Research Topics
| B RoozendaalSummaryAffiliation: University of California Country: USA Publications
| Collaborators
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Detail Information
Publications
Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor--cAMP/cAMP/PKA system in influencing memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Eur J Neurosci 15:553-60. 2002....- 1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidationB Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697 3800, USA
Psychoneuroendocrinology 25:213-38. 2000..However, the BLA is not a permanent locus of storage for this information, but modulates consolidation processes for explicit/associative memories in other brain regions, including the hippocampus... 
Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 99:13908-13. 2002..These findings indicate that activation of CRH receptors in the BLA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation...- The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 100:1328-33. 2003.... - Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrievalBenno Roozendaal
Center for the Neurobiology of Learning, Department of Neurobiology and Behavior, University of Caliornia, Irvine 92697 3800, USA
Neurobiol Learn Mem 78:578-95. 2002.... - Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Learn Mem 14:29-35. 2007..These findings indicate that endogenously released OFQ/N interacts with noradrenergic activity within the BLA in modulating memory consolidation... - Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiencesBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Prog Brain Res 167:79-97. 2008..Such effects also require noradrenergic activation of the amygdala and interactions with other brain regions... - Systems mediating acute glucocorticoid effects on memory consolidation and retrievalBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:1213-23. 2003..The BLA appears to be a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on both memory consolidation and memory retrieval... - Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 103:6741-6. 2006.... - Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functionsB Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, 92697 3800, USA
Neuroscience 138:901-10. 2006.... - The basolateral amygdala interacts with the medial prefrontal cortex in regulating glucocorticoid effects on working memory impairmentBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 24:1385-92. 2004..These findings indicate that BLA activity is essential for enabling glucocorticoid effects in the mPFC on working memory and suggest that stress hormone-induced modulation of working memory involves noradrenergic activation... - A systemically administered beta-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in ratsBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 81:150-4. 2004..These findings provide evidence for the view that glucocorticoids interact with noradrenergic mechanisms in influencing memory retrieval... - Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activationBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 28:6642-51. 2008.... - Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 24:8161-9. 2004.... - Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppressionB Roozendaal
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Nat Neurosci 4:1169-71. 2001..These findings suggest that elevated adrenocortical activity is critical in mediating memory retrieval deficits induced by hippocampal damage... - Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidationB Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 21:2518-25. 2001..These findings indicate that the BLA-NAc pathway plays an essential role in mediating glucocorticoid effects on memory consolidation and suggest that the BLA interacts with hippocampal effects on memory consolidation via this pathway... - Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activationB Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 96:11642-7. 1999.... - Glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdalaB Roozendaal
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697 3800, USA
Eur J Neurosci 11:1317-23. 1999..These findings provide evidence that memory storage is modulated by glucocorticoid binding to GRs in noradrenergic cell bodies in the NTS and suggest that these modulatory effects are conveyed by ascending projections to the BLA... - Involvement of alpha1-adrenoceptors in the basolateral amygdala in modulation of memory storageB Ferry
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697 3800, USA
Eur J Pharmacol 372:9-16. 1999.... - Involvement of a basolateral amygdala complex-nucleus accumbens pathway in glucocorticoid-induced modulation of memory consolidationB Setlow
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behaviour, University of California, Irvine, CA 92697 3800, USA
Eur J Neurosci 12:367-75. 2000..These findings indicate that an intact BLC-NA pathway is critical for the enhancing effects of glucocorticoids on memory consolidation, and are consistent with the view that the BLC regulates memory consolidation in other brain regions... - Involvement of the amygdala in memory storage: interaction with other brain systemsJ L McGaugh
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697 3800, USA
Proc Natl Acad Sci U S A 93:13508-14. 1996..These findings provide strong evidence supporting the hypothesis that the amygdala is involved in modulating long-term memory storage... - Glucocorticoid enhancement of memory consolidation in the rat is blocked by muscarinic receptor antagonism in the basolateral amygdalaA E Power
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Eur J Neurosci 12:3481-7. 2000.... - Basolateral amygdala lesions block the memory-enhancing effect of 8-Br-cAMP infused into the entorhinal cortex of rats after trainingRafael Roesler
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Eur J Neurosci 15:905-10. 2002.... - Adrenocortical suppression blocks the memory-enhancing effects of amphetamine and epinephrineB Roozendaal
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717 3800, USA
Proc Natl Acad Sci U S A 93:1429-33. 1996..These findings provide further evidence that the sympathoadrenal and adrenocortical systems are intimately coupled during processes of memory storage... - Basolateral amygdala noradrenergic activity mediates corticosterone-induced enhancement of auditory fear conditioningBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Neurobiol Learn Mem 86:249-55. 2006.... - Fat-induced satiety factor oleoylethanolamide enhances memory consolidationPatrizia Campolongo
Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
Proc Natl Acad Sci U S A 106:8027-31. 2009..The results indicate that OEA, acting as a PPAR-alpha agonist, facilitates memory consolidation through noradrenergic activation of the BLA, a mechanism that is also critically involved in memory enhancement induced by emotional arousal... - Role of adrenal stress hormones in forming lasting memories in the brainJames L McGaugh
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697-3800, USA
Curr Opin Neurobiol 12:205-10. 2002..Release of norepinephrine and activation of beta-adrenoceptors within the basolateral amygdala is critical in mediating adrenal stress hormone regulation of memory consolidation... - Role of the basolateral amygdala in memory consolidationChrista K McIntyre
Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
Ann N Y Acad Sci 985:273-93. 2003..The findings suggest further that this memory-modulatory system may be involved in the formation of traumatic memories and posttraumatic stress disorder in human subjects... 
Drug enhancement of memory consolidation: historical perspective and neurobiological implicationsJames L McGaugh
Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
Psychopharmacology (Berl) 202:3-14. 2009..Many subsequent studies confirmed that finding and found that stimulant drugs also enhance the learning of a wide range of tasks...- Glucocorticoid effects on object recognition memory require training-associated emotional arousalShoki Okuda
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 101:853-8. 2004..Thus, the present findings suggest that training-induced emotional arousal may be essential for glucocorticoid effects on object recognition memory... - Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memoryBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 90:576-9. 2008..Thus, regardless of the degree of emotional arousal induced by an experience, noradrenergic activation of the BLA after the experience ensures that it will be better remembered... - Memory enhancement of classical fear conditioning by post-training injections of corticosterone in ratsGabriel K Hui
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Neurobiol Learn Mem 81:67-74. 2004.... - Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's diseaseKim N Green
Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 4545, USA
J Neurosci 26:9047-56. 2006..These findings suggest that high levels of glucocorticoids, found in AD, are not merely a consequence of the disease process but rather play a central role in the development and progression of AD... - Basolateral amygdala interacts with other brain regions in regulating glucocorticoid effects on different memory functionsSheila V Nathan
Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697-3800, USA
Ann N Y Acad Sci 1032:179-82. 2004..Thus, these findings suggest that the BLA is a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on different memory functions... - Posttraining handling facilitates memory for auditory-cue fear conditioning in ratsIsabel R Hui
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Neurobiol Learn Mem 86:160-3. 2006..These findings thus indicate that the posttraining injection or handling procedure is sufficiently arousing or stressful to facilitate memory consolidation of auditory-cue classical fear conditioning... - Insular cortex is involved in consolidation of object recognition memoryFederico Bermudez-Rattoni
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Learn Mem 12:447-9. 2005 - Relaxin receptor activation in the basolateral amygdala impairs memory consolidationSherie Ma
Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria 3010, Australia
Eur J Neurosci 22:2117-22. 2005..These findings suggest a novel function for endogenous relaxin-LGR7 signalling in rat brain involving regulation of memory consolidation... - Glucocorticoids enhance taste aversion memory via actions in the insular cortex and basolateral amygdalaMaria Isabel Miranda
Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, 76230, Mexico
Learn Mem 15:468-76. 2008.... - Dexamethasone reverses the memory impairment induced by antagonism of hippocampal gastrin-releasing peptide receptorsRoberta Venturella
Graduate Program in Medical Sciences and Department of Internal Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
Peptides 26:821-5. 2005..Together with previous results, these findings suggest that endogenous activation of GRPRs in the hippocampus modulates the consolidation of emotional memory, but is not a critical receptor system mediating memory formation... - Can posttraumatic stress disorder be prevented with glucocorticoids?Gustav Schelling
Ludwig Maximilians University, Klinikum Grosshadern, Department of Anaesthesiology, 81377 Muenchen, Germany
Ann N Y Acad Sci 1032:158-66. 2004..Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD... - Glucocorticoid therapy and memory function: lessons learned from basic researchBenno Roozendaal
Neurology 64:184-5. 2005 - Glucocorticoid therapy-induced memory deficits: acute versus chronic effectsDaniel Coluccia
Department of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
J Neurosci 28:3474-8. 2008..Thus, these findings indicate that memory deficits observed under chronically elevated glucocorticoid levels result, at least in part, from acute and reversible glucocorticoid effects on memory retrieval... - Preventive effect of beta-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficitsDominique J F de Quervain
Division of Psychiatry Research and the Center for Integrative Human Physiology, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
Am J Psychiatry 164:967-9. 2007..The authors investigated whether the beta-adrenoceptor antagonist propranolol blocks glucocorticoid-induced memory retrieval impairments in human subjects... - Glucocorticoid administration into the dorsal striatum [corrected] facilitates memory consolidation of inhibitory avoidance training but not of the context or footshock componentsAndrea C Medina
Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla Querétaro 76230, Mexico
Learn Mem 14:673-7. 2007.... - Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobeDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Eur J Neurosci 17:1296-302. 2003.... - Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgeryGustav Schelling
Ludwig Maximilians University, Klinikum Grosshadern, Department of Anaesthesiology, 81377 Muenchen, Germany
Ann N Y Acad Sci 1071:46-53. 2006.... - Exposure to high stress in the intensive care unit may have negative effects on health-related quality-of-life outcomes after cardiac surgeryGustav Schelling
Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
Crit Care Med 31:1971-80. 2003..52, p <.01). CONCLUSIONS: Exposure to high stress in the cardiovascular intensive care unit can have negative effects on HRQL outcomes of cardiac surgery... - Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized studyFlorian Weis
Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
J Thorac Cardiovasc Surg 131:277-82. 2006.... - Low-dose cortisol for symptoms of posttraumatic stress disorderAmanda Aerni
Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland
Am J Psychiatry 161:1488-90. 2004..CONCLUSIONS: The results of this pilot study indicate that low-dose cortisol treatment reduces the cardinal symptoms of PTSD... - Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized studyGustav Schelling
Department of Anesthesiology, Ludwig-Maximilians-University, Munich, Germany
Biol Psychiatry 55:627-33. 2004..CONCLUSIONS: Stress doses of hydrocortisone in patients undergoing CS are associated with a lower intensity of chronic stress and PTSD symptoms at 6 months after CS...