Howard Rosen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
  2. ncbi request reprint Self-conscious emotion deficits in frontotemporal lobar degeneration
    Virginia E Sturm
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Brain 129:2508-16. 2006
  3. pmc Dextromethorphan/quinidine sulfate for pseudobulbar affect
    Howard Rosen
    UCSF Department of Neurology, Memory and Aging Center, San Francisco, California 94143, USA
    Drugs Today (Barc) 44:661-8. 2008
  4. ncbi request reprint A real reason for patients with pseudobulbar affect to smile
    Howard J Rosen
    Department of Neurology, University of California, San Francisco 94143, USA
    Ann Neurol 61:92-6. 2007
  5. doi request reprint Anosognosia in neurodegenerative disease
    Howard J Rosen
    UCSF Department of Neurology, Memory and Aging Center, San Francisco, CA 94143, USA
    Neurocase 17:231-41. 2011
  6. pmc Neuroanatomical correlates of behavioural disorders in dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    Brain 128:2612-25. 2005
  7. pmc The emotional brain: combining insights from patients and basic science
    Howard J Rosen
    Department of Neurology, University of California, Memory and Aging Center, 350 Parnassus Ave, Suite 905, Box 1207, San Francisco, CA 94143 1207, USA
    Neurocase 15:173-81. 2009
  8. pmc Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease
    Howard J Rosen
    Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Neuroimage 49:3358-64. 2010
  9. pmc Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis
    Nicholas T Olney
    UCSF School of Medicine, San Francisco, CA 94143 1207, USA
    Brain 134:3458-69. 2011
  10. pmc MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 59:2098-109. 2012

Research Grants

  1. Awareness of Deficits in Dementia
    Howard J Rosen; Fiscal Year: 2010
  2. Emotion in Dementia
    Howard Rosen; Fiscal Year: 2004
  3. The Frontotemporal Lobar Degeneration Neuroimaging Initiative
    Howard Rosen; Fiscal Year: 2009
  4. The Frontotemporal Lobar Degeneration Neuroimaging Initiative
    Howard J Rosen; Fiscal Year: 2010

Detail Information

Publications47

  1. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  2. ncbi request reprint Self-conscious emotion deficits in frontotemporal lobar degeneration
    Virginia E Sturm
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Brain 129:2508-16. 2006
    ..Disrupted self-conscious emotions in FTLD patients may have clinical importance because these deficits may underlie some of the socially inappropriate behaviours that are common in these patients...
  3. pmc Dextromethorphan/quinidine sulfate for pseudobulbar affect
    Howard Rosen
    UCSF Department of Neurology, Memory and Aging Center, San Francisco, California 94143, USA
    Drugs Today (Barc) 44:661-8. 2008
    ..Currently, the antidepressants are probably the most attractive pharmacologic options for treatment of PBA. The choice of whether to use DM/Q in this setting will likely depend on individual patient factors as well as cost...
  4. ncbi request reprint A real reason for patients with pseudobulbar affect to smile
    Howard J Rosen
    Department of Neurology, University of California, San Francisco 94143, USA
    Ann Neurol 61:92-6. 2007
    ..The growing number of treatment options, some of great benefit to patients, highlights the importance of accurate diagnosis of this disorder...
  5. doi request reprint Anosognosia in neurodegenerative disease
    Howard J Rosen
    UCSF Department of Neurology, Memory and Aging Center, San Francisco, CA 94143, USA
    Neurocase 17:231-41. 2011
    ..Specification of the specific processes whose potential failure results in anosognosia can establish a roadmap for future studies...
  6. pmc Neuroanatomical correlates of behavioural disorders in dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    Brain 128:2612-25. 2005
    ..Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions...
  7. pmc The emotional brain: combining insights from patients and basic science
    Howard J Rosen
    Department of Neurology, University of California, Memory and Aging Center, 350 Parnassus Ave, Suite 905, Box 1207, San Francisco, CA 94143 1207, USA
    Neurocase 15:173-81. 2009
    ..A thorough understanding of emotional dysfunction in neurological disease will require a sophisticated approach to studying emotion, which takes into account these various processes and links them to neuroanatomical changes...
  8. pmc Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease
    Howard J Rosen
    Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Neuroimage 49:3358-64. 2010
    ..We hypothesize that emotional/physiological processing carried out by vmPFC is an important factor mediating self-appraisal accuracy in dementia...
  9. pmc Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis
    Nicholas T Olney
    UCSF School of Medicine, San Francisco, CA 94143 1207, USA
    Brain 134:3458-69. 2011
    ....
  10. pmc MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia
    Duygu Tosun
    Center for Imaging Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroimage 59:2098-109. 2012
    ....
  11. pmc Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia
    Karl Young
    Department of Radiology, University of California San Francisco, and VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Hum Brain Mapp 30:1667-77. 2009
    ....
  12. ncbi request reprint AVP-923, a combination of dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar affect and neuropathic pain
    Nicholas Olney
    University of California, San Francisco, Department of Neurology, Memory and Aging Center, Suite 706, San Francisco, CA 94143, USA
    IDrugs 13:254-65. 2010
    ..Pending approval of the data from the FDA, AVP-923 would be the first FDA-approved treatment for PBA...
  13. pmc Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Brain 133:512-28. 2010
    ..Our data are consistent with a model in which both early amyloid-beta accumulation and increased vulnerability to amyloid-beta pathology play critical roles in the pathogenesis of Alzheimer's disease in young patients...
  14. pmc Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
    An Tao Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 130:1159-66. 2007
    ..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia...
  15. pmc Magnetic resonance imaging correlates of set shifting
    Joel H Kramer
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Int Neuropsychol Soc 13:386-92. 2007
    ..Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning...
  16. pmc Patterns of white matter atrophy in frontotemporal lobar degeneration
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Arch Neurol 64:1619-24. 2007
    ..Structural magnetic resonance imaging (MRI) has been used to investigate the in vivo pathology of frontotemporal lobar degeneration. However, few neuroimaging studies have focused on white matter (WM) alterations in this disease...
  17. pmc Neuroimaging in dementia
    Maria Carmela Tartaglia
    University of California, San Francisco Memory and Aging Center, San Francisco, California 94143, USA
    Neurotherapeutics 8:82-92. 2011
    ..Structural and functional imaging modalities contribute to the diagnosis and understanding of the different dementias...
  18. pmc Standardised measurement of self-awareness deficits in FTD and AD
    Craig Williamson
    Department of Neurology, University of California, San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Box 1207, Suite 905, San Francisco, CA 94143 1207, USA
    J Neurol Neurosurg Psychiatry 81:140-5. 2010
    ..Here, the authors introduce a new method that allows objective quantification of an individual's awareness of their cognitive abilities and relies upon objective bedside testing...
  19. pmc Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease
    Katherine L Possin
    Department of Neurology, University of California San Francisco, San Francisco, California, USA
    J Int Neuropsychol Soc 15:354-64. 2009
    ..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region...
  20. pmc Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease
    Casey E Krueger
    UCSF Department of Neurology, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:43-8. 2010
    ..Measuring specific regions of cerebral volume changes by serial neuroimaging may serve as a useful biomarker outcome measure for clinical trials in neurodegenerative diseases...
  21. pmc White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 132:2579-92. 2009
    ..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease...
  22. pmc Multiple cognitive deficits in amnestic mild cognitive impairment
    Joel H Kramer
    San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Dement Geriatr Cogn Disord 22:306-11. 2006
    ..To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form of mild cognitive impairment (MCI)...
  23. pmc Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD
    Katherine P Rankin
    University of California San Francisco, San Francisco, Calif, USA
    Dement Geriatr Cogn Disord 17:328-32. 2004
    ..These data support the hypothesis that regulation of agreeableness arises from a balanced, mutually inhibitory circuit involving both hemispheres...
  24. pmc Cognition and anatomy in three variants of primary progressive aphasia
    Maria Luisa Gorno-Tempini
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
    Ann Neurol 55:335-46. 2004
    ..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes...
  25. ncbi request reprint Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia
    Adam L Boxer
    Memory and Aging Center and the Department of Neurology, University of California at San Francisco, 94143, USA
    Arch Neurol 60:949-56. 2003
    ..Progressive brain atrophy is associated with Alzheimer disease (AD) and other dementias. Regional differences in brain atrophy may reflect clinical features of disease...
  26. ncbi request reprint Recognition of emotion in the frontal and temporal variants of frontotemporal dementia
    Howard J Rosen
    Department of Neurology, University of California, Memory and Aging Center, San Francisco, Calif, USA
    Dement Geriatr Cogn Disord 17:277-81. 2004
    ..These results suggest that damage to frontal lobe regions in FTD may lead to more profound impairment in recognition of emotion than when damage is more limited to the temporal lobe...
  27. ncbi request reprint Emotion comprehension in the temporal variant of frontotemporal dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
    Brain 125:2286-95. 2002
    ..These results have implications both for the clinical presentation in tvFTD patients and for the study of the neuroanatomical basis of emotion...
  28. pmc Hippocampal volume and retention in Alzheimer's disease
    Joel H Kramer
    Department of Neurology, University of California at San Francisco, 94143, USA
    J Int Neuropsychol Soc 10:639-43. 2004
    ..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
  29. ncbi request reprint Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, San Francisco, California 94143 1207, USA
    Alzheimer Dis Assoc Disord 18:202-7. 2004
    ..Thus, in FTD the CDR reveals functional impairments in a wide variety of domains that are more severe than those seen in AD or SD patients with an equivalent Mini-Mental State Examination...
  30. ncbi request reprint Frontotemporal lobar degeneration: demographic characteristics of 353 patients
    Julene K Johnson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, 94117, USA
    Arch Neurol 62:925-30. 2005
    ..The publication of consensus criteria for FTLD, however, prompted systematic studies. The criteria categorize FTLD into 3 subgroups: frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia...
  31. ncbi request reprint Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease
    Joel H Kramer
    University of California Medical Center, San Francisco, California 94143, USA
    Cogn Behav Neurol 16:211-8. 2003
    ..To assess the ability of a brief neuropsychological bedside screening battery to discriminate between Alzheimer disease, frontotemporal dementia, and semantic dementia...
  32. ncbi request reprint Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Arch Neurol 63:81-6. 2006
    ..Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease...
  33. pmc Dissociations in hippocampal and frontal contributions to episodic memory performance
    Joel H Kramer
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Neuropsychology 19:799-805. 2005
    ....
  34. ncbi request reprint Clinical and neuropsychological features of corticobasal degeneration
    Nataliya Belfor
    University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
    Mech Ageing Dev 127:203-7. 2006
    ..Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis...
  35. ncbi request reprint Patterns of cerebral atrophy in primary progressive aphasia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
    Am J Geriatr Psychiatry 10:89-97. 2002
    ..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis...
  36. ncbi request reprint Neuroanatomical correlates of impaired recognition of emotion in dementia
    Howard J Rosen
    University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
    Neuropsychologia 44:365-73. 2006
    ....
  37. ncbi request reprint Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, San Francisco, CA 94143 1207, USA
    Neurology 58:1608-15. 2002
    ..To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD...
  38. pmc Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration
    Carole S Scherling
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA
    Ann Neurol 75:116-26. 2014
    ..Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD...
  39. pmc A tensor based morphometry study of longitudinal gray matter contraction in FTD
    Simona M Brambati
    Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
    Neuroimage 35:998-1003. 2007
    ..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD...
  40. pmc Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
    Katya Rascovsky
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA 19104, USA
    Brain 134:2456-77. 2011
    ..Future studies will be needed to establish the reliability and specificity of these revised diagnostic guidelines...
  41. pmc Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease
    Siobhan Garbutt
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Brain 131:1268-81. 2008
    ..These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders...
  42. pmc Progranulin mutations as risk factors for Alzheimer disease
    David C Perry
    Department of Neurology, University of California, San Francisco, CA 94158, USA
    JAMA Neurol 70:774-8. 2013
    ..We describe 2 patients with progranulin gene mutations and evidence of Alzheimer disease (AD) pathology. We also conducted a literature review...
  43. pmc The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
    Alzheimers Dement 9:189-98. 2013
    ..We conclude that FTD research has reached sufficient maturity to pursue clinical development of specific FTD therapies...
  44. ncbi request reprint 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions
    Kirk C Wilhelmsen
    Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
    Arch Neurol 61:398-406. 2004
    ..The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with neuronal or glial tau inclusions...
  45. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  46. pmc Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease
    Michael D Geschwind
    Departments of Neurology, University of California, San Francisco, UCSF Memory and Aging Center, Box 1207, SanFrancisco, CA 94143 1207, USA
    Alzheimer Dis Assoc Disord 23:82-87. 2009
    ..77; P=0.0006), followed by reactive astrocytic gliosis (r=0.63, P=0.008). This case provides further evidence that DWI abnormalities correlate well with the clinical features and with PrP(Sc) accumulation and vacuolation...
  47. pmc Neuroimaging in dementia
    Paolo Vitali
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, CA 94143, USA
    Semin Neurol 28:467-83. 2008
    ..Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging is clearly an invaluable tool for the clinician in the differential diagnosis...

Research Grants4

  1. Awareness of Deficits in Dementia
    Howard J Rosen; Fiscal Year: 2010
    ..This project will attempt to understand why patients with dementia have such poor awareness of their disability using cognitive tests developed by neuroscientists, and using brain imaging. ..
  2. Emotion in Dementia
    Howard Rosen; Fiscal Year: 2004
    ..b>Howard Rosen to supplement his skills in behavioral neurology and neuroimaging with training in theoretical and experimental ..
  3. The Frontotemporal Lobar Degeneration Neuroimaging Initiative
    Howard Rosen; Fiscal Year: 2009
    ..This information will be valuable to researchers planning trials of new medications for FTLD, so they can use brain imaging to help decide which drugs show the most promise for treating the disease. ..
  4. The Frontotemporal Lobar Degeneration Neuroimaging Initiative
    Howard J Rosen; Fiscal Year: 2010
    ..This information will be valuable to researchers planning trials of new medications for FTLD, so they can use brain imaging to help decide which drugs show the most promise for treating the disease. ..