Avtar Roopra

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling
    Wyatt B Potter
    Department of Neuroscience, Medical Science Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Biol 11:e1001627. 2013
  2. pmc Epigenetics and epilepsy
    Avtar Roopra
    Department of Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Epilepsia 53:2-10. 2012
  3. pmc Metabolic regulation of neuronal plasticity by the energy sensor AMPK
    Wyatt B Potter
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e8996. 2010
  4. ncbi request reprint 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure
    Mireia Garriga-Canut
    Department of Neurology, Medical Science Center, Room 1715, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Neurosci 9:1382-7. 2006
  5. pmc Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors
    Kearney T W Gunsalus
    Graduate Program in Cellular and Molecular Biology, Department of Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 72:3207-16. 2012
  6. doi request reprint Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG)
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Epilepsia 49:97-100. 2008
  7. pmc A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease
    Matthew P Wagoner
    Department of Neuroscience, University of Wisconsin at Madison, Madison, WI 53706, USA
    BMC Genomics 13:686. 2012
  8. pmc The transcription factor REST is lost in aggressive breast cancer
    Matthew P Wagoner
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Genet 6:e1000979. 2010
  9. pmc Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
    Ann Neurol 65:435-47. 2009
  10. pmc Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons
    Sean D Ryan
    Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 109:E2205-14. 2012

Collaborators

  • Matthew P Wagoner
  • Corinna Burger
  • Brenda M Ogle
  • Andrea L Richardson
  • Jenny Hsieh
  • Beth A Weaver
  • Anjon Audhya
  • Andreas Friedl
  • Wyatt B Potter
  • Carl E Stafstrom
  • Kassondra Meyer
  • Jayne M Squirrell
  • Kearney T W Gunsalus
  • Sean D Ryan
  • Kenneth J O'Riordan
  • Barry Schoenike
  • Thomas P Sutula
  • Mireia Garriga-Canut
  • Trina Basu
  • Paul Rutecki
  • Allison Kirchner
  • Timothy J Kamp
  • Kristen Witte
  • Eric M C Britigan
  • Gary E Lyons
  • Lauren M Zasadil
  • Soyoung Kim
  • Caroline M Alexander
  • Carlos A Ariza
  • Kevin W Eliceiri
  • Nirupama K Shevde
  • Amber Mael
  • Jimmy J Fong
  • David Barnett
  • Susan M K Osting
  • Matthew T Valley
  • Jeffrey C Ockuly
  • Lauren Murphree
  • Jeffrey Ockuly
  • Thomas Sutula
  • Romena Qazi
  • Timothy J Daley
  • John F Morrison
  • Rebecca M Pfender
  • Carl Stafstrom
  • Karen Bergendahl

Detail Information

Publications12

  1. pmc Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling
    Wyatt B Potter
    Department of Neuroscience, Medical Science Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Biol 11:e1001627. 2013
    ..These findings highlight the potential of modulating the mGluR5-Erk pathway in a developmental stage-specific manner to treat TSC. ..
  2. pmc Epigenetics and epilepsy
    Avtar Roopra
    Department of Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Epilepsia 53:2-10. 2012
    ..Finally we highlight possible future directions in the field of epigenetics and epilepsy...
  3. pmc Metabolic regulation of neuronal plasticity by the energy sensor AMPK
    Wyatt B Potter
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e8996. 2010
    ..Our work opens up the possibility of using modulators of energy metabolism to control neuronal plasticity in diseases and conditions of aberrant plasticity such as epilepsy...
  4. ncbi request reprint 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure
    Mireia Garriga-Canut
    Department of Neurology, Medical Science Center, Room 1715, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Neurosci 9:1382-7. 2006
    ..The metabolic regulation of neuronal genes by CtBP will open avenues of therapy for neurological disorders and cancer...
  5. pmc Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors
    Kearney T W Gunsalus
    Graduate Program in Cellular and Molecular Biology, Department of Neuroscience, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 72:3207-16. 2012
    ..Our findings therefore show a critical role for the REST-LIN28A axis in tumor aggression and suggest a causative relationship between REST loss and tumorigenicity in vivo...
  6. doi request reprint Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG)
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Epilepsia 49:97-100. 2008
    ..Finally, 2DG has a favorable preliminary toxicity profile. These factors support the possibility that 2DG or other modifiers of glycolysis can be used as novel treatments for epilepsy...
  7. pmc A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease
    Matthew P Wagoner
    Department of Neuroscience, University of Wisconsin at Madison, Madison, WI 53706, USA
    BMC Genomics 13:686. 2012
    ..Recent work has highlighted the role of the transcription factor RE1 Silencing Transcription Factor, REST in glioblastoma but how REST function correlates with disease outcome has not been described...
  8. pmc The transcription factor REST is lost in aggressive breast cancer
    Matthew P Wagoner
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Genet 6:e1000979. 2010
    ..Additionally, the alternative splicing observed in REST-less breast cancer is an attractive therapeutic target...
  9. pmc Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
    Ann Neurol 65:435-47. 2009
    ....
  10. pmc Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons
    Sean D Ryan
    Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 109:E2205-14. 2012
    ..These results suggest that levels of Mad1 must be tightly regulated to prevent aneuploidy and transformation and that Mad1 up-regulation may promote tumors and cause resistance to current therapies...
  11. pmc Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potency
    Jayne M Squirrell
    Laboratory for Optical and Computational Instrumentation, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 7:e43708. 2012
    ..What emerges is a practical and accessible approach to evaluate, and ultimately enrich, living stem cell populations based on changes in metabolism that could be exploited for both research and clinical applications...
  12. ncbi request reprint Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes
    Avtar Roopra
    Department of Neurology, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA
    Mol Cell 14:727-38. 2004
    ..Finally, we demonstrate that dominant-negative G9a abrogates silencing of chromosomal neuronal genes. These findings implicate a role for histone methylation in targeting neuronal gene expression to the nervous system...