B Roozendaal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor--cAMP/cAMP/PKA system in influencing memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Eur J Neurosci 15:553-60. 2002
  2. ncbi 1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation
    B Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697 3800, USA
    Psychoneuroendocrinology 25:213-38. 2000
  3. pmc Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:13908-13. 2002
  4. pmc The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 100:1328-33. 2003
  5. ncbi Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
    Benno Roozendaal
    Center for the Neurobiology of Learning, Department of Neurobiology and Behavior, University of Caliornia, Irvine 92697 3800, USA
    Neurobiol Learn Mem 78:578-95. 2002
  6. pmc Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    Learn Mem 14:29-35. 2007
  7. ncbi Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Prog Brain Res 167:79-97. 2008
  8. ncbi Systems mediating acute glucocorticoid effects on memory consolidation and retrieval
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1213-23. 2003
  9. pmc Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 103:6741-6. 2006
  10. ncbi Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions
    B Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, 92697 3800, USA
    Neuroscience 138:901-10. 2006

Collaborators

Detail Information

Publications50

  1. ncbi Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor--cAMP/cAMP/PKA system in influencing memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Eur J Neurosci 15:553-60. 2002
    ....
  2. ncbi 1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation
    B Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697 3800, USA
    Psychoneuroendocrinology 25:213-38. 2000
    ..However, the BLA is not a permanent locus of storage for this information, but modulates consolidation processes for explicit/associative memories in other brain regions, including the hippocampus...
  3. pmc Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:13908-13. 2002
    ..These findings indicate that activation of CRH receptors in the BLA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation...
  4. pmc The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 100:1328-33. 2003
    ....
  5. ncbi Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
    Benno Roozendaal
    Center for the Neurobiology of Learning, Department of Neurobiology and Behavior, University of Caliornia, Irvine 92697 3800, USA
    Neurobiol Learn Mem 78:578-95. 2002
    ....
  6. pmc Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    Learn Mem 14:29-35. 2007
    ..These findings indicate that endogenously released OFQ/N interacts with noradrenergic activity within the BLA in modulating memory consolidation...
  7. ncbi Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Prog Brain Res 167:79-97. 2008
    ..Such effects also require noradrenergic activation of the amygdala and interactions with other brain regions...
  8. ncbi Systems mediating acute glucocorticoid effects on memory consolidation and retrieval
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1213-23. 2003
    ..The BLA appears to be a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on both memory consolidation and memory retrieval...
  9. pmc Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 103:6741-6. 2006
    ....
  10. ncbi Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions
    B Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, 92697 3800, USA
    Neuroscience 138:901-10. 2006
    ....
  11. ncbi The basolateral amygdala interacts with the medial prefrontal cortex in regulating glucocorticoid effects on working memory impairment
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 24:1385-92. 2004
    ..These findings indicate that BLA activity is essential for enabling glucocorticoid effects in the mPFC on working memory and suggest that stress hormone-induced modulation of working memory involves noradrenergic activation...
  12. ncbi A systemically administered beta-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in rats
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 81:150-4. 2004
    ..These findings provide evidence for the view that glucocorticoids interact with noradrenergic mechanisms in influencing memory retrieval...
  13. pmc Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 28:6642-51. 2008
    ....
  14. ncbi Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 24:8161-9. 2004
    ....
  15. ncbi Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression
    B Roozendaal
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    Nat Neurosci 4:1169-71. 2001
    ..These findings suggest that elevated adrenocortical activity is critical in mediating memory retrieval deficits induced by hippocampal damage...
  16. ncbi Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation
    B Roozendaal
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    J Neurosci 21:2518-25. 2001
    ..These findings indicate that the BLA-NAc pathway plays an essential role in mediating glucocorticoid effects on memory consolidation and suggest that the BLA interacts with hippocampal effects on memory consolidation via this pathway...
  17. pmc Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation
    B Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 96:11642-7. 1999
    ....
  18. ncbi Glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdala
    B Roozendaal
    Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697 3800, USA
    Eur J Neurosci 11:1317-23. 1999
    ..These findings provide evidence that memory storage is modulated by glucocorticoid binding to GRs in noradrenergic cell bodies in the NTS and suggest that these modulatory effects are conveyed by ascending projections to the BLA...
  19. ncbi Involvement of alpha1-adrenoceptors in the basolateral amygdala in modulation of memory storage
    B Ferry
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine 92697 3800, USA
    Eur J Pharmacol 372:9-16. 1999
    ....
  20. ncbi Involvement of a basolateral amygdala complex-nucleus accumbens pathway in glucocorticoid-induced modulation of memory consolidation
    B Setlow
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behaviour, University of California, Irvine, CA 92697 3800, USA
    Eur J Neurosci 12:367-75. 2000
    ..These findings indicate that an intact BLC-NA pathway is critical for the enhancing effects of glucocorticoids on memory consolidation, and are consistent with the view that the BLC regulates memory consolidation in other brain regions...
  21. pmc Involvement of the amygdala in memory storage: interaction with other brain systems
    J L McGaugh
    Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697 3800, USA
    Proc Natl Acad Sci U S A 93:13508-14. 1996
    ..These findings provide strong evidence supporting the hypothesis that the amygdala is involved in modulating long-term memory storage...
  22. ncbi Glucocorticoid enhancement of memory consolidation in the rat is blocked by muscarinic receptor antagonism in the basolateral amygdala
    A E Power
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Eur J Neurosci 12:3481-7. 2000
    ....
  23. ncbi Basolateral amygdala lesions block the memory-enhancing effect of 8-Br-cAMP infused into the entorhinal cortex of rats after training
    Rafael Roesler
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Eur J Neurosci 15:905-10. 2002
    ....
  24. pmc Adrenocortical suppression blocks the memory-enhancing effects of amphetamine and epinephrine
    B Roozendaal
    Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717 3800, USA
    Proc Natl Acad Sci U S A 93:1429-33. 1996
    ..These findings provide further evidence that the sympathoadrenal and adrenocortical systems are intimately coupled during processes of memory storage...
  25. ncbi Basolateral amygdala noradrenergic activity mediates corticosterone-induced enhancement of auditory fear conditioning
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 86:249-55. 2006
    ....
  26. pmc Fat-induced satiety factor oleoylethanolamide enhances memory consolidation
    Patrizia Campolongo
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 106:8027-31. 2009
    ..The results indicate that OEA, acting as a PPAR-alpha agonist, facilitates memory consolidation through noradrenergic activation of the BLA, a mechanism that is also critically involved in memory enhancement induced by emotional arousal...
  27. ncbi Role of adrenal stress hormones in forming lasting memories in the brain
    James L McGaugh
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    Curr Opin Neurobiol 12:205-10. 2002
    ..Release of norepinephrine and activation of beta-adrenoceptors within the basolateral amygdala is critical in mediating adrenal stress hormone regulation of memory consolidation...
  28. ncbi Role of the basolateral amygdala in memory consolidation
    Christa K McIntyre
    Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
    Ann N Y Acad Sci 985:273-93. 2003
    ..The findings suggest further that this memory-modulatory system may be involved in the formation of traumatic memories and posttraumatic stress disorder in human subjects...
  29. doi Drug enhancement of memory consolidation: historical perspective and neurobiological implications
    James L McGaugh
    Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
    Psychopharmacology (Berl) 202:3-14. 2009
    ..Many subsequent studies confirmed that finding and found that stimulant drugs also enhance the learning of a wide range of tasks...
  30. pmc Glucocorticoid effects on object recognition memory require training-associated emotional arousal
    Shoki Okuda
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 101:853-8. 2004
    ..Thus, the present findings suggest that training-induced emotional arousal may be essential for glucocorticoid effects on object recognition memory...
  31. pmc Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memory
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 90:576-9. 2008
    ..Thus, regardless of the degree of emotional arousal induced by an experience, noradrenergic activation of the BLA after the experience ensures that it will be better remembered...
  32. ncbi Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats
    Gabriel K Hui
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 81:67-74. 2004
    ....
  33. ncbi Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease
    Kim N Green
    Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 4545, USA
    J Neurosci 26:9047-56. 2006
    ..These findings suggest that high levels of glucocorticoids, found in AD, are not merely a consequence of the disease process but rather play a central role in the development and progression of AD...
  34. ncbi Basolateral amygdala interacts with other brain regions in regulating glucocorticoid effects on different memory functions
    Sheila V Nathan
    Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
    Ann N Y Acad Sci 1032:179-82. 2004
    ..Thus, these findings suggest that the BLA is a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on different memory functions...
  35. ncbi Posttraining handling facilitates memory for auditory-cue fear conditioning in rats
    Isabel R Hui
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Neurobiol Learn Mem 86:160-3. 2006
    ..These findings thus indicate that the posttraining injection or handling procedure is sufficiently arousing or stressful to facilitate memory consolidation of auditory-cue classical fear conditioning...
  36. ncbi Insular cortex is involved in consolidation of object recognition memory
    Federico Bermudez-Rattoni
    Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Learn Mem 12:447-9. 2005
  37. ncbi Relaxin receptor activation in the basolateral amygdala impairs memory consolidation
    Sherie Ma
    Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria 3010, Australia
    Eur J Neurosci 22:2117-22. 2005
    ..These findings suggest a novel function for endogenous relaxin-LGR7 signalling in rat brain involving regulation of memory consolidation...
  38. pmc Glucocorticoids enhance taste aversion memory via actions in the insular cortex and basolateral amygdala
    Maria Isabel Miranda
    Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, 76230, Mexico
    Learn Mem 15:468-76. 2008
    ....
  39. ncbi Dexamethasone reverses the memory impairment induced by antagonism of hippocampal gastrin-releasing peptide receptors
    Roberta Venturella
    Graduate Program in Medical Sciences and Department of Internal Medicine, Federal University of Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Peptides 26:821-5. 2005
    ..Together with previous results, these findings suggest that endogenous activation of GRPRs in the hippocampus modulates the consolidation of emotional memory, but is not a critical receptor system mediating memory formation...
  40. ncbi Can posttraumatic stress disorder be prevented with glucocorticoids?
    Gustav Schelling
    Ludwig Maximilians University, Klinikum Grosshadern, Department of Anaesthesiology, 81377 Muenchen, Germany
    Ann N Y Acad Sci 1032:158-66. 2004
    ..Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD...
  41. ncbi Glucocorticoid therapy and memory function: lessons learned from basic research
    Benno Roozendaal
    Neurology 64:184-5. 2005
  42. doi Glucocorticoid therapy-induced memory deficits: acute versus chronic effects
    Daniel Coluccia
    Department of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    J Neurosci 28:3474-8. 2008
    ..Thus, these findings indicate that memory deficits observed under chronically elevated glucocorticoid levels result, at least in part, from acute and reversible glucocorticoid effects on memory retrieval...
  43. ncbi Preventive effect of beta-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficits
    Dominique J F de Quervain
    Division of Psychiatry Research and the Center for Integrative Human Physiology, University of Zurich, Lenggstr 31, 8032 Zurich, Switzerland
    Am J Psychiatry 164:967-9. 2007
    ..The authors investigated whether the beta-adrenoceptor antagonist propranolol blocks glucocorticoid-induced memory retrieval impairments in human subjects...
  44. ncbi Glucocorticoid administration into the dorsal striatum [corrected] facilitates memory consolidation of inhibitory avoidance training but not of the context or footshock components
    Andrea C Medina
    Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus Juriquilla Querétaro 76230, Mexico
    Learn Mem 14:673-7. 2007
    ....
  45. ncbi Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Eur J Neurosci 17:1296-302. 2003
    ....
  46. ncbi Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery
    Gustav Schelling
    Ludwig Maximilians University, Klinikum Grosshadern, Department of Anaesthesiology, 81377 Muenchen, Germany
    Ann N Y Acad Sci 1071:46-53. 2006
    ....
  47. ncbi Exposure to high stress in the intensive care unit may have negative effects on health-related quality-of-life outcomes after cardiac surgery
    Gustav Schelling
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Crit Care Med 31:1971-80. 2003
    ..We sought to determine whether failed improvements in HRQL after cardiac surgery are associated with the development of traumatic memories and chronic stress states as a result of high perioperative stress exposure...
  48. ncbi Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized study
    Florian Weis
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Thorac Cardiovasc Surg 131:277-82. 2006
    ....
  49. ncbi Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  50. ncbi Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study
    Gustav Schelling
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 55:627-33. 2004
    ....