Debra Romberger

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase Cepsilon in human bronchial epithelial cells
    Todd A Wyatt
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Omaha, NE, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1163-70. 2007
  2. ncbi request reprint Motile cilia harbor serum response factor as a mechanism of environment sensing and injury response in the airway
    Tara M Nordgren
    988090 Nebraska Medical Center, Omaha, NE 68198
    Am J Physiol Lung Cell Mol Physiol 306:L829-39. 2014
  3. ncbi request reprint beta-Adrenergic agonist modulation of monocyte adhesion to airway epithelial cells in vitro
    D J Romberger
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 278:L139-47. 2000
  4. ncbi request reprint Alcohol consumption and smoking status: the role of smoking cessation
    Debra J Romberger
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198 5300, USA
    Biomed Pharmacother 58:77-83. 2004
  5. ncbi request reprint Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation
    D J Romberger
    Research Service, Department of Veterans Affairs Medical Center, Omaha 68105, Nebraska, USA
    J Appl Physiol (1985) 93:289-96. 2002
  6. pmc Alcohol functionally upregulates Toll-like receptor 2 in airway epithelial cells
    KRISTINA L BAILEY
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5815, USA
    Alcohol Clin Exp Res 33:499-504. 2009
  7. ncbi request reprint Hog barn dust slows airway epithelial cell migration in vitro through a PKCalpha-dependent mechanism
    Rebecca E Slager
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1469-74. 2007
  8. pmc Repetitive organic dust exposure in vitro impairs macrophage differentiation and function
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Neb 68198 5300, USA
    J Allergy Clin Immunol 122:375-82, 382.e1-4. 2008
  9. doi request reprint Agricultural exposures in patients with COPD in health systems serving rural areas
    KRISTINA L BAILEY
    Department of Internal Medicine Pulmonary, University of Nebraska Medical Center, Ohmaha, NE 68198 5300, USA
    J Agromedicine 12:71-6. 2007
  10. ncbi request reprint Anesthetic-related cardiac arrest and its mortality: a report covering 72,959 anesthetics over 10 years from a US teaching hospital
    Myrna C Newland
    Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4455, USA
    Anesthesiology 97:108-15. 2002

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Feedlot dust stimulation of interleukin-6 and -8 requires protein kinase Cepsilon in human bronchial epithelial cells
    Todd A Wyatt
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Omaha, NE, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1163-70. 2007
    ..These data support the hypothesis that FLDE exposure stimulates bronchial epithelial IL-8 and IL-6 release via a PKCepsilon-dependent pathway...
  2. ncbi request reprint Motile cilia harbor serum response factor as a mechanism of environment sensing and injury response in the airway
    Tara M Nordgren
    988090 Nebraska Medical Center, Omaha, NE 68198
    Am J Physiol Lung Cell Mol Physiol 306:L829-39. 2014
    ....
  3. ncbi request reprint beta-Adrenergic agonist modulation of monocyte adhesion to airway epithelial cells in vitro
    D J Romberger
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 278:L139-47. 2000
    ..A specific protein kinase A inhibitor, KT-5720, inhibited subsequent isoproterenol augmentation of THP-1 cell adhesion, further supporting the role of cAMP-dependent mechanisms in modulating THP-1 cell adhesion to HBECs...
  4. ncbi request reprint Alcohol consumption and smoking status: the role of smoking cessation
    Debra J Romberger
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198 5300, USA
    Biomed Pharmacother 58:77-83. 2004
    ..In recent years, smoking cessation approaches have been initiated in this population, but much work remains in order to define the optimal smoking cessation strategies for persons in alcohol treatment programs...
  5. ncbi request reprint Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation
    D J Romberger
    Research Service, Department of Veterans Affairs Medical Center, Omaha 68105, Nebraska, USA
    J Appl Physiol (1985) 93:289-96. 2002
    ..These data support the hypothesis that HDE exposure augments HBEC IL-8 and IL-6 release via a PKC-dependent pathway...
  6. pmc Alcohol functionally upregulates Toll-like receptor 2 in airway epithelial cells
    KRISTINA L BAILEY
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5815, USA
    Alcohol Clin Exp Res 33:499-504. 2009
    ..Little is known about why this phenomenon is observed. We hypothesized that alcohol may modulate Toll-like receptor 2 (TLR2), which regulates inflammation caused by gram-positive bacteria...
  7. ncbi request reprint Hog barn dust slows airway epithelial cell migration in vitro through a PKCalpha-dependent mechanism
    Rebecca E Slager
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1469-74. 2007
    ..These results suggest that the PKCalpha isoform is an important regulator of cell migration in response to agricultural dust exposure...
  8. pmc Repetitive organic dust exposure in vitro impairs macrophage differentiation and function
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Neb 68198 5300, USA
    J Allergy Clin Immunol 122:375-82, 382.e1-4. 2008
    ..Organic dust exposure in the agricultural industry results in significant airway disease and lung function decrease. Mononuclear phagocytes are key cells that mediate the inflammatory and innate immune response after dust exposure...
  9. doi request reprint Agricultural exposures in patients with COPD in health systems serving rural areas
    KRISTINA L BAILEY
    Department of Internal Medicine Pulmonary, University of Nebraska Medical Center, Ohmaha, NE 68198 5300, USA
    J Agromedicine 12:71-6. 2007
    ..Agricultural exposure is a risk factor for the development of chronic obstructive pulmonary disease (COPD). However, there are no good estimates of the number of COPD patients with a history of agricultural exposure...
  10. ncbi request reprint Anesthetic-related cardiac arrest and its mortality: a report covering 72,959 anesthetics over 10 years from a US teaching hospital
    Myrna C Newland
    Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4455, USA
    Anesthesiology 97:108-15. 2002
    ....
  11. pmc Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice
    Jill A Poole
    Pulmonary, Critical Care, Sleep, and Allergy Section, Univ of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1085-95. 2009
    ..Collectively, intranasal exposure to DE results in significant lung inflammatory and pathological responses marked by a modulated innate immune response to single and repetitive dust exposures that is associated with PKC activity...
  12. pmc Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor
    Todd A Wyatt
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Am J Respir Cell Mol Biol 42:706-15. 2010
    ..These results suggest a temporal ordering of events responsible for the release of cytokines, which initiate and exacerbate inflammatory events in the airways of people exposed to agricultural dust...
  13. pmc Organic dust exposure alters monocyte-derived dendritic cell differentiation and maturation
    Jill A Poole
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    Am J Physiol Lung Cell Mol Physiol 297:L767-76. 2009
    ..The first 48 h of monocyte differentiation appears to be the susceptible period to exposure. Environmental exposures present during early monocyte differentiation may impact the critical balance of DCs in the lung...
  14. pmc Alcohol up-regulates TLR2 through a NO/cGMP dependent pathway
    KRISTINA L BAILEY
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Alcohol Clin Exp Res 34:51-6. 2010
    ..We have previously shown that alcohol up-regulates TLR2 in the airway epithelium. However, the mechanism of alcohol-mediated up-regulation of TLR2 has not been identified...
  15. pmc Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts
    Jill A Poole
    Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA
    J Toxicol Environ Health A 73:684-700. 2010
    ..Large animal farming dust(s)-induced inflammation is not entirely dependent on endotoxin. Addition of muramic acid to endotoxin in large animal farming environment monitoring is warranted...
  16. ncbi request reprint Repeat organic dust exposure-induced monocyte inflammation is associated with protein kinase C activity
    Jill A Poole
    Pulmonary, Critical Care, Sleep and Allergy Section, Department of Internal Medicine, University of Nebraska Medical Center, 985300 The Nebraska Medical Center, Omaha, NE 68198 5300, USA
    J Allergy Clin Immunol 120:366-73. 2007
    ..Organic dust exposure results in an inflammatory response that attenuates over time, but repetitive exposures can result in chronic respiratory diseases. Mechanisms underlying this modulated response are not clear...
  17. ncbi request reprint Lysophosphatidic acid in airway function and disease
    Myron L Toews
    Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
    Biochim Biophys Acta 1582:240-50. 2002
    ....
  18. ncbi request reprint Alcohol intake is associated with altered pulmonary function
    Joseph H Sisson
    Pulmonary and Critical Medicine Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Alcohol 36:19-30. 2005
    ..Our analyses indicate that alcohol consumption, even at very modest intake levels, is associated with less lung restriction...
  19. ncbi request reprint Agricultural lung disease
    John R Spurzem
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha VA Medical Center, Omaha, NE, USA
    Clin Chest Med 23:795-810. 2002
    ..The recent description of the innate immune system is very exciting because it will lead to increased understanding of the pathogenesis of organic dust induced disorders...
  20. ncbi request reprint Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobacco
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198, USA
    Nicotine Tob Res 4:467-76. 2002
    ..One individual experienced a transient twofold increase in CO and concurrently experienced transient headaches. Eclipse use may be a strategy to reduce the health risks for heavy smokers unwilling or unable to quit...
  21. pmc Bupropion and nicotine patch as smoking cessation aids in alcoholics
    Kathleen M Grant
    Substance Use Disorders Program, 116A4, Veterans Administration Nebraska Western Iowa Health Care System Omaha site, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol 41:381-91. 2007
    ..All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes...
  22. ncbi request reprint Bronchodilator responsiveness in swine veterinarians
    Jill A Poole
    Department of Medicine, University of Nebraska Medical Center, Omaha 68198 5300, USA
    J Agromedicine 12:49-54. 2007
    ..The present study reassessed the prevalence of respiratory complaints and pulmonary function abnormalities in swine veterinarians and sought to characterize their response to bronchodilators...
  23. ncbi request reprint Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells
    Xiangde Liu
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1049-56. 2002
    ..These findings suggest that IL-4 and IL-13 may modulate airway tissue remodeling and, therefore, could play a role in the altered airway connective tissue which characterizes asthma...
  24. ncbi request reprint Tumor necrosis factor-alpha hyper-responsiveness to endotoxin in whole blood is associated with chronic bronchitis in farmers
    G Patrick Lambert
    Department of Exercise Science and Athletic Training, Creighton University, Omaha, NE 68178, USA
    J Agromedicine 10:39-44. 2005
    ....
  25. ncbi request reprint Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction
    Huijung Kim
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Respir Cell Mol Biol 28:111-21. 2003
    ..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects...
  26. ncbi request reprint Glucocorticoids modulate TGF-beta production
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Inflammation 26:279-90. 2002
    ..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun...
  27. ncbi request reprint Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Inflammation 27:9-19. 2003
    ..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun...
  28. ncbi request reprint Methamphetamine use in rural Midwesterners
    Kathleen M Grant
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Addict 16:79-84. 2007
    ..This is of significant concern given the limited substance abuse, mental health, and specialty care available in most rural Midwestern communities...
  29. ncbi request reprint Resuscitating a bad patient
    Toby L Schonfeld
    Department of Preventive and Societal Medicine, University of Nebraska Medical Center, USA
    Hastings Cent Rep 37:14; discussion 14-6. 2007
  30. ncbi request reprint Polymorphisms in the CD14 gene associated with pulmonary function in farmers
    Tricia D LeVan
    Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona, USA
    Am J Respir Crit Care Med 171:773-9. 2005
    ..Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin...
  31. ncbi request reprint Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density
    Hangjun Wang
    Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Am J Physiol Lung Cell Mol Physiol 284:L205-13. 2003
    ..These effects may help explain the varied pathologies associated with exposure to cigarette smoke...

Research Grants5

  1. Organic dust epithelial PKC activation & airway disease
    Debra Romberger; Fiscal Year: 2006
    ..4) Determine how HDE modulates airway epithelial PKC activation and inflammatory responses in vivo utilizing an animal model of exposure, including testing the potential role of LPA. ..
  2. Organic dust epithelial PKC activation & airway disease
    Debra Romberger; Fiscal Year: 2007
    ..4) Determine how HDE modulates airway epithelial PKC activation and inflammatory responses in vivo utilizing an animal model of exposure, including testing the potential role of LPA. ..
  3. Organic dust epithelial PKC activation & airway disease
    Debra Romberger; Fiscal Year: 2009
    ..4) Determine how HDE modulates airway epithelial PKC activation and inflammatory responses in vivo utilizing an animal model of exposure, including testing the potential role of LPA. ..
  4. Targeting Airway Inflammation from Concentrated Animal Feeding Operation Dust
    Debra Romberger; Fiscal Year: 2010
    ....