Timothy M Rose

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species
    T M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 71:4138-44. 1997
  2. ncbi Analysis of 4.3 kilobases of divergent locus B of macaque retroperitoneal fibromatosis-associated herpesvirus reveals a close similarity in gene sequence and genome organization to Kaposi's sarcoma-associated herpesvirus
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 77:5084-97. 2003
  3. ncbi CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer) PCR primer design
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 31:3763-6. 2003
  4. ncbi CODEHOP-mediated PCR - a powerful technique for the identification and characterization of viral genomes
    Timothy M Rose
    Department of Pathobiology, Box 357238, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:20. 2005
  5. ncbi The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques
    A Gregory Bruce
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Virol J 6:205. 2009
  6. ncbi High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    J Gen Virol 87:3529-38. 2006
  7. ncbi RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells
    Kellie L Burnside
    Department of Pathobiology, School of Public Health and Community Medicine, HSB Rm F161E, Box 357238, University of Washington, Seattle, WA 98195, USA
    Virology 354:103-15. 2006
  8. ncbi Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species
    Jeannette Philipp-Staheli
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Virol J 3:11. 2006
  9. ncbi Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV
    Lidia Cherezova
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e18920. 2011
  10. ncbi Consensus-degenerate hybrid oligonucleotide primers (CODEHOPs) for the detection of novel viruses in non-human primates
    Jeannette P Staheli
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101 1304, USA
    Methods 49:32-41. 2009

Research Grants

  1. Viral Etiology of Kaposi's sarcoma-like Tumors
    TIMOTHY ROSE; Fiscal Year: 2005
  2. A macaque model for AIDS-related oral malignancies
    TIMOTHY ROSE; Fiscal Year: 2007
  3. CODEHOP: Unique web-based technology for gene discovery
    TIMOTHY ROSE; Fiscal Year: 2007
  4. Herpesvirus latency and reactivation in macaque models of human disease
    TIMOTHY ROSE; Fiscal Year: 2007
  5. Viral and cellular factors involved in KSHV entry in cells of the oral mucosa
    TIMOTHY ROSE; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. ncbi Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species
    T M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 71:4138-44. 1997
    ..Our data suggest that KSHV and the putative macaque herpesviruses define a new group within the subfamily Gammaherpesvirinae whose members are implicated in the pathogenesis of KS and KS-like neoplasms in different primate species...
  2. ncbi Analysis of 4.3 kilobases of divergent locus B of macaque retroperitoneal fibromatosis-associated herpesvirus reveals a close similarity in gene sequence and genome organization to Kaposi's sarcoma-associated herpesvirus
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    J Virol 77:5084-97. 2003
    ....
  3. ncbi CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primer) PCR primer design
    Timothy M Rose
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 31:3763-6. 2003
    ..The CODEHOP designer (http://blocks.fhcrc.org/codehop.html) is linked to BlockMaker and the Multiple Alignment Processor within the Blocks Database World Wide Web (http://blocks.fhcrc.org)...
  4. ncbi CODEHOP-mediated PCR - a powerful technique for the identification and characterization of viral genomes
    Timothy M Rose
    Department of Pathobiology, Box 357238, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:20. 2005
    ..While this review describes techniques for the identification of members of the herpesvirus family of DNA viruses, the same methodology and approach is applicable to other virus families...
  5. ncbi The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques
    A Gregory Bruce
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA 98101 1304, USA
    Virol J 6:205. 2009
    ..KSHV ORF59 is antigenic in the infected host and is used as a marker for virus activation and replication...
  6. ncbi High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    J Gen Virol 87:3529-38. 2006
    ..This pattern of infectivity is similar to that seen in KS tumours latently infected with KSHV. Our study demonstrates similarities in the biology of KSHV and RFHV and supports a role for RFHV in the aetiology of SAIDS-RF...
  7. ncbi RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells
    Kellie L Burnside
    Department of Pathobiology, School of Public Health and Community Medicine, HSB Rm F161E, Box 357238, University of Washington, Seattle, WA 98195, USA
    Virology 354:103-15. 2006
    ..These data suggest that RFHV LANA is an ortholog of KSHV LANA and will function similarly to maintain viral latency and play a role in tumorigenicity in macaques...
  8. ncbi Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species
    Jeannette Philipp-Staheli
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Virol J 3:11. 2006
    ....
  9. ncbi Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV
    Lidia Cherezova
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e18920. 2011
    ....
  10. ncbi Consensus-degenerate hybrid oligonucleotide primers (CODEHOPs) for the detection of novel viruses in non-human primates
    Jeannette P Staheli
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101 1304, USA
    Methods 49:32-41. 2009
    ..We demonstrate that our pan-papillomavirus CODEHOP assay is broadly reactive with all major branches of the virus family and show its utility in identifying a novel non-human primate papillomavirus in cynomolgus macaques...
  11. ncbi CODEHOP PCR and CODEHOP PCR primer design
    Jeannette P Staheli
    Center for Childhood Infection and Prematurity Research, Seattle Children s Research Institute, Seattle, WA, USA
    Methods Mol Biol 687:57-73. 2011
    ..Here, we describe the workflow of a typical CODEHOP PCR assay design and optimization and give a specific implementation example along with "best-practice" advice...
  12. ncbi Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta)
    H Bielefeldt-Ohmann
    Washington National Primate Research Center, University of Washington, Box 357331, Seattle, WA 98195, USA
    Vet Pathol 42:391-6. 2005
    ..Collectively, these findings suggest a relation to but not absolute identity with simian mesenchymoproliferative disorders (MPD) or typical gastrointestinal stromal tumors (GISTs)...
  13. ncbi Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons
    A Gregory Bruce
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Virol J 2:2. 2005
    ..To determine viral loads per cell, an additional TaqMan QPCR assay was developed to detect the single copy cellular oncostatin M gene...
  14. ncbi Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
    H Jacques Garrigues
    Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195, USA
    J Virol 82:1570-80. 2008
    ..Our studies demonstrate that alpha(V)beta(3) is a cellular receptor mediating both the cell adhesion and entry of KSHV into target cells through binding the virion-associated gB(RGD)...
  15. ncbi Development of whole-virus multiplex luminex-based serological assays for diagnosis of infections with kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 homologs in macaques
    Jonathan T Ryan
    Center for Childhood Infections and Prematurity Research, Seattle Children s Research Institute, Seattle, WA, USA
    Clin Vaccine Immunol 20:409-19. 2013
    ..This will help advance our understanding of rhadinovirus biology and associated host immunological responses...
  16. ncbi Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor
    V H Gersuk
    Virginia Mason Research Center, Department of Immunology, Seattle, Washington 98101, USA
    Genomics 25:469-76. 1995
    ..We show that ACBP/DBI is correctly placed on chromosome 2 and that the gene identified on chromosome 6 is DBIP1...
  17. ncbi Evolution of the acyl-CoA binding protein (ACBP)
    Mark Burton
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Biochem J 392:299-307. 2005
    ..The appearance of ACBP very early on in evolution points towards a fundamental role of ACBP in acyl-CoA metabolism, including ceramide synthesis and in signalling...

Research Grants5

  1. Viral Etiology of Kaposi's sarcoma-like Tumors
    TIMOTHY ROSE; Fiscal Year: 2005
    ..Additional training and focused research in virology would allow Dr. Rose to expand upon his initial discovery and make further significant contributions in the fields of herpesviruses and viral pathogenicity. ..
  2. A macaque model for AIDS-related oral malignancies
    TIMOTHY ROSE; Fiscal Year: 2007
    ..Such a model could directly impact the prevention, diagnosis, and treatment of this devastating human disease. ..
  3. CODEHOP: Unique web-based technology for gene discovery
    TIMOTHY ROSE; Fiscal Year: 2007
    ..We expect that this will lead to an increased pace of discovery of pathogens implicated in disease, as well as genes of biological and biomedical importance. ..
  4. Herpesvirus latency and reactivation in macaque models of human disease
    TIMOTHY ROSE; Fiscal Year: 2007
    ....
  5. Viral and cellular factors involved in KSHV entry in cells of the oral mucosa
    TIMOTHY ROSE; Fiscal Year: 2007
    ..abstract_text> ..