Daniel W Rosenberg

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
    Daniel W Rosenberg
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Cancer Res 67:3551-4. 2007
  2. doi request reprint Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis
    Masako Nakanishi
    Center for Molecular Medicine, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Cancer Res 68:3251-9. 2008
  3. ncbi request reprint Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer
    Prashant R Nambiar
    Center for Molecular Medicine and Program in Colorectal Cancer, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Cancer Res 64:6394-401. 2004
  4. ncbi request reprint Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis
    Mei Dong
    Center for Molecular Medicine, Program in Colorectal Cancer, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Clin Cancer Res 11:2265-71. 2005
  5. ncbi request reprint Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice
    Kishore Guda
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Int J Oncol 31:837-42. 2007
  6. ncbi request reprint Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Carcinogenesis 28:769-76. 2007
  7. ncbi request reprint Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells
    Mei Dong
    The University of Connecticut Health Center, Center for Molecular Medicine, Farmington, Connecticut, USA
    Carcinogenesis 25:2239-46. 2004
  8. ncbi request reprint Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis
    Jillian N M Ilsley
    Program in Colorectal Cancer, Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Cancer Res 65:2636-43. 2005
  9. pmc Molecular alterations associated with sulindac-resistant colon tumors in ApcMin/+ mice
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Cancer Prev Res (Phila) 3:1187-97. 2010
  10. ncbi request reprint Deoxycholic acid promotes the growth of colonic aberrant crypt foci
    Christopher Flynn
    The Carole and Ray Neag Comprehensive Cancer Center, The University of Connecticut Health Center, Farmington, Connecticut, USA
    Mol Carcinog 46:60-70. 2007

Research Grants

  1. Altered Arachidonic Acid Balance and Colon Cancer
    Daniel Rosenberg; Fiscal Year: 2006

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
    Daniel W Rosenberg
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Cancer Res 67:3551-4. 2007
    ....
  2. doi request reprint Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis
    Masako Nakanishi
    Center for Molecular Medicine, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Cancer Res 68:3251-9. 2008
    ..Our data show the feasibility of targeting mPGES-1 for cancer chemoprevention with the potential for improved tolerability over traditional nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors...
  3. ncbi request reprint Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer
    Prashant R Nambiar
    Center for Molecular Medicine and Program in Colorectal Cancer, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Cancer Res 64:6394-401. 2004
    ..In addition to providing insight into colon cancer promotion, our data identify potential biomarkers for determining colon cancer risk in humans...
  4. ncbi request reprint Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis
    Mei Dong
    Center for Molecular Medicine, Program in Colorectal Cancer, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Clin Cancer Res 11:2265-71. 2005
    ..Our data further support the model in which colon cancer growth is favored when intracellular arachidonic acid levels are suppressed by inhibition of cPLA(2) or by a high-COX-2/low-cPLA(2) phenotype...
  5. ncbi request reprint Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice
    Kishore Guda
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Int J Oncol 31:837-42. 2007
    ....
  6. ncbi request reprint Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Carcinogenesis 28:769-76. 2007
    ..These lesions may be precursors to MSI-low CRC, providing a potential early biomarker to assess the effects of cancer prevention strategies...
  7. ncbi request reprint Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells
    Mei Dong
    The University of Connecticut Health Center, Center for Molecular Medicine, Farmington, Connecticut, USA
    Carcinogenesis 25:2239-46. 2004
    ..In addition, detection of Pref-1 in a human colon tumor cell line suggests that it may also participate in human colon tumorigenesis...
  8. ncbi request reprint Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis
    Jillian N M Ilsley
    Program in Colorectal Cancer, Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Cancer Res 65:2636-43. 2005
    ..Our findings indicate that the proapoptotic role of cPLA(2) in the colon may supercede its contribution to eicosanoid production in tumor development...
  9. pmc Molecular alterations associated with sulindac-resistant colon tumors in ApcMin/+ mice
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Cancer Prev Res (Phila) 3:1187-97. 2010
    ..Together, these observations may be translatable to designing novel clinical therapies using combinations of agents that target multiple molecular pathways to overcome sulindac resistance...
  10. ncbi request reprint Deoxycholic acid promotes the growth of colonic aberrant crypt foci
    Christopher Flynn
    The Carole and Ray Neag Comprehensive Cancer Center, The University of Connecticut Health Center, Farmington, Connecticut, USA
    Mol Carcinog 46:60-70. 2007
    ....
  11. pmc Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity
    Masako Nakanishi
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Cancer Prev Res (Phila) 4:1198-208. 2011
    ..These results provide new insights into how PGE(2) controls antitumor immunity...
  12. doi request reprint Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy
    Joseph C Anderson
    Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030 1845, USA
    Cancer Causes Control 23:355-61. 2012
    ..To estimate the risk for colorectal neoplasia detected on repeat colonoscopy in relation to aberrant crypt foci (ACF) frequency reported during the previous baseline examination...
  13. ncbi request reprint Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth
    Glenn S Belinsky
    Center for Molecular Medicine, The Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Mol Carcinog 46:106-16. 2007
    ..Mechanisms that may account for differences between the tumor explant model versus the Apc(Min) model of intestinal cancer are discussed...
  14. ncbi request reprint Dietary iron promotes azoxymethane-induced colon tumors in mice
    Jillian N M Ilsley
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nutr Cancer 49:162-9. 2004
    ..Our results suggest that, following carcinogen exposure, elevated dietary iron promotes the growth of tumors with altered cellular homeostasis through a mechanism that is independent of oxidative stress...
  15. ncbi request reprint Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer
    Richard G Stevens
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, CT, USA
    Cancer Lett 248:262-8. 2007
    ..4; the mean was significantly higher in the patients with a positive family history of CRC (9.0, p<0.01; n=43) or a personal history of advanced adenoma (7.5, p<0.05; n=34)...
  16. pmc Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis
    David C Montrose
    Center for Molecular Medicine and Colon Cancer Prevention Program, University of Connecticut Health Center, Farmington, CT 06030, USA
    Carcinogenesis 32:343-50. 2011
    ..These findings demonstrate a potent anti-inflammatory effect of BRB during DSS-induced colonic injury, supporting its possible therapeutic or preventive role in the pathogenesis of UC and related neoplastic events...
  17. pmc Epigenetic alterations in RASSF1A in human aberrant crypt foci
    Emily J Greenspan
    Center for Molecular Medicine, UCHC School of Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Carcinogenesis 27:1316-22. 2006
    ..Importantly, CIM of RASSF1A is an early epigenetic aberration, occurring in the absence of synchronous colon tumors and is not accompanied by field effects into the surrounding epithelium...
  18. pmc Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions
    David A Drew
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Proteomics 13:1428-36. 2013
    ..This study describes the novel use of a sensitive nanofluidic platform to measure oncogene-driven proteomic changes in diminutive lesions and highlights the advantage of this approach over classical immunohistochemistry-based analyses...
  19. ncbi request reprint Multistage gene expression profiling in a differentially susceptible mouse colon cancer model
    Kishore Guda
    Center for Molecular Medicine, University of Connecticut Health Center, 263, Farmington Avenue, Farmington, CT 06030 3101, USA
    Cancer Lett 191:17-25. 2003
    ..Overall, our data indicate time- and strain-specific genetic alterations during different stages of colon tumorigenesis following AOM treatment...
  20. doi request reprint Increased frequency of serrated aberrant crypt foci among smokers
    Joseph C Anderson
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030 1845, USA
    Am J Gastroenterol 105:1648-54. 2010
    ..Our goal was to examine whether smoking at least 20 pack years was associated with an increased frequency of ACF...
  21. pmc Dietary methyl donor depletion protects against intestinal tumorigenesis in Apc(Min/+) mice
    Krishna Kadaveru
    Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cancer Prev Res (Phila) 5:911-20. 2012
    ..Further studies are warranted to investigate the complex interplay of methyl donor status and cancer protection in high-risk populations...
  22. ncbi request reprint Vascular endothelial growth factor and enhanced angiogenesis do not promote metastatic conversion of a newly established azoxymethane-induced colon cancer cell line
    Glenn S Belinsky
    Center for Molecular Medicine, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Mol Carcinog 43:65-74. 2005
    ..The established murine colon epithelial cell line provides a useful experimental model to further elaborate genetic and epigenetic factors that may promote or inhibit colon tumorigenesis and metastasis...
  23. pmc Mouse models for the study of colon carcinogenesis
    Daniel W Rosenberg
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Carcinogenesis 30:183-96. 2009
    ..We will also describe the general features of lesions formed in response to carcinogen treatment, including the underlying molecular aberrations and how these changes may relate to the pathogenesis of human colorectal cancer...
  24. pmc Role of Notch signaling in colon homeostasis and carcinogenesis
    Shingo Miyamoto
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Cancer Sci 102:1938-42. 2011
    ..Moreover, we discuss novel therapeutic strategies that are under development for targeting Notch signaling in cancer stem cells...
  25. pmc Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}
    Emily J Greenspan
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Cancer Prev Res (Phila) 4:161-71. 2011
    ..These data suggest that ibuprofen can effectively target both the Wnt/β-catenin and NF-κB pathways, and potentially uncovers a novel mechanism through which NSAIDS may exert their chemopreventive efficacy...
  26. pmc Roles of cPLA2alpha and arachidonic acid in cancer
    Masako Nakanishi
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 0603, USA
    Biochim Biophys Acta 1761:1335-43. 2006
    ..We also discuss the potential contribution of cPLA(2)alpha and AA to apoptosis, and the regulatory mechanisms leading to aberrant expression of cPLA(2)alpha...
  27. ncbi request reprint Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors
    Kishore Guda
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Mol Carcinog 37:51-9. 2003
    ....
  28. pmc Suppression of colon carcinogenesis by targeting Notch signaling
    Shingo Miyamoto
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3103, USA
    Carcinogenesis 34:2415-23. 2013
    ..Our results suggest that inhibition of Notch signaling by DAPM provides a potential chemopreventive strategy for patients with tubular adenomas, in part via activation of the KLF4-p21 axis...
  29. pmc Planar spindle orientation and asymmetric cytokinesis in the mouse small intestine
    Elizabeth S Fleming
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    J Histochem Cytochem 55:1173-80. 2007
    ..This type of image analysis may be useful for studying the regulation of spindle position during tissue remodeling and tumor formation...
  30. pmc HD Chromoendoscopy Coupled with DNA Mass Spectrometry Profiling Identifies Somatic Mutations in Microdissected Human Proximal Aberrant Crypt Foci
    David A Drew
    Authors Affiliations Center for Molecular Medicine Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut and
    Mol Cancer Res 12:823-9. 2014
    ..Combined, these data highlight the significance of ACF within the context of colon cancer pathogenesis, particularly in the proximal colon...
  31. pmc Multifaceted roles of PGE2 in inflammation and cancer
    Masako Nakanishi
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Semin Immunopathol 35:123-37. 2013
    ..Future studies to fully understand the complex role of PGE(2) in both inflammation and cancer will be required to develop novel strategies for cancer prevention that are both effective and safe...
  32. pmc mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators"
    Masako Nakanishi
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3101, USA
    Biochimie 92:660-4. 2010
    ..The role of mPGES-1 in the pathogenesis of various cancers is discussed. In addition, an overview of recent efforts to develop small molecule inhibitors that target the protein with high selectivity is also be reviewed...
  33. pmc cPLA2 is protective against COX inhibitor-induced intestinal damage
    David C Montrose
    Center for Molecular Medicine and Colon Cancer Prevention Program, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Toxicol Sci 117:122-32. 2010
    ..Our data demonstrate that cPLA(2) appears to be an important component in conferring protection against COX inhibitor-induced enteropathy, which may be mediated through affects on enterocytic mitochondria...
  34. ncbi request reprint The contribution of methotrexate exposure and host factors on transcriptional variance in human liver
    Glenn S Belinsky
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Toxicol Sci 97:582-94. 2007
    ..Differences in complement expression provide the rationale for future correlative studies between MTX-induced liver fibrosis and C5 alleles in order to identify patients with increased risk for fibrosis...
  35. pmc Epidemiology of colonic aberrant crypt foci: review and analysis of existing studies
    Richard G Stevens
    Colon Cancer Prevention Program CCPP, Neag Comprehensive Cancer Center, University of Connecticut Health Center UCHC, 263 Farmington Avenue, Farmington, CT 06030 6325, United States
    Cancer Lett 252:171-83. 2007
    ..This information can then be used to improve the design of prospective studies, and of clinical intervention trials that use ACF as an intermediate endpoint...
  36. ncbi request reprint Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability
    Kishore Guda
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Oncogene 23:3813-21. 2004
    ..Based on our molecular and cytogenetic findings, we propose that carcinogen-induced tumors may develop via mechanisms independent of the 'classical' CIN or MSI pathways...
  37. pmc Number of aberrant crypt foci associated with adiposity and IGF1 bioavailability
    Helen Swede
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 6325, USA
    Cancer Causes Control 20:653-61. 2009
    ..Evidence has been derived from studies of cancer and polyps. Supporting data about aberrant crypt foci (ACF), putative pre-polyp changes, have been generated only from animal studies to date...
  38. doi request reprint Utilizing endoscopic technology to reveal real-time proteomic alterations in response to chemoprevention
    Masako Nakanishi
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Proteomics Clin Appl 1:1660-6. 2007
    ..This approach should be broadly applicable for assessing lesion responsiveness in a wide range of translational and human clinical studies...
  39. ncbi request reprint Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis
    Mei Dong
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Carcinogenesis 24:307-15. 2003
    ....
  40. pmc CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse
    Beata Winnicka
    Center for Vascular Biology, Department of Immunology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    J Leukoc Biol 88:347-59. 2010
    ....
  41. ncbi request reprint Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model
    Prashant R Nambiar
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    Cancer Res 62:3667-74. 2002
    ..The AOM colon cancer model may be well suited for studying tumor promotion events that precede p53 disruption...
  42. ncbi request reprint Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors
    Prashant R Nambiar
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030 3101, USA
    Int J Oncol 22:145-50. 2003
    ..Lack of invasiveness and metastasis in even the most sensitive strains provides a model system for studying the potential role of 'metastasis genes' in imparting a malignant phenotype...
  43. ncbi request reprint Murine models of ulcerative colitis
    Christopher Flynn
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3101, USA
    Arch Pharm Res 26:433-40. 2003
    ..This review examines and distills what has been leamed from these models and how this information is related back to human UC...
  44. ncbi request reprint Oxidative damage in colon and mammary tissue of the HFE-knockout mouse
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Free Radic Biol Med 34:1212-6. 2003
    ..226, p =.02) tissue among those mice on the standard iron diet compared to those on the low iron diet. These results suggest that dietary modification may affect the course of iron overload from HFE mutations...
  45. ncbi request reprint Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells
    Hongyi Cui
    Center for Molecular Medicine, University of Conneticut Health Center, Farmington 06030, USA
    Exp Cell Res 280:12-23. 2002
    ..These data indicate that KHC-mediated APC translocation is tightly coordinated with beta-catenin turnover in the cell...
  46. ncbi request reprint The induction of aberrant crypt foci (ACF) in the colons of rats by trihalomethanes administered in the drinking water
    Anthony B DeAngelo
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency MD 68, Research Triangle Park, NC 27711, USA
    Cancer Lett 187:25-31. 2002
    ..These studies demonstrate that brominated THMs administered in the drinking water significantly induced preneoplastic ACF in the colon of rats...
  47. pmc APC-dependent suppression of colon carcinogenesis by PPARgamma
    Geoffrey D Girnun
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13771-6. 2002
    ..This finding suggests a potentially important use for PPARgamma ligands as chemopreventative agents in colon cancer...
  48. ncbi request reprint Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
    Jason R Mann
    Departments of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2300 Pierce Avenue, Nashville, TN 37232, USA
    Cancer Res 66:6649-56. 2006
    ..These data indicate that PGDH may serve a tumor suppressor function in colorectal cancer and provide a possible COX-2-independent way to target PGE(2) to inhibit cancer progression...
  49. ncbi request reprint Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors
    Wataru Aizu
    Department of Molecular and Cell Biology, 91 North Eagleville Road, University of Connecticut, Storrs, CT 06269 3125, USA
    Biochem Pharmacol 72:981-91. 2006
    ....
  50. ncbi request reprint Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors
    Xin Tong
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269 3125, USA
    J Biol Chem 280:15503-9. 2005
    ..We propose that histone deacetylases regulate a transcriptional block on the Cox-2 and c-myc genes and that this block may be a potential target for pharmacological intervention...
  51. ncbi request reprint The p50-p50 NF-kappaB complex as a stimulus-specific repressor of gene activation
    Xin Tong
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
    Mol Cell Biochem 265:171-83. 2004
    ..Our findings demonstrate a novel gene regulatory mechanism for the NF-kappaB p50-p50 complex: a signal-specific transcriptional repression that appears to selectively inhibit stimuli that transiently activate p65-p50 complexes...
  52. ncbi request reprint p53 and its co-activator p300 are inversely regulated in the mouse colon in response to carcinogen
    Wataru Aizu
    Department of Molecular and Cell Biology, University of Connecticut, 75 North Eagleville Road, U 3125, Storrs, CT 06269, USA
    Toxicol Lett 144:213-24. 2003
    ..We propose that inefficient gene activation by p53 in the colon contributes to the organotrophic effects of AOM...
  53. ncbi request reprint HDAC3 overexpression and colon cancer cell proliferation and differentiation
    Colleen C Spurling
    Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA
    Mol Carcinog 47:137-47. 2008
    ..Our data support a central role for HDAC3 in regulating the cell proliferation and differentiation of colon cancer cells and suggest a potential mechanism by which colon cancers may become resistant to luminal butyrate...

Research Grants2

  1. Altered Arachidonic Acid Balance and Colon Cancer
    Daniel Rosenberg; Fiscal Year: 2006
    ..Our goal would be to improve targeting of individuals most likely to respond to chemopreventive agents that impact the AA metabolic pathway. ..