Henry Rosen

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Differential effects of myeloperoxidase-derived oxidants on Escherichia coli DNA replication
    H Rosen
    Departments of Medicine, University of Washington, Seattle, Washington 98195, USA
    Infect Immun 66:2655-9. 1998
  2. ncbi request reprint Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis
    Henry Rosen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 277:30463-8. 2002
  3. pmc Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils
    Henry Rosen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:18686-91. 2009
  4. ncbi request reprint Bacterial responses to neutrophil phagocytosis
    Henry Rosen
    Department of Medicine, University of Washington, Seattle 98195, USA
    Curr Opin Hematol 11:1-6. 2004
  5. ncbi request reprint Neutrophil microbicidal activity: screening bacterial mutants for survival after phagocytosis using quantitative PCR
    Henry Rosen
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Jpn J Infect Dis 57:S19-21. 2004
  6. pmc mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils
    Benjamin J Staudinger
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 110:1151-63. 2002
  7. ncbi request reprint Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007
  8. pmc Myeloperoxidase: a front-line defender against phagocytosed microorganisms
    Seymour J Klebanoff
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Leukoc Biol 93:185-98. 2013
  9. ncbi request reprint Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella
    William Wiley Navarre
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Science 313:236-8. 2006
  10. pmc The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region
    Raquel Herrero
    Medical Research Service of the VA Puget Sound Health Center, Seattle, Washington, USA
    J Clin Invest 121:1174-90. 2011

Research Grants

  1. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2003
  2. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2004
  3. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2005
  4. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2006

Collaborators

Detail Information

Publications14

  1. pmc Differential effects of myeloperoxidase-derived oxidants on Escherichia coli DNA replication
    H Rosen
    Departments of Medicine, University of Washington, Seattle, Washington 98195, USA
    Infect Immun 66:2655-9. 1998
    ..coli chromosomal DNA synthesis...
  2. ncbi request reprint Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis
    Henry Rosen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 277:30463-8. 2002
    ..Nitration required NADPH oxidase but appeared to be independent of myeloperoxidase, suggesting that neutrophils can nitrate proteins through a pathway that requires nitrite but is independent of myeloperoxidase...
  3. pmc Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils
    Henry Rosen
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:18686-91. 2009
    ..The findings further suggest that protein translocation to the cell envelope is one important pathway targeted for damage...
  4. ncbi request reprint Bacterial responses to neutrophil phagocytosis
    Henry Rosen
    Department of Medicine, University of Washington, Seattle 98195, USA
    Curr Opin Hematol 11:1-6. 2004
    ..This review focuses on adaptive bacterial interactions with neutrophils, emphasizing information communicated within the past year about bacterial factors that respond to contact with or phagocytosis by PMN...
  5. ncbi request reprint Neutrophil microbicidal activity: screening bacterial mutants for survival after phagocytosis using quantitative PCR
    Henry Rosen
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Jpn J Infect Dis 57:S19-21. 2004
    ....
  6. pmc mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils
    Benjamin J Staudinger
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 110:1151-63. 2002
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about bacterial defenses mounted in response to this hostile environment...
  7. ncbi request reprint Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
    Yi Wang
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98195, USA
    J Biol Chem 282:31826-34. 2007
    ..Our findings suggest that pericellular production of HOCl by phagocytes is a pathogenic mechanism for impairing TIMP-1 activity during inflammation...
  8. pmc Myeloperoxidase: a front-line defender against phagocytosed microorganisms
    Seymour J Klebanoff
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Leukoc Biol 93:185-98. 2013
    ....
  9. ncbi request reprint Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella
    William Wiley Navarre
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Science 313:236-8. 2006
    ..Characteristic GC/AT ratios of bacterial genomes may facilitate discrimination between a cell's own DNA and foreign DNA...
  10. pmc The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region
    Raquel Herrero
    Medical Research Service of the VA Puget Sound Health Center, Seattle, Washington, USA
    J Clin Invest 121:1174-90. 2011
    ..These data provide what we believe to be new insights into the structural determinants of sFasL bioactivity in the lungs of patients with ALI...
  11. ncbi request reprint Clinical problem-solving. A jaundiced eye
    John K Amory
    Department of Internal Medicine, University of Washington, Seattle, WA 98195, USA
    N Engl J Med 354:1516-20. 2006
  12. doi request reprint A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the Sec pathway
    Gregory J Crowther
    University of Washington, Seattle, WA, USA
    J Biomol Screen 17:535-41. 2012
    ..Testing of current antibiotics confirmed that they do not generally act through the Sec pathway. A mini-screen of 800 compounds indicated the assay's readiness for larger screening projects...
  13. ncbi request reprint Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils
    Chien Ying Liu
    Department of Medicine, Pathology, and Surgery, University of Washington, Seattle, USA
    Blood 101:295-304. 2003
    ..Furthermore, they suggest that TNF-alpha activates a caspase-dependent pathway that negatively regulates reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity...
  14. pmc Effect of inactivation of the global oxidative stress regulator oxyR on the colonization ability of Escherichia coli O1:K1:H7 in a mouse model of ascending urinary tract infection
    James R Johnson
    University of Minnesota Department of Medicine, Infectious Diseases 111F, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Infect Immun 74:461-8. 2006
    ..coli. They also suggest that neutrophil phagocyte oxidase is not critical for defense against E. coli UTI and that the major oxidative stresses against which OxyR protects E. coli within the host milieu are not phagocyte derived...

Research Grants4

  1. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2003
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about important bacterial defenses mounted in response to this hostile environment. ..
  2. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2004
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about important bacterial defenses mounted in response to this hostile environment. ..
  3. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2005
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about important bacterial defenses mounted in response to this hostile environment. ..
  4. Microbial Response to Neutrophil Phagocytosis
    Henry Rosen; Fiscal Year: 2006
    ..Expression profiling of phagocytosed bacteria appears to provide useful information about conditions in the phagocytic vacuole and about important bacterial defenses mounted in response to this hostile environment. ..