Oskar W Rokhlin

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, 1163 ML, IA, USA
    Oncogene 24:6773-84. 2005
  2. ncbi request reprint Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    Mol Cancer Res 4:113-23. 2006
  3. ncbi request reprint Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 6:732-42. 2007
  4. ncbi request reprint MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 7:1288-96. 2008
  5. ncbi request reprint KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, IA, USA
    Cancer Biol Ther 9:224-35. 2010
  6. ncbi request reprint Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 3:761-8. 2004
  7. ncbi request reprint Bisindolylmaleimide IX Induces Reversible and Time-Dependent Tumor Necrosis Factor Receptor Family-Mediated Caspase Activation and Cell Death
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa Iowa City, Iowa 52242, USA
    Cancer Biol Ther 2:266-70. 2003
  8. ncbi request reprint Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 277:33213-9. 2002
  9. ncbi request reprint TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 1:631-7. 2002
  10. ncbi request reprint Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP
    Oskar W Rokhlin
    Departments of Pathology, The University of Iowa, Iowa City 52242 1087, USA
    Prostate 52:1-11. 2002

Collaborators

Detail Information

Publications26

  1. pmc Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, 1163 ML, IA, USA
    Oncogene 24:6773-84. 2005
    ..Our study suggests that androgen-dependent outcome of apoptotic treatment can occur, at least in part, via the caspase-2, Akt and p53-mediated pathways...
  2. ncbi request reprint Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, IA 52242, USA
    Mol Cancer Res 4:113-23. 2006
    ..The synergistic effect of simultaneous treatment with trichostatin A and doxorubicin is mediated via inhibition of AR expression, induction of protease activity, increased expression of p53, and proteolysis of p21...
  3. ncbi request reprint Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival
    Oskar W Rokhlin
    Department of Pathology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 6:732-42. 2007
    ..The results of this study suggest that CaMKII is an important player in prostate cancer cells ability to escape apoptosis under androgen ablation and facilitate the progression of prostate cancer cells to an androgen independent state...
  4. ncbi request reprint MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 7:1288-96. 2008
    ..Taken together, our data indicate that cooperation between miR-34a and 34c plays an important role in AR-dependent p53-mediated apoptosis in prostate cancer...
  5. ncbi request reprint KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, IA, USA
    Cancer Biol Ther 9:224-35. 2010
    ..These data suggest that KN-93 could be used for novel therapeutic approaches when hormonal therapy has failed...
  6. ncbi request reprint Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 3:761-8. 2004
    ..Together, these features suggest that TPCK could be used as a therapeutic agent for treatment of those tumor cells that are resistant to ligand-induced treatment because of aberrant signaling pathways downstream of the DISC...
  7. ncbi request reprint Bisindolylmaleimide IX Induces Reversible and Time-Dependent Tumor Necrosis Factor Receptor Family-Mediated Caspase Activation and Cell Death
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa Iowa City, Iowa 52242, USA
    Cancer Biol Ther 2:266-70. 2003
    ....
  8. ncbi request reprint Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 277:33213-9. 2002
    ..In summary, these results suggest that Bis IX potentiates TNF receptor family-mediated cell death in part as an inhibitor of transcription...
  9. ncbi request reprint TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP
    Oskar W Rokhlin
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Biol Ther 1:631-7. 2002
    ..Our data suggest that TRAIL-DISC formation and sensitivity to TRAIL treatment are androgen-dependent in LNCaP...
  10. ncbi request reprint Caspase-8 activation is necessary but not sufficient for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in the prostatic carcinoma cell line LNCaP
    Oskar W Rokhlin
    Departments of Pathology, The University of Iowa, Iowa City 52242 1087, USA
    Prostate 52:1-11. 2002
    ....
  11. ncbi request reprint Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP
    Agshin F Taghiyev
    Department of Pathology, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1087, USA
    Mol Cancer Res 1:500-7. 2003
    ..Lastly, recombinant BAD cleaved by caspase-3 is a more potent inducer of cytochrome c and Smac/DIABLO release than BAD WT. In summary, BAD-mediated sensitivity of LNCaP to TRAIL depends on the phosphorylation status of BAD WT and tBAD...
  12. ncbi request reprint TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome
    Agshin F Taghiyev
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242 1087, USA
    Cancer Biol Ther 5:1199-205. 2006
    ..Together, these data indicate that caspase-2 initiates caspase cascade after TSA treatment and involves the formation of the PIDDosome...
  13. ncbi request reprint Trichostatin A (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment
    Agshin F Taghiyev
    Department of Pathology, The University of Iowa, Iowa City, Iowa, USA
    Cancer Biol Ther 4:382-90. 2005
    ..The combination of TSA and TNF-family ligands could potentially be the basis for the treatment of prostate cancer...
  14. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand-mediated activation of mitochondria-associated nuclear factor-kappaB in prostatic carcinoma cell lines
    Natalya V Guseva
    Department of Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1087, USA
    Mol Cancer Res 2:574-84. 2004
    ..In summary, NF-kappaB is found in mitochondria of prostatic carcinoma cells, where it is thought to regulate mitochondria genome encoded mRNA levels in response to TRAIL treatment...
  15. ncbi request reprint Death receptor-induced cell death in prostate cancer
    Natalya V Guseva
    Department of Pathology, University of Iowa, Iowa City, Iowa 52242 1087, USA
    J Cell Biochem 91:70-99. 2004
    ..In this review we have focused on what is known about apoptosis in prostate cancer and, more specifically, the receptor/ligand-mediated pathways of apoptosis as potential therapeutic targets...
  16. ncbi request reprint Unique resistance of breast carcinoma cell line T47D to TRAIL but not anti-Fas is linked to p43cFLIP(L)
    Natalya V Guseva
    Department of Pathology, The University of Iowa, 200 Hawkins Drive, C670, Iowa City, IA 52242 1087, USA
    Breast Cancer Res Treat 107:349-57. 2008
    ..We propose that in T47D p43 cFLIP(L) in the Fas-DISC may promote caspase-8 activation. The mechanism by which different amounts of p43cFLIP(L) regulates caspase-8 activation remains to be investigated...
  17. doi request reprint TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status
    Natalya V Guseva
    University of Iowa, Iowa City, USA
    Cancer Biol Ther 12:80-5. 2011
    ..Here, we show for the first time that NRP1 expression is under AR control. Taken together, our data suggest that TOFA is a potent cell death inducing agent in prostate cancer cells...
  18. ncbi request reprint Contribution of death receptor and mitochondrial pathways to Fas-mediated apoptosis in the prostatic carcinoma cell line PC3
    Natalya V Guseva
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242 1087, USA
    Prostate 51:231-40. 2002
    ..Human prostatic carcinoma cell line, PC3 is sensitive to Fas-mediated apoptosis, but relation of receptor and mitochondrial pathways is not clear...
  19. doi request reprint P53 and the proteasome regulate androgen receptor activity
    Natalya V Guseva
    Department of Pathology, University of Iowa, Iowa City, Iowa, USA
    Cancer Biol Ther 13:553-8. 2012
    ..Therefore, the role of p53 during treatment with proteasome inhibitors in different tumors should be further investigated...
  20. pmc Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor
    Natalya V Guseva
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Oncotarget 3:183-94. 2012
    ..Overall, our results point to p53 playing an important role in regulating AR activity across the genome...
  21. ncbi request reprint Chemotherapeutic agents up-regulate the cytomegalovirus promoter: implications for bioluminescence imaging of tumor response to therapy
    Robert U Svensson
    Department of Molecular Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52240, USA
    Cancer Res 67:10445-54. 2007
    ....
  22. doi request reprint Mechanisms of prostate cancer cell survival after inhibition of AR expression
    Michael B Cohen
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Cell Biochem 106:363-71. 2009
    ..This implies that there may be a need for re-evaluation of the therapeutic approaches to human prostate cancer...
  23. pmc Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP
    Agshin F Taghiyev
    Department of Pathology, The University of Iowa, Iowa City, IA, USA
    Genes Cancer 2:745-52. 2011
    ....
  24. pmc Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis
    Andrei P Komarov
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 105:14453-8. 2008
    ..These results reveal a cytochrome c-independent branch of FAS-induced apoptosis involving cleavage and cytoplasmic release of mitochondrial Cyt b...
  25. ncbi request reprint Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells
    Katerina V Gurova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Res 63:2905-12. 2003
    ..These results indicate that two different p53 mutants that are separately rather weak can cooperate to generate p53 protein with anti-Fas function that is likely to provide additional selective advantages to the tumor...
  26. ncbi request reprint p53 is a suppressor of inflammatory response in mice
    Elena A Komarova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 19:1030-2. 2005
    ....