Dorit Ron

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Coordinated movement of RACK1 with activated betaIIPKC
    D Ron
    Department of Neurology, University of California, San Francisco, California 94110 3518, USA
    J Biol Chem 274:27039-46. 1999
  2. pmc Signaling cascades regulating NMDA receptor sensitivity to ethanol
    Dorit Ron
    Department of Neurology, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Emeryville 94608, USA
    Neuroscientist 10:325-36. 2004
  3. ncbi request reprint GDNF and addiction
    Dorit Ron
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, USA
    Rev Neurosci 16:277-85. 2005
  4. ncbi request reprint The "ups and downs" of signaling cascades in addiction
    Dorit Ron
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Sci STKE 2005:re14. 2005
  5. ncbi request reprint New insights into the regulation of protein kinase C and novel phorbol ester receptors
    D Ron
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    FASEB J 13:1658-76. 1999
  6. ncbi request reprint Uncoupling of betaIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain
    D Ron
    Ernest Gallo Research Center, Department of Neurology, San Francisco, CA 94110 3518, USA
    FASEB J 14:2303-14. 2000
  7. pmc Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse
    Jun Wang
    Ernest Gallo Research Center and Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
    J Neurosci 30:10187-98. 2010
  8. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:9630-8. 2003
  9. pmc Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior
    Jun Wang
    Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, California 94608, USA
    J Neurosci 32:15124-32. 2012
  10. pmc Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system
    Jun Wang
    Gallo Research Center, Emeryville, California 94608, USA
    J Neurosci 30:14502-12. 2010

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Coordinated movement of RACK1 with activated betaIIPKC
    D Ron
    Department of Neurology, University of California, San Francisco, California 94110 3518, USA
    J Biol Chem 274:27039-46. 1999
    ..We further show that association of RACK1 and betaIIPKC is required for the movement of both proteins. Our results suggest that RACK1 is a PKC shuttling protein that moves betaIIPKC from one intracellular site to another...
  2. pmc Signaling cascades regulating NMDA receptor sensitivity to ethanol
    Dorit Ron
    Department of Neurology, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Emeryville 94608, USA
    Neuroscientist 10:325-36. 2004
    ..Specifically, the role of the scaffolding protein RACK1 and the regulatory protein DARPP-32 in mediating the distinct effects of ethanol is presented...
  3. ncbi request reprint GDNF and addiction
    Dorit Ron
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, USA
    Rev Neurosci 16:277-85. 2005
    ..We also provide evidence to suggest that therapies that activate GDNF signaling may be useful for the treatment of drug and alcohol addiction...
  4. ncbi request reprint The "ups and downs" of signaling cascades in addiction
    Dorit Ron
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Sci STKE 2005:re14. 2005
    ..Signaling cascades that contribute to addiction, as well as those that protect or delay the development of addiction, are presented...
  5. ncbi request reprint New insights into the regulation of protein kinase C and novel phorbol ester receptors
    D Ron
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    FASEB J 13:1658-76. 1999
    ....
  6. ncbi request reprint Uncoupling of betaIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain
    D Ron
    Ernest Gallo Research Center, Department of Neurology, San Francisco, CA 94110 3518, USA
    FASEB J 14:2303-14. 2000
    ..Thus, some of the cellular and neuroadaptive responses to ethanol may be related to ethanol-induced movement of RACK1 to the nucleus, thereby preventing the translocation and corresponding function of betaIIPKC...
  7. pmc Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse
    Jun Wang
    Ernest Gallo Research Center and Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
    J Neurosci 30:10187-98. 2010
    ..Our results suggest that the upregulation of NR2B-NMDAR activity within the DMS by alcohol contributes to the maladaptive synaptic changes that lead to excessive alcohol intake and relapse...
  8. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:9630-8. 2003
    ..This in turn leads to NMDA receptor phosphorylation, enhanced activity mediated by Fyn, and to the induction of brain-derived neurotrophic factor expression by RACK1...
  9. pmc Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior
    Jun Wang
    Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, California 94608, USA
    J Neurosci 32:15124-32. 2012
    ....
  10. pmc Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system
    Jun Wang
    Gallo Research Center, Emeryville, California 94608, USA
    J Neurosci 30:14502-12. 2010
    ..Together, these results demonstrate that NAc-produced GDNF serves as a retrograde enhancer that upregulates the activity of the mesocorticolimbic DA system...
  11. pmc Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
    Segev Barak
    The Ernest Gallo Research Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    Nat Neurosci 16:1111-7. 2013
    ..Our findings provide evidence that the mTORC1 pathway and its downstream substrates are crucial in alcohol-related memory reconsolidation and highlight this pathway as a therapeutic target to prevent relapse. ..
  12. ncbi request reprint Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior
    Jun Wang
    Ernest Gallo Research Center, Emeryville, California 94608, USA
    J Neurosci 27:3593-602. 2007
    ....
  13. pmc GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse
    Sebastien Carnicella
    The Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 105:8114-9. 2008
    ..Together, these results suggest that GDNF, via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to consume and seek alcohol...
  14. pmc Endogenous BDNF in the dorsolateral striatum gates alcohol drinking
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 29:13494-502. 2009
    ..Importantly, our results suggest that an endogenous signaling pathway within the same brain region that mediates drug-taking behavior also plays a critical role in gating the level of ethanol intake...
  15. pmc Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption
    Dao Yao He
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 25:619-28. 2005
    ..These findings highlight the importance of GDNF as a new target for drug development for alcoholism that may mimic the effect of ibogaine against alcohol consumption but avoid the negative side effects...
  16. doi request reprint Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward
    Stuart L Gibb
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 31:2180-7. 2011
    ..Together, our results suggest a novel role for Lyn kinase in the regulation of DA release in the mesolimbic system, which leads to the control of alcohol reward...
  17. doi request reprint Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
    Taban Seif
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, San Francisco, California, USA
    Nat Neurosci 16:1094-100. 2013
    ..Our results identify a mechanism by which hyperpolarization-active NMDA receptors under mPFC- and insula-to-NAcore inputs sustain aversion-resistant alcohol intake. ..
  18. ncbi request reprint The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption
    Jerome Jeanblanc
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 26:1457-64. 2006
    ....
  19. pmc Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner
    Rachel Jurd
    Gallo Research Center, Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
    J Biol Chem 283:301-10. 2008
    ..These results identify a specific E3 ubiquitin ligase as a novel interactant with the NR2B subunit and suggest a possible mechanism for the regulation of NMDAR function involving both phosphorylation and ubiquitination...
  20. pmc Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription
    Jérémie Neasta
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Biol Chem 287:322-36. 2012
    ..As RACK1 and 14-3-3ζ are two multifunctional scaffolding proteins that coordinate a wide variety of signaling events, their interaction is likely to regulate other essential cellular functions...
  21. doi request reprint Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake
    Marian L Logrip
    Ernest Gallo Research Center, Emeryville, CA 94608, USA
    FASEB J 22:2393-404. 2008
    ..Taken together, these results demonstrate that BDNF regulates ethanol intake by initiation of MAP kinase signaling and the ensuing production of downstream gene products, including Pdyn...
  22. ncbi request reprint RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction
    Nancy N H McGough
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 24:10542-52. 2004
    ..Taken together, these findings suggest that RACK1 and BDNF are part of a regulatory pathway that opposes adaptations that lead to the development of alcohol addiction...
  23. pmc Epigenetic regulation of BDNF expression via the scaffolding protein RACK1
    Dao Yao He
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Biol Chem 285:19043-50. 2010
    ..Furthermore, this novel mechanism for the regulation of exon-specific expression of the BDNF gene by RACK1 could have implications on the neuronal functions of the growth factor including synaptic plasticity, learning, and memory...
  24. pmc Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking
    Segev Barak
    The Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 31:9885-94. 2011
    ..In addition, as it lacks abuse liability, the study further highlights GDNF as a promising target for treatment of alcohol use/abuse disorders...
  25. pmc The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors
    Sami Ben Hamida
    Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 32:15849-58. 2012
    ..Together, these results position H-Ras as a central molecular mediator of alcohol's actions within the mesolimbic system and put forward the potential value of the enzyme as a novel target to treat alcohol use disorders...
  26. pmc AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors
    Jérémie Neasta
    Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, USA
    Biol Psychiatry 70:575-82. 2011
    ..We therefore hypothesized that the activation of AKT in the NAc in response to alcohol exposure plays an important role in mechanisms that underlie excessive alcohol consumption...
  27. ncbi request reprint Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization
    Claire Thornton
    Ernest Gallo Research Center, Emeryville, California 94608, USA
    J Biol Chem 279:31357-64. 2004
    ..Based on these results, we propose that WD40-mediated homo- and heterodimerization of RACK1 mediate the formation of a transient signaling complex that includes the NMDAR, a G protein and Fyn...
  28. pmc Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor
    Sebastien Carnicella
    The Gallo Research Center, University of California, San Francisco, Emeryville, California, USA
    Biol Psychiatry 66:146-53. 2009
    ..We recently showed that GDNF in the ventral tegmental area (VTA) reduces the motivation to consume alcohol. We therefore set out to determine whether cabergoline administration decreases alcohol-drinking and -seeking behaviors via GDNF...
  29. pmc Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol
    Rami Yaka
    Ernest Gallo Research Center and the Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
    J Neurosci 23:3623-32. 2003
    ....
  30. pmc Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol
    Mridula Rewal
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, 5858 Horton Street, Emeryville, CA 94608, USA
    Addict Biol 17:309-21. 2012
    ..Possible pharmacological and non-pharmacological explanations for these effects are considered...
  31. pmc GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence
    Sebastien Carnicella
    The Ernest Gallo Research Center, University of California San Francisco, Emeryville, CA 94608, USA
    Alcohol Clin Exp Res 33:1012-24. 2009
    ..In this study, we set out to assess the contribution of endogenous GDNF or its receptor GFRalpha1 to the regulation of ethanol-related behaviors...
  32. pmc Escalating ethanol intake is associated with altered corticostriatal BDNF expression
    Marian L Logrip
    The Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurochem 109:1459-68. 2009
    ..These results suggest that the persistence of altered BDNF signaling may contribute to the inflexibility of addictive behaviors...
  33. pmc Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration
    Sebastien Carnicella
    The Ernest Gallo Research Center, Emeryville, CA, USA
    Addict Biol 15:424-33. 2010
    ..Together, our results suggest that noribogaine and 18-MC have different mechanisms and sites of action...
  34. pmc Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol
    Mridula Rewal
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 29:543-9. 2009
    ..These results indicate that the GABA(A) receptor alpha4 subunit in the NAc shell mediates alcohol intake...
  35. pmc Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors
    Sami Ben Hamida
    Gallo Center at the Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:14369-78. 2013
    ..Together, these results position PTPα upstream of Fyn within the DMS and demonstrate the important contribution of the phosphatase to the maladaptive synaptic changes that lead to excessive ethanol intake. ..
  36. pmc Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase α
    Stuart L Gibb
    Ernest Gallo Research Center, University of California San Francisco, Emeryville, California, USA
    J Neurochem 119:879-89. 2011
    ..Such neuroadaptations could be part of a mechanism that leads to the development of excessive ethanol consumption...
  37. pmc Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders
    Jérémie Neasta
    Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, CA 94608, USA
    Proc Natl Acad Sci U S A 107:20093-8. 2010
    ..Our data therefore put forward the possibility that targeting the mTORC1 signaling cascade is an innovative and valuable strategy for the treatment of alcohol use and abuse disorders...
  38. pmc BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis
    Jerome Jeanblanc
    Gallo Research Center, University of California, San Francisco, Emeryville, CA, 94608, USA
    Eur J Neurosci 37:607-12. 2013
    ..Together, our results show that BDNF attenuates ethanol drinking via activation of the MAPK pathway in a protein synthesis-dependent manner within the DLS...
  39. pmc Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90
    Dao Yao He
    Ernest Gallo Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    J Biol Chem 283:12811-8. 2008
    ..GDNF reverses this ethanol-mediated adaptation by inhibiting the interaction of TH with HSP90...
  40. ncbi request reprint Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1
    Alicia J Vagts
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, USA
    Alcohol Clin Exp Res 27:1599-605. 2003
    ..Therefore, we sought to determine the effects of chronic exposure of cells to ethanol on the cellular compartmentalization of RACK1 and on c-fos messenger RNA (mRNA) and protein expression...
  41. pmc Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor
    Sebastien Carnicella
    The Ernest Gallo Research Center, 5858 Horton St, Ste 200, Emeryville, CA 94608, USA
    Alcohol 43:35-43. 2009
    ..These data suggest that GDNF is a rapid and long-lasting inhibitor of "binge-like" ethanol consumption...
  42. pmc Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward
    Rami Yaka
    Ernst Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville 94608, USA
    Alcohol Clin Exp Res 27:1736-42. 2003
    ....
  43. ncbi request reprint Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras
    Neesha Suvarna
    Ernest Gallo Research Center, Emeryville, California 94608, USA
    J Biol Chem 280:31450-9. 2005
    ..Our results suggest that addictive drugs such as ethanol alter NMDAR trafficking and subunit composition. This may be an important mechanism by which ethanol exerts its effects on NMDARs to produce alcohol-induced aberrant plasticity...
  44. ncbi request reprint Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons
    Mark A Ungless
    Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    Neuron 39:401-7. 2003
    ..These results provide evidence of the first specific roles for CRF-R2 and CRF-BP in the modulation of neuronal activity and suggest that NMDARs in the VTA may be a target for both drugs of abuse and stress...
  45. pmc Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum
    Jun Wang
    Ernest Gallo Research Center, University of California, San Francisco, Emeryville, CA, USA
    Channels (Austin) 5:205-9. 2011
    ..Together, these results suggest that upregulation of NR2B-NMDAR activity by ethanol is selective and that ethanol's effect on NMDAR activity is gradual and cumulative...
  46. pmc H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity
    Claire Thornton
    Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
    J Biol Chem 278:23823-9. 2003
    ..This mechanism is specific for Src and NR2A and has implications for studies in which regulation of NMDA receptor-mediated LTP is important, such as synaptic plasticity, learning, and memory and addiction...
  47. ncbi request reprint Ethanol induces gene expression via nuclear compartmentalization of receptor for activated C kinase 1
    Dao Yao He
    Ernest Gallo Research Center, Emeryville, California, USA
    Mol Pharmacol 62:272-80. 2002
    ..These results may therefore have important implications for the study of alcohol addiction...
  48. ncbi request reprint Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine
    Dao Yao He
    Ernest Gallo Research Center, Emeryville, California, USA
    FASEB J 20:2420-2. 2006
    ..The identification of a GDNF-mediated, autoregulatory long-lasting feedback loop could have important implications for GDNF's potential value as a treatment for addiction and neurodegenerative diseases...
  49. pmc Regulation of operant oral ethanol self-administration: a dose-response curve study in rats
    Sebastien Carnicella
    Gallo Research Center, University of California, San Francisco, Emeryville, USA
    Alcohol Clin Exp Res 35:116-25. 2011
    ..In this study, we set out to determine whether a meaningful dose-response curve for oral ethanol self-administration can be obtained in rats...
  50. pmc Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake
    Hong Nie
    Ernest Gallo Clinic and Research Center, University of California, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 108:4459-64. 2011
    ..These results provide strong evidence that extrasynaptic δ-subunit-containing GABA(A) receptors in the medial shell of the NAc are critical for the reinforcing effects of oral ethanol...
  51. pmc Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H
    Marian L Logrip
    The Ernest Gallo Research Center, Suite 200, Emeryville, CA 94608, USA
    Alcohol 43:359-65. 2009
    ..Taken together, these data indicate that the KOR/dynorphin system may acutely regulate ethanol intake via inhibition of the rewarding properties of ethanol...
  52. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002
    ..Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory...
  53. ncbi request reprint Alcohol addiction
    M Foster Olive
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA
    Methods Mol Biol 233:555-70. 2003
  54. pmc GDNF--a potential target to treat addiction
    Sebastien Carnicella
    The Ernest Gallo Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
    Pharmacol Ther 122:9-18. 2009
    ..In this article, we review these data and highlight the possibility that the GDNF pathway may be a promising target for the treatment of addiction...
  55. ncbi request reprint Protein kinase C and alcohol addiction
    Philip M Newton
    Ernest Gallo Clinic and Research Center, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Pharmacol Res 55:570-7. 2007
    ..These findings suggest that drugs targeting PKCgamma and PKCepsilon may be useful to curb excessive drinking, the key symptom of alcohol use disorders...
  56. ncbi request reprint BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF
    Patricia H Janak
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Alcohol Clin Exp Res 30:214-21. 2006
    ..Dr. Pandey showed that amygdalar BDNF regulates alcohol's anxiolytic effects and preference. Finally, Dr. Janak presented evidence that increases in the expression of GDNF in the midbrain reduce alcohol self-administration in rats...
  57. doi request reprint Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area
    Dennis R Sparta
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California
    Alcohol Clin Exp Res 37:1680-7. 2013
    ....
  58. pmc Signaling pathways mediating alcohol effects
    Dorit Ron
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Curr Top Behav Neurosci 13:87-126. 2013
    ....
  59. pmc Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268
    Somayeh Ahmadiantehrani
    Gallo Research Center, Emeryville, California, USA Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, California, USA
    J Neurochem . 2013
    ..These results suggest that D2R activation induces a Gβγ- and extracellular signal-regulated kinase 1/2-dependent increase in the level of Zif268, which functions to directly up-regulate the expression of GDNF...
  60. ncbi request reprint Homer isoforms differentially regulate cocaine-induced neuroplasticity
    Karen K Szumlinski
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Neuropsychopharmacology 31:768-77. 2006
    ..Together, these data indicate that the enduring reduction of long Homer isoforms in the nucleus accumbens of cocaine-withdrawn rats is necessary for the expression of cocaine-induced neuroplasticity...
  61. ncbi request reprint From blue states to up states: a regional view of NMDA-ethanol interactions
    John J Woodward
    Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:359-67. 2006
    ..Woodward and Dorit Ron. The purpose of the symposium was to discuss recent findings that extend our understanding of the importance of ..
  62. doi request reprint PKCbetaII modulates translation independently from mTOR and through RACK1
    Stefano Grosso
    Molecular Histology and Cell Growth, HSR, 20132 Milan, Italy
    Biochem J 415:77-85. 2008
    ..Taken together the results of the present study show that PKCbetaII can act as a specific PKC isoform regulating translation, in an mTOR-independent fashion, possibly close to the ribosomal machinery...
  63. ncbi request reprint Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors
    Björn Schilström
    Section of Neuropsychopharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Neurosci 26:8549-58. 2006
    ..These results provide a potential mechanism by which acute cocaine promotes synaptic plasticity of VTA neurons, which could ultimately lead to the development of addictive behaviors...
  64. pmc Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration
    Patrick A Kiely
    Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, National University of Ireland, Cork, Ireland
    Mol Cell Biol 26:4041-51. 2006
    ..Taken together, our findings indicate that RACK1 enhances IGF-I-mediated cell migration through its ability to exclusively associate with either beta1 integrin or PP2A in a complex at the IGF-IR...
  65. ncbi request reprint Glutathione S-transferase pull-down assay
    Deborah Schechtman
    Department of Molecular Pharmacology, Stanford University School of Medicine, CA, USA
    Methods Mol Biol 233:345-50. 2003