GARY ALLEN ROSENBERG

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. ncbi request reprint Matrix metalloproteinases biomarkers in multiple sclerosis
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Lancet 365:1291-3. 2005
  2. pmc Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke
    Saeid Taheri
    Department of Neurology, University of New Mexico, Health Sciences Center, Albuquerque, NM, USA
    PLoS ONE 4:e6597. 2009
  3. pmc Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke
    Kimberly E Hawkins
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Mol Brain 6:14. 2013
  4. pmc 1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment
    Charles Gasparovic
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    J Neurol Neurosurg Psychiatry 84:715-21. 2013
  5. pmc Neurological diseases in relation to the blood-brain barrier
    Gary A Rosenberg
    Departments of Neurology, Neurosciences, Cell Biology and Physiology and Mathematics and Statistics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    J Cereb Blood Flow Metab 32:1139-51. 2012
  6. pmc Myelin loss associated with neuroinflammation in hypertensive rats
    Fakhreya Y Jalal
    Department of Neurology, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 43:1115-22. 2012
  7. pmc Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Neuroinflammation 8:108. 2011
  8. ncbi request reprint Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Lancet Neurol 8:205-16. 2009
  9. ncbi request reprint Matrix metalloproteinases and neuroinflammation in multiple sclerosis
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Neuroscientist 8:586-95. 2002
  10. ncbi request reprint Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Neurosurg Focus 22:E4. 2007

Research Grants

  1. Matrix Metalloproteinases and the Blood-Brain Barrier
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
  2. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
  3. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2006
  4. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2006
  5. Pathobiology of Vascular Cognitive Impairment
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
  6. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2009
  7. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
  8. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2003
  9. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2007
  10. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2005

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Matrix metalloproteinases biomarkers in multiple sclerosis
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Lancet 365:1291-3. 2005
  2. pmc Spatiotemporal correlations between blood-brain barrier permeability and apparent diffusion coefficient in a rat model of ischemic stroke
    Saeid Taheri
    Department of Neurology, University of New Mexico, Health Sciences Center, Albuquerque, NM, USA
    PLoS ONE 4:e6597. 2009
    ..Our results suggest that regions with vasogenic edema alone are not likely to develop low ADC by 48 h and may undergo recovery...
  3. pmc Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke
    Kimberly E Hawkins
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Mol Brain 6:14. 2013
    ..Here we developed an immunocapture assay with high efficiency, specificity, and sensitivity for quantifying endogenously active as well as total MMP-9 activity...
  4. pmc 1H-MR spectroscopy metabolite levels correlate with executive function in vascular cognitive impairment
    Charles Gasparovic
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    J Neurol Neurosurg Psychiatry 84:715-21. 2013
    ..As proton MR spectroscopy ((1)H-MRS) can identify ischaemic tissue, we hypothesised that MRS detectable brain metabolites would be superior to WMHs in predicting performance on neuropsychological tests...
  5. pmc Neurological diseases in relation to the blood-brain barrier
    Gary A Rosenberg
    Departments of Neurology, Neurosciences, Cell Biology and Physiology and Mathematics and Statistics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    J Cereb Blood Flow Metab 32:1139-51. 2012
    ..This review will describe the molecular and cellular events associated with NVU disruption and potential strategies directed toward restoring its integrity...
  6. pmc Myelin loss associated with neuroinflammation in hypertensive rats
    Fakhreya Y Jalal
    Department of Neurology, MSC10 5620, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Stroke 43:1115-22. 2012
    ..Therefore, we used spontaneously hypertensive stroke-prone rats to study the role of neuroinflammation in white matter damage...
  7. pmc Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Neuroinflammation 8:108. 2011
    ..TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α superfamily of death receptors. Since OLs undergo apoptosis during ischemia, we hypothesized that TIMP-3 contributes to OL death...
  8. ncbi request reprint Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Lancet Neurol 8:205-16. 2009
    ..Therapeutic strategies that use inhibitors of MMPs could represent potential novel treatments for neurological diseases...
  9. ncbi request reprint Matrix metalloproteinases and neuroinflammation in multiple sclerosis
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Neuroscientist 8:586-95. 2002
    ..Such agents may eventually be useful in the control of excessive proteolysis that contributes to the pathology of MS and other neuroinflammatory conditions...
  10. ncbi request reprint Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Neurosurg Focus 22:E4. 2007
    ..Because these inhibitors block MMPs involved in angiogenesis and neurogenesis, they also slow recovery. The challenge is to identify agents that will protect the BBB, blocking vasogenic edema without interfering with recovery...
  11. pmc Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: Differences in response based on strains and solvents
    Gary A Rosenberg
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Brain Res 1133:186-92. 2007
    ..Understanding these differences may provide important clues that could guide selection of MMPIs in treatment of neurological diseases...
  12. pmc Inflammation and white matter damage in vascular cognitive impairment
    Gary A Rosenberg
    Professor and Chairman, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Stroke 40:S20-3. 2009
    ....
  13. ncbi request reprint Matrix metalloproteinases in neuroinflammation
    Gary A Rosenberg
    Departments of Neurology, Neurosciences, and Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Glia 39:279-91. 2002
    ..MPs have both beneficial and detrimental roles; understanding their expression in various CNS insults will allow for the use of MMP inhibitors in the treatment of neurological disorders...
  14. ncbi request reprint Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures
    G A Rosenberg
    Department of Neurology, University of New Mexico, Albuquerque, NM 87131, USA
    Brain Res 893:104-12. 2001
    ..MMP-3 in microglia/macrophages may be activating proMMP-9. Our results show that a differential expression of MMPs by astrocytes, microglia, and endothelial cells at the blood vessels is involved in the proteolytic disruption of the BBB...
  15. ncbi request reprint White matter damage is associated with matrix metalloproteinases in vascular dementia
    G A Rosenberg
    Department of Neurology, University of New Mexico, Albuquerque 87131, USA
    Stroke 32:1162-8. 2001
    ..Because matrix metalloproteinases (MMPs) are important in cerebral infarction, we hypothesized that disturbances in the MMPs may be involved in VAD:..
  16. ncbi request reprint Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion
    Thomas Pfefferkorn
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    Stroke 34:2025-30. 2003
    ..We hypothesized that rtPA-mediated adverse effects depend on the timing of reperfusion and injury to the blood-brain barrier (BBB)...
  17. ncbi request reprint Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 27:697-709. 2007
    ..Disrupted TJPs previously seen in endothelial cells appeared in the surrounding astrocytes. Our results provide direct evidence that MMPs open the BBB by degrading TJPs and that an MMP inhibitor prevents degradation of the TJPs by MMPs...
  18. pmc TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia
    Espen J Walker
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Exp Neurol 216:122-31. 2009
    ..Our results indicate a novel additive role for TIMP-3 and MMP-3 in delayed neuronal death, and show that delayed treatment with MMP inhibitors can be used to reduce hippocampal death...
  19. ncbi request reprint Divergent role for MMP-2 in myelin breakdown and oligodendrocyte death following transient global ischemia
    Espen J Walker
    Departments of Neurology, Neurosciences, and Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurosci Res 88:764-73. 2010
    ..We propose that MMP-mediated myelin loss is important in hypoxic injury to the white matter...
  20. ncbi request reprint Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation
    Kate J Gurney
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    Neurobiol Dis 23:87-96. 2006
    ..Our results provide the first in vivo evidence that MMP-3 attacks the basal lamina and tight junction proteins, opening the BBB, thereby facilitating neutrophil influx...
  21. pmc Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat
    Eduardo Candelario-Jalil
    Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
    J Pharmacol Exp Ther 323:488-98. 2007
    ..Modulation of COX in brain injury by COX inhibitors or agents modulating prostaglandin E(2) formation/signaling may be useful in clinical settings associated with BBB disruption...
  22. ncbi request reprint Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia
    Yi Yang
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 112:134-49. 2010
    ..Our data suggest that intranuclear MMP activity cleaves PARP-1 and XRCC1, interfering with oxidative DNA repair. This novel role for MMPs could contribute to neuronal apoptosis in ischemic injuries...
  23. pmc Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain
    Rohit R Sood
    Department of Neurology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 28:431-8. 2008
    ....
  24. doi request reprint Increased apparent diffusion coefficients on MRI linked with matrix metalloproteinases and edema in white matter after bilateral carotid artery occlusion in rats
    Rohit Sood
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Cereb Blood Flow Metab 29:308-16. 2009
    ..We propose that increased ADC, which is a marker of vasogenic edema, is related to activity of MMP-2 and MMP-9. MRI provides unique information that can be used to guide tissue studies of WM injury...
  25. doi request reprint Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping
    Saeid Taheri
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Magn Reson Med 65:1036-42. 2011
    ....
  26. ncbi request reprint Multiple roles for MMPs and TIMPs in cerebral ischemia
    Lee Anna Cunningham
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    Glia 50:329-39. 2005
    ..These processes will have important implications for therapies using MMP inhibitors in stroke...
  27. ncbi request reprint Quantitative evaluation of the effect of propylene glycol on BBB permeability
    Rohit Sood
    Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA
    J Magn Reson Imaging 25:39-47. 2007
    ....
  28. ncbi request reprint Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation
    Sheila Mun-Bryce
    Department of Neurology, University of New Mexico Health Science Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Brain Res 933:42-9. 2002
    ..Our results show that MMP genes are up-regulated prior to the induction of cytokines such as TNF-alpha, and that MMP proteins are prominent around blood vessels in LPS-induced neuroinflammation...
  29. ncbi request reprint Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse
    Mark Grossetete
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 28:752-63. 2008
    ..Our results fail to implicate TIMP-3 in apoptosis in CIH, but show that BB-94 increased apoptosis in CIH, possibly by blocking shedding of TNF death receptors and/or their ligands...
  30. ncbi request reprint Tissue inhibitor of metalloproteinase-3 is associated with neuronal death in reperfusion injury
    James A Wallace
    Department of Neuroscience, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    J Cereb Blood Flow Metab 22:1303-10. 2002
    ..Further studies are needed to identify the sheddases inhibited by the TIMP-3, and on the effect of inhibition of matrix metalloproteinases on cell death mechanisms...
  31. ncbi request reprint Differential expression of tissue inhibitor of metalloproteinases-3 in cultured astrocytes and neurons regulates the activation of matrix metalloproteinase-2
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Neurosci Res 85:829-36. 2007
    ..TIMP-3 may be the key factor determining the differential activation of MMP-2 in astrocytes and neurons...
  32. ncbi request reprint Matrix metalloproteinases and free radicals in cerebral ischemia
    K Jian Liu
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Free Radic Biol Med 39:71-80. 2005
    ..Understanding the relationship between proteases and free radicals in cerebral ischemia is critical for the design of therapeutic agents aimed at controlling cell death in ischemic tissues...
  33. ncbi request reprint Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia
    Shimin Liu
    College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    J Cereb Blood Flow Metab 26:1274-84. 2006
    ..These results suggest that maintaining penumbral oxygenation by normobaric oxygen treatment during ischemia lead to neuroprotection, which is further reflected by the decreased production of ROS, MMP-9, and caspase-8...
  34. ncbi request reprint AUF-1 mediates inhibition by nitric oxide of lipopolysaccharide-induced matrix metalloproteinase-9 expression in cultured astrocytes
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    J Neurosci Res 84:360-9. 2006
    ..Our results suggest that elevated NO concentrations may suppress MMP-9 and restrict the inflammatory response in neurodegenerative diseases...
  35. pmc Elevation of matrix metalloproteinases 3 and 9 in cerebrospinal fluid and blood in patients with severe traumatic brain injury
    Mark Grossetete
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Neurosurgery 65:702-8. 2009
    ..We hypothesized that patients with TBI have an increase in MMPs in ventricular cerebrospinal fluid (CSF) and plasma...
  36. ncbi request reprint Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease
    John C Adair
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Stroke 35:e159-62. 2004
    ....
  37. ncbi request reprint Xanthine oxidase activates pro-matrix metalloproteinase-2 in cultured rat vascular smooth muscle cells through non-free radical mechanisms
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Arch Biochem Biophys 426:11-7. 2004
    ..The results also suggest that caution needs to be taken when interpreting the reported results on activation of MMPs where X/XO had been used as an "authentic" source of superoxide anion...
  38. pmc Blood-brain barrier breakdown in acute and chronic cerebrovascular disease
    Yi Yang
    Department of Neurology, University of New Mexico, Albuquerque, NM 87107, USA
    Stroke 42:3323-8. 2011
    ..This review will describe the molecular and cellular events associated with BBB disruption and potential therapies directed toward restoring the integrity of the neurovascular unit...
  39. pmc Blood-brain barrier permeability abnormalities in vascular cognitive impairment
    Saeid Taheri
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Stroke 42:2158-63. 2011
    ..Twenty volunteers were controls for the dynamic contrast-enhanced MRI studies, and control cerebrospinal fluid was obtained from 20 individuals undergoing spinal anesthesia for nonneurological problems...
  40. pmc Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment
    Eduardo Candelario-Jalil
    Department of Neurology, MSC 10 5620, 1 University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Stroke 42:1345-50. 2011
    ..Brain tissues and cerebrospinal fluid (CSF) of patients with VCI have increased levels of MMPs. We hypothesized that patients with SIVD have increased MMPs in the CSF, which are associated with increased CSF albumin...
  41. ncbi request reprint Strategies to advance translational research into brain barriers
    Edward Neuwelt
    Oregon Health and Science University, Department of Neurology, Veterans Administration Medical Center, Portland, OR, USA
    Lancet Neurol 7:84-96. 2008
    ..At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here...

Research Grants13

  1. Matrix Metalloproteinases and the Blood-Brain Barrier
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..Matrix metalloproteinase inhibitors will be studied that have the potential to be used to prevent the death of vulnerable cells in the white matter. ..
  2. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  3. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2006
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  4. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2006
    ..Understanding the molecular events in the BBB disruption by MMPs will provide a rational basis for drug design, and will lead to novel treatments in many important neurological diseases. ..
  5. Pathobiology of Vascular Cognitive Impairment
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  6. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2009
    ..Matrix metalloproteinase inhibitors will be studied that have the potential to be used to prevent the death of vulnerable cells in the white matter. ..
  7. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  8. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2003
    ..Understanding the molecular events in the BBB disruption by MMPs will provide a rational basis for drug design, and will lead to novel treatments in many important neurological diseases. ..
  9. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2007
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..
  10. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2005
    ..Understanding the molecular events in the BBB disruption by MMPs will provide a rational basis for drug design, and will lead to novel treatments in many important neurological diseases. ..
  11. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2004
    ..Understanding the molecular events in the BBB disruption by MMPs will provide a rational basis for drug design, and will lead to novel treatments in many important neurological diseases. ..
  12. Pathobiology of Vascular Cognitive Impairment
    Gary Rosenberg; Fiscal Year: 2009
    ..These studies will determine the role of protease-mediated nflammation in the progressive form of SIVD, and could lead to novel treatments to suppress proteases. ..