Research Topics
| Howard RosenSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Frontotemporal dementia: clinicopathological correlationsMark S Forman
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Neurol 59:952-62. 2006....
Self-conscious emotion deficits in frontotemporal lobar degenerationVirginia E Sturm
Department of Psychology, University of California, Berkeley, CA 94720-1650, USA
Brain 129:2508-16. 2006..Disrupted self-conscious emotions in FTLD patients may have clinical importance because these deficits may underlie some of the socially inappropriate behaviours that are common in these patients...- Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative diseaseHoward J Rosen
Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Neuroimage 49:3358-64. 2010..We hypothesize that emotional/physiological processing carried out by vmPFC is an important factor mediating self-appraisal accuracy in dementia... - Dextromethorphan/quinidine sulfate for pseudobulbar affectHoward Rosen
UCSF Department of Neurology, Memory and Aging Center, San Francisco, California 94143, USA
Drugs Today (Barc) 44:661-8. 2008..Currently, the antidepressants are probably the most attractive pharmacologic options for treatment of PBA. The choice of whether to use DM/Q in this setting will likely depend on individual patient factors as well as cost... 
Anosognosia in neurodegenerative diseaseHoward J Rosen
UCSF Department of Neurology, Memory and Aging Center, San Francisco, CA 94143, USA
Neurocase 17:231-41. 2011..Specification of the specific processes whose potential failure results in anosognosia can establish a roadmap for future studies...- Neuroanatomical correlates of behavioural disorders in dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
Brain 128:2612-25. 2005..Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions... - The emotional brain: combining insights from patients and basic scienceHoward J Rosen
Department of Neurology, University of California, Memory and Aging Center, 350 Parnassus Ave, Suite 905, Box 1207, San Francisco, CA 94143 1207, USA
Neurocase 15:173-81. 2009..A thorough understanding of emotional dysfunction in neurological disease will require a sophisticated approach to studying emotion, which takes into account these various processes and links them to neuroanatomical changes... - A real reason for patients with pseudobulbar affect to smileHoward J Rosen
Department of Neurology, University of California, San Francisco 94143, USA
Ann Neurol 61:92-6. 2007..The growing number of treatment options, some of great benefit to patients, highlights the importance of accurate diagnosis of this disorder... - Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosisNicholas T Olney
UCSF School of Medicine, San Francisco, CA 94143 1207, USA
Brain 134:3458-69. 2011.... - MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementiaDuygu Tosun
Center for Imaging Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Neuroimage 59:2098-109. 2012.... - Patterns of structural complexity in Alzheimer's disease and frontotemporal dementiaKarl Young
Department of Radiology, University of California San Francisco, and VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Hum Brain Mapp 30:1667-77. 2009.... - AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic painNicholas Olney
University of California, San Francisco, Department of Neurology, Memory and Aging Center, Suite 706, San Francisco, CA 94143, USA
IDrugs 13:254-65. 2010..Pending approval of the data from the FDA, AVP-923 would be the first FDA-approved treatment for PBA... - Neuroimaging in dementiaMaria Carmela Tartaglia
University of California, San Francisco Memory and Aging Center, San Francisco, California 94143, USA
Neurotherapeutics 8:82-92. 2011..Structural and functional imaging modalities contribute to the diagnosis and understanding of the different dementias... - Magnetic resonance imaging correlates of set shiftingJoel H Kramer
Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
J Int Neuropsychol Soc 13:386-92. 2007..Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning... - Patterns of white matter atrophy in frontotemporal lobar degenerationLinda L Chao
Center for Imaging of Neurodegenerative Diseases, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Arch Neurol 64:1619-24. 2007..Structural magnetic resonance imaging (MRI) has been used to investigate the in vivo pathology of frontotemporal lobar degeneration. However, few neuroimaging studies have focused on white matter (WM) alterations in this disease... - Standardised measurement of self-awareness deficits in FTD and ADCraig Williamson
Department of Neurology, University of California, San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Box 1207, Suite 905, San Francisco, CA 94143 1207, USA
J Neurol Neurosurg Psychiatry 81:140-5. 2010..Here, the authors introduce a new method that allows objective quantification of an individual's awareness of their cognitive abilities and relies upon objective bedside testing... - Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative diseaseKatherine L Possin
Department of Neurology, University of California San Francisco, San Francisco, California, USA
J Int Neuropsychol Soc 15:354-64. 2009..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region... - White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRIYu Zhang
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain 132:2579-92. 2009..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease... - Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's diseaseCasey E Krueger
UCSF Department of Neurology, San Francisco, CA, USA
Alzheimer Dis Assoc Disord 24:43-8. 2010..Measuring specific regions of cerebral volume changes by serial neuroimaging may serve as a useful biomarker outcome measure for clinical trials in neurodegenerative diseases... - Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burdenGil D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Brain 133:512-28. 2010..Our data are consistent with a model in which both early amyloid-beta accumulation and increased vulnerability to amyloid-beta pathology play critical roles in the pathogenesis of Alzheimer's disease in young patients... - Multiple cognitive deficits in amnestic mild cognitive impairmentJoel H Kramer
San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
Dement Geriatr Cogn Disord 22:306-11. 2006..To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form of mild cognitive impairment (MCI)... - Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTDKatherine P Rankin
University of California San Francisco, San Francisco, Calif, USA
Dement Geriatr Cogn Disord 17:328-32. 2004..These data support the hypothesis that regulation of agreeableness arises from a balanced, mutually inhibitory circuit involving both hemispheres... - Recognition of emotion in the frontal and temporal variants of frontotemporal dementiaHoward J Rosen
Department of Neurology, University of California, Memory and Aging Center, San Francisco, Calif, USA
Dement Geriatr Cogn Disord 17:277-81. 2004..These results suggest that damage to frontal lobe regions in FTD may lead to more profound impairment in recognition of emotion than when damage is more limited to the temporal lobe... - Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer diseaseJoel H Kramer
University of California Medical Center, San Francisco, California 94143, USA
Cogn Behav Neurol 16:211-8. 2003..To assess the ability of a brief neuropsychological bedside screening battery to discriminate between Alzheimer disease, frontotemporal dementia, and semantic dementia... - Hippocampal volume and retention in Alzheimer's diseaseJoel H Kramer
Department of Neurology, University of California at San Francisco, 94143, USA
J Int Neuropsychol Soc 10:639-43. 2004..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories... - Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementiaAdam L Boxer
Memory and Aging Center and the Department of Neurology, University of California at San Francisco, 94143, USA
Arch Neurol 60:949-56. 2003..Progressive brain atrophy is associated with Alzheimer disease (AD) and other dementias. Regional differences in brain atrophy may reflect clinical features of disease... - Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, San Francisco, California 94143 1207, USA
Alzheimer Dis Assoc Disord 18:202-7. 2004..Thus, in FTD the CDR reveals functional impairments in a wide variety of domains that are more severe than those seen in AD or SD patients with an equivalent Mini-Mental State Examination... - Frontotemporal lobar degeneration: demographic characteristics of 353 patientsJulene K Johnson
Department of Neurology, Memory and Aging Center, University of California, San Francisco, 94117, USA
Arch Neurol 62:925-30. 2005..The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia... - Emotion comprehension in the temporal variant of frontotemporal dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
Brain 125:2286-95. 2002..These results have implications both for the clinical presentation in tvFTD patients and for the study of the neuroanatomical basis of emotion... - Neuroanatomical correlates of impaired recognition of emotion in dementiaHoward J Rosen
University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
Neuropsychologia 44:365-73. 2006.... - Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from ADHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, San Francisco, CA 94143 1207, USA
Neurology 58:1608-15. 2002..To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD... - Clinical and neuropsychological features of corticobasal degenerationNataliya Belfor
University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
Mech Ageing Dev 127:203-7. 2006..Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis... - Dissociations in hippocampal and frontal contributions to episodic memory performanceJoel H Kramer
Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
Neuropsychology 19:799-805. 2005.... - Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsyAdam L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Arch Neurol 63:81-6. 2006..Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease... - Patterns of cerebral atrophy in primary progressive aphasiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
Am J Geriatr Psychiatry 10:89-97. 2002..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis... - Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementiaAn Tao Du
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain 130:1159-66. 2007..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia... - Cognition and anatomy in three variants of primary progressive aphasiaMaria Luisa Gorno-Tempini
Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
Ann Neurol 55:335-46. 2004..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes... - A tensor based morphometry study of longitudinal gray matter contraction in FTDSimona M Brambati
Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
Neuroimage 35:998-1003. 2007..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD... - Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's diseaseSiobhan Garbutt
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Brain 131:1268-81. 2008..These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders... - Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementiaKatya Rascovsky
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA 19104, USA
Brain 134:2456-77. 2011..Future studies will be needed to establish the reliability and specificity of these revised diagnostic guidelines... - The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)Adam L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
Alzheimers Dement 9:189-98. 2013..We conclude that FTD research has reached sufficient maturity to pursue clinical development of specific FTD therapies... - 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusionsKirk C Wilhelmsen
Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
Arch Neurol 61:398-406. 2004..The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with neuronal or glial tau inclusions... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Neuroimaging in dementiaPaolo Vitali
Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
Semin Neurol 28:467-83. 2008..Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging is clearly an invaluable tool for the clinician in the differential diagnosis... - Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt diseaseMichael D Geschwind
Departments of Neurology, University of California, San Francisco, UCSF Memory and Aging Center, Box 1207, SanFrancisco, CA 94143 1207, USA
Alzheimer Dis Assoc Disord 23:82-87. 2009..77; P=0.0006), followed by reactive astrocytic gliosis (r=0.63, P=0.008). This case provides further evidence that DWI abnormalities correlate well with the clinical features and with PrP(Sc) accumulation and vacuolation...
Research Grants
- Awareness of Deficits in DementiaHoward J Rosen; Fiscal Year: 2010..This project will attempt to understand why patients with dementia have such poor awareness of their disability using cognitive tests developed by neuroscientists, and using brain imaging. ..
- Emotion in DementiaHoward Rosen; Fiscal Year: 2004..b>Howard Rosen to supplement his skills in behavioral neurology and neuroimaging with training in theoretical and experimental ..
- The Frontotemporal Lobar Degeneration Neuroimaging InitiativeHoward J Rosen; Fiscal Year: 2010..This information will be valuable to researchers planning trials of new medications for FTLD, so they can use brain imaging to help decide which drugs show the most promise for treating the disease. ..