C J Rosen

Summary

Affiliation: University of Maine
Country: USA

Publications

  1. ncbi request reprint Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities
    C J Rosen
    St Joseph Hospital, Bangor, ME 04401, USA
    Bone 21:217-23. 1997
  2. ncbi request reprint Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density
    C J Rosen
    Jackson Laboratory, Bar Harbor, Maine 04605, USA
    J Clin Endocrinol Metab 83:2286-90. 1998
  3. ncbi request reprint Insulin-like growth factors and bone: the osteoporosis connection revisited
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 04401, USA
    Proc Soc Exp Biol Med 219:1-7. 1998
  4. ncbi request reprint Biochemical markers of bone turnover. A look at laboratory tests that reflect bone status
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 00401, USA
    Postgrad Med 104:101-2, 107-10, 113-4. 1998
  5. doi request reprint Mouse models for understanding the growth hormone insulin-like growth factor-I axis
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Horm Res 68:2-4. 2007
  6. ncbi request reprint Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice
    W G Beamer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 10:1043-9. 1999
  7. ncbi request reprint Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice
    W G Beamer
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 16:1195-206. 2001
  8. ncbi request reprint Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition
    K M Delahunty
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Endocrinology 147:3915-23. 2006
  9. pmc Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice
    V E DeMambro
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Endocrinology 149:2051-61. 2008
  10. pmc Gender- and compartment-specific bone loss in C57BL/6J mice: correlation to season?
    K M Delahunty
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Clin Densitom 12:89-94. 2009

Detail Information

Publications76

  1. ncbi request reprint Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities
    C J Rosen
    St Joseph Hospital, Bangor, ME 04401, USA
    Bone 21:217-23. 1997
    ..05). These data suggest that a possible mechanism for the difference in acquisition and maintenance of bone mass between these two inbred strains is related to systemic and skeletal IGF-I synthesis...
  2. ncbi request reprint Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density
    C J Rosen
    Jackson Laboratory, Bar Harbor, Maine 04605, USA
    J Clin Endocrinol Metab 83:2286-90. 1998
    ..Further family and pedigree studies are needed to characterize the relationship of bone mass acquisition to the IGF-I genotype...
  3. ncbi request reprint Insulin-like growth factors and bone: the osteoporosis connection revisited
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 04401, USA
    Proc Soc Exp Biol Med 219:1-7. 1998
    ....
  4. ncbi request reprint Biochemical markers of bone turnover. A look at laboratory tests that reflect bone status
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 00401, USA
    Postgrad Med 104:101-2, 107-10, 113-4. 1998
    ..In the future, biochemical markers may provide important information on fracture risks as well...
  5. doi request reprint Mouse models for understanding the growth hormone insulin-like growth factor-I axis
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Horm Res 68:2-4. 2007
    ..The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass...
  6. ncbi request reprint Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice
    W G Beamer
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 10:1043-9. 1999
    ..The current large size of the QTL regions (6-->31 cM) renders premature any discussion of candidate genes at this time. Fine mapping of these QTLs is in progress to refine their genetic positions and to evaluate human homologies...
  7. ncbi request reprint Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice
    W G Beamer
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 16:1195-206. 2001
    ..Importantly, the BMD QTLs that we have identified are in regions of the mouse genome that have known human homology, and the QTLs will become useful experimental tools for mechanistic and therapeutic analyses of bone regulatory genes...
  8. ncbi request reprint Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition
    K M Delahunty
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Endocrinology 147:3915-23. 2006
    ..Congenic mice establish proof of concept of shared genetic determinants for both circulating IGF-I and bone acquisition...
  9. pmc Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice
    V E DeMambro
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Endocrinology 149:2051-61. 2008
    ..In summary, there are gender- and compartment-specific changes in Igfbp2(-/-) mice. IGFBP-2 may regulate bone turnover in both an IGF-I-dependent and -independent manner...
  10. pmc Gender- and compartment-specific bone loss in C57BL/6J mice: correlation to season?
    K M Delahunty
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Clin Densitom 12:89-94. 2009
    ..Further studies are needed to determine the environmental factors that cue seasonal changes in body composition and the mechanisms that produce these changes...
  11. pmc Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo
    B Lecka-Czernik
    St Joseph Hospital, Maine Center for Osteoporosis Research and Education, 360 Broadway, Bangor, Maine 04401, USA
    Endocrinology 148:903-11. 2007
    ..05), and at 16 wk their levels were reduced 14% vs. placebo (P = 0.15). We conclude that Rosi suppresses IGF-I expression in bone and liver; these changes could affect skeletal acquisition through endocrine and paracrine pathways...
  12. ncbi request reprint Clinical review 123: Anabolic therapy for osteoporosis
    C J Rosen
    St Joseph Hospital, Bangor, Maine 04401, USA
    J Clin Endocrinol Metab 86:957-64. 2001
    ..Fluoride, GH, insulin-like growth factor I, the statins, and PTH will be reviewed. Although still in development, approaches to combination therapy with antiresorptives and anabolic agents are also promising...
  13. ncbi request reprint Defining the genetics of osteoporosis: using the mouse to understand man
    C J Rosen
    The Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 04401, USA
    Osteoporos Int 12:803-10. 2001
    ..The future of the mouse as a tool to map the genes that define the osteoporosis syndrome is extremely promising...
  14. ncbi request reprint Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Bone 27:521-8. 2000
    ..C3H-6 congenic mice demonstrated effects on both the IGF-1 and BMD phenotypes. The genetic determinants of these Igf1sl QTLs will provide much insight into the regulation of IGF-1 and the subsequent acquisition of peak bone mass...
  15. ncbi request reprint Growth hormone and aging
    C J Rosen
    The Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 04401, USA
    Endocrine 12:197-201. 2000
    ..Hence, there is less enthusiasm for reversing the changes of the "somatopause" with recombinant growth factors. An overview of these issues and the prospects for the future will be discussed in this article...
  16. ncbi request reprint IGF-I and osteoporosis
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, USA
    Clin Lab Med 20:591-602. 2000
    ..Caution must be undertaken in deciphering the results of a low, normal, or high IGF-I in relation to osteoporosis. Future studies should help define more clearly the possible pathogenic relationship between IGF-I and bone mass...
  17. ncbi request reprint Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation
    W G Beamer
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Bone 27:619-26. 2000
    ....
  18. ncbi request reprint Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, 360 Broadway, Bangor, ME 04401, USA
    Clin Chem 45:1384-90. 1999
    ..The IGFs remain a major area for basic and clinical investigations; future studies may define both diagnostic and therapeutic roles for these peptides or their related proteins in several disease states...
  19. pmc PPARgamma2 Regulates a Molecular Signature of Marrow Mesenchymal Stem Cells
    K R Shockley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    PPAR Res 2007:81219. 2007
    ..These observations may have important therapeutic consequences and indicate a need for more detailed studies of PPARgamma2 role in stem cell biology...
  20. ncbi request reprint Emerging anabolic treatments for osteoporosis
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, USA
    Rheum Dis Clin North Am 27:215-33, viii. 2001
    ..The two most promising agents, parathyroid hormone (PTH) and GH/IGF-I, act to increase osteoblast mediated bone formation. A review of the potential usefulness of PTH and GH/IGF-I is presented...
  21. ncbi request reprint Older women track and field athletes have enhanced calcaneal stiffness
    J M Welch
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, Maine, USA
    Osteoporos Int 16:871-8. 2005
    ....
  22. ncbi request reprint Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Pediatr Nephrol 20:255-60. 2005
    ..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...
  23. ncbi request reprint Adolescent girls in Maine are at risk for vitamin D insufficiency
    Susan S Sullivan
    Department of Food Science and Human Nutrition, University of Maine, Orono 04469, USA
    J Am Diet Assoc 105:971-4. 2005
    ..Mean parathyroid hormone levels increased 4 pg/mL (15%) from September to March. Vitamin D intakes need to be increased in winter at northern latitudes...
  24. ncbi request reprint Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies
    Clifford J Rosen
    St Joseph Hospital, The Jackson Laboratory, 900 Broadway, Bldg No 2, Bangor, ME 04401, USA
    Best Pract Res Clin Endocrinol Metab 18:423-35. 2004
    ..The implications from these animal models are far-reaching and suggest that newer approaches for manipulating the IGF regulatory system may one day be useful as therapeutic adjuncts for the treatment of osteoporosis...
  25. ncbi request reprint Vignettes in osteoporosis: a road map to successful therapeutics
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, Maine 04401, USA
    J Bone Miner Res 19:3-10. 2004
    ..We describe five common clinical scenarios encountered in the practice of osteoporosis medicine and various road maps that could lead to successful therapy...
  26. ncbi request reprint The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone
    Shoshana Yakar
    National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
    J Endocrinol 189:289-99. 2006
    ..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)...
  27. ncbi request reprint The cellular and clinical parameters of anabolic therapy for osteoporosis
    Clifford J Rosen
    The Jackson Laboratory and St Joseph Hospital, Bangor, ME 04401, USA
    Crit Rev Eukaryot Gene Expr 13:25-38. 2003
    ..Novel in vivo strategies, including temporal and conditional mutagenesis, will almost certainly lead to newer therapeutic paradigms for the treatment of postmenopausal osteoporosis...
  28. ncbi request reprint Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ....
  29. pmc PPARG by dietary fat interaction influences bone mass in mice and humans
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1398-408. 2008
    ..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene...
  30. ncbi request reprint Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone
    Daniel D Bikle
    Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA
    J Bone Miner Res 17:1570-8. 2002
    ..These results indicate that IGF-I is required for the anabolic actions of PTH on bone formation, but the defect lies distal to the initial response of the osteoblast to PTH...
  31. ncbi request reprint Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuse
    Jean D Sibonga
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Bone 40:1013-20. 2007
    ..These results suggest that alcohol consumption, in addition to inducing bone loss, may reduce the efficacy of PTH therapy to reverse osteoporosis...
  32. ncbi request reprint The role of parathyroid hormone in the management of osteoporosis
    Clifford J Rosen
    The Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME, USA
    Horm Res 64:81-5. 2005
    ....
  33. ncbi request reprint A rational approach to evidence gaps in the management of osteoporosis
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Am J Med 118:1183-9. 2005
    ..Evidence gaps in each treatment scenario are presented, and rational approaches to management are suggested...
  34. ncbi request reprint IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo
    Janet Rubin
    Department of Medicine, Emory University and VAMC, Decatur, Georgia
    Prostate 66:789-800. 2006
    ..IGF-I is an important growth and differentiative factor for osteoblasts and may have a role in defining prostate cancer risk and skeletal metastases...
  35. ncbi request reprint Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men
    Yah Tyng Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 91:307-12. 2006
    ..Nuclear receptor coactivator-3 (NCOA3) is a member of the steroid receptor coactivator family that interacts with nuclear hormone receptors to enhance their transcriptional activation function and may play a role in somatic growth...
  36. pmc Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways
    Farhan A Syed
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:1992-2001. 2005
    ..This study defines the skeletal phenotype and responses to ovariectomy and estrogen replacement in these mice...
  37. ncbi request reprint Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3h/HeJ inbred strains of mice. (2001)
    Wesley G Beamer
    J Bone Miner Res 20:1701-12; discussion 1700. 2005
  38. pmc Serum concentrations of insulin-like growth factor and insulin-like growth factor binding protein 3 and recurrent colorectal adenomas
    Andrew Flood
    Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Cancer Epidemiol Biomarkers Prev 17:1493-8. 2008
    ..Why IGF-I would decrease risk of recurrent adenoma (as distinct from incident adenoma or colorectal cancer) is not clear...
  39. ncbi request reprint Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men
    Thomas Münzer
    Endocrine Section, Laboratory of Clinical Investigations, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Am J Physiol Endocrinol Metab 290:E1006-13. 2006
    ..Whether GH and/or sex steroid administration alters local tissue production of IGFBPs and whether the latter influence autocrine or paracrine actions of IGF-I remain to be determined...
  40. ncbi request reprint Postnatal growth and bone mass in mice with IGF-I haploinsufficiency
    Jianing He
    Department of Medicine, The University of Connecticut Health Center, Farmington, 06030 1850, USA
    Bone 38:826-35. 2006
    ..These studies show that IGF-I is a determinant of bone size and mass in postnatal life. We speculate that impaired osteoblast proliferation may contribute to the skeletal phenotype of mice with IGF-I haploinsufficiency...
  41. pmc Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 93:2166-72. 2008
    ..Daily PTH administration increases bone mineral density (BMD) and reduces fracture risk. However, cost and compliance significantly limit clinical use...
  42. pmc Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton
    Sharon J Tanner
    Endocrine Research Unit, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Bone Miner Res 23:655-62. 2008
    ....
  43. ncbi request reprint Genetic increase in serum insulin-like growth factor-I (IGF-I) in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter
    Martin L Adamo
    Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Endocrinology 147:2944-55. 2006
    ..The increased IGF binding protein-5 mRNA levels in fat and muscle suggest that IGF-I signaling is increased in these tissues in C3H mice...
  44. ncbi request reprint A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesis
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Ann N Y Acad Sci 1116:291-305. 2007
    ..Rather, 6T demonstrates that disordered regulation of gene expression by genomic rearrangement can have a profound effect on a complex trait, such as BMD, and that genomic rearrangement can supersede the effects of various alleles...
  45. ncbi request reprint Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling
    Jin Jiang
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 39:494-504. 2006
    ..Thus, broad overexpression of IGF-I in cells of the osteoblast lineage increased indices of bone formation and resorption...
  46. ncbi request reprint Effects of loss of classical estrogen response element signaling on bone in male mice
    Farhan A Syed
    Endocrine Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    Endocrinology 148:1902-10. 2007
    ..Collectively, these data demonstrate that classical ERalpha signaling is crucial for the development of the murine male skeleton...
  47. ncbi request reprint Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development
    Aimee V Loladze
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 147:5412-23. 2006
    ..Taken together, our results support distinct roles for IGF-I expressed in epithelial and stromal compartments in mediating growth of the postnatal mammary gland...
  48. ncbi request reprint The insulin-like growth factor-I gene and osteoporosis: a critical appraisal
    Tianhua Niu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Gene 361:38-56. 2005
    ..Molecular dissection of the IGF regulatory system and its signaling pathway in bone may reveal novel therapeutic targets for the treatment of osteoporosis...
  49. ncbi request reprint Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D
    Mara J Horwitz
    Division of Endocrinology, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 20:1792-803. 2005
    ..Continuous infusion of both PTH and PTHrP results in marked and prolonged suppression of bone formation; renal 1,25(OH)2D synthesis was stimulated effectively by PTH but poorly by PTHrP...
  50. ncbi request reprint Clinical practice. Postmenopausal osteoporosis
    Clifford J Rosen
    St Joseph Hospital, Maine Center for Osteoporosis Research and Education, Bangor, ME 04401, USA
    N Engl J Med 353:595-603. 2005
  51. ncbi request reprint From mouse to man: redefining the role of insulin-like growth factor-I in the acquisition of bone mass
    Shoshana Yakar
    The National Institutes of Health and The Jackson Laboratory and St Joseph Hospital, Bangor, Maine 04401, USA
    Exp Biol Med (Maywood) 228:245-52. 2003
    ..The implications are far reaching and suggest that newer approaches for manipulating the IGF regulatory system may one day be useful as therapeutic adjuncts for the treatment of osteoporosis...
  52. ncbi request reprint The role of circulating IGF-I: lessons from human and animal models
    Shoshana Yakar
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, NIDDK, National Institute of Health, Bethesda, MD 20892, USA
    Endocrine 19:239-48. 2002
    ..This review will revisit the IGF system with particular attention to the role of circulating IGF-I in growth regulation, metabolism, and cancer...
  53. ncbi request reprint Growth hormone rising: did we quit too quickly?
    Clifford J Rosen
    J Bone Miner Res 18:406-9. 2003
  54. ncbi request reprint Restoring aging bones
    Clifford J Rosen
    Sci Am 288:70-7. 2003
  55. ncbi request reprint Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density
    Kathryn L Shultz
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 18:175-85. 2003
    ....
  56. ncbi request reprint Effects of oral dehydroepiandrosterone on bone density in young women with anorexia nervosa: a randomized trial
    Catherine M Gordon
    Division of Adolescent Young Adult Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Clin Endocrinol Metab 87:4935-41. 2002
    ..Both therapies significantly decreased bone resorption. Replicating results from studies of the elderly, DHEA resulted in improvements in specific psychological parameters in these young women...
  57. pmc Circulating levels of IGF-1 directly regulate bone growth and density
    Shoshana Yakar
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 110:771-81. 2002
    ....
  58. ncbi request reprint Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
    ..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
  59. ncbi request reprint Physiologic regulators of bone turnover in young women with anorexia nervosa
    Catherine M Gordon
    Division of Adolescent Young Adult Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    J Pediatr 141:64-70. 2002
    ..To clarify the role of physiologic regulators of bone turnover in patients with anorexia nervosa (AN)...
  60. ncbi request reprint Lack of association between adipose tissue distribution and IGF-1 and IGFBP-3 in men and women
    Robert E Schoen
    Departments of Epidemiology, Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Cancer Epidemiol Biomarkers Prev 11:581-6. 2002
    ..The lack of association between obesity and the IGF-1 axis suggests that the IGF-1 axis is not a likely mediator between VAT and disease...
  61. ncbi request reprint North American male reference population for speed of sound in bone at multiple skeletal sites
    Stephen R Hayman
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Clin Densitom 5:63-71. 2002
    ..Longitudinal monitoring of healthy men should be performed to confirm these cross-sectional results...
  62. ncbi request reprint Severe hypocalcemia after intravenous bisphosphonate therapy in occult vitamin D deficiency
    Clifford J Rosen
    N Engl J Med 348:1503-4. 2003
  63. ncbi request reprint PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver
    Yulin Li
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Endocrinology 144:3505-13. 2003
    ..We propose that PERK is required to regulate the expression of IGF-I in the liver during the neonatal period, when IGF-I expression is GH-independent, and that the lack of this regulation results in severe neonatal growth retardation...
  64. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  65. ncbi request reprint One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94105, USA
    N Engl J Med 353:555-65. 2005
    ..In the continuation of this trial, we asked whether antiresorptive therapy is required to maintain gains in bone mineral density after one year of therapy with parathyroid hormone (1-84)...
  66. ncbi request reprint Serum insulin-like growth factor binding protein-1 levels and bone mineral density in older adults: the Rancho Bernardo Study
    Simerjot K Jassal
    Department of Medicine, University of California San Diego and VA San Diego Healthcare System, La Jolla, CA, USA
    Osteoporos Int 16:1948-54. 2005
    ..Studies are needed to further investigate the relationship between inhibitory components of IGF-1 and bone loss...
  67. ncbi request reprint Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps
    Robert E Schoen
    Department of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Gastroenterology 129:464-75. 2005
    ..We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein (IGFBP) 3, and visceral adipose tissue (VAT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer...
  68. ncbi request reprint Ovariectomy-induced bone loss varies among inbred strains of mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 20:1085-92. 2005
    ..We show that patterns of bone loss after ovariectomy vary among inbred strains of mice, providing evidence that there may be genetic regulation of bone loss induced by estrogen deficiency...
  69. ncbi request reprint Igf-I and postnatal growth of weaver mutant mice
    Weiguo Yao
    Department of Anatomy, Indiana University, IN 46202, USA
    Endocrine 26:117-25. 2005
    ..In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice...
  70. ncbi request reprint Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, ME, USA
    Bone 35:1046-58. 2004
    ..Congenic mice are useful models not only for mapping genes related to bone mass but also for elucidating the biology underlying various skeletal phenotypes associated with more subtle manipulation of the mouse genome...
  71. ncbi request reprint Insulin-like growth factor-1
    Lisa H Colbert
    J Am Geriatr Soc 52:1962-3. 2004
  72. ncbi request reprint Idiopathic osteoporosis in premenopausal women
    Mishaela R Rubin
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, N Y 10032, USA
    Osteoporos Int 16:526-33. 2005
    ..4+/-1.6 ng/ml versus 14.7+/-0.8 ng/ml), although the difference was not statistically significant. These results suggest differences in the pathogenesis of idiopathic osteoporosis in women as compared to men with IOP...
  73. ncbi request reprint What's new with PTH in osteoporosis: where are we and where are we headed?
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, 900 Broadway, Bldg 2, Bangor, ME 04401, USA
    Trends Endocrinol Metab 15:229-33. 2004
    ..This review presents recent findings on PTH signaling in bone and discusses how they could be used to design randomized trials and establish clinical practice guidelines for this novel anabolic peptide...
  74. ncbi request reprint Perturbations in bone formation and resorption in insulin-like growth factor binding protein-3 transgenic mice
    Josef V Silha
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Bone Miner Res 18:1834-41. 2003
    ....
  75. ncbi request reprint Insulin-like growth factor I and calcium balance: evolving concepts of an evolutionary process
    Clifford J Rosen
    Jackson Laboratory and St Joseph Hospital, Bangor, Maine 04401, USA
    Endocrinology 144:4679-81. 2003
  76. ncbi request reprint Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo
    Mary L Bouxsein
    The The Jackson Laboratory, Bar Harbor, Maine, USA
    J Bone Miner Res 17:570-9. 2002
    ..This locus also influences bone density and morphology, with more dramatic effects in cancellous bone than in cortical bone...