Research Topics
| Caterina RosanoSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Association between lower digit symbol substitution test score and slower gait and greater risk of mortality and of developing incident disability in well-functioning older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennylvania, USA
J Am Geriatr Soc 56:1618-25. 2008....- Slower gait, slower information processing and smaller prefrontal area in older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, 130 N Bellefield Avenue, Pittsburgh, PA 15213, USA
Age Ageing 41:58-64. 2012..Understanding slowing gait could help improve function in older age. We examine whether the association between smaller PFAv and slower gait is explained by lower performance on numerous neuropsychological tests... - Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adultsCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Hypertension 61:160-5. 2013.... - Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 67:957-62. 2012..Identify the neuroimaging correlates of parkinsonian signs in older adults living in the community... 
Neuroimaging differences between older adults with maintained versus declining cognition over a 10-year periodCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 12513, United States
Neuroimage 62:307-13. 2012..This study aims to identify the neuroimaging correlates of maintenance of higher global cognition as measured by the Modified Mini Mental State Test (3 MS) score...- Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and womenCaterina Rosano
University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA
Neurobiol Aging 31:1197-204. 2010.... - Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adultsCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
J Gerontol A Biol Sci Med Sci 63:1380-8. 2008..Our objective was to identify the spatial distribution of focal atrophy within mobility-related brain regions in relationship with quantitative gait characteristics... - Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroepidemiology 29:193-200. 2007..The brain anatomical correlates of gait variability have not been studied in high-functioning community-dwelling older adults... 
A regions-of-interest volumetric analysis of mobility limitations in community-dwelling older adultsCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 62:1048-55. 2007..This study examined the association between gray matter volumes of regions related to motor control, gait, and balance and whether this association is independent of burden of white matter hyperintensities...- Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adultsCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
J Neuroimaging 17:148-55. 2007.... - Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatmentCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 65:639-47. 2010..It is not known whether these associations are also significant for longer-term adherence to moderate-intensity activities... - Cardiovascular disease and risk of Alzheimer's diseaseCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neurol Res 28:612-20. 2006..This review will examine the evidence for these associations and possible pathogenetic pathways. Clinical relevance and implications of these associations will also be discussed... - High blood pressure accelerates gait slowing in well-functioning older adults over 18-years of follow-upCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 59:390-7. 2011..To examine whether the association between hypertension and decline in gait speed is significant in well-functioning older adults and whether other health-related factors, such as brain, kidney, and heart function, can explain it... - The human precentral sulcus: chemoarchitecture of a region corresponding to the frontal eye fieldsCaterina Rosano
Graduate School of Public Health, University of Pittsburgh, 130 Bellefield, 519, Pittsburgh, PA, USA
Brain Res 972:16-30. 2003..These specific chemoarchitectural features may differentiate the location of the human FEF from rostral cortical regions and support the functions for which it is specialized... - Association between physical and cognitive function in healthy elderly: the health, aging and body composition studyCaterina Rosano
Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuroepidemiology 24:8-14. 2005..Longitudinal studies are needed to determine the direction of causality in this relationship... - Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adultsCaterina Rosano
Department of Epidemiology, School of Public Health, University of Pittsburgh, 130 N Bellefield Avenue, Pittsburgh, PA 15260, USA
J Am Geriatr Soc 53:649-54. 2005..To determine whether severity of subclinical brain magnetic resonance imaging (MRI) abnormalities predicts incident self-reported physical impairment or rate of decline in motor performance... - Coronary artery calcium: associations with brain magnetic resonance imaging abnormalities and cognitive statusCaterina Rosano
Department of Epidemiology, School of Public Health, University of Pittsburgh, 130 N Bellefield Avenue, Pittsburgh, PA 15260, USA
J Am Geriatr Soc 53:609-15. 2005..To evaluate the association between coronary atherosclerosis and subclinical brain magnetic resonance imaging (MRI) abnormalities and between coronary atherosclerosis and abnormal cognitive function (dementia/mild cognitive impairment)... - Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adultsCaterina Rosano
Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroepidemiology 26:52-60. 2006..In summary, in this group of high-functioning older adults, poorer gait speed, shorter stride and longer double support time are associated with high white matter disease and subclinical strokes... - Gait speed predicts decline in attention and psychomotor speed in older adults: the health aging and body composition studyMarco Inzitari
Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroepidemiology 29:156-62. 2007..Gait speed is cross-sectionally associated with attention and psychomotor speed in older community dwellers. It is unclear if gait speed predicts decline in these cognitive domains over time... - Multitasking: association between poorer performance and a history of recurrent fallsKimberly A Faulkner
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:570-6. 2007..To examine the association between poorer performance on concurrent walking and reaction time and recurrent falls... - Executive control function, brain activation and white matter hyperintensities in older adultsVijay K Venkatraman
Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
Neuroimage 49:3436-42. 2010..It is not clear whether greater fMRI activation indicates a strategy to compensate for underlying brain structural abnormalities while maintaining higher performance... - Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) studyAlka M Kanaya
Department of Medicine, University of California San Francisco, 94115, USA
Arch Neurol 66:329-35. 2009.... - Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adultsKira Leishear
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 60:1057-63. 2012..To examine whether deficient B12 status or low serum B12 levels are associated with worse sensory and motor peripheral nerve function in older adults... - Limited literacy in older people and disparities in health and healthcare accessRebecca L Sudore
Department of Medicine, Division of Geriatrics, University of California San Francisco, San Francisco, CA, USA
J Am Geriatr Soc 54:770-6. 2006..To determine the relationship between health literacy, demographics, and access to health care... - Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairmentCaterina Rosano
School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 57:761-7. 2005..76, p = .02) but not with changes in accuracy rates. CONCLUSIONS: PPC and dlPFC may show early functional changes associated with MCI... - Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's diseaseTimothy M Hughes
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 N Bellefield Street, Pittsburgh, PA 15213, USA
J Alzheimers Dis 30:53-61. 2012..Measurement of oxysterols may provide information about cholesterol metabolism and brain disease over the cognitive impairment process... - Arterial stiffness and cognitive decline in well-functioning older adultsNora L Watson
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213 3545, USA
J Gerontol A Biol Sci Med Sci 66:1336-42. 2011..Few studies of older adults have evaluated the association of central arterial stiffness with longitudinal cognitive decline... - Delays in auditory-cued step initiation are related to increased volume of white matter hyperintensities in older adultsPatrick J Sparto
Department of Physical Therapy, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
Exp Brain Res 188:633-40. 2008.... - Reciprocal influence of concurrent walking and cognitive testing on performance in older adultsKimberly A Faulkner
University of Pittsburgh, 130 DeSoto Street, Parran 509, Pittsburgh, PA 15261, USA
Gait Posture 24:182-9. 2006..062). Findings suggest that walking requires significant cognitive resources among older adults and slower-walking adults and weaker adults may require higher cognitive loading while walking... - Lower Digit Symbol Substitution Score in the Oldest Old is Related to Magnetization Transfer and Diffusion Tensor Imaging of the White MatterVijay K Venkatraman
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh Pittsburgh, PA, USA
Front Aging Neurosci 3:11. 2011..Since processing slowing is a potent index of mortality and disability, these indices may serve as biomarkers in prevention or treatment trials of disability... - Gait speed and survival in older adultsStephanie Studenski
Department of Medicine, Division of Geratric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 305:50-8. 2011..Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates... - Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signsKira Leishear
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 67:537-43. 2012..The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms... - Anemia is associated with the progression of white matter disease in older adults with high blood pressure: the cardiovascular health studyMarco Inzitari
Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 56:1867-72. 2008..To investigate whether anemia predicts worsening white matter hyperintensities (WMHs) in older community-dwellers... - A fully automated method for quantifying and localizing white matter hyperintensities on MR imagesMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, USA
Psychiatry Res 148:133-42. 2006..Given the emergence of large NeuroImage databases, techniques, such as that described here, will allow for a better understanding of the relationship between WMHs and neuropsychiatric disorders... - Arterial stiffness and gait speed in older adults with and without peripheral arterial diseaseNora L Watson
Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA
Am J Hypertens 24:90-5. 2011.... - A randomized trial of two forms of therapeutic activity to improve walking: effect on the energy cost of walkingJessie M VanSwearingen
Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Gerontol A Biol Sci Med Sci 64:1190-8. 2009..Because walking may also be energy inefficient in people with decreased mobility, another approach is to reduce energy cost by improving timing and coordination (TC) of movement... - Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy womenIsabella Soreca
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychosom Med 71:485-90. 2009..Cross-sectional results indicate that reduced GMV may be associated with excess body weight... - Optimum template selection for atlas-based segmentationMinjie Wu
Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroimage 34:1612-8. 2007..Moreover, the improved accuracy of atlas-based segmentation using optimum templates approaches the accuracy of manual tracing, and thus is valid for automated brain imaging analyses... - Brain cholesterol metabolism, oxysterols, and dementiaTimothy M Hughes
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
J Alzheimers Dis 33:891-911. 2013.... - A protocol for a randomized clinical trial of interactive video dance: potential for effects on cognitive functionJelena Jovancevic
School of Medicine, University of Pittsburgh, Pittsburgh, USA
BMC Geriatr 12:23. 2012..Most video games do not involve physical exercise, but some novel forms of interactive video games combine physical activity and cognitive challenge... - Maintaining brain health by monitoring inflammatory processes: a mechanism to promote successful agingCaterina Rosano
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Aging Dis 3:16-33. 2012..Hence, we also identify plausible ways and novel experimental study designs of maintaining brain health late in age through interventions that target the immune system... - Pursuit and saccadic eye movement subregions in human frontal eye field: a high-resolution fMRI investigationCaterina Rosano
Neurobehavioral Studies Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Cereb Cortex 12:107-15. 2002..These findings localize distinct pursuit and saccadic subregions of FEF in humans and demonstrate a high degree of homology in the organization of these FEF subregions in the human and the macaque monkey... - Scared to death: results from the Health, Aging, and Body Composition studyGretchen A Brenes
Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Geriatr Psychiatry 15:262-5. 2007..The purpose of this study is to determine if anxiety is associated with mortality and if race moderates and depression mediates this relationship... - Vascular disease and future risk of depressive symptomatology in older adults: findings from the Health, Aging, and Body Composition studyBenjamin T Mast
Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292, USA
Biol Psychiatry 64:320-6. 2008..Although neuroimaging studies provide evidence for an association between depression and severity of vascular lesions in the brain, studies of depression and indicators of vascular risk have been less consistent... - Socioeconomic differences in cognitive decline and the role of biomedical factorsAnnemarie Koster
Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
Ann Epidemiol 15:564-71. 2005..This study examines the association between socioeconomic status and cognitive decline in a community-based cohort of well-functioning older adults and seeks to determine whether this link could be explained by biomedical factors... - Cystatin C as a marker of cognitive function in elders: findings from the health ABC studyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
Ann Neurol 63:798-802. 2008..92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15)... - Limited literacy and mortality in the elderly: the health, aging, and body composition studyRebecca L Sudore
University of California, San Francisco, CA 94121, USA
J Gen Intern Med 21:806-12. 2006..While limited literacy is common and its prevalence increases with age, no prospective study has assessed whether limited literacy is associated with mortality in older adults... - Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition studyHal H Atkinson
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Claude D Pepper Older Americans Independence Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Gerontol A Biol Sci Med Sci 62:844-50. 2007..This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults... - Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition StudySandra K Pope
Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Epidemiol 163:1084-90. 2006..Interactions between MPO and race, sex, or the apolipoprotein gene were not significant. In this sample, MPO AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for cognitive decline...
Research Grants
- Novel Brain Neuroimaging Markers of Age-Related Mobility ImpairmentCaterina Rosano; Fiscal Year: 2007..Rosano's knowledge of longitudinal data analysis, will advance her expertise of cutting-edge neuroimaging techniques, and will strengthen her ability to independently execute large longitudinal epidemiological studies. ..
- Global vs. Focal Neuroimaging Markers of Dementia RiskCaterina Rosano; Fiscal Year: 2007....
- Brain anatomical correlates of mobility control in the oldest oldCaterina Rosano; Fiscal Year: 2007....
- Brain anatomical correlates of mobility control in the oldest oldCaterina Rosano; Fiscal Year: 2010....
- Imaging biomarkers of accelerated brain aging in Type-1 DiabetesCaterina Rosano; Fiscal Year: 2010..We propose to characterize the nature of accelerated brain aging in T1D (cerebral perfusion, neural activation and micro-structure level) and identify their determinants. ..