Martin J J Ronis

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi request reprint Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 134:904-12. 2004
  2. pmc Differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat
    Jian Zhang
    Arkansas Children s Nutrition Center, Little Rock, Arkansas, United States of America
    PLoS ONE 7:e35736. 2012
  3. doi request reprint Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity
    Martin J J Ronis
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Physiol Genomics 45:351-66. 2013
  4. ncbi request reprint Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats
    Kartik Shankar
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 23:338-49. 2008
  5. pmc Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: role of the TNF signaling axis
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Toxicol Appl Pharmacol 220:302-10. 2007
  6. pmc Feeding blueberry diets to young rats dose-dependently inhibits bone resorption through suppression of RANKL in stromal cells
    Jian Zhang
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 8:e70438. 2013
  7. pmc Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice
    Kelly E Mercer
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 343:401-12. 2012
  8. doi request reprint Short term effects on bone quality associated with consumption of soy protein isolate and other dietary protein sources in rapidly growing female rats
    Jin Ran Chen
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 233:1348-58. 2008
  9. ncbi request reprint A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet
    January N Baumgardner
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Physiol Gastrointest Liver Physiol 294:G27-38. 2008
  10. pmc Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition
    Martin J J Ronis
    Arkansas Children s Nutrition Center University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Free Radic Biol Med 39:619-30. 2005

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 134:904-12. 2004
    ..These findings may be important in the nutritional management and treatment of alcoholic liver disease...
  2. pmc Differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat
    Jian Zhang
    Arkansas Children s Nutrition Center, Little Rock, Arkansas, United States of America
    PLoS ONE 7:e35736. 2012
    ..However, mechanistic studies comparing the effects of soy diet and estrogens on bone, particularly in rapidly growing animals are lacking...
  3. doi request reprint Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity
    Martin J J Ronis
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Physiol Genomics 45:351-66. 2013
    ..05) and had reduced serum triglycerides, leptin, and adiponectin relative to WT-HFD mice (P < 0.05). These data suggest that NOX2 is an important regulator of metabolic homeostasis and diet-induced obesity...
  4. ncbi request reprint Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats
    Kartik Shankar
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 23:338-49. 2008
    ..EtOH-induced skeletal deficits were prevented by treatment with either NAC or sTNFR1. These data suggest that postlactational anabolic rebuilding is influenced by EtOH consumption and may affect the long-term risk of osteopenia...
  5. pmc Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: role of the TNF signaling axis
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Toxicol Appl Pharmacol 220:302-10. 2007
    ..We conclude that chronic ethanol-associated inhibition of direct bone formation is mediated to a significant extent by the TNF signaling axis in a mouse model...
  6. pmc Feeding blueberry diets to young rats dose-dependently inhibits bone resorption through suppression of RANKL in stromal cells
    Jian Zhang
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 8:e70438. 2013
    ..These results suggest that inhibition of bone resorption may contribute to increased bone mass during early development after BB consumption. ..
  7. pmc Vitamin D supplementation protects against bone loss associated with chronic alcohol administration in female mice
    Kelly E Mercer
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 343:401-12. 2012
    ..These findings suggest dietary VitD supplementation may prevent skeletal toxicity in chronic drinkers by normalizing calcium homeostasis, preventing apoptosis, and suppressing EtOH-induced increases in bone resorption...
  8. doi request reprint Short term effects on bone quality associated with consumption of soy protein isolate and other dietary protein sources in rapidly growing female rats
    Jin Ran Chen
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 233:1348-58. 2008
    ..05). These data suggest beneficial bone effects of a soy diet in rapidly growing animals and the potential for early soy consumption to increase peak bone mass...
  9. ncbi request reprint A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet
    January N Baumgardner
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Physiol Gastrointest Liver Physiol 294:G27-38. 2008
    ..These data suggest that intragastric infusion of a high-polyunsaturated fat diet at a caloric level of 17% excess total calories results in pathology similar to clinical NASH...
  10. pmc Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition
    Martin J J Ronis
    Arkansas Children s Nutrition Center University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Free Radic Biol Med 39:619-30. 2005
    ..These data suggest that ethanol-induced oxidative stress can contribute to inflammation and liver injury even in the absence of Kupffer cell activation by endotoxemia...
  11. doi request reprint Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet
    Jin Ran Chen
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, AR 72202, USA
    FASEB J 26:1131-41. 2012
    ..These results suggest that maternal obesity impairs fetal skeletal development through down-regulation of the HoxA10 gene, which may lead to an increase in the prevalence of low bone mass in the offspring later in life...
  12. doi request reprint Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition
    Martin J J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 233:344-55. 2008
    ....
  13. doi request reprint Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
    Jin Ran Chen
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Bone Miner Res 25:2399-411. 2010
    ....
  14. pmc N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis
    January N Baumgardner
    Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 138:1872-9. 2008
    ..Using NAC in a TEN model of NASH, we have demonstrated that NAC prevents many aspects of NASH progression by decreasing development of oxidative stress and subsequent increases in TNFalpha but does not block development of steatosis...
  15. doi request reprint Mammary gland morphology and gene expression differ in female rats treated with 17β-estradiol or fed soy protein isolate
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Endocrinology 153:6021-32. 2012
    ..05). These data suggest that SPI is only minimally estrogenic in the rat mammary gland even in the absence of endogenous estrogens...
  16. pmc Maternal overweight programs insulin and adiponectin signaling in the offspring
    Kartik Shankar
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 151:2577-89. 2010
    ..Our results strongly suggest that gestational exposure to maternal obesity programs multiple aspects of energy-balance regulation in the offspring...
  17. doi request reprint Soy protein isolates prevent loss of bone quantity associated with obesity in rats through regulation of insulin signaling in osteoblasts
    Jin Ran Chen
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, AR 72202, USA
    FASEB J 27:3514-23. 2013
    ....
  18. ncbi request reprint Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts
    Jin Ran Chen
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Pharmacol Exp Ther 319:1182-90. 2006
    ..Therefore, E(2) prevents EtOH-induced bone loss by opposing the induction of RANKL mRNA in osteoblasts and ethanol-induced osteoclastogenesis, through opposing effects on sustained ERK signaling...
  19. pmc Inhibition of NADPH oxidases prevents chronic ethanol-induced bone loss in female rats
    Jin Ran Chen
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Pharmacol Exp Ther 336:734-42. 2011
    ..These data suggest that inhibition of Nox expression and activity may be critical for prevention of chronic EtOH-induced osteoblast-dependent bone loss...
  20. ncbi request reprint Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation
    Ling He
    Arkansas Children s Nutrition Center and the Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Biol Chem 281:11126-34. 2006
    ..Ethanol inhibition of insulin signaling reduces nuclear SREBP accumulation and results in disinhibition of Class 1 ADH transcription...
  21. ncbi request reprint Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver
    Ling He
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
    J Biol Chem 279:28113-21. 2004
    ..We conclude that SREBP-1 is a negative regulator of the ADH gene and may work in concert with the CCAAT/enhancer-binding proteins to mediate ethanol induction of ADH in vivo...
  22. doi request reprint Carbohydrate-responsive gene expression in the adipose tissue of rats
    Kartik Shankar
    U S Department of Agriculture Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 151:153-64. 2010
    ..These results suggest that C/F and interactions with excessive caloric intake per se may regulate body composition and play important roles in the development of obesity and metabolic syndrome...
  23. doi request reprint Infant formula promotes bone growth in neonatal piglets by enhancing osteoblastogenesis through bone morphogenic protein signaling
    Jin Ran Chen
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 139:1839-47. 2009
    ..SF piglets had the highest bone volume over tissue volume. This suggests that SF-fed piglets may have the best quality bone. The anabolic effects of SF on bone appear to be mediated through enhanced BMP signaling...
  24. pmc Effects of long-term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease
    Martin J J Ronis
    epartment of Pharmacology and Toxicology, 2University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Am J Physiol Gastrointest Liver Physiol 300:G109-19. 2011
    ....
  25. ncbi request reprint Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition
    January N Baumgardner
    Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Am J Physiol Gastrointest Liver Physiol 293:G355-64. 2007
    ..However, enhanced ethanol-induced cellular proliferation, perhaps as a result of enhanced PPAR-alpha signaling, may contribute to an increased risk of hepatocellular carcinoma in undernourished alcoholics...
  26. ncbi request reprint Lack of sexual dimorphism in alcohol-induced liver damage (ALD) in rats treated chronically with ethanol-containing low carbohydrate diets: The role of ethanol metabolism and endotoxin
    Martin J J Ronis
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Life Sci 75:469-83. 2004
    ..These data do not support previous observations that female rats have a greater susceptibility to ethanol-induced hepatotoxicity than males...
  27. ncbi request reprint Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity
    Kartik Shankar
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 231:1379-97. 2006
    ..Our data suggest that undernutrition potentiates the fetal toxicity of EtOH in part by disrupting maternal GH-IGF-1, signaling thereby decreasing maternal uterine capacity and placental growth...
  28. pmc Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats
    Jian Zhang
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 6:e24486. 2011
    ....
  29. pmc Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells
    Jian Zhang
    Arkansas Children s Nutrition Center, Slot 512 20B 15 Children s Way, Little Rock, AR 72202, USA
    Age (Dordr) 35:807-20. 2013
    ....
  30. ncbi request reprint A novel mouse model for the study of the inhibitory effects of chronic ethanol exposure on direct bone formation
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Alcohol 39:159-67. 2006
    ..002). We conclude that this model can be used to study the mechanisms underlying inhibition of bone formation by chronic ethanol exposure and to test preclinical interventions...
  31. ncbi request reprint Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/
    Jin Ran Chen
    Arkansas Children s Nutrition Center, Slot 512 20B, 1120 Marshall St, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 324:50-9. 2008
    ..These data suggest that the molecular mechanisms whereby E(2) prevents EtOH-induced bone loss involve interference with ROS generation and cytoplasmic kinase activation...
  32. pmc Maternal obesity enhances white adipose tissue differentiation and alters genome-scale DNA methylation in male rat offspring
    Sarah J Borengasser
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202
    Endocrinology 154:4113-25. 2013
    ..Our findings strongly suggest that the maternal OB in utero alters adipocyte commitment and differentiation via epigenetic mechanisms...
  33. pmc Chronic ethanol consumption leads to disruption of vitamin D3 homeostasis associated with induction of renal 1,25 dihydroxyvitamin D3-24-hydroxylase (CYP24A1)
    Kartik Shankar
    Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, AR 72202, USA
    Endocrinology 149:1748-56. 2008
    ....
  34. ncbi request reprint IL-1 and TNF antagonists prevent inhibition of fracture healing by ethanol in rats
    Daniel S Perrien
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 722021, USA
    Toxicol Sci 82:656-60. 2004
    ..These results support, for the first time, the hypothesis that IL-1 and TNF antagonists are capable of protecting fracture healing from the inhibition associated with chronic ethanol consumption...
  35. doi request reprint Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease
    Martin J J Ronis
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 238:151-62. 2013
    ..These data suggest that replacing unsaturated fats like corn oil with MCT oil in the diet could be utilized as a potential treatment for NAFLD...
  36. doi request reprint Formula feeding alters hepatic gene expression signature, iron and cholesterol homeostasis in the neonatal pig
    Martin J J Ronis
    Arkansas Children s Nutrition Center and Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Physiol Genomics 43:1281-93. 2011
    ....
  37. pmc Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning
    Sarah J Borengasser
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 6:e24068. 2011
    ..Mitochondrial dysfunction may be an underlying event that reduces hepatic fatty acid oxidation and precedes the development of detrimental obesity associated co-morbidities such as insulin resistance and NAFLD...
  38. ncbi request reprint Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis
    Daniel S Perrien
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Pharmacol Exp Ther 303:904-8. 2002
    ....
  39. doi request reprint Lipid fatty acid profile analyses in liver and serum in rats with nonalcoholic steatohepatitis using improved gas chromatography-mass spectrometry methodology
    Xianli Wu
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 15 Children s Way, Little Rock, Arkansas 72202, United States
    J Agric Food Chem 59:747-54. 2011
    ..Alteration of FA composition in liver after overfeeding of high polyunsaturated fat diets may contribute to the progression of pathological changes from steatosis to inflammation, necrosis, and fibrosis observed in NASH...
  40. pmc Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst
    Kartik Shankar
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 152:4158-70. 2011
    ..Our results suggest that ectopic lipid and inflammation may link maternal obesity to increased predisposition of offspring to obesity later in life...
  41. pmc Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats
    Jin Ran Chen
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 5:e13704. 2010
    ..It is well established that excessive consumption of a high fat diet (HFD) results in obesity; however, the consequences of obesity on postnatal skeletal development have not been well studied...
  42. pmc Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN)
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Little Rock, AR, USA Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Electronic address
    Alcohol 48:133-44. 2014
    ..Importantly, it appears that diet composition does not affect alcohol-associated skeletal toxicity. ..
  43. ncbi request reprint Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid diets
    Martin J J Ronis
    Department of Pharmacology and Toxicology, UAMS, Arkansas Children s Nutrition Center, Little Rock Arkansas, 72205, USA
    Exp Biol Med (Maywood) 229:351-60. 2004
    ....
  44. pmc Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficient mice
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Bone 46:410-7. 2010
    ..We conclude that exogenous rmTNF and/or endogenous TNF act to inhibit new bone formation during DO by signaling primarily through TNFR1...
  45. doi request reprint Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats
    John C Marecki
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    J Nutr Biochem 22:142-52. 2011
    ....
  46. pmc Effects of pregnancy and nutritional status on alcohol metabolism
    Kartik Shankar
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Alcohol Res Health 30:55-9. 2007
    ..Research using the TEN system has demonstrated that alcohol-induced fetal growth retardation is potentiated by undernutrition in part via impaired alcohol metabolism and clearance...
  47. ncbi request reprint Different molecular mechanisms underlie ethanol-induced bone loss in cycling and pregnant rats
    Kartik Shankar
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Endocrinology 147:166-78. 2006
    ....
  48. pmc Distraction osteogenesis in TNF receptor 1 deficient mice is protected from chronic ethanol exposure
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Alcohol 46:133-8. 2012
    ..We conclude that exogenous rmTNF and ethanol-induced endogenous TNF act to inhibit new bone formation during DO by signaling primarily through TNFR1...
  49. doi request reprint Enhanced expression and glucocorticoid-inducibility of hepatic cytochrome P450 3A involve recruitment of the pregnane-X-receptor to promoter elements in rats fed soy protein isolate
    Martin J J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 141:10-6. 2011
    ....
  50. ncbi request reprint Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition
    Mats Hidestrand
    Arkansas Children s Nutrition Center and University of Arkansas for Medical Sciences, Department of Pharmacology and Toxicology, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 29:888-95. 2005
    ....
  51. ncbi request reprint Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health
    Ling He
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Mol Endocrinol 21:2541-50. 2007
    ....
  52. ncbi request reprint Maternal obesity at conception programs obesity in the offspring
    Kartik Shankar
    Arkansas Children s Nutrition Center, 1212 Marshall Street, Little Rock, AR 72202, USA
    Am J Physiol Regul Integr Comp Physiol 294:R528-38. 2008
    ..Our data suggest that maternal obesity at conception leads to fetal programming of offspring, which could result in obesity in later life...
  53. ncbi request reprint Agouti signaling protein stimulates cell division in "viable yellow" (A(vy)/a) mouse liver
    George L Wolff
    Arkansas Children s Nutrition Center, Little Rock, AR72202, USA
    Exp Biol Med (Maywood) 232:1326-9. 2007
    ..We found that ASIP levels were approximately 100-fold higher in yellow than in pseudoagouti or black mice and that the proportion of PCNA-positive hepatocytes was greater (P < 0.001) in yellow than in pseudoagouti or black mice...
  54. pmc Effects of nutrition and alcohol consumption on bone loss
    Martin J J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
    Curr Osteoporos Rep 9:53-9. 2011
    ..New data suggest that Wnt and bone morphogenetic protein signaling pathways are the molecular targets for bone anabolic factors derived from the diet...
  55. ncbi request reprint Isoflavone conjugates are underestimated in tissues using enzymatic hydrolysis
    Liwei Gu
    Arkansas Children s Nutrition Center, Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 53:6858-63. 2005
    ..2-0.25 nmol/g range, far below the concentrations required for most in vitro effects of genistein or daidzein...
  56. ncbi request reprint Alcohol-induced disruption of endocrine signaling
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 31:1269-85. 2007
    ..Lang; (5) The role of reduced plasma estradiol and impaired estrogen signaling in alcohol-induced bone loss, by Martin J. Ronis; and (6) Short-term influence of alcohol on appetite-regulating hormones in man, by Jan Calissendorff...
  57. ncbi request reprint Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms
    Nianbai Fang
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Altern Complement Med 12:125-32. 2006
    ..In this study, potential roles of an ethyl acetate fraction from shiitake mushrooms were investigated by in vitro bioassays...
  58. ncbi request reprint Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women
    Liwei Gu
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    J Nutr 136:1215-21. 2006
    ..Thus, there were significant interspecies differences in isoflavone metabolism, and the overall metabolic profile of pigs was closer to that of women than that of rats or monkeys...
  59. ncbi request reprint Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice
    Jin Ran Chen
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Bone Miner Res 29:1043-53. 2014
    ..2014 American Society for Bone and Mineral Research...
  60. ncbi request reprint Alcohol metabolism: role in toxicity and carcinogenesis
    Thomas M Badger
    Arkansas Children s Nutrition Center and Departments of Physiology and Biophysics, Pediatrics at the University of Arkansas for Medical Sciences, Little Rock, Arkansas 72211, USA
    Alcohol Clin Exp Res 27:336-47. 2003
    ....
  61. ncbi request reprint Non-isoflavone phytochemicals in soy and their health effects
    Jie Kang
    USDA Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Agric Food Chem 58:8119-33. 2010
    ..This review attempts to summarize major non-isoflavone phytochemicals in soy, as well as their bioavailability and health effects. In addition, a brief discussion of components formed during food processing is also included...
  62. ncbi request reprint Soy protein isolate and protection against cancer
    Thomas M Badger
    Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Am Coll Nutr 24:146S-149S. 2005
    ..The purpose of this presentation was to evaluate the potential of soy protein to prevent occurrence of prostate, breast and colon cancer...
  63. ncbi request reprint Altered mammary gland differentiation and progesterone receptor expression in rats fed soy and whey proteins
    J Craig Rowlands
    Arkansas Children s Nutrition Center and Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Toxicol Sci 70:40-5. 2002
    ..The SPI- and WPH-dependent changes in mammary differentiation may contribute to the reduced sensitivity to DMBA-induced mammary cancer in rats fed these proteins...
  64. ncbi request reprint Ethanol induction of class I alcohol dehydrogenase expression in the rat occurs through alterations in CCAAT/enhancer binding proteins beta and gamma
    Ling He
    Arkansas Children s Nutrition Center, Little Rock 72202, USA
    J Biol Chem 277:43572-7. 2002
    ..05). These data provide the first evidence for the mechanism by which ethanol regulates rat hepatic Class I ADH gene expression in vivo. This mechanism involves the C/EBP site and the enhancer binding proteins beta and gamma...
  65. ncbi request reprint Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage
    Susan R Shelnutt
    Arkansas Children s Nutrition Center and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Am J Clin Nutr 76:588-94. 2002
    ..Isoflavone conjugates may serve as sources of aglycones at specific target tissues and may have bioactivity. Yet, very little is known about the plasma pharmacokinetics of isoflavone conjugates after soy ingestion...
  66. ncbi request reprint Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition
    Elizabeth C Brown
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, 1120 Marshall Street, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 301:1132-8. 2002
    ..Also, the DO studies demonstrate, for the first time, that chronic ethanol inhibits rapid bone formation during limb lengthening...
  67. ncbi request reprint The health consequences of early soy consumption
    Thomas M Badger
    Arkansas Children s Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 132:559S-565S. 2002
    ..Further research is needed to confirm the results of the few studies that have been conducted and new studies are needed to investigate the more subtle effects that could occur during development or that could surface later in life...
  68. ncbi request reprint Type 1 diabetic mice are protected from acetaminophen hepatotoxicity
    Kartik Shankar
    Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Toxicol Sci 73:220-34. 2003
    ..In conclusion, the resistance of DB mice against hepatotoxic and lethal effects of APAP appears to be mediated by a combination of enhanced APAP clearance and robust compensatory tissue repair...