Genomes and Genes
Affiliation: University of Wisconsin
- Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signalingWyatt B Potter
Department of Neuroscience, Medical Science Center, University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS Biol 11:e1001627. 2013..These findings highlight the potential of modulating the mGluR5-Erk pathway in a developmental stage-specific manner to treat TSC. ..
- Epigenetics and epilepsyAvtar Roopra
Department of Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Epilepsia 53:2-10. 2012..Finally we highlight possible future directions in the field of epigenetics and epilepsy...
- Metabolic regulation of neuronal plasticity by the energy sensor AMPKWyatt B Potter
Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS ONE 5:e8996. 2010..Our work opens up the possibility of using modulators of energy metabolism to control neuronal plasticity in diseases and conditions of aberrant plasticity such as epilepsy...
- 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structureMireia Garriga-Canut
Department of Neurology, Medical Science Center, Room 1715, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
Nat Neurosci 9:1382-7. 2006..The metabolic regulation of neuronal genes by CtBP will open avenues of therapy for neurological disorders and cancer...
- Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumorsKearney T W Gunsalus
Graduate Program in Cellular and Molecular Biology, Department of Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Cancer Res 72:3207-16. 2012..Our findings therefore show a critical role for the REST-LIN28A axis in tumor aggression and suggest a causative relationship between REST loss and tumorigenicity in vivo...
- Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG)Carl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
Epilepsia 49:97-100. 2008..Finally, 2DG has a favorable preliminary toxicity profile. These factors support the possibility that 2DG or other modifiers of glycolysis can be used as novel treatments for epilepsy...
- A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive diseaseMatthew P Wagoner
Department of Neuroscience, University of Wisconsin at Madison, Madison, WI 53706, USA
BMC Genomics 13:686. 2012..Recent work has highlighted the role of the transcription factor RE1 Silencing Transcription Factor, REST in glioblastoma but how REST function correlates with disease outcome has not been described...
- The transcription factor REST is lost in aggressive breast cancerMatthew P Wagoner
Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, USA
PLoS Genet 6:e1000979. 2010..Additionally, the alternative splicing observed in REST-less breast cancer is an attractive therapeutic target...
- Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy modelsCarl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
Ann Neurol 65:435-47. 2009....
- Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsSean D Ryan
Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA
Proc Natl Acad Sci U S A 109:E2205-14. 2012..These results suggest that levels of Mad1 must be tightly regulated to prevent aneuploidy and transformation and that Mad1 up-regulation may promote tumors and cause resistance to current therapies...
- Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potencyJayne M Squirrell
Laboratory for Optical and Computational Instrumentation, University of Wisconsin, Madison, Wisconsin, United States of America
PLoS ONE 7:e43708. 2012..What emerges is a practical and accessible approach to evaluate, and ultimately enrich, living stem cell populations based on changes in metabolism that could be exploited for both research and clinical applications...
- Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genesAvtar Roopra
Department of Neurology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
Mol Cell 14:727-38. 2004..Finally, we demonstrate that dominant-negative G9a abrogates silencing of chromosomal neuronal genes. These findings implicate a role for histone methylation in targeting neuronal gene expression to the nervous system...