Research Topics
| Debra RombergerSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase Cepsilon in human bronchial epithelial cellsTodd A Wyatt
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Omaha, NE, USA
Am J Physiol Lung Cell Mol Physiol 293:L1163-70. 2007..These data support the hypothesis that FLDE exposure stimulates bronchial epithelial IL-8 and IL-6 release via a PKCepsilon-dependent pathway...- beta-Adrenergic agonist modulation of monocyte adhesion to airway epithelial cells in vitroD J Romberger
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
Am J Physiol Lung Cell Mol Physiol 278:L139-47. 2000..A specific protein kinase A inhibitor, KT-5720, inhibited subsequent isoproterenol augmentation of THP-1 cell adhesion, further supporting the role of cAMP-dependent mechanisms in modulating THP-1 cell adhesion to HBECs... - Alcohol consumption and smoking status: the role of smoking cessationDebra J Romberger
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198 5300, USA
Biomed Pharmacother 58:77-83. 2004..In recent years, smoking cessation approaches have been initiated in this population, but much work remains in order to define the optimal smoking cessation strategies for persons in alcohol treatment programs... - Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activationD J Romberger
Research Service, Department of Veterans Affairs Medical Center, Omaha 68105, Nebraska, USA
J Appl Physiol 93:289-96. 2002..These data support the hypothesis that HDE exposure augments HBEC IL-8 and IL-6 release via a PKC-dependent pathway... 
Alcohol functionally upregulates Toll-like receptor 2 in airway epithelial cellsKRISTINA L BAILEY
Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5815, USA
Alcohol Clin Exp Res 33:499-504. 2009..Little is known about why this phenomenon is observed. We hypothesized that alcohol may modulate Toll-like receptor 2 (TLR2), which regulates inflammation caused by gram-positive bacteria...- Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activityJill A Poole
Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
J Allergy Clin Immunol 120:366-73. 2007..Organic dust exposure results in an inflammatory response that attenuates over time, but repetitive exposures can result in chronic respiratory diseases. Mechanisms underlying this modulated response are not clear... - Hog barn dust slows airway epithelial cell migration in vitro through a PKCalpha-dependent mechanismRebecca E Slager
Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
Am J Physiol Lung Cell Mol Physiol 293:L1469-74. 2007..These results suggest that the PKCalpha isoform is an important regulator of cell migration in response to agricultural dust exposure... - Repetitive organic dust exposure in vitro impairs macrophage differentiation and functionJill A Poole
Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Neb 68198 5300, USA
J Allergy Clin Immunol 122:375-82, 382.e1-4. 2008..Organic dust exposure in the agricultural industry results in significant airway disease and lung function decrease. Mononuclear phagocytes are key cells that mediate the inflammatory and innate immune response after dust exposure... 
Agricultural exposures in patients with COPD in health systems serving rural areasKRISTINA L BAILEY
Department of Internal Medicine Pulmonary, University of Nebraska Medical Center, Ohmaha, NE 68198 5300, USA
J Agromedicine 12:71-6. 2007..Agricultural exposure is a risk factor for the development of chronic obstructive pulmonary disease (COPD). However, there are no good estimates of the number of COPD patients with a history of agricultural exposure...- Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in miceJill A Poole
Pulmonary, Critical Care, Sleep, and Allergy Section, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
Am J Physiol Lung Cell Mol Physiol 296:L1085-95. 2009..Collectively, intranasal exposure to DE results in significant lung inflammatory and pathological responses marked by a modulated innate immune response to single and repetitive dust exposures that is associated with PKC activity... - Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factorTodd A Wyatt
Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
Am J Respir Cell Mol Biol 42:706-15. 2010..These results suggest a temporal ordering of events responsible for the release of cytokines, which initiate and exacerbate inflammatory events in the airways of people exposed to agricultural dust... - Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturationJill A Poole
Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
Am J Physiol Lung Cell Mol Physiol 297:L767-76. 2009..The first 48 h of monocyte differentiation appears to be the susceptible period to exposure. Environmental exposures present during early monocyte differentiation may impact the critical balance of DCs in the lung... - Alcohol up-regulates TLR2 through a NO/cGMP dependent pathwayKRISTINA L BAILEY
Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Alcohol Clin Exp Res 34:51-6. 2010..We have previously shown that alcohol up-regulates TLR2 in the airway epithelium. However, the mechanism of alcohol-mediated up-regulation of TLR2 has not been identified... - Alcohol intake is associated with altered pulmonary functionJoseph H Sisson
Pulmonary and Critical Medicine Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
Alcohol 36:19-30. 2005..Our analyses indicate that alcohol consumption, even at very modest intake levels, is associated with less lung restriction... - Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dustsJill A Poole
Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
J Toxicol Environ Health A 73:684-700. 2010..Large animal farming dust(s)-induced inflammation is not entirely dependent on endotoxin. Addition of muramic acid to endotoxin in large animal farming environment monitoring is warranted... - Lysophosphatidic acid in airway function and diseaseMyron L Toews
Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
Biochim Biophys Acta 1582:240-50. 2002.... - Anesthetic-related cardiac arrest and its mortality: a report covering 72,959 anesthetics over 10 years from a US teaching hospitalMyrna C Newland
Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4455, USA
Anesthesiology 97:108-15. 2002.... - Agricultural lung diseaseJohn R Spurzem
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha VA Medical Center, Omaha, NE, USA
Clin Chest Med 23:795-810. 2002..The recent description of the innate immune system is very exciting because it will lead to increased understanding of the pathogenesis of organic dust induced disorders... - Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobaccoStephen I Rennard
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198, USA
Nicotine Tob Res 4:467-76. 2002..One individual experienced a transient twofold increase in CO and concurrently experienced transient headaches. Eclipse use may be a strategy to reduce the health risks for heavy smokers unwilling or unable to quit... - Bupropion and nicotine patch as smoking cessation aids in alcoholicsKathleen M Grant
Substance Use Disorders Program, 116A4, Veterans Administration Nebraska Western Iowa Health Care System Omaha site, 4101 Woolworth Avenue, Omaha, NE 68105, USA
Alcohol 41:381-91. 2007..All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes... - Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cellsXiangde Liu
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Am J Physiol Lung Cell Mol Physiol 282:L1049-56. 2002..These findings suggest that IL-4 and IL-13 may modulate airway tissue remodeling and, therefore, could play a role in the altered airway connective tissue which characterizes asthma... - Tumor necrosis factor-alpha hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmersG Patrick Lambert
Department of Exercise Science and Athletic Training, Creighton University, Omaha, NE 68178, USA
J Agromedicine 10:39-44. 2005.... - Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contractionHuijung Kim
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Am J Respir Cell Mol Biol 28:111-21. 2003..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects... - Glucocorticoids modulate TGF-beta production by human fetal lung fibroblastsFu Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
Inflammation 27:9-19. 2003..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun... - Methamphetamine use in rural MidwesternersKathleen M Grant
University of Nebraska Medical Center, Omaha, Nebraska, USA
Am J Addict 16:79-84. 2007..This is of significant concern given the limited substance abuse, mental health, and specialty care available in most rural Midwestern communities... - Resuscitating a bad patientToby L Schonfeld
Department of Preventive and Societal Medicine, University of Nebraska Medical Center, USA
Hastings Cent Rep 37:14; discussion 14-6. 2007 - Glucocorticoids modulate TGF-beta productionFu-Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Inflammation 26:279-90. 2002..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun... - Polymorphisms in the CD14 gene associated with pulmonary function in farmersTricia D LeVan
Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona, USA
Am J Respir Crit Care Med 171:773-9. 2005..Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin... - Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell densityHangjun Wang
Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Am J Physiol Lung Cell Mol Physiol 284:L205-13. 2003..These effects may help explain the varied pathologies associated with exposure to cigarette smoke...
Research Grants
- Organic dust epithelial PKC activation & airway diseaseDebra Romberger; Fiscal Year: 2007..4) Determine how HDE modulates airway epithelial PKC activation and inflammatory responses in vivo utilizing an animal model of exposure, including testing the potential role of LPA. ..
- Organic dust epithelial PKC activation & airway diseaseDebra Romberger; Fiscal Year: 2009..4) Determine how HDE modulates airway epithelial PKC activation and inflammatory responses in vivo utilizing an animal model of exposure, including testing the potential role of LPA. ..
- Targeting Airway Inflammation from Concentrated Animal Feeding Operation DustDebra Romberger; Fiscal Year: 2010....