Scott Rogers

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Reconstructing the behaviors of extinct species: an excursion into comparative paleoneurology
    Scott W Rogers
    Salt Lake City VA Geriatrics Research, Education and Clinical Center and Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132 3401, USA
    Am J Med Genet A 134:349-56. 2005
  2. pmc The expression of nicotinic receptor alpha7 during cochlear development
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, University of Utah Salt Lake City, Utah, 84132 Department of Neurobiology and Anatomy, University of Utah School of Medicine Salt Lake City, Utah, 84132
    Brain Behav 2:628-39. 2012
  3. pmc Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy
    Scott W Rogers
    Geriatric Research, Education and Clinical Center, Veteran s Administration, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e36467. 2012
  4. pmc Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, USA
    Am J Med Genet A 158:1135-44. 2012
  5. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
  6. pmc Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression
    Scott W Rogers
    SLC VA GRECC and University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hippocampus 18:750-7. 2008
  7. pmc Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation
    Amber V Osborne-Hereford
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
    J Neuroimmunol 193:130-9. 2008
  8. pmc Choline promotes nicotinic receptor alpha4 + beta2 up-regulation
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education, and Clinical Center, Salt Lake City, Utah, USA
    J Biol Chem 285:19793-801. 2010
  9. pmc Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    Hippocampus 18:737-49. 2008
  10. pmc A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction
    Robert B Weiss
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000125. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Reconstructing the behaviors of extinct species: an excursion into comparative paleoneurology
    Scott W Rogers
    Salt Lake City VA Geriatrics Research, Education and Clinical Center and Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132 3401, USA
    Am J Med Genet A 134:349-56. 2005
    ....
  2. pmc The expression of nicotinic receptor alpha7 during cochlear development
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, University of Utah Salt Lake City, Utah, 84132 Department of Neurobiology and Anatomy, University of Utah School of Medicine Salt Lake City, Utah, 84132
    Brain Behav 2:628-39. 2012
    ..Our findings suggest that alpha7 expression by both neuronal and non-neuronal cells has the potential to impact multiple auditory functions through mechanisms that are not traditionally attributed to this receptor...
  3. pmc Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy
    Scott W Rogers
    Geriatric Research, Education and Clinical Center, Veteran s Administration, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e36467. 2012
    ..These results demonstrate distinct and varied spatiotemporal expression of alpha7 during tooth development, and they suggest that dysfunction of this receptor would have diverse impacts upon the adult organ...
  4. pmc Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, USA
    Am J Med Genet A 158:1135-44. 2012
    ..These studies identify the Chrna7 cell lineage as participating in posterior neuropore closure and present a novel model of lower SB that can be substantially modified by the prenatal environment...
  5. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
    ..Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7...
  6. pmc Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression
    Scott W Rogers
    SLC VA GRECC and University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Hippocampus 18:750-7. 2008
    ..These finding suggest that this chromosomal segment harbors genes that regulate strain distinct hippocampal morphology that is revealed by nAChR alpha 4 expression...
  7. pmc Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation
    Amber V Osborne-Hereford
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
    J Neuroimmunol 193:130-9. 2008
    ..Altered pro-inflammatory responses correlated with changes in SOCS3 protein. These results demonstrate that nAChRalpha7 can participate in modulating a local pro-inflammatory response in the absence of parasympathetic innervation...
  8. pmc Choline promotes nicotinic receptor alpha4 + beta2 up-regulation
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education, and Clinical Center, Salt Lake City, Utah, USA
    J Biol Chem 285:19793-801. 2010
    ..These findings extend the view that up-regulation of alpha4 + beta2 nAChRs is a normal physiological response to altered metabolic and inflammatory conditions...
  9. pmc Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    Hippocampus 18:737-49. 2008
    ..These findings define a genetic frame-work in which the strain-specific responses to nicotine include underlying contributions by the varied anatomical context in which nAChRs are expressed...
  10. pmc A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction
    Robert B Weiss
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000125. 2008
    ..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies...
  11. pmc Nicotinic receptor subunit alpha5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 285:26049-57. 2010
    ..These findings suggest that alpha5 is an influential modulator of alpha4+beta2 nicotinic acetylcholine receptor assembly and stabilizes their expression in response to fluctuations in external conditions...
  12. ncbi request reprint Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway
    Lorise C Gahring
    Salt Lake City Veterans Affairs Geriatrics Research, Education, Clinical Center, Salt Lake City, Utah 84148, USA
    J Biol Chem 283:693-9. 2008
    ..This finding extends the possibilities for nAChR-inflammatory interactions in normal physiological processes and offers novel insights into endogenous mechanisms that can modify up-regulation...
  13. pmc Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells
    Lorise C Gahring
    Geriatric Research Education and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah 84132, USA
    AAPS J 7:E885-94. 2005
    ..Understanding these processes may offer novel therapeutic strategies to approach inflammatory diseases, as well as precautions in the design of interventional drugs...
  14. ncbi request reprint Autoimmunity to glutamate receptors in the central nervous system
    Lorise C Gahring
    Salt Lake City VA GRECC, University of Utah School of Medicine, Department of Internal Medicine, 84132, USA
    Crit Rev Immunol 22:295-316. 2002
    ....
  15. ncbi request reprint Nicotine-induced neuroprotection against N-methyl-D-aspartic acid or beta-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA, Salt Lake City, UT 84132, USA
    J Neurochem 87:1125-36. 2003
    ..These results provide insight into how nicotine imparts neuroprotection and modulates inflammatory responses...
  16. ncbi request reprint Neuronal and astrocyte expression of nicotinic receptor subunit beta4 in the adult mouse brain
    Lorise C Gahring
    Salt Lake City Veterans Administration Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah 84132, USA
    J Comp Neurol 468:322-33. 2004
    ....
  17. ncbi request reprint Mouse strain-specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus
    Lorise C Gahring
    Salt Lake City Veterans Administration Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah 84132, USA
    J Comp Neurol 468:334-46. 2004
    ....
  18. ncbi request reprint Age-related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase-2 and PPAR gamma expression and is altered by long-term NS398 administration
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, Utah, USA
    J Neurobiol 62:453-68. 2005
    ..These results provide evidence that the interaction during aging between oral administration of nicotine and NSAIDs are not straightforward and could even be antagonistic when combined...
  19. ncbi request reprint Mouse strain-specific changes in nicotinic receptor expression with age
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, UT 84148, USA
    Neurobiol Aging 26:973-80. 2005
    ..These results suggest that mouse strains of different genetic backgrounds undergo dissimilar age-related changes in the expression of nAChRs...
  20. ncbi request reprint Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly
    Lorise C Gahring
    Salt Lake City VA Geriatrics Research, Education and Clinical Center, Salt Lake City, UT 84132, USA
    J Neuroimmunol 166:88-101. 2005
    ..These results show that the emerging rules governing assembly of nAChRs are subject to modification by the pro-inflammatory cytokine environment...
  21. ncbi request reprint Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase
    Erin L Meyer
    Salt Lake City Veteran s Affairs Geriatrics Research, Education and Clinical Center, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 278:23786-96. 2003
    ..These results suggest that limited proteolysis is another post-translational mechanism through which functional diversity and specialization between closely related GluR subunits is accomplished...
  22. ncbi request reprint Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor
    Erin L Meyer
    Salt Lake City Veterans Affairs Geriatrics Research, Education, and Clinical Center and the University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 277:10869-75. 2002
    ..The modulation of GluR1 agonist-initiated caspase-mediated cleavage by nicotine preconditioning offers a novel insight into how this agent can impart its numerous effects on the nervous system...
  23. pmc Crystallization of the SH2-binding site of p130Cas in complex with Lck, a Src-family kinase
    Fariborz Nasertorabi
    Cancer Center, The Burnham Institute, La Jolla, CA 92037, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:174-7. 2005
    ..The crystals formed at 295 K in space group P2(1)2(1)2(1), with unit-cell parameters a = 77.4, b = 107.3, c = 166.4 A, and diffract to 2.7 A resolution...

Research Grants17

  1. Nicotine Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2009
    ....
  2. Nicotine Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2007
    ....
  3. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2005
    ..abstract_text> ..
  4. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2004
    ..abstract_text> ..
  5. Nicotinic Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2003
    ..many cellular functions including the ability to respond to inflammatory agents, we will ask in Specific Aim 3 using microarray chip analysis; Do these treatments contribute to maintaining normal transcriptional responses by the brain? ..
  6. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2003
    ..abstract_text> ..
  7. Nicotinic Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2002
    ..many cellular functions including the ability to respond to inflammatory agents, we will ask in Specific Aim 3 using microarray chip analysis; Do these treatments contribute to maintaining normal transcriptional responses by the brain? ..
  8. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2002
    ..abstract_text> ..
  9. CNS DISEASE AND AUTOIMMUNITY TO GLUTAMATE RECEPTORS
    Scott Rogers; Fiscal Year: 2001
    ..The relevance of these findings will be tested by measuring the neurotoxic effect of GluR autoantibodies on cultured cells that express GluRs of defined subunit composition. ..
  10. Nicotinic Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2001
    ..many cellular functions including the ability to respond to inflammatory agents, we will ask in Specific Aim 3 using microarray chip analysis; Do these treatments contribute to maintaining normal transcriptional responses by the brain? ..
  11. CNS DISEASE AND AUTOIMMUNITY TO GLUTAMATE RECEPTORS
    Scott Rogers; Fiscal Year: 2000
    ..The relevance of these findings will be tested by measuring the neurotoxic effect of GluR autoantibodies on cultured cells that express GluRs of defined subunit composition. ..
  12. CNS DISEASE AND AUTOIMMUNITY TO GLUTAMATE RECEPTORS
    Scott Rogers; Fiscal Year: 2000
    ..The relevance of these findings will be tested by measuring the neurotoxic effect of GluR autoantibodies on cultured cells that express GluRs of defined subunit composition. ..
  13. CNS DISEASE AND AUTOIMMUNITY TO GLUTAMATE RECEPTORS
    Scott Rogers; Fiscal Year: 1999
    ..The relevance of these findings will be tested by measuring the neurotoxic effect of GluR autoantibodies on cultured cells that express GluRs of defined subunit composition. ..
  14. Nicotine Receptors and COX2 in the Aging Brain
    SCOTT WARREN ROGERS; Fiscal Year: 2010
    ....