S D Rosen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse
    Annemieke van Zante
    Department of Anatomy, Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Exp Med 198:1289-300. 2003
  2. pmc Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis
    Jiwei Yang
    Thios Pharmaceuticals Inc, P, O, Box 20010, Oakland, CA 94620, USA
    BMC Immunol 7:12. 2006
  3. pmc A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells
    Jose L Pablos
    Servicio de Reumatología y Unidad de Investigación, Hospital 12 de Octubre, 28041 Madrid, Spain
    BMC Immunol 6:6. 2005
  4. pmc HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1
    Kenji Uchimura
    Department of Anatomy, Comprehensive Cancer Center, University of California, San Francisco, CA 94143 0452, USA
    BMC Biochem 7:2. 2006
  5. pmc Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma
    Steven D Rosen
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Am J Pathol 166:935-44. 2005
  6. ncbi Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes
    S Hemmerich
    Department of Respiratory Diseases, Roche Bioscience, 3401 Hillview Avenue, Palo Alto, CA 94304, USA
    Immunity 15:237-47. 2001
  7. ncbi Ligands for L-selectin: homing, inflammation, and beyond
    Steven D Rosen
    Department of Anatomy and Program in Immunology, University of California, San Francisco, San Francisco, California 94143 0452, USA
    Annu Rev Immunol 22:129-56. 2004
  8. ncbi Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin
    S Hemmerich
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    J Biol Chem 270:12035-47. 1995
  9. pmc Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin
    A Bistrup
    Department of Anatomy and Program in Immunology, University of California, San Francisco, California 94143, USA
    J Cell Biol 145:899-910. 1999
  10. pmc Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34
    C Sassetti
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Exp Med 187:1965-75. 1998

Collaborators

Detail Information

Publications51

  1. pmc Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse
    Annemieke van Zante
    Department of Anatomy, Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Exp Med 198:1289-300. 2003
    ..Our results demonstrate that HEC-GlcNAc6ST contributes predominantly, but not exclusively, to the sulfation of HEV ligands for L-selectin and that alternative, non-MECA79-reactive ligands are present in the absence of HEC-GlcNAc6ST...
  2. pmc Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis
    Jiwei Yang
    Thios Pharmaceuticals Inc, P, O, Box 20010, Oakland, CA 94620, USA
    BMC Immunol 7:12. 2006
    ..Induction of PNAd has also been shown to occur in a number of human inflammatory diseases including rheumatoid arthritis (RA)...
  3. pmc A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells
    Jose L Pablos
    Servicio de Reumatología y Unidad de Investigación, Hospital 12 de Octubre, 28041 Madrid, Spain
    BMC Immunol 6:6. 2005
    ....
  4. pmc HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1
    Kenji Uchimura
    Department of Anatomy, Comprehensive Cancer Center, University of California, San Francisco, CA 94143 0452, USA
    BMC Biochem 7:2. 2006
    ..To determine whether HSulf-2 modulates the interactions between heparin-binding factors and heparin, we developed an ELISA, in which soluble factors were allowed to bind to immobilized heparin...
  5. pmc Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma
    Steven D Rosen
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Am J Pathol 166:935-44. 2005
    ..Furthermore, MECA-79 inhibited the accumulation of all classes of leukocytes in bronchoalveolar lavage fluid. These findings represent the first demonstration that targeting of PNAd has therapeutic efficacy in an inflammatory disease...
  6. ncbi Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes
    S Hemmerich
    Department of Respiratory Diseases, Roche Bioscience, 3401 Hillview Avenue, Palo Alto, CA 94304, USA
    Immunity 15:237-47. 2001
    ..These results establish a critical role for HEC-GlcNAc6ST in lymphocyte trafficking and suggest it as an important therapeutic target...
  7. ncbi Ligands for L-selectin: homing, inflammation, and beyond
    Steven D Rosen
    Department of Anatomy and Program in Immunology, University of California, San Francisco, San Francisco, California 94143 0452, USA
    Annu Rev Immunol 22:129-56. 2004
    ..The rapid "homing" of labeled cells into the lymph nodes presumably had its basis in the special affinity of small lymphocytes for the endothelium of the postcapillary venules...
  8. ncbi Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin
    S Hemmerich
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    J Biol Chem 270:12035-47. 1995
    ..The structures of two O-glycans, based on core-2, were determined to be: [sequence: see text] The implications of these structures and more complex O-glycans for binding by L-selectin are discussed...
  9. pmc Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin
    A Bistrup
    Department of Anatomy and Program in Immunology, University of California, San Francisco, California 94143, USA
    J Cell Biol 145:899-910. 1999
    ..When coexpressed, the two sulfotransferases synergize to produce strongly enhanced chimera binding...
  10. pmc Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34
    C Sassetti
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Exp Med 187:1965-75. 1998
    ..These results suggest a novel function for PCLP as an adhesion molecule and allow the definition of conserved structural features in PCLP and CD34, which may be important for L-selectin ligand function...
  11. ncbi Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family
    S Hemmerich
    Department of Respiratory Diseases, Roche Bioscience, Palo Alto, CA 94304, USA
    Glycobiology 11:75-87. 2001
    ..5'UTRs of the same enzyme expressed in different cell types are sometimes derived from different exons located upstream of the ORF. The genomic organization of the GSTs resembles that of certain glycosyltransferase gene families...
  12. ncbi The selectins and their ligands
    S D Rosen
    Department of Anatomy, University of California, San Francisco 94143 0452
    Curr Opin Cell Biol 6:663-73. 1994
    ....
  13. ncbi Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity
    A Prakobphol
    Department of Stomatology, University of California, San Francisco, San Francisco, California 94143, USA
    Biochemistry 37:4916-27. 1998
    ..Together, these results suggest that the saccharides that MG2 carries could specify some of its important functions, which may include mediating leukocyte interactions in the oral cavity...
  14. ncbi Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue
    J K Lee
    Department of Anatomy and Program in Immunology, University of California, San Francisco, California, 94143, USA
    Biochem Biophys Res Commun 263:543-9. 1999
    ..Based on these characteristics, the novel sulfotransferase is designated I-GlcNAc6ST for intestinal GlcNAc 6-O-sulfotransferase...
  15. ncbi Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins
    C Sassetti
    Department of Anatomy, Program in Immunology, and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0452, USA
    J Biol Chem 275:9001-10. 2000
    ..While the members of this family may perform overlapping functions at these sites, the unique structural features of endoglycan suggest distinct functions for this molecule...
  16. pmc Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody
    S Hemmerich
    Department of Anatomy, University of California, San Francisco 94143 0452
    J Exp Med 180:2219-26. 1994
    ..Thus, this molecule, which we designate Sgp200, is an additional ligand for L-selectin...
  17. ncbi Sulphated endothelial ligands for L-selectin in lymphocyte homing and inflammation
    A van Zante
    Department of Anatomy, Program in Immunology, University of California, San Francisco, CA 94143 0452, U S A
    Biochem Soc Trans 31:313-7. 2003
    ..MECA79-reactive vessels are also common at sites of chronic inflammation, suggesting mechanistic parallels between lymphocyte homing and inflammatory trafficking...
  18. ncbi Polymerized liposome assemblies: bifunctional macromolecular selectin inhibitors mimicking physiological selectin ligands
    R E Bruehl
    Department of Anatomy and Program in Biomedical Sciences, University of California, San Francisco, California 94143, USA
    Biochemistry 40:5964-74. 2001
    ....
  19. ncbi Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5)
    S Bhakta
    Department of Respiratory Diseases, Roche Bioscience, Palo Alto, California 94304, USA
    J Biol Chem 275:40226-34. 2000
    ....
  20. ncbi Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells
    D Palmeri
    Department of Anatomy and the Cardiovascular Research Institute, the Program in Immunology, University of California, USA
    J Biol Chem 275:19139-45. 2000
    ..Because the Junctional Adhesion Molecule has been strongly implicated in the processes of neutrophil and monocyte transendothelial migration, an analogous function of VE-JAM during lymphocyte homing is plausible...
  21. ncbi 6'-sulfated sialyl Lewis x is a major capping group of GlyCAM-1
    S Hemmerich
    Department of Anatomy, University of California, San Francisco 94143 0452
    Biochemistry 33:4830-5. 1994
    ..The nature of the capping group was further defined by studying the effects of sulfation, sialylation, and fucosylation on the ability of exo-beta(1-->4)galactosidase to release [3H]Gal from GlyCAM-1.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x
    Claudia B Fieger
    Department of Anatomy, Program in Immunology, University of California, San Francisco, California 94143 0452, USA
    J Biol Chem 278:27390-8. 2003
    ..Since the distribution of endoglycan includes hematopoietic precursors and leukocyte subpopulations, in addition to endothelial cells, our findings suggest several potential settings for endoglycan-mediated adhesion events...
  23. pmc Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope
    Annette Bistrup
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Am J Pathol 164:1635-44. 2004
    ..Analysis of the progeny of RIP-BLC by HEC-GlcNAc6ST-null mice establishes that the enzyme is responsible for the MECA-79 defined luminal ligands...
  24. ncbi Sulfated L-selectin ligands as a therapeutic target in chronic inflammation
    Kenji Uchimura
    Department of Anatomy and Program in Immunology, University of California, San Francisco, CA 94143 0452, USA
    Trends Immunol 27:559-65. 2006
    ..Experiments in a sheep model of asthma demonstrate that a chronic inflammatory disease can be ameliorated by targeting PNAd...
  25. ncbi Purification and quantification of L-selectin-reactive GlyCAM-1 from mouse serum
    M S Singer
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    J Immunol Methods 196:153-61. 1996
    ..This material may now be used to address the biological functions of GlyCAM-1 and to further define its structural features...
  26. ncbi Calcium-dependent lectin activity with novel distribution on thymocyte subsets
    S Mallett
    Department of Anatomy, University of California, San Francisco, USA
    Eur J Immunol 26:77-83. 1996
    ..This lectin is not found on mature T cells or other leukocytes in lymph nodes, spleen or bone marrow. It is proposed that this novel cell surface has a function in the maturation of T cells in the thymus...
  27. ncbi A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules
    Kenji Uchimura
    Department of Anatomy, Program in Immunology, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Nat Immunol 6:1105-13. 2005
    ..Our results establish an essential function for the sulfotransferases in L-selectin ligand synthesis and may have relevance for therapy of inflammatory diseases...
  28. pmc Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection
    J H Kim
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Cell Microbiol 15:1560-71. 2013
    ..Collectively, these studies demonstrate that the level of HSPG 6-O sulfation is a critical determinant of C. muridarum infection in vivo and that 6-O endosulfatases are previously unappreciated modulators of microbial pathogenesis. ..
  29. ncbi Identification of the sulfated monosaccharides of GlyCAM-1, an endothelial-derived ligand for L-selectin
    S Hemmerich
    Department of Anatomy, University of California, San Francisco 94143 0452
    Biochemistry 33:4820-9. 1994
    ..amp; Rosen, S.D. (1994) Biochemistry 33, 4830-4835] evidence is presented that (SO4-6)Gal beta 1-->4GlcNAc forms the core of a sulfated sialyl Lewis x structure that may comprise a recognition determinant on GlyCAM-1...
  30. pmc Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis
    H Lemjabbar-Alaoui
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Oncogene 29:635-46. 2010
    ..Conversely, forced Sulf-2 expression in non-malignant bronchial epithelial cells produced a partially transformed phenotype. Our findings support an essential role for Sulf-2 in lung cancer, the leading cancer killer...
  31. ncbi Homing in on L-selectin
    Steven D Rosen
    Department of Anatomy and Program in Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 177:3-4. 2006
  32. pmc Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate
    Steven D Rosen
    University of California, Department of Anatomy and Comprehensive Cancer Center, San Francisco, 94143, USA
    Expert Opin Ther Targets 14:935-49. 2010
    ..Take home message: Sulf-2 is an extracellular enzyme and as such would be an attractive therapeutic target for the treatment of NSCLC and other cancers...
  33. ncbi A potential role for annexin 1 as a physiologic mediator of glucocorticoid-induced L-selectin shedding from myeloid cells
    H J Strausbaugh
    Department of Anatomy, Program in Immunology and Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 166:6294-300. 2001
    ..These data may provide the basis for further understanding of mechanisms involved in the down-regulation of inflammatory responses...
  34. pmc Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins
    Sheena C Kerr
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    J Immunol 181:1480-90. 2008
    ..These in vitro findings indicate that EG can function as a ligand for the vascular selectins...
  35. pmc Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer
    Megumi Morimoto-Tomita
    Department of Anatomy and the UCSF Comprehensive Cancer Center, University of California, San Francisco, 94143 0452, USA
    Neoplasia 7:1001-10. 2005
    ..In support of the possible mechanistic relevance of Sulf-2 upregulation in tumors, purified recombinant Sulf-2 promoted angiogenesis in the chick chorioallantoic membrane assay...
  36. pmc Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans
    Megumi Morimoto-Tomita
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    J Biol Chem 277:49175-85. 2002
    ..Taken together, our results establish that the mammalian Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment...
  37. ncbi Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase
    Ola M Saad
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Glycobiology 15:818-26. 2005
    ..Proof of principle was performed by using various heparin/HS samples isolated from bovine and porcine tissues...
  38. pmc A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
    M D Gunn
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 95:258-63. 1998
    ..In addition, the expression of SLC in lymphatic endothelium suggests that the migration of lymphocytes from tissues into efferent lymphatics may be an active process mediated by this molecule...
  39. ncbi Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface
    Olga D Genbacev
    Departments of Stomatology, Anatomy, and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Science 299:405-8. 2003
    ..These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy...
  40. pmc Functional consequences of the subdomain organization of the sulfs
    Renhong Tang
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:21505-14. 2009
    ..The uncleavable Sulfs retained enzymatic activity. However, they were unable to potentiate Wnt signaling, which may be due to their defective localization into lipid rafts on the plasma membrane...
  41. ncbi Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases
    Kenji Uchimura
    Department of Anatomy, Program in Immunology, UCSF, USA
    Methods Enzymol 416:243-53. 2006
    ..The example illustrated is vascular endothelial growth factor (VEGF). This assay is projected to be very useful in the investigation of the biological functions of the Sulfs...
  42. ncbi Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications
    Jin Kyu Lee
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Glycobiology 13:245-54. 2003
    ..These latter findings argue that GlcNAc6ST-3 is not involved in generating HEV-expressed ligands for L-selectin...
  43. pmc Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs
    Hidenobu Kanda
    Department of Anatomy, Program in Immunology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 9:415-23. 2008
    ..Our results support the idea of a new and general step in the homing cascade in which the ectoenzyme ATX facilitates the entry of lymphocytes into lymphoid organs...
  44. pmc Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2
    David H Lum
    Department of Anatomy, HSW 1323, University of California San Francisco, CA 94143 0452, USA
    Mol Cell Biol 27:678-88. 2007
    ..These data suggest that Sulf2 may have roles in several tissues but that there is compensation by and/or redundancy with Sulf1...
  45. pmc Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
    Roman Nawroth
    Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e392. 2007
    ..Emerging evidence indicates the importance of reactivated Wnt signaling in a number of cancers, including pancreatic adenocarcinoma...
  46. ncbi Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial cell N-acetylglucosamine-6-sulfotransferase exert differential control over B- and T-lymphocyte homing to peripheral lymph nodes
    Jean Marc Gauguet
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 104:4104-12. 2004
    ..These results demonstrate distinct functions for C2GlcNAcT-I and HEC-GlcNAc6ST in the differential elaboration of HEV glycoproteins that set a threshold for the amount of L-selectin needed for lymphocyte homing...
  47. ncbi N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing
    Kenji Uchimura
    Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 279:35001-8. 2004
    ..The importance of GlcNAc6ST-1 is particularly high-lighted by its involvement in lymphocyte homing to Peyer's patches where GlcNAc6ST-2 expression is undetectable...
  48. ncbi Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
    Krystle M Veerman
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Immunol 8:532-9. 2007
    ..Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule...
  49. ncbi Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan
    Krishna K Sarangapani
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Biol Chem 279:2291-8. 2004
    ..By contrast, only slip bonds were observed for L-selectin-antibody interactions. These findings suggest that catch bonds contribute to the shear threshold for rolling and are a common characteristic of selectin-ligand interactions...
  50. ncbi Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking
    Diana Palmeri
    Department of Anatomy and Program of Immunology, University of California, San Francisco, USA
    J Leukoc Biol 75:910-27. 2004
    ..The library contains a great diversity of transcripts, and studies of the encoded proteins will provide further insight into the complex biology of these specialized endothelial cells...

Research Grants37

  1. SULFOTRANSFERASE IN THE SYNTHESIS OF L-SELECTIN LIGANDS
    Steven Rosen; Fiscal Year: 2001
    ....
  2. Conference: Molecular Mechanism of Leukocyte Trafficking
    Steven Rosen; Fiscal Year: 2002
    ..The resulting interactions are likely to stimulate new approaches to the critical remaining problems in trafficking research. ..
  3. SULFOTRANSFERASE IN THE SYNTHESIS OF L-SELECTIN LIGANDS
    Steven Rosen; Fiscal Year: 2002
    ....
  4. Sulfotransferases in the Synthesis on L-Selectin Ligands
    Steven Rosen; Fiscal Year: 2003
    ..Gaining further understanding of these sulfotransferases has considerable biomedical relevance, because these enzymes are potential therapeutic targets for blocking inflammatory diseases. ..
  5. Sulfotransferases in the Synthesis on L-Selectin Ligands
    Steven Rosen; Fiscal Year: 2006
    ..Gaining further understanding of these sulfotransferases has considerable biomedical relevance, because these enzymes are potential therapeutic targets for blocking inflammatory diseases. ..
  6. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2006
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  7. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2007
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  8. Role of Heparan Sulfate-Degrading Sulfatases in Pancreatic Adenocarcinomas
    Steven Rosen; Fiscal Year: 2007
    ..Positive results from these studies should stimulate considerable interest in the Sulfs as possible targets (for small molecules or function-blocking antibodies) for the treatment of pancreatic adenocarcinoma in humans. ..
  9. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2006
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..
  10. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven Rosen; Fiscal Year: 2007
    ..Understanding this mechanism may lead to new pharmacologic approaches for dampening eosinophil responses. ..
  11. Sulfotransferases in the Synthesis on L-Selectin Ligands
    Steven Rosen; Fiscal Year: 2007
    ..Gaining further understanding of these sulfotransferases has considerable biomedical relevance, because these enzymes are potential therapeutic targets for blocking inflammatory diseases. ..
  12. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven Rosen; Fiscal Year: 2009
    ..Understanding this mechanism may lead to new pharmacologic approaches for dampening eosinophil responses. ..
  13. SULFOTRANSFERASE IN THE SYNTHESIS OF L-SELECTIN LIGANDS
    Steven Rosen; Fiscal Year: 2000
    ....
  14. SULFOTRANSFERASE IN THE SYNTHESIS OF L-SELECTIN LIGANDS
    Steven Rosen; Fiscal Year: 1999
    ....
  15. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 1992
    ....
  16. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 1990
    ....
  17. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 1991
    ....
  18. CELL SURFACE LECTINS AND INTERCELLUAR ADHESION
    Steven Rosen; Fiscal Year: 1993
    ....
  19. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 1980
    ..In fibroblasts, we will determine the role of the rosette-mediating component in density-dependent inhibition of growth and contact inhibition of movement. ..
  20. CELL SURFACE LECTINS AND INTERCELLULAR ADHESION
    Steven Rosen; Fiscal Year: 2009
    ..As the molecular machinery of normal lymphocyte homing is elucidated, new targets for anti-inflammatory therapeutics are likely to emerge. ..