Stephen L Rose

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Notch signaling pathway in ovarian cancer
    Stephen L Rose
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Gynecol Cancer 19:564-6. 2009
  2. ncbi Notch 1 signaling is active in ovarian cancer
    Stephen L Rose
    The Department of Obstetrics and Gynecology, The University of Wisconsin, Madison, WI 53792, USA
    Gynecol Oncol 117:130-3. 2010
  3. ncbi The impact of p53 protein core domain structural alteration on ovarian cancer survival
    Stephen L Rose
    The Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:4139-44. 2003
  4. ncbi The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer
    Michael J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA
    Clin Cancer Res 11:3733-42. 2005
  5. ncbi The influence of microvessel density on ovarian carcinogenesis
    Pamela J B Stone
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4630 John Carver Pavilion, Iowa City, IA 52242, USA
    Gynecol Oncol 90:566-71. 2003
  6. ncbi Epigenetic regulation of maspin expression in human ovarian carcinoma cells
    Stephen L Rose
    Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, The Holden Comprehensive Cancer Center, 4630 John Colloton Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Gynecol Oncol 102:319-24. 2006
  7. ncbi Xanthohumol decreases Notch1 expression and cell growth by cell cycle arrest and induction of apoptosis in epithelial ovarian cancer cell lines
    Jessica G Drenzek
    Department of Obstetrics and Gynecology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Gynecol Oncol 122:396-401. 2011
  8. ncbi p21 expression predicts outcome in p53-null ovarian carcinoma
    Stephen L Rose
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:1028-32. 2003

Collaborators

Detail Information

Publications8

  1. ncbi Notch signaling pathway in ovarian cancer
    Stephen L Rose
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Gynecol Cancer 19:564-6. 2009
    ..I will review the evidence for Notch activation in ovarian cancer and potential strategies for Notch inactivation as targeted treatment of ovarian cancer...
  2. ncbi Notch 1 signaling is active in ovarian cancer
    Stephen L Rose
    The Department of Obstetrics and Gynecology, The University of Wisconsin, Madison, WI 53792, USA
    Gynecol Oncol 117:130-3. 2010
    ..These findings support the hypothesis that Notch 1 plays a role in ovarian cancer proliferation, encouraging the investigation of this pathway as a therapeutic target...
  3. ncbi The impact of p53 protein core domain structural alteration on ovarian cancer survival
    Stephen L Rose
    The Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:4139-44. 2003
    ..By evaluating ovarian cancer survival based upon a structure function analysis of the p53 protein, we tested the hypothesis that not all missense mutations are equivalent...
  4. ncbi The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer
    Michael J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA
    Clin Cancer Res 11:3733-42. 2005
    ..Multiple angiogenic factors may influence tumor progression and metastasis. Several are modified by the p53 gene. We sought to identify molecular markers for high-risk stage I epithelial ovarian cancers...
  5. ncbi The influence of microvessel density on ovarian carcinogenesis
    Pamela J B Stone
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4630 John Carver Pavilion, Iowa City, IA 52242, USA
    Gynecol Oncol 90:566-71. 2003
    ..The rate of decline of CA 125 during the initial response to treatment cannot be predicted based on CD31 counts, confirming a complex relationship between tumor vascularity, metastasis, and response to treatment...
  6. ncbi Epigenetic regulation of maspin expression in human ovarian carcinoma cells
    Stephen L Rose
    Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, The Holden Comprehensive Cancer Center, 4630 John Colloton Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Gynecol Oncol 102:319-24. 2006
    ..Deregulation of maspin expression in ovarian cancer is due to loss of epigenetic control as has been shown in other cancers. This observation provides further evidence of the strict epigenetic control of the maspin gene...
  7. ncbi Xanthohumol decreases Notch1 expression and cell growth by cell cycle arrest and induction of apoptosis in epithelial ovarian cancer cell lines
    Jessica G Drenzek
    Department of Obstetrics and Gynecology, The University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Gynecol Oncol 122:396-401. 2011
    ..We hypothesized that the Notch1 signaling pathway is targeted by xanthohumol leading to decreased ovarian cancer cell growth...
  8. ncbi p21 expression predicts outcome in p53-null ovarian carcinoma
    Stephen L Rose
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:1028-32. 2003
    ..A dual role for p21 activity, dependent on levels of expression, appears to explain these paradoxical results and is consistent with a complex model for regulation of p21...