Richard J Roller

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint The Herpes Simplex Virus 1 UL51 Protein Interacts with the UL7 Protein and Plays a Role in Its Recruitment into the Virion
    Richard J Roller
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 89:3112-22. 2015
  2. pmc Analysis of a charge cluster mutation of herpes simplex virus type 1 UL34 and its extragenic suppressor suggests a novel interaction between pUL34 and pUL31 that is necessary for membrane curvature around capsids
    Richard J Roller
    Department of Microbiology, The University of Iowa, 3 432 Bowen Science Building, Iowa City, IA 52242, USA
    J Virol 84:3921-34. 2010
  3. pmc Intragenic and extragenic suppression of a mutation in herpes simplex virus 1 UL34 that affects both nuclear envelope targeting and membrane budding
    Richard J Roller
    Department of Microbiology, University of Iowa, BSB 3 432, Iowa City, IA 52242, USA
    J Virol 85:11615-25. 2011
  4. pmc Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3
    Natalie Leach
    Department of Microbiology, The University of Iowa, 3 432 Bowen Science Building, Iowa City, IA 52242, USA
    J Virol 81:10792-803. 2007
  5. pmc Significance of host cell kinases in herpes simplex virus type 1 egress and lamin-associated protein disassembly from the nuclear lamina
    Natalie R Leach
    Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA
    Virology 406:127-37. 2010
  6. pmc The herpes simplex virus 1 UL51 gene product has cell type-specific functions in cell-to-cell spread
    Richard J Roller
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 88:4058-68. 2014
  7. pmc Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship
    Brent J Ryckman
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52246, USA
    J Virol 78:399-412. 2004
  8. pmc Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress
    Susan L Bjerke
    Department of Microbiology, The University of Iowa, 3115 Medical Laboratories, Iowa City, IA 52242, USA
    Virology 347:261-76. 2006
  9. pmc Herpes simplex virus 1 pUL34 plays a critical role in cell-to-cell spread of virus in addition to its role in virus replication
    Alison C Haugo
    Department of Microbiology, The University of Iowa, 3 432 Bowen Science Building, Iowa City, IA 52242, USA
    J Virol 85:7203-15. 2011
  10. ncbi request reprint The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members
    Paul D Ogg
    Molecular Biology Program, Roy J and Lucille P Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Virology 319:212-24. 2004

Research Grants

  1. UL34 and herpes simplex virus envelopment
    Richard J Roller; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. doi request reprint The Herpes Simplex Virus 1 UL51 Protein Interacts with the UL7 Protein and Plays a Role in Its Recruitment into the Virion
    Richard J Roller
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 89:3112-22. 2015
    ..Incomplete colocalization of pUL51 and pUL7 in infected cells, however, suggests that a significant fraction of the population of each protein is not complexed with the other and that they may accomplish independent functions...
  2. pmc Analysis of a charge cluster mutation of herpes simplex virus type 1 UL34 and its extragenic suppressor suggests a novel interaction between pUL34 and pUL31 that is necessary for membrane curvature around capsids
    Richard J Roller
    Department of Microbiology, The University of Iowa, 3 432 Bowen Science Building, Iowa City, IA 52242, USA
    J Virol 84:3921-34. 2010
    ..pUL34 and pUL31 may make two essential interactions-one for the targeting of the complex to the nuclear envelope and another for nuclear membrane curvature around capsids...
  3. pmc Intragenic and extragenic suppression of a mutation in herpes simplex virus 1 UL34 that affects both nuclear envelope targeting and membrane budding
    Richard J Roller
    Department of Microbiology, University of Iowa, BSB 3 432, Iowa City, IA 52242, USA
    J Virol 85:11615-25. 2011
    ..The mutant defects in virus production, plaque formation, and pUL31 interaction can be suppressed by other mutations in the INM-targeting domain of pUL31 and by additional mutations in the pUL34 coding sequence...
  4. pmc Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3
    Natalie Leach
    Department of Microbiology, The University of Iowa, 3 432 Bowen Science Building, Iowa City, IA 52242, USA
    J Virol 81:10792-803. 2007
    ....
  5. pmc Significance of host cell kinases in herpes simplex virus type 1 egress and lamin-associated protein disassembly from the nuclear lamina
    Natalie R Leach
    Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA
    Virology 406:127-37. 2010
    ..These data support hypothesis that phosphorylation of lamina components mediates lamina disruption during HSV nuclear egress...
  6. pmc The herpes simplex virus 1 UL51 gene product has cell type-specific functions in cell-to-cell spread
    Richard J Roller
    Department of Microbiology, University of Iowa, Iowa City, Iowa, USA
    J Virol 88:4058-68. 2014
    ..The cell-to-cell spread defect associated with the pUL51 mutation was more severe than that associated with gE-null virus, suggesting that pUL51 has gE-independent functions in epithelial cell spread...
  7. pmc Herpes simplex virus type 1 primary envelopment: UL34 protein modification and the US3-UL34 catalytic relationship
    Brent J Ryckman
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52246, USA
    J Virol 78:399-412. 2004
    ..The data presented suggest that the significance of UL34 phosphorylation is cell type dependent and that efficient viral morphogenesis requires US3-mediated phosphorylation of an infected cell protein other than UL34...
  8. pmc Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress
    Susan L Bjerke
    Department of Microbiology, The University of Iowa, 3115 Medical Laboratories, Iowa City, IA 52242, USA
    Virology 347:261-76. 2006
    ..The data presented in this paper argue for crucial roles for both UL34 and US3 in regulating the state of the nuclear lamina during viral infection...
  9. pmc Herpes simplex virus 1 pUL34 plays a critical role in cell-to-cell spread of virus in addition to its role in virus replication
    Alison C Haugo
    Department of Microbiology, The University of Iowa, 3 432 Bowen Science Building, Iowa City, IA 52242, USA
    J Virol 85:7203-15. 2011
    ..The US9 mutation alone is not sufficient to suppress the Y68A spread phenotype, indicating a likely role for multiple viral factors...
  10. ncbi request reprint The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members
    Paul D Ogg
    Molecular Biology Program, Roy J and Lucille P Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Virology 319:212-24. 2004
    ..Gen. Virol. 82 (2001) 2363]. Experiments published here demonstrate that PRV Us3 can also block apoptosis induced by Bax, suggesting that the anti-apoptotic activity of Us3 is conserved across alpha-herpesviruses...
  11. pmc BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1)
    Philip H Jones
    Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Virology 438:37-49. 2013
    ..We conclude that BST-2 tethers CHIKV VLPs on the host cell plasma membrane and identify CHIKV nsP1 as a novel BST-2 antagonist...
  12. pmc Effects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein
    Susan L Bjerke
    Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA
    J Virol 77:7601-10. 2003
    ....
  13. pmc Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins
    Martina Maric
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    Virology 460:128-37. 2014
    ..Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. ..
  14. pmc A functional role for TorsinA in herpes simplex virus 1 nuclear egress
    Martina Maric
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    J Virol 85:9667-79. 2011
    ..This implies novel functions for TA at the NE...
  15. pmc Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo
    Philip H Jones
    Department of Microbiology, University of Iowa, Carver College of Medicine, Iowa City, IA, USA
    Retrovirology 9:10. 2012
    ..In this present study, we used the beta-retrovirus, mouse mammary tumor virus (MMTV) as a model to examine the role of mouse BST-2 in host infection in vivo...

Research Grants1

  1. UL34 and herpes simplex virus envelopment
    Richard J Roller; Fiscal Year: 2010
    ..3. We will fully characterize changes in the host cell nuclear lamina associated with infection and determine the mechanism by which UL34 and other viral proteins accomplish those changes. ..