Research Topics
Genomes and Genes
| Dorit RonSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Coordinated movement of RACK1 with activated betaIIPKCD Ron
Department of Neurology, University of California, San Francisco, California 94110 3518, USA
J Biol Chem 274:27039-46. 1999..We further show that association of RACK1 and betaIIPKC is required for the movement of both proteins. Our results suggest that RACK1 is a PKC shuttling protein that moves betaIIPKC from one intracellular site to another...- New insights into the regulation of protein kinase C and novel phorbol ester receptorsD Ron
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
FASEB J 13:1658-76. 1999.... - Uncoupling of betaIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brainD Ron
Ernest Gallo Research Center, Department of Neurology, San Francisco, CA 94110 3518, USA
FASEB J 14:2303-14. 2000..Thus, some of the cellular and neuroadaptive responses to ethanol may be related to ethanol-induced movement of RACK1 to the nucleus, thereby preventing the translocation and corresponding function of betaIIPKC... - The "ups and downs" of signaling cascades in addictionDorit Ron
Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
Sci STKE 2005:re14. 2005..Signaling cascades that contribute to addiction, as well as those that protect or delay the development of addiction, are presented... - GDNF and addictionDorit Ron
Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, USA
Rev Neurosci 16:277-85. 2005..We also provide evidence to suggest that therapies that activate GDNF signaling may be useful for the treatment of drug and alcohol addiction... - Signaling cascades regulating NMDA receptor sensitivity to ethanolDorit Ron
Department of Neurology, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Emeryville 94608, USA
Neuroscientist 10:325-36. 2004..Specifically, the role of the scaffolding protein RACK1 and the regulatory protein DARPP-32 in mediating the distinct effects of ethanol is presented... - Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapseJun Wang
Ernest Gallo Research Center and Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
J Neurosci 30:10187-98. 2010..Our results suggest that the upregulation of NR2B-NMDAR activity within the DMS by alcohol contributes to the maladaptive synaptic changes that lead to excessive alcohol intake and relapse... - Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1Rami Yaka
Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
J Biol Chem 278:9630-8. 2003..This in turn leads to NMDA receptor phosphorylation, enhanced activity mediated by Fyn, and to the induction of brain-derived neurotrophic factor expression by RACK1... - Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic systemJun Wang
Gallo Research Center, Emeryville, California 94608, USA
J Neurosci 30:14502-12. 2010..Together, these results demonstrate that NAc-produced GDNF serves as a retrograde enhancer that upregulates the activity of the mesocorticolimbic DA system... - GDNF is a fast-acting potent inhibitor of alcohol consumption and relapseSebastien Carnicella
The Ernest Gallo Research Center and Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 105:8114-9. 2008..Together, these results suggest that GDNF, via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to consume and seek alcohol... - Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behaviorJun Wang
Ernest Gallo Research Center, Emeryville, California 94608, USA
J Neurosci 27:3593-602. 2007.... - Endogenous BDNF in the dorsolateral striatum gates alcohol drinkingJerome Jeanblanc
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 29:13494-502. 2009..Importantly, our results suggest that an endogenous signaling pathway within the same brain region that mediates drug-taking behavior also plays a critical role in gating the level of ethanol intake... - Lyn kinase regulates mesolimbic dopamine release: implication for alcohol rewardStuart L Gibb
Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 31:2180-7. 2011..Together, our results suggest a novel role for Lyn kinase in the regulation of DA release in the mesolimbic system, which leads to the control of alcohol reward... - Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumptionDao-Yao He
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 25:619-28. 2005..These findings highlight the importance of GDNF as a new target for drug development for alcoholism that may mimic the effect of ibogaine against alcohol consumption but avoid the negative side effects... - Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent mannerRachel Jurd
Gallo Research Center, Department of Neurology, University of California San Francisco, Emeryville, CA 94608, USA
J Biol Chem 283:301-10. 2008..These results identify a specific E3 ubiquitin ligase as a novel interactant with the NR2B subunit and suggest a possible mechanism for the regulation of NMDAR function involving both phosphorylation and ubiquitination... - The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumptionJerome Jeanblanc
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 26:1457-64. 2006.... - Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcriptionJérémie Neasta
Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Biol Chem 287:322-36. 2012..As RACK1 and 14-3-3ζ are two multifunctional scaffolding proteins that coordinate a wide variety of signaling events, their interaction is likely to regulate other essential cellular functions... - RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addictionNancy N H McGough
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 24:10542-52. 2004..Taken together, these findings suggest that RACK1 and BDNF are part of a regulatory pathway that opposes adaptations that lead to the development of alcohol addiction... - Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intakeMarian L Logrip
Ernest Gallo Research Center, Emeryville, CA 94608, USA
FASEB J 22:2393-404. 2008..Taken together, these results demonstrate that BDNF regulates ethanol intake by initiation of MAP kinase signaling and the ensuing production of downstream gene products, including Pdyn... - Epigenetic regulation of BDNF expression via the scaffolding protein RACK1Dao Yao He
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Biol Chem 285:19043-50. 2010..Furthermore, this novel mechanism for the regulation of exon-specific expression of the BDNF gene by RACK1 could have implications on the neuronal functions of the growth factor including synaptic plasticity, learning, and memory... - Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seekingSegev Barak
The Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 31:9885-94. 2011..In addition, as it lacks abuse liability, the study further highlights GDNF as a promising target for treatment of alcohol use/abuse disorders... - AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviorsJérémie Neasta
Ernest Gallo Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, USA
Biol Psychiatry 70:575-82. 2011..We therefore hypothesized that the activation of AKT in the NAc in response to alcohol exposure plays an important role in mechanisms that underlie excessive alcohol consumption... - Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factorSebastien Carnicella
The Gallo Research Center, University of California, San Francisco, Emeryville, California, USA
Biol Psychiatry 66:146-53. 2009..We recently showed that GDNF in the ventral tegmental area (VTA) reduces the motivation to consume alcohol. We therefore set out to determine whether cabergoline administration decreases alcohol-drinking and -seeking behaviors via GDNF... - Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanolRami Yaka
Ernest Gallo Research Center and the Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
J Neurosci 23:3623-32. 2003.... - Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerizationClaire Thornton
Ernest Gallo Research Center, Emeryville, California 94608, USA
J Biol Chem 279:31357-64. 2004..Based on these results, we propose that WD40-mediated homo- and heterodimerization of RACK1 mediate the formation of a transient signaling complex that includes the NMDAR, a G protein and Fyn... - Alpha4 subunit-containing GABA(A) receptors in the accumbens shell contribute to the reinforcing effects of alcoholMridula Rewal
Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA Department of Neurology, University of California at San Francisco, San Francisco, CA, USA Wheeler Center for the Neurobiology of Addiction, University of California at San Francisco, San Francisco, CA, USA
Addict Biol 17:309-21. 2012..Possible pharmacological and non-pharmacological explanations for these effects are considered... - Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administrationSebastien Carnicella
The Ernest Gallo Research Center, Emeryville, CA, USA
Addict Biol 15:424-33. 2010..Together, our results suggest that noribogaine and 18-MC have different mechanisms and sites of action... - GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinenceSebastien Carnicella
The Ernest Gallo Research Center, University of California San Francisco, Emeryville, CA 94608, USA
Alcohol Clin Exp Res 33:1012-24. 2009..In this study, we set out to assess the contribution of endogenous GDNF or its receptor GFRalpha1 to the regulation of ethanol-related behaviors... - Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcoholMridula Rewal
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 29:543-9. 2009..These results indicate that the GABA(A) receptor alpha4 subunit in the NAc shell mediates alcohol intake... - Escalating ethanol intake is associated with altered corticostriatal BDNF expressionMarian L Logrip
The Gallo Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurochem 109:1459-68. 2009..These results suggest that the persistence of altered BDNF signaling may contribute to the inflexibility of addictive behaviors... - Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disordersJérémie Neasta
Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, CA 94608, USA
Proc Natl Acad Sci U S A 107:20093-8. 2010..Our data therefore put forward the possibility that targeting the mTORC1 signaling cascade is an innovative and valuable strategy for the treatment of alcohol use and abuse disorders... - Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of protein tyrosine phosphatase αStuart L Gibb
Ernest Gallo Research Center, University of California San Francisco, Emeryville, California, USA
J Neurochem 119:879-89. 2011..Such neuroadaptations could be part of a mechanism that leads to the development of excessive ethanol consumption... - Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90Dao Yao He
Ernest Gallo Research Center, University of California at San Francisco, Emeryville, California 94608, USA
J Biol Chem 283:12811-8. 2008..GDNF reverses this ethanol-mediated adaptation by inhibiting the interaction of TH with HSP90... - Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1Alicia J Vagts
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, USA
Alcohol Clin Exp Res 27:1599-605. 2003..These findings could have implications for the molecular signaling pathways leading to pathologic states associated with alcoholism, including toxicity... - Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned rewardRami Yaka
Ernst Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville 94608, USA
Alcohol Clin Exp Res 27:1736-42. 2003.... - Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factorSebastien Carnicella
The Ernest Gallo Research Center, 5858 Horton St, Ste 200, Emeryville, CA 94608, USA
Alcohol 43:35-43. 2009..These data suggest that GDNF is a rapid and long-lasting inhibitor of "binge-like" ethanol consumption... - Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neuronsMark A Ungless
Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
Neuron 39:401-7. 2003..These results provide evidence of the first specific roles for CRF-R2 and CRF-BP in the modulation of neuronal activity and suggest that NMDARs in the VTA may be a target for both drugs of abuse and stress... - Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, IbogaineDao Yao He
Ernest Gallo Research Center, Emeryville, California, USA
FASEB J 20:2420-2. 2006..The identification of a GDNF-mediated, autoregulatory long-lasting feedback loop could have important implications for GDNF's potential value as a treatment for addiction and neurodegenerative diseases... - Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-RasNeesha Suvarna
Ernest Gallo Research Center, Emeryville, California 94608, USA
J Biol Chem 280:31450-9. 2005..Our results suggest that addictive drugs such as ethanol alter NMDAR trafficking and subunit composition. This may be an important mechanism by which ethanol exerts its effects on NMDARs to produce alcohol-induced aberrant plasticity... - Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatumJun Wang
Ernest Gallo Research Center, University of California, San Francisco, Emeryville, CA, USA
Channels (Austin) 5:205-9. 2011..Together, these results suggest that upregulation of NR2B-NMDAR activity by ethanol is selective and that ethanol's effect on NMDAR activity is gradual and cumulative... - Ethanol induces gene expression via nuclear compartmentalization of receptor for activated C kinase 1Dao-Yao He
Ernest Gallo Research Center, Emeryville, California, USA
Mol Pharmacol 62:272-80. 2002..These results may therefore have important implications for the study of alcohol addiction... - H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activityClaire Thornton
Ernest Gallo Clinic and Research Center, University of California San Francisco, San Francisco, California 94110 3518, USA
J Biol Chem 278:23823-9. 2003..This mechanism is specific for Src and NR2A and has implications for studies in which regulation of NMDA receptor-mediated LTP is important, such as synaptic plasticity, learning, and memory and addiction... - Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intakeHong Nie
Ernest Gallo Clinic and Research Center, University of California, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 108:4459-64. 2011..These results provide strong evidence that extrasynaptic δ-subunit-containing GABA(A) receptors in the medial shell of the NAc are critical for the reinforcing effects of oral ethanol... - Regulation of operant oral ethanol self-administration: a dose-response curve study in ratsSebastien Carnicella
Gallo Research Center, University of California, San Francisco, Emeryville, USA
Alcohol Clin Exp Res 35:116-25. 2011..In this study, we set out to determine whether a meaningful dose-response curve for oral ethanol self-administration can be obtained in rats... - The small g protein h-ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviorsSami Ben Hamida
Ernest Gallo Research Center and Department of Neurology, University of California, San Francisco, Emeryville, California 94608
J Neurosci 32:15849-58. 2012..Together, these results position H-Ras as a central molecular mediator of alcohol's actions within the mesolimbic system and put forward the potential value of the enzyme as a novel target to treat alcohol use disorders... - Blockade of ethanol reward by the kappa opioid receptor agonist U50,488HMarian L Logrip
The Ernest Gallo Research Center, Suite 200, Emeryville, CA 94608, USA
Alcohol 43:359-65. 2009..Taken together, these data indicate that the KOR/dynorphin system may acutely regulate ethanol intake via inhibition of the rewarding properties of ethanol... - BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNFPatricia H Janak
Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
Alcohol Clin Exp Res 30:214-21. 2006..Dr. Pandey showed that amygdalar BDNF regulates alcohol's anxiolytic effects and preference. Finally, Dr. Janak presented evidence that increases in the expression of GDNF in the midbrain reduce alcohol self-administration in rats... - GDNF--a potential target to treat addictionSebastien Carnicella
The Ernest Gallo Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
Pharmacol Ther 122:9-18. 2009..In this article, we review these data and highlight the possibility that the GDNF pathway may be a promising target for the treatment of addiction... - Protein kinase C and alcohol addictionPhilip M Newton
Ernest Gallo Clinic and Research Center, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Pharmacol Res 55:570-7. 2007..These findings suggest that drugs targeting PKCgamma and PKCepsilon may be useful to curb excessive drinking, the key symptom of alcohol use disorders... - NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1Rami Yaka
Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
Proc Natl Acad Sci U S A 99:5710-5. 2002..Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory... - Alcohol addictionM Foster Olive
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, USA
Methods Mol Biol 233:555-70. 2003 - Signaling pathways mediating alcohol effectsDorit Ron
Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Curr Top Behav Neurosci 13:87-126. 2013.... - From blue states to up states: a regional view of NMDA-ethanol interactionsJohn J Woodward
Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 30:359-67. 2006..Woodward and Dorit Ron. The purpose of the symposium was to discuss recent findings that extend our understanding of the importance of .. - Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptorsBjörn Schilström
Section of Neuropsychopharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Neurosci 26:8549-58. 2006..These results provide a potential mechanism by which acute cocaine promotes synaptic plasticity of VTA neurons, which could ultimately lead to the development of addictive behaviors... - Homer isoforms differentially regulate cocaine-induced neuroplasticityKaren K Szumlinski
Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
Neuropsychopharmacology 31:768-77. 2006..Together, these data indicate that the enduring reduction of long Homer isoforms in the nucleus accumbens of cocaine-withdrawn rats is necessary for the expression of cocaine-induced neuroplasticity... - PKCbetaII modulates translation independently from mTOR and through RACK1Stefano Grosso
Molecular Histology and Cell Growth, HSR, 20132 Milan, Italy
Biochem J 415:77-85. 2008..Taken together the results of the present study show that PKCbetaII can act as a specific PKC isoform regulating translation, in an mTOR-independent fashion, possibly close to the ribosomal machinery... - Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migrationPatrick A Kiely
Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, National University of Ireland, Cork, Ireland
Mol Cell Biol 26:4041-51. 2006..Taken together, our findings indicate that RACK1 enhances IGF-I-mediated cell migration through its ability to exclusively associate with either beta1 integrin or PP2A in a complex at the IGF-IR... - Glutathione S-transferase pull-down assayDeborah Schechtman
Department of Molecular Pharmacology, Stanford University School of Medicine, CA, USA
Methods Mol Biol 233:345-50. 2003