extrude basally could potentially invade the underlying tissue and migrate to other sites in the body...
  10. doi request reprint Apoptotic regulation of epithelial cellular extrusion
    DANIEL ANDRADE
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, 84112, USA
    Apoptosis 16:491-501. 2011
    ..Further, necrosis does not trigger the cellular extrusion response, but instead necrotic cells are removed from epithelia by a passive, stochastic movement of epithelial cells...
  11. ncbi request reprint Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly
    Jody Rosenblatt
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London SC1E 6BT, United Kingdom
    Cell 117:361-72. 2004
    ..We propose that after NEBD, completion of centrosome separation and positioning around chromosomes depends on astral microtubule connections to a moving cell cortex...
  12. ncbi request reprint Spindle assembly: asters part their separate ways
    Jody Rosenblatt
    MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
    Nat Cell Biol 7:219-22. 2005
    ..Although certain cell types use one mechanism predominantly, most rely on both to ensure proper spindle assembly...