Research Topics
| M A RogawskiSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Common pathophysiologic mechanisms in migraine and epilepsyMichael A Rogawski
Department of Neurology, University of California Davis School of Medicine, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
Arch Neurol 65:709-14. 2008..Greater understanding of the shared mechanisms of epilepsy and migraine can provide a basis for the development of improved treatment approaches that may be applicable to both conditions...
Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramineDorota Zolkowska
Department of Neurology, School of Medicine, University of California Davis, Sacramento, California, USA
J Pharmacol Exp Ther 341:435-46. 2012....- Brivaracetam: a rational drug discovery success storyM A Rogawski
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Br J Pharmacol 154:1555-7. 2008..Brivaracetam is among the first clinically effective AEDs to be discovered by optimization of pharmacodynamic activity at a molecular target... - New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channelsMichael A Rogawski
Department of Neurology, School of Medicine, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
Curr Neurol Neurosci Rep 8:345-52. 2008..Functionally, all of the new targets modulate neurotransmitter output at synapses, focusing attention on presynaptic terminals as critical sites of action for AEDs... - Convection-enhanced delivery in the treatment of epilepsyMichael A Rogawski
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
Neurotherapeutics 6:344-51. 2009..The prolonged duration of action of nondiffusible toxins would allow seizure protection to be maintained chronically with infrequent reinfusions... - Disclosure of clinical trial results when product development is abandonedMichael A Rogawski
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Sci Transl Med 3:102cm29. 2011.... - Seizure protection by intrapulmonary delivery of propofol hemisuccinateAshish Dhir
Department of Neurology, School of Medicine, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
J Pharmacol Exp Ther 336:215-22. 2011..Intrapulmonary PHS may be useful for preventing the spread of seizures or aborting seizure clusters without causing prolonged sedation... 
Clinical spectrum of succinic semialdehyde dehydrogenase deficiencyP L Pearl
Department of Neurology, Children s National Medical Center, George Washington University School of Health Sciences, Washington, DC 20010 2970, USA
Neurology 60:1413-7. 2003..Urine organic acid analysis should include a sensitive method for the detection of 4-hydroxybutyrate and should be obtained from patients with mental retardation or neuropsychiatric disturbance of unknown etiology...- The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acidMaciej Gasior
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
Epilepsia 48:793-800. 2007..The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role... - Molecular targets for antiepileptic drug developmentBrian S Meldrum
Centre for Neuroscience, Division of Biomedical and Health Sciences, School of Medicine, Kings College, London, United Kingdom
Neurotherapeutics 4:18-61. 2007..The growing understanding of the pathophysiology of epilepsy and the structural and functional characterization of the molecular targets provide many opportunities to create improved epilepsy therapies... - Diverse mechanisms of antiepileptic drugs in the development pipelineMichael A Rogawski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive MSC 3702, Bethesda, MD 20892 3702, United States
Epilepsy Res 69:273-94. 2006.... - Molecular targets versus models for new antiepileptic drug discoveryMichael A Rogawski
Epilepsy Res 68:22-8. 2006..In vitro testing is not likely to replace screening in animal models because in vitro systems cannot model the specific pharmacodynamic actions required for seizure protection, and do not assess bioavailability and brain accessibility... - Anticonvulsant activity of androsterone and etiocholanoloneRafal M Kaminski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3702, USA
Epilepsia 46:819-27. 2005..CONCLUSIONS: 5alpha,3alpha-A and 5beta,3alpha-A have anticonvulsant properties. Although of low potency, the steroids are present in high abundance and could represent endogenous modulators of seizure susceptibility... - New strategies for the identification of drugs to prevent the development or progression of epilepsyDieter Schmidt
Epilepsy Research Group, Goethestr 5, Berlin, Germany
Epilepsy Res 50:71-8. 2002..Overall, it was felt that the current preclinical strategies for the discovery and development of new AEDs have to be redefined in order to identify agents that are clearly superior to current medications... - The neurobiology of antiepileptic drugsMichael A Rogawski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Neurosci 5:553-64. 2004 - Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdalaDivina S Gryder
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
J Neurochem 94:1728-38. 2005..Many BLA synaptic AMPA receptors are likely to be calcium permeable and could play roles in synaptic plasticity, epileptogenesis and excitoxicity... - Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsyJohn R Pace
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosurg 97:450-4. 2002..CONCLUSIONS: Lesioning of an epileptic focus by convective distribution of ibotenate can produce an enduring suppression of seizure activity, indicating a chemical neurosurgical approach for epilepsy therapy... - Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsyMichael A Rogawski
Ann Neurol 53:288-91. 2003 - GluR5 kainate receptors, seizures, and the amygdalaMichael A Rogawski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4475, USA
Ann N Y Acad Sci 985:150-62. 2003.... - Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neuronsDivina S Gryder
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4457, USA
J Neurosci 23:7069-74. 2003..Moreover, these results support the concept that GluR5 kainate receptors represent a novel target for antiepileptic drug development... - Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slicePatricia Salazar
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive Room 5A75 MSC 4457, Bethesda, MD 20892-4457, USA
Epilepsy Res 55:71-82. 2003..PTX and 4-AP-induced bursting in the hippocampal slice are useful models for directly assessing neurosteroid effects on seizure susceptibility under conditions that eliminate the factor of brain bioavailability... - The anticonvulsant activity of acetone does not depend upon its metabolitesMaciej Gasior
Epilepsia 49:936-7. 2008 - Efficacy of the ketogenic diet in the 6-Hz seizure testAdam L Hartman
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Epilepsia 49:334-9. 2008.... - The neuropharmacology of the ketogenic dietAdam L Hartman
John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Pediatr Neurol 36:281-92. 2007.... - The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditionsMichael A Rogawski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 10:685-92. 2004.... - Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy modelsGholam K Motamedi
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-3702, USA
Epilepsy Res 70:200-10. 2006..Practical devices to inhibit seizure activity may only need to induce small temperature drops, if the cooling can be applied sufficiently rapidly... - Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in miceRafal M Kaminski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4457, U.S.A
Epilepsia 45:864-7. 2004..The 6-Hz model may be a valuable tool in drug development for the identification of GABAergic AEDs... - Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 geneSergey V Ivanov
Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland, USA
Am J Pathol 165:1007-18. 2004.... - Astrocytes get in the act in epilepsyMichael A Rogawski
Nat Med 11:919-20. 2005 - Neurosteroids and infantile spasms: the deoxycorticosterone hypothesisMichael A Rogawski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 49:199-219. 2002..In addition, it further confirms the utility of pharmacological enhancement of GABA-mediated inhibition in the control of infantile spasms...