M A Rogawski

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Common pathophysiologic mechanisms in migraine and epilepsy
    Michael A Rogawski
    Department of Neurology, University of California Davis School of Medicine, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
    Arch Neurol 65:709-14. 2008
  2. doi request reprint The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs
    Michael A Rogawski
    Department of Neurology, School of Medicine and Center for Neuroscience, University of California, Davis, Sacramento, California 95817, USA
    Epilepsia 54:33-40. 2013
  3. pmc Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine
    Dorota Zolkowska
    Department of Neurology, School of Medicine, University of California Davis, Sacramento, California, USA
    J Pharmacol Exp Ther 341:435-46. 2012
  4. pmc Brivaracetam: a rational drug discovery success story
    M A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Br J Pharmacol 154:1555-7. 2008
  5. pmc New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels
    Michael A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Curr Neurol Neurosci Rep 8:345-52. 2008
  6. pmc Convection-enhanced delivery in the treatment of epilepsy
    Michael A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Neurotherapeutics 6:344-51. 2009
  7. doi request reprint Disclosure of clinical trial results when product development is abandoned
    Michael A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Sci Transl Med 3:102cm29. 2011
  8. doi request reprint Seizure protection by intrapulmonary delivery of propofol hemisuccinate
    Ashish Dhir
    Department of Neurology, School of Medicine, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Pharmacol Exp Ther 336:215-22. 2011
  9. ncbi request reprint Clinical spectrum of succinic semialdehyde dehydrogenase deficiency
    P L Pearl
    Department of Neurology, Children s National Medical Center, George Washington University School of Health Sciences, Washington, DC 20010 2970, USA
    Neurology 60:1413-7. 2003
  10. ncbi request reprint The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 48:793-800. 2007

Collaborators

Detail Information

Publications31

  1. doi request reprint Common pathophysiologic mechanisms in migraine and epilepsy
    Michael A Rogawski
    Department of Neurology, University of California Davis School of Medicine, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
    Arch Neurol 65:709-14. 2008
    ..Greater understanding of the shared mechanisms of epilepsy and migraine can provide a basis for the development of improved treatment approaches that may be applicable to both conditions...
  2. doi request reprint The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs
    Michael A Rogawski
    Department of Neurology, School of Medicine and Center for Neuroscience, University of California, Davis, Sacramento, California 95817, USA
    Epilepsia 54:33-40. 2013
    ..By overcoming pharmacoresistance, this new approach to epilepsy therapy may allow drug refractory patients to achieve seizure freedom without side effects...
  3. pmc Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine
    Dorota Zolkowska
    Department of Neurology, School of Medicine, University of California Davis, Sacramento, California, USA
    J Pharmacol Exp Ther 341:435-46. 2012
    ....
  4. pmc Brivaracetam: a rational drug discovery success story
    M A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Br J Pharmacol 154:1555-7. 2008
    ..Brivaracetam is among the first clinically effective AEDs to be discovered by optimization of pharmacodynamic activity at a molecular target...
  5. pmc New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels
    Michael A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Curr Neurol Neurosci Rep 8:345-52. 2008
    ..Functionally, all of the new targets modulate neurotransmitter output at synapses, focusing attention on presynaptic terminals as critical sites of action for AEDs...
  6. pmc Convection-enhanced delivery in the treatment of epilepsy
    Michael A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Neurotherapeutics 6:344-51. 2009
    ..The prolonged duration of action of nondiffusible toxins would allow seizure protection to be maintained chronically with infrequent reinfusions...
  7. doi request reprint Disclosure of clinical trial results when product development is abandoned
    Michael A Rogawski
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Sci Transl Med 3:102cm29. 2011
    ....
  8. doi request reprint Seizure protection by intrapulmonary delivery of propofol hemisuccinate
    Ashish Dhir
    Department of Neurology, School of Medicine, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Pharmacol Exp Ther 336:215-22. 2011
    ..Intrapulmonary PHS may be useful for preventing the spread of seizures or aborting seizure clusters without causing prolonged sedation...
  9. ncbi request reprint Clinical spectrum of succinic semialdehyde dehydrogenase deficiency
    P L Pearl
    Department of Neurology, Children s National Medical Center, George Washington University School of Health Sciences, Washington, DC 20010 2970, USA
    Neurology 60:1413-7. 2003
    ..Urine organic acid analysis should include a sensitive method for the detection of 4-hydroxybutyrate and should be obtained from patients with mental retardation or neuropsychiatric disturbance of unknown etiology...
  10. ncbi request reprint The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 48:793-800. 2007
    ..The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role...
  11. pmc Molecular targets for antiepileptic drug development
    Brian S Meldrum
    Centre for Neuroscience, Division of Biomedical and Health Sciences, School of Medicine, Kings College, London, United Kingdom
    Neurotherapeutics 4:18-61. 2007
    ..The growing understanding of the pathophysiology of epilepsy and the structural and functional characterization of the molecular targets provide many opportunities to create improved epilepsy therapies...
  12. pmc Diverse mechanisms of antiepileptic drugs in the development pipeline
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive MSC 3702, Bethesda, MD 20892 3702, United States
    Epilepsy Res 69:273-94. 2006
    ....
  13. pmc Molecular targets versus models for new antiepileptic drug discovery
    Michael A Rogawski
    Epilepsy Res 68:22-8. 2006
    ..In vitro testing is not likely to replace screening in animal models because in vitro systems cannot model the specific pharmacodynamic actions required for seizure protection, and do not assess bioavailability and brain accessibility...
  14. ncbi request reprint New strategies for the identification of drugs to prevent the development or progression of epilepsy
    Dieter Schmidt
    Epilepsy Research Group, Goethestr 5, Berlin, Germany
    Epilepsy Res 50:71-8. 2002
    ..Overall, it was felt that the current preclinical strategies for the discovery and development of new AEDs have to be redefined in order to identify agents that are clearly superior to current medications...
  15. pmc Anticonvulsant activity of androsterone and etiocholanolone
    Rafal M Kaminski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 46:819-27. 2005
    ..This study sought to determine whether these endogenous steroid metabolites can protect against seizures...
  16. ncbi request reprint The neurobiology of antiepileptic drugs
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 5:553-64. 2004
  17. pmc Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala
    Divina S Gryder
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    J Neurochem 94:1728-38. 2005
    ..Many BLA synaptic AMPA receptors are likely to be calcium permeable and could play roles in synaptic plasticity, epileptogenesis and excitoxicity...
  18. ncbi request reprint Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy
    John R Pace
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosurg 97:450-4. 2002
    ..The long-term antiseizure effects of local convection-enhanced infusion of the excitotoxin ibotenate were examined in a rat model of temporal lobe epilepsy...
  19. ncbi request reprint Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy
    Michael A Rogawski
    Ann Neurol 53:288-91. 2003
  20. ncbi request reprint GluR5 kainate receptors, seizures, and the amygdala
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4475, USA
    Ann N Y Acad Sci 985:150-62. 2003
    ....
  21. ncbi request reprint Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons
    Divina S Gryder
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4457, USA
    J Neurosci 23:7069-74. 2003
    ..Moreover, these results support the concept that GluR5 kainate receptors represent a novel target for antiepileptic drug development...
  22. ncbi request reprint Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice
    Patricia Salazar
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive Room 5A75 MSC 4457, Bethesda, MD 20892 4457, USA
    Epilepsy Res 55:71-82. 2003
    ..PTX and 4-AP-induced bursting in the hippocampal slice are useful models for directly assessing neurosteroid effects on seizure susceptibility under conditions that eliminate the factor of brain bioavailability...
  23. doi request reprint The anticonvulsant activity of acetone does not depend upon its metabolites
    Maciej Gasior
    Epilepsia 49:936-7. 2008
  24. pmc Efficacy of the ketogenic diet in the 6-Hz seizure test
    Adam L Hartman
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 49:334-9. 2008
    ....
  25. pmc The neuropharmacology of the ketogenic diet
    Adam L Hartman
    John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:281-92. 2007
    ....
  26. ncbi request reprint The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 10:685-92. 2004
    ....
  27. ncbi request reprint Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice
    Rafal M Kaminski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4457, U S A
    Epilepsia 45:864-7. 2004
    ....
  28. ncbi request reprint Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models
    Gholam K Motamedi
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 3702, USA
    Epilepsy Res 70:200-10. 2006
    ..Practical devices to inhibit seizure activity may only need to induce small temperature drops, if the cooling can be applied sufficiently rapidly...
  29. pmc Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene
    Sergey V Ivanov
    Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
    Am J Pathol 165:1007-18. 2004
    ....
  30. pmc Astrocytes get in the act in epilepsy
    Michael A Rogawski
    Nat Med 11:919-20. 2005
  31. ncbi request reprint Neurosteroids and infantile spasms: the deoxycorticosterone hypothesis
    Michael A Rogawski
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int Rev Neurobiol 49:199-219. 2002
    ..In addition, it further confirms the utility of pharmacological enhancement of GABA-mediated inhibition in the control of infantile spasms...