S D Roper

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Individual mouse taste cells respond to multiple chemical stimuli
    Alejandro Caicedo
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Physiol 544:501-9. 2002
  2. pmc Breadth of tuning and taste coding in mammalian taste buds
    Seth M Tomchik
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 27:10840-8. 2007
  3. pmc Signal transduction and information processing in mammalian taste buds
    Stephen D Roper
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Pflugers Arch 454:759-76. 2007
  4. pmc Cell communication in taste buds
    S D Roper
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Ave, Miami, FL, 33136, USA
    Cell Mol Life Sci 63:1494-500. 2006
  5. ncbi request reprint Monosodium glutamate (MSG) and taste-mGluR4, a candidate for an umami taste receptor
    Stephen D Roper
    Department of Physiology and Biophysics, University of Miami School of Medicine, FL 33101, USA
    Forum Nutr 56:87-9. 2003
  6. pmc Using biosensors to detect the release of serotonin from taste buds during taste stimulation
    Y J Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    Arch Ital Biol 143:87-96. 2005
  7. pmc Norepinephrine is coreleased with serotonin in mouse taste buds
    Yijen A Huang
    Department of Physiology and Biophysics, and Program in Neuroscience, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 28:13088-93. 2008
  8. pmc Autocrine and paracrine roles for ATP and serotonin in mouse taste buds
    Yijen A Huang
    Department of Physiology and Biophysics and Program in Neuroscience, University of Miami School of Medicine, Miami, FL 33136, USA
    J Neurosci 29:13909-18. 2009
  9. ncbi request reprint Mouse taste buds release serotonin in response to taste stimuli
    Yi Jen Huang
    University of Miami School of Medicine, Miami, FL 33136, USA
    Chem Senses 30:i39-40. 2005
  10. pmc Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells
    Yijen A Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Physiol 588:2343-50. 2010

Research Grants

  1. A new method to measure taste bud function
    Stephen Roper; Fiscal Year: 2004

Collaborators

  • N Chaudhari
  • Trevor A Richter
  • Alejandro Caicedo
  • Robert F Margolskee
  • Alan C Spector
  • Yijen A Huang
  • Yutaka Maruyama
  • Yi Jen Huang
  • Elizabeth Pereira
  • Gennady Dvoryanchikov
  • Robin Dando
  • Michael S Sinclair
  • CRAIG D ROBERTS
  • Seth M Tomchik
  • Joung Woul Kim
  • Richard A DeFazio
  • Cedrick D Dotson
  • Kuo Shyan Lu
  • Y J Huang
  • Isabel Perea-Martinez
  • Katsuhiko Nishimori
  • Masahide Yoshida
  • Robert Stimac
  • Stephanie Berg
  • Y Maruyama
  • I Plonsky
  • J E Baur
  • Dianqing Wu
  • John E Baur
  • K S Lu
  • E Pereira
  • D Wu
  • Ilya Plonsky

Detail Information

Publications33

  1. pmc Individual mouse taste cells respond to multiple chemical stimuli
    Alejandro Caicedo
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Physiol 544:501-9. 2002
    ..Thus, there appears to be no strict and separate detection of taste qualities by distinct subpopulations of taste cells in peripheral gustatory sensory organs in mice...
  2. pmc Breadth of tuning and taste coding in mammalian taste buds
    Seth M Tomchik
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 27:10840-8. 2007
    ....
  3. pmc Signal transduction and information processing in mammalian taste buds
    Stephen D Roper
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Pflugers Arch 454:759-76. 2007
    ..This suggests that there is important information processing and signal coding taking place in the mammalian taste bud after gustatory stimulation...
  4. pmc Cell communication in taste buds
    S D Roper
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Ave, Miami, FL, 33136, USA
    Cell Mol Life Sci 63:1494-500. 2006
    ..There is strong evidence that serotonin and ATP play a role in cell-to-cell signaling and sensory output in the gustatory end organs...
  5. ncbi request reprint Monosodium glutamate (MSG) and taste-mGluR4, a candidate for an umami taste receptor
    Stephen D Roper
    Department of Physiology and Biophysics, University of Miami School of Medicine, FL 33101, USA
    Forum Nutr 56:87-9. 2003
  6. pmc Using biosensors to detect the release of serotonin from taste buds during taste stimulation
    Y J Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    Arch Ital Biol 143:87-96. 2005
    ..Sour- and depolarization-evoked release of 5HT from taste buds is triggered by Ca2+ influx from the extracellular fluid. In contrast, bitter- and sweet-evoked release of 5HT is triggered by Ca2+ derived from intracellular stores...
  7. pmc Norepinephrine is coreleased with serotonin in mouse taste buds
    Yijen A Huang
    Department of Physiology and Biophysics, and Program in Neuroscience, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 28:13088-93. 2008
    ..Stimulus-evoked NE release depended on Ca(2+) in the bathing medium. Using dual biosensors (sensitive to 5-HT and NE), we found all presynaptic cells secrete 5-HT and 33% corelease NE with 5-HT...
  8. pmc Autocrine and paracrine roles for ATP and serotonin in mouse taste buds
    Yijen A Huang
    Department of Physiology and Biophysics and Program in Neuroscience, University of Miami School of Medicine, Miami, FL 33136, USA
    J Neurosci 29:13909-18. 2009
    ..These results begin to sort out how purinergic and aminergic transmitters function within the taste bud to modulate gustatory signaling in these peripheral sensory organs...
  9. ncbi request reprint Mouse taste buds release serotonin in response to taste stimuli
    Yi Jen Huang
    University of Miami School of Medicine, Miami, FL 33136, USA
    Chem Senses 30:i39-40. 2005
  10. pmc Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells
    Yijen A Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Physiol 588:2343-50. 2010
    ....
  11. ncbi request reprint Acid-sensing ion channel-2 is not necessary for sour taste in mice
    Trevor A Richter
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 24:4088-91. 2004
    ..Our results indicate that ASIC2 is not required for acid taste in mice, and that if a universal mammalian acid taste transduction mechanism exists, it likely uses other acid-sensitive receptors or ion channels...
  12. ncbi request reprint Molecular and physiological evidence for glutamate (umami) taste transduction via a G protein-coupled receptor
    N Chaudhari
    Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101, USA
    Ann N Y Acad Sci 855:398-406. 1998
    ..In patch-clamp studies, glutamate evokes two types of currents, similar to those elicited by N-methyl-D-aspartate (NMDA) and L-AP4. We speculate upon the significance of two glutamate receptor pathways in taste buds...
  13. pmc Taste receptor cells that discriminate between bitter stimuli
    A Caicedo
    Department of Physiology and Biophysics, Program in Neuroscience, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Science 291:1557-60. 2001
    ..Instead, different bitter stimuli may activate different subpopulations of bitter-sensitive taste cells...
  14. ncbi request reprint Mouse taste buds use serotonin as a neurotransmitter
    Yi Jen Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 25:843-7. 2005
    ..These experiments strongly implicate serotonin as a taste bud neurotransmitter and reveal unexpected transmitter release mechanisms...
  15. pmc The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds
    Yi Jen Huang
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:6436-41. 2007
    ..They also indicate a route for cell-cell communication and signal processing within the taste bud...
  16. ncbi request reprint A metabotropic glutamate receptor variant functions as a taste receptor
    N Chaudhari
    Program in Neuroscience, University of Miami School of Medicine, P O Box 016430 R430, Miami, Florida 33101, USA
    Nat Neurosci 3:113-9. 2000
    ..The receptor couples negatively to a cAMP cascade and shows an unusual concentration-response relationship. The similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate...
  17. ncbi request reprint In situ Ca2+ imaging reveals neurotransmitter receptors for glutamate in taste receptor cells
    A Caicedo
    Department of Physiology and Biophysics and Program in Neuroscience, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 20:7978-85. 2000
    ..The function of GluRs in taste buds is not yet known, but the data suggest that glutamate is a neurotransmitter there. GluRs in taste cells might be presynaptic autoreceptors or postsynaptic receptors at afferent or efferent synapses...
  18. ncbi request reprint Glutamate-induced cobalt uptake reveals non-NMDA receptors in rat taste cells
    A Caicedo
    Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101, USA
    J Comp Neurol 417:315-24. 2000
    ..These receptors might be autoreceptors at afferent synapses, postsynaptic receptors of a putative efferent system, or postsynaptic receptors at synapses with other taste cells...
  19. pmc Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells
    CRAIG D ROBERTS
    Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Physiol 587:1657-68. 2009
    ..Collectively, these data demonstrate cross-talk between cAMP and Ca(2+) signalling in a subclass of taste cells that form synapses with gustatory fibres and may integrate tastant-evoked signals...
  20. pmc Parallel processing in mammalian taste buds?
    Stephen D Roper
    Department of Physiology and Biophysics and Program in Neuroscience, Miller School of Medicine, University of Miami R430, Miami, FL 33136, USA
    Physiol Behav 97:604-8. 2009
    ..This speculative concept is explored in this review of taste signal processing in mammalian taste buds...
  21. pmc Taste receptors for umami: the case for multiple receptors
    Nirupa Chaudhari
    Department of Physiology and Biophysics, University of Miami, FL 33136, USA
    Am J Clin Nutr 90:738S-742S. 2009
    ..This receptor diversity may underlie the complex perception of umami, with different mixtures of amino acids, peptides, and nucleotides yielding subtly distinct taste qualities...
  22. pmc Processing umami and other tastes in mammalian taste buds
    Stephen D Roper
    Department of Physiology and Biophysics, and Program in Neuroscience, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Ann N Y Acad Sci 1170:60-5. 2009
    ..The following paragraphs summarize current thinking about how taste signals generally, and umami taste in particular, are processed in taste buds...
  23. pmc The cell biology of taste
    Nirupa Chaudhari
    Department of Physiology and Biophysics, and Program in Neurosciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Biol 190:285-96. 2010
    ..This review discusses the functional classes of taste cells, their cell biology, and current thinking on how taste information is transmitted to the brain...
  24. ncbi request reprint Rat gustatory neurons in the geniculate ganglion express glutamate receptor subunits
    Alejandro Caicedo
    Department of Ophthalmology, University of Miami School of Medicine, 1638 NW 10th Avenue, William L McKnight Vision Research Center, Miami, FL 33136, USA
    Chem Senses 29:463-71. 2004
    ..We conclude that gustatory neurons express glutamate receptors and that glutamate receptors of the AMPA type are likely targeted to synapses within taste buds...
  25. ncbi request reprint Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli
    Alejandro Caicedo
    Department of Physiology and Biophysics and Program in Neuroscience, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosci 23:9947-52. 2003
    ..The reduced behavioral sensitivity to bitter stimuli in alpha-gustducin knock-out mice thus appears to be the consequence of a reduced number of bitter-activated taste cells, as well as reduced sensitivity...
  26. pmc Umami responses in mouse taste cells indicate more than one receptor
    Yutaka Maruyama
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 26:2227-34. 2006
    ..Furthermore, umami responses were still observed in mutant mice lacking T1R3. A full explanation of umami taste transduction may involve novel combinations of the proposed receptors and/or as-yet-undiscovered taste receptors...
  27. ncbi request reprint Acid-sensitive two-pore domain potassium (K2P) channels in mouse taste buds
    Trevor A Richter
    Dept of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Neurophysiol 92:1928-36. 2004
    ..However, our results do not unambiguously identify any one channel as the acid taste transducer...
  28. pmc Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste
    Yijen A Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    J Physiol 586:2903-12. 2008
    ..These findings may also have implications for other sensory receptors that respond to acids, such as nociceptors...
  29. pmc Separate populations of receptor cells and presynaptic cells in mouse taste buds
    Richard A DeFazio
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 26:3971-80. 2006
    ..These data demonstrate the existence of at least two molecularly distinct functional classes of taste cells: receptor cells and synapse-forming cells...
  30. pmc Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels
    Robin Dando
    Miller School of Medicine, University of Miami Physiology and Biophysics and Program in Neuroscience, 1600 NW 10th Ave, Miami, FL 33136, USA
    J Physiol 587:5899-906. 2009
    ..These findings are consistent with the model for peripheral signal processing via ATP and pannexin 1 hemichannels in mammalian taste buds...
  31. pmc Sour taste stimuli evoke Ca2+ and pH responses in mouse taste cells
    T A Richter
    Department of Physiology and Biophysics, University of Miami Medical School, Miami, FL 33134, USA
    J Physiol 547:475-83. 2003
    ..The primary transducer protein(s) for sour taste remain undiscovered...
  32. pmc Oxytocin signaling in mouse taste buds
    Michael S Sinclair
    Program in Neurosciences, Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 5:e11980. 2010
    ..Mutant mice lacking OXT (OXT knockout) overconsume salty and sweet (i.e. sucrose, saccharin) solutions. We asked if OXT might also act on taste buds via its receptor, OXTR...
  33. pmc PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands
    Cedrick D Dotson
    Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL 32611 2250, USA
    Chem Senses 30:593-600. 2005
    ....

Research Grants1

  1. A new method to measure taste bud function
    Stephen Roper; Fiscal Year: 2004
    ..If these cells turn out to be mechanoreceptors, the results may explain how taste buds detect food texture. This will greatly further our understanding of food selection and diet. ..