LAWRENCE ROME

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Paying the piper: the cost of Ca2+ pumping during the mating call of toadfish
    Claire L Harwood
    L C Rome Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 and the Whitman Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    J Physiol 589:5467-84. 2011
  2. ncbi The effect of temperature and thermal acclimation on the sustainable performance of swimming scup
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Philos Trans R Soc Lond B Biol Sci 362:1995-2016. 2007
  3. ncbi Biomechanics: rubber bands reduce the cost of carrying loads
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 444:1023-4. 2006
  4. ncbi Design and function of superfast muscles: new insights into the physiology of skeletal muscle
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 68:193-221. 2006
  5. ncbi Generating electricity while walking with loads
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 309:1725-8. 2005
  6. ncbi Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implications
    Sanford Levine
    Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Respir Crit Care Med 168:706-13. 2003
  7. ncbi Is high concentration of parvalbumin a requirement for superfast relaxation?
    Boris A Tikunov
    Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Muscle Res Cell Motil 30:57-65. 2009
  8. ncbi Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm
    Taitan Nguyen
    Respiratory Muscle Research Laboratory, Section of General Thoracic Surgery 4 Silverstein Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 98:2004-10. 2005
  9. ncbi Cross-bridge blocker BTS permits direct measurement of SR Ca2+ pump ATP utilization in toadfish swimbladder muscle fibers
    Iain S Young
    Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 285:C781-7. 2003
  10. ncbi A simple experimentally based model using proprioceptive regulation of motor primitives captures adjusted trajectory formation in spinal frogs
    William J Kargo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 103:573-90. 2010

Research Grants

  1. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2001
  2. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 2003
  3. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 1993
  4. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2007

Collaborators

Detail Information

Publications12

  1. ncbi Paying the piper: the cost of Ca2+ pumping during the mating call of toadfish
    Claire L Harwood
    L C Rome Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 and the Whitman Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    J Physiol 589:5467-84. 2011
    ..If inactivation did not occur, the SR would run out of Ca(2+) well before the end of even a 40-twitch call. Hence, inactivation of the Ca(2+) release channel plays a critical role in swimbladder muscle during normal in vivo function...
  2. ncbi The effect of temperature and thermal acclimation on the sustainable performance of swimming scup
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Philos Trans R Soc Lond B Biol Sci 362:1995-2016. 2007
    ..However, the increased rate of activation alone produced an even greater effect. Hence, to fully understand thermal acclimation, it is necessary to examine the whole system under realistic physiological conditions...
  3. ncbi Biomechanics: rubber bands reduce the cost of carrying loads
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 444:1023-4. 2006
    ..This permits larger loads to be carried while moving rapidly, and at the same time reduces the risk of orthopaedic and muscular injury...
  4. ncbi Design and function of superfast muscles: new insights into the physiology of skeletal muscle
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 68:193-221. 2006
    ..Hence the locomotory and sound-producing muscles have mutually exclusive designs...
  5. ncbi Generating electricity while walking with loads
    Lawrence C Rome
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 309:1725-8. 2005
    ..This electricity generation can help give field scientists, explorers, and disaster-relief workers freedom from the heavy weight of replacement batteries and thereby extend their ability to operate in remote areas...
  6. ncbi Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implications
    Sanford Levine
    Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Respir Crit Care Med 168:706-13. 2003
    ..Moreover, our single-fiber results suggest that COPD-associated diaphragm remodeling decreases diaphragmatic force generation by adaptations within each fiber type as well as by fiber type transformations...
  7. ncbi Is high concentration of parvalbumin a requirement for superfast relaxation?
    Boris A Tikunov
    Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Muscle Res Cell Motil 30:57-65. 2009
    ..By amino acid composition, toadfish PA-Ia and PA-I isoforms were different from PA-II and PA-III isoforms (by 24 and 14 residues, respectively)...
  8. ncbi Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm
    Taitan Nguyen
    Respiratory Muscle Research Laboratory, Section of General Thoracic Surgery 4 Silverstein Pavilion, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    J Appl Physiol 98:2004-10. 2005
    ..Am J Respir Crit Care Med 168: 706-713, 2003) suggests that diaphragm remodeling elicited by severe COPD should decrease ATP utilization by the diaphragm...
  9. ncbi Cross-bridge blocker BTS permits direct measurement of SR Ca2+ pump ATP utilization in toadfish swimbladder muscle fibers
    Iain S Young
    Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Cell Physiol 285:C781-7. 2003
    ..Furthermore, we found that BTS also effectively eliminates force generation in bundles of intact swimbladder muscle, suggesting that it will be an important tool for studying integrated SR function during normal motor behavior...
  10. ncbi A simple experimentally based model using proprioceptive regulation of motor primitives captures adjusted trajectory formation in spinal frogs
    William J Kargo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 103:573-90. 2010
    ..Such synergy choices and control strategies may simplify the circuitry required for reflex trajectory construction and adaptation...
  11. ncbi Jumping in frogs: assessing the design of the skeletal system by anatomically realistic modeling and forward dynamic simulation
    William J Kargo
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Biol 205:1683-702. 2002
    ..The results of this study form a foundation upon which additional model subsystems (e.g. musculotendon and neural) can be added to test the integrative action of the neuromusculoskeletal system during frog jumping...
  12. ncbi Functional morphology of proximal hindlimb muscles in the frog Rana pipiens
    William J Kargo
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    J Exp Biol 205:1987-2004. 2002
    ..g. neural) and more sophisticated muscle models can be appended...

Research Grants20

  1. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2001
    ..Finally, we will measure how the muscles are actually used in vivo, to better understand the molecular desig for different motor functions. ..
  2. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 2003
    ..abstract_text> ..
  3. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 1993
    ..These approaches will give us new insights into how muscle is designed and the functional importance of the observed variation seen in different fiber types...
  4. MUSCLE FUNCTION DURING LOCOMOTION
    LAWRENCE ROME; Fiscal Year: 2007
    ..abstract_text> ..