Jeffrey B Rosen

Summary

Affiliation: University of Delaware
Country: USA

Publications

  1. ncbi request reprint Not all rat strains are equal: differential unconditioned fear responses to the synthetic fox odor 2,4,5-trimethylthiazoline in three outbred rat strains
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, Newark, DE 19716, USA
    Behav Neurosci 120:290-7. 2006
  2. ncbi request reprint Hyperexcitability: exaggerated fear-potentiated startle produced by partial amygdala kindling
    J B Rosen
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Behav Neurosci 110:43-50. 1996
  3. ncbi request reprint Expression of egr-1 (zif268) mRNA in select fear-related brain regions following exposure to a predator
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
    Behav Brain Res 162:279-88. 2005
  4. ncbi request reprint Animal studies of amygdala function in fear and uncertainty: relevance to human research
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, 19716, USA
    Biol Psychol 73:49-60. 2006
  5. doi request reprint Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: a model for animal phobias
    Jeffrey B Rosen
    Behavioral Neuroscience Program, Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE 19716, United States
    Neurosci Biobehav Rev 32:1267-76. 2008
  6. doi request reprint Chronic corticosterone administration does not potentiate unconditioned freezing to the predator odor, trimethylthiazoline
    Jeffrey B Rosen
    Behavioral Neuroscience Program, Department of Psychology, University of Delaware, Newark, DE 19716, United States
    Behav Brain Res 194:32-8. 2008
  7. ncbi request reprint Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning
    J B Rosen
    Department of Psychology, University of Delaware, Newark 19716, USA
    Brain Res 796:132-42. 1998
  8. ncbi request reprint From normal fear to pathological anxiety
    J B Rosen
    Department of Psychology, University of Delaware, Newark 19716, USA
    Psychol Rev 105:325-50. 1998
  9. pmc An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning
    Seema Malkani
    Program in Behavioral Neuroscience, Department of Psychology, University of Delaware, Newark, Delaware 19716, USA
    Learn Mem 11:617-24. 2004
  10. ncbi request reprint Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs
    Barbara L Thompson
    Department of Psychology, University of Delaware, Newark, USA
    Neuropharmacology 50:57-68. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Not all rat strains are equal: differential unconditioned fear responses to the synthetic fox odor 2,4,5-trimethylthiazoline in three outbred rat strains
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, Newark, DE 19716, USA
    Behav Neurosci 120:290-7. 2006
    ..Thus, TMT is a robust unconditioned fear stimulus in rats, and prior negative results from other laboratories were due to the choice of a rat strain (Wistar) that is less responsive to TMT...
  2. ncbi request reprint Hyperexcitability: exaggerated fear-potentiated startle produced by partial amygdala kindling
    J B Rosen
    Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Behav Neurosci 110:43-50. 1996
    ..In contrast, partial hippocampus kindling induced c-fos mRNA in the hippocampus only. The data suggest that kindled-induced hyperexcitability of the amygdala and limbic cortices produced exaggerated conditioned fear-potentiated startle...
  3. ncbi request reprint Expression of egr-1 (zif268) mRNA in select fear-related brain regions following exposure to a predator
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
    Behav Brain Res 162:279-88. 2005
    ..The results are discussed in a context of differences and similarities in neural circuitry for conditioned and unconditioned fear...
  4. ncbi request reprint Animal studies of amygdala function in fear and uncertainty: relevance to human research
    Jeffrey B Rosen
    Department of Psychology, University of Delaware, 19716, USA
    Biol Psychol 73:49-60. 2006
    ..We conclude that progress on elucidating the role of the amygdala in fear is facilitated by corroboration of findings from both animal and human research...
  5. doi request reprint Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: a model for animal phobias
    Jeffrey B Rosen
    Behavioral Neuroscience Program, Department of Psychology, University of Delaware, 108 Wolf Hall, Newark, DE 19716, United States
    Neurosci Biobehav Rev 32:1267-76. 2008
    ..The importance of these findings of innate predator odor fear in rodents to animal phobias in humans is discussed...
  6. doi request reprint Chronic corticosterone administration does not potentiate unconditioned freezing to the predator odor, trimethylthiazoline
    Jeffrey B Rosen
    Behavioral Neuroscience Program, Department of Psychology, University of Delaware, Newark, DE 19716, United States
    Behav Brain Res 194:32-8. 2008
    ..Thus, chronic CORT appears to increase fear as measured by freezing, possibly by enhancing vigilance, but does not facilitate fear behavior induced by the innate fear stimulus, TMT...
  7. ncbi request reprint Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning
    J B Rosen
    Department of Psychology, University of Delaware, Newark 19716, USA
    Brain Res 796:132-42. 1998
    ..This elevation in NGFI-A mRNA was not seen in the immediate-footshock group. This suggests that NGFI-A mRNA in the lateral nucleus of the amygdala may play a role in contextual fear conditioning...
  8. ncbi request reprint From normal fear to pathological anxiety
    J B Rosen
    Department of Psychology, University of Delaware, Newark 19716, USA
    Psychol Rev 105:325-50. 1998
    ..Hyperexcitability in fear circuits is expressed as pathological anxiety that is manifested in the various anxiety disorders...
  9. pmc An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning
    Seema Malkani
    Program in Behavioral Neuroscience, Department of Psychology, University of Delaware, Newark, Delaware 19716, USA
    Learn Mem 11:617-24. 2004
    ....
  10. ncbi request reprint Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs
    Barbara L Thompson
    Department of Psychology, University of Delaware, Newark, USA
    Neuropharmacology 50:57-68. 2006
    ..We suggest that IEG expression in the CeA may be due to activation of circuits that are associated with systemic physiological homeostasis perturbed by a number of drugs including anxiogenic and anxiolytic compounds...
  11. ncbi request reprint Glucocorticoid receptor antagonism in the basolateral amygdala and ventral hippocampus interferes with long-term memory of contextual fear
    Melanie P Donley
    Department of Psychology, Behavioral Neuroscience Program, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
    Behav Brain Res 164:197-205. 2005
    ..The data indicate that GR activation within the BLA and VH is important for the establishment of long-term memory for contextual fear conditioning...
  12. pmc Oxytocin reduces background anxiety in a fear-potentiated startle paradigm: peripheral vs central administration
    Luke W Ayers
    Department of Psychology, Behavioral Neuroscience Program, University of Delaware, Newark, DE 19716, USA
    Neuropsychopharmacology 36:2488-97. 2011
    ..Oxytocin given systemically may have anti-anxiety properties that are particularly germane to the hypervigilance and exaggerated startle typically seen in many anxiety and mental health disorder patients...
  13. ncbi request reprint N-Methyl-D-aspartate receptor antagonism blocks contextual fear conditioning and differentially regulates early growth response-1 messenger RNA expression in the amygdala: implications for a functional amygdaloid circuit of fear
    S Malkani
    Program in Neuroscience and Department of Psychology, 220 Wolf Hall, University of Delaware, Newark, DE 19716, USA
    Neuroscience 102:853-61. 2001
    ....
  14. ncbi request reprint Corticosterone facilitates retention of contextually conditioned fear and increases CRH mRNA expression in the amygdala
    Barbara L Thompson
    Department of Psychology and Neuroscience Program, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
    Behav Brain Res 149:209-15. 2004
    ..The data suggest that repeated administration of CORT given before fear conditioning facilitates the acquisition of emotional memory, whereas CORT given after consolidation does not increase emotional memory...
  15. doi request reprint The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions
    Jerome H Pagani
    University of Delaware, Department of Psychology, Newark, DE 19716, USA
    Brain Res 1286:133-46. 2009
    ..The data suggest that fibers passing through the AHN and VMH, and not cells in the MHDC, mediate unconditioned freezing to the predator odor TMT...
  16. ncbi request reprint Neurotoxic lesions of the lateral nucleus of the amygdala decrease conditioned fear but not unconditioned fear of a predator odor: comparison with electrolytic lesions
    K J Wallace
    Department of Psychology and Neuroscience Program, University of Delaware, Newark, Delaware 19716, USA
    J Neurosci 21:3619-27. 2001
    ..The studies suggest that the LA and BA play different roles in fear conditioning, but neither of them has a significant role in unconditioned freezing to a predator odor...
  17. pmc Oxytocin reduces background anxiety in a fear-potentiated startle paradigm
    Galen Missig
    Department of Psychology, Behavioral Neuroscience Program, University of Delaware, Newark, DE 19716, USA
    Neuropsychopharmacology 35:2607-16. 2010
    ..Oxytocin may have antianxiety properties that are particularly germane to the hyper-vigilance and exaggerated startle typically seen in PTSD patients...
  18. ncbi request reprint The neurobiology of conditioned and unconditioned fear: a neurobehavioral system analysis of the amygdala
    Jeffrey B Rosen
    University of Delaware, USA
    Behav Cogn Neurosci Rev 3:23-41. 2004
    ..Finally, the relevance of the animal studies to human anxiety disorders is discussed...
  19. ncbi request reprint Specific amygdaloid nuclei are involved in suppression or propagation of epileptiform activity during transition stage between oral automatisms and generalized clonic seizures
    M Sitcoske O'Shea
    Biological Psychiatry Branch, National Institutes of Mental Health, Bethesda, MD 0892, USA
    Brain Res 873:1-17. 2000
    ..A neuroanatomical model of Am-induced seizure propagation is proposed suggesting that the Claust-Ins-PRh play a pivotal role during the transition between oral automatisms and generalized clonic convulsions...
  20. doi request reprint Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal deafferentation
    Luke W Ayers
    Behavioral Neuroscience Program, Department of Psychology, University of Delaware, Newark, DE, USA Electronic address
    Behav Brain Res 253:54-9. 2013
    ..Taken together, these findings support TMT's role as an ecologically relevant predator odor useful in experiments of unconditioned fear that is mediated via olfaction and not nociception. ..
  21. doi request reprint Immediate early gene and neuropeptide expression following exposure to the predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT)
    Arun Asok
    Program in Behavioral Neuroscience, Department of Psychology, University of Delaware, Newark, DE 19716, USA
    Behav Brain Res 248:85-93. 2013
    ....
  22. doi request reprint Factors governing single-trial contextual fear conditioning in the weanling rat
    M A Burman
    University of Delaware, Newark, DE 19716, USA
    Behav Neurosci 123:1148-52. 2009
    ..Thus, the conjuctive representations underlying the CPFE are NMDA-dependent as early as PND23 in the rat...
  23. ncbi request reprint Translational research: parallels of human and animal research in biological psychology
    Jeffrey B Rosen
    Biol Psychol 73:1-2. 2006
  24. ncbi request reprint Demythologizing the emotions: adaptation, cognition, and visceral representations of emotion in the nervous system
    Jay Schulkin
    Department of Physiology and Biophysics, School of Medicine, Georgetown University, Washington DC 20007, USA
    Brain Cogn 52:15-23. 2003
    ..Thus, in addition to the experiential aspects of emotions, emotions embody appraisal systems that are pervasive to all levels of the brain to facilitate function, adaptation, and survival...
  25. ncbi request reprint A neuroendocrine mechanism for sustaining fear
    Jay Schulkin
    Department of Physiology and Biophysics, Georgetown University, Washington, DC 20007, USA
    Trends Neurosci 28:629-35. 2005
    ..Central regulation of CRH by glucocorticoids is important for adaptive and sustained fear-related behaviors, and its aberration is associated with anxiety and depressive disorders...