Timothy M Rose

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc iCODEHOP: a new interactive program for designing COnsensus-DEgenerate Hybrid Oligonucleotide Primers from multiply aligned protein sequences
    Richard Boyce
    Department of Biomedical Informatics, University of Pittsburgh, UPMC Cancer Pavilion, Suite 301, Pittsburgh, PA 15232, USA
    Nucleic Acids Res 37:W222-8. 2009
  2. pmc Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species
    T M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 71:4138-44. 1997
  3. pmc Analysis of 4.3 kilobases of divergent locus B of macaque retroperitoneal fibromatosis-associated herpesvirus reveals a close similarity in gene sequence and genome organization to Kaposi's sarcoma-associated herpesvirus
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 77:5084-97. 2003
  4. pmc CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer) PCR primer design
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 31:3763-6. 2003
  5. pmc CODEHOP-mediated PCR - a powerful technique for the identification and characterization of viral genomes
    Timothy M Rose
    Department of Pathobiology, Box 357238, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:20. 2005
  6. pmc The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques
    A Gregory Bruce
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Virol J 6:205. 2009
  7. ncbi request reprint High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    J Gen Virol 87:3529-38. 2006
  8. pmc Next-generation sequence analysis of the genome of RFHVMn, the macaque homolog of Kaposi's sarcoma (KS)-associated herpesvirus, from a KS-like tumor of a pig-tailed macaque
    A Gregory Bruce
    Seattle Children s Research Institute, Seattle, Washington, USA
    J Virol 87:13676-93. 2013
  9. ncbi request reprint RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells
    Kellie L Burnside
    Department of Pathobiology, School of Public Health and Community Medicine, HSB Rm F161E, Box 357238, University of Washington, Seattle, WA 98195, USA
    Virology 354:103-15. 2006
  10. pmc Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV
    Lidia Cherezova
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e18920. 2011

Collaborators

Detail Information

Publications21

  1. pmc iCODEHOP: a new interactive program for designing COnsensus-DEgenerate Hybrid Oligonucleotide Primers from multiply aligned protein sequences
    Richard Boyce
    Department of Biomedical Informatics, University of Pittsburgh, UPMC Cancer Pavilion, Suite 301, Pittsburgh, PA 15232, USA
    Nucleic Acids Res 37:W222-8. 2009
    ..It also allows the user to bias primer design to favor specific clades or sequences using sequence weights. iCODEHOP is freely available to all interested researchers at https://icodehop.cphi.washington.edu/i-codehop-context/Welcome...
  2. pmc Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species
    T M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 71:4138-44. 1997
    ..Our data suggest that KSHV and the putative macaque herpesviruses define a new group within the subfamily Gammaherpesvirinae whose members are implicated in the pathogenesis of KS and KS-like neoplasms in different primate species...
  3. pmc Analysis of 4.3 kilobases of divergent locus B of macaque retroperitoneal fibromatosis-associated herpesvirus reveals a close similarity in gene sequence and genome organization to Kaposi's sarcoma-associated herpesvirus
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 77:5084-97. 2003
    ....
  4. pmc CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer) PCR primer design
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 31:3763-6. 2003
    ..The CODEHOP designer (http://blocks.fhcrc.org/codehop.html) is linked to BlockMaker and the Multiple Alignment Processor within the Blocks Database World Wide Web (http://blocks.fhcrc.org)...
  5. pmc CODEHOP-mediated PCR - a powerful technique for the identification and characterization of viral genomes
    Timothy M Rose
    Department of Pathobiology, Box 357238, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:20. 2005
    ..While this review describes techniques for the identification of members of the herpesvirus family of DNA viruses, the same methodology and approach is applicable to other virus families...
  6. pmc The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques
    A Gregory Bruce
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Virol J 6:205. 2009
    ..KSHV ORF59 is antigenic in the infected host and is used as a marker for virus activation and replication...
  7. ncbi request reprint High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    J Gen Virol 87:3529-38. 2006
    ..This pattern of infectivity is similar to that seen in KS tumours latently infected with KSHV. Our study demonstrates similarities in the biology of KSHV and RFHV and supports a role for RFHV in the aetiology of SAIDS-RF...
  8. pmc Next-generation sequence analysis of the genome of RFHVMn, the macaque homolog of Kaposi's sarcoma (KS)-associated herpesvirus, from a KS-like tumor of a pig-tailed macaque
    A Gregory Bruce
    Seattle Children s Research Institute, Seattle, Washington, USA
    J Virol 87:13676-93. 2013
    ....
  9. ncbi request reprint RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells
    Kellie L Burnside
    Department of Pathobiology, School of Public Health and Community Medicine, HSB Rm F161E, Box 357238, University of Washington, Seattle, WA 98195, USA
    Virology 354:103-15. 2006
    ..These data suggest that RFHV LANA is an ortholog of KSHV LANA and will function similarly to maintain viral latency and play a role in tumorigenicity in macaques...
  10. pmc Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV
    Lidia Cherezova
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e18920. 2011
    ....
  11. doi request reprint A critical Sp1 element in the rhesus rhadinovirus (RRV) Rta promoter confers high-level activity that correlates with cellular permissivity for viral replication
    Laura K DeMaster
    Department of Global Health, University of Washington, Seattle, WA 98195, USA Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101, USA Electronic address
    Virology 448:196-209. 2014
    ..Instead, the outcome of RRV infection is determined by host factors, such as Sp1...
  12. pmc Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species
    Jeannette Philipp-Staheli
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Virol J 3:11. 2006
    ....
  13. pmc Consensus-degenerate hybrid oligonucleotide primers (CODEHOPs) for the detection of novel viruses in non-human primates
    Jeannette P Staheli
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101 1304, USA
    Methods 49:32-41. 2009
    ..We demonstrate that our pan-papillomavirus CODEHOP assay is broadly reactive with all major branches of the virus family and show its utility in identifying a novel non-human primate papillomavirus in cynomolgus macaques...
  14. pmc Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques
    Jonathan T Ryan
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, Seattle, WA, USA
    Clin Vaccine Immunol 20:409-19. 2013
    ..This will help advance our understanding of rhadinovirus biology and associated host immunological responses...
  15. doi request reprint CODEHOP PCR and CODEHOP PCR primer design
    Jeannette P Staheli
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA, USA
    Methods Mol Biol 687:57-73. 2011
    ..Here, we describe the workflow of a typical CODEHOP PCR assay design and optimization and give a specific implementation example along with "best-practice" advice...
  16. ncbi request reprint Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta)
    H Bielefeldt-Ohmann
    Washington National Primate Research Center, University of Washington, Box 357331, Seattle, WA 98195, USA
    Vet Pathol 42:391-6. 2005
    ..Collectively, these findings suggest a relation to but not absolute identity with simian mesenchymoproliferative disorders (MPD) or typical gastrointestinal stromal tumors (GISTs)...
  17. pmc Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:2. 2005
    ..To determine viral loads per cell, an additional TaqMan QPCR assay was developed to detect the single copy cellular oncostatin M gene...
  18. pmc Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
    ..Our studies demonstrate that alpha(V)beta(3) is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)...
  19. ncbi request reprint Oral Squamous Cell Carcinoma in a Pigtailed Macaque (Macaca nemestrina)
    Diane E Stockinger
    Washington National Primate Research Center, Seattle Children s Research Institute, Seattle, Washington, USA Valley Biosystems, West Sacramento, California, USA
    Comp Med 64:234-9. 2014
    ..Although squamous cell carcinomas are one of the most common oral neoplasia in many species, to our knowledge this case represents the first reported oral squamous cell carcinoma in a pigtailed macaque. ..
  20. ncbi request reprint Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor
    V H Gersuk
    Virginia Mason Research Center, Department of Immunology, Seattle, Washington 98101, USA
    Genomics 25:469-76. 1995
    ..We show that ACBP/DBI is correctly placed on chromosome 2 and that the gene identified on chromosome 6 is DBIP1...
  21. pmc Evolution of the acyl-CoA binding protein (ACBP)
    Mark Burton
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Biochem J 392:299-307. 2005
    ..The appearance of ACBP very early on in evolution points towards a fundamental role of ACBP in acyl-CoA metabolism, including ceramide synthesis and in signalling...

Research Grants5

  1. Viral Etiology of Kaposi's sarcoma-like Tumors
    TIMOTHY ROSE; Fiscal Year: 2005
    ..Additional training and focused research in virology would allow Dr. Rose to expand upon his initial discovery and make further significant contributions in the fields of herpesviruses and viral pathogenicity. ..
  2. A macaque model for AIDS-related oral malignancies
    TIMOTHY ROSE; Fiscal Year: 2007
    ..Such a model could directly impact the prevention, diagnosis, and treatment of this devastating human disease. ..
  3. CODEHOP: Unique web-based technology for gene discovery
    TIMOTHY ROSE; Fiscal Year: 2007
    ..We expect that this will lead to an increased pace of discovery of pathogens implicated in disease, as well as genes of biological and biomedical importance. ..
  4. Herpesvirus latency and reactivation in macaque models of human disease
    TIMOTHY ROSE; Fiscal Year: 2007
    ....
  5. Viral and cellular factors involved in KSHV entry in cells of the oral mucosa
    TIMOTHY ROSE; Fiscal Year: 2007
    ..abstract_text> ..