Donald J Roohk
Affiliation: University of California
- Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisoloneDonald J Roohk
Department of Nutritional Sciences and Toxicology, 309 Morgan Hall, University of California, Berkeley, CA 94720 3104, USA
J Pharmacol Exp Ther 333:281-9. 2010..Because multiple actions can be measured concurrently in a single animal, this method is a powerful systems approach for characterizing and differentiating the effects of ligands that bind nuclear receptors...
- Dexamethasone-mediated changes in adipose triacylglycerol metabolism are exaggerated, not diminished, in the absence of a functional GR dimerization domainDonald J Roohk
Department of Nutritional Science and Toxicology, University of California Berkeley, Berkeley, California 94720, USA
Endocrinology 154:1528-39. 2013..In conclusion, some metabolic effects of GC treatment are exaggerated in adipose tissue of GR(dim/dim) mice, suggesting that selective GR modulators based on dissociating GR transactivation from repression should be evaluated carefully...
- Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restrictionKrista A Varady
Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA 94720, USA
J Nutr Biochem 21:188-95. 2010..These findings indicate that ADF (both modified and true) produces similar beneficial modulations in body fat distribution and adiponectin levels as daily CR...
- Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in miceKrista A Varady
Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California, USA
Nutrition 25:486-91. 2009..Accordingly, we examined the effects of 85% restriction on the fast day (ADF-85%) with an LF or HF background diet on proliferation rates of various tissues...