Eleanor G Rogan

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint The natural chemopreventive compound indole-3-carbinol: state of the science
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    In Vivo 20:221-8. 2006
  2. ncbi request reprint Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha 68198 6805, USA
    Carcinogenesis 24:697-702. 2003
  3. doi request reprint NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 117:56-66. 2009
  4. pmc Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 48:318-24. 2010
  5. pmc Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteine
    Divya Venugopal
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 109:22-30. 2008
  6. pmc Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 45:136-45. 2008
  7. doi request reprint Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells
    Fang Lu
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Cancer Prev Res (Phila) 1:135-45. 2008
  8. ncbi request reprint A unifying mechanism in the initiation of cancer and other diseases by catechol quinones
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Ann N Y Acad Sci 1028:247-57. 2004
  9. ncbi request reprint Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leuk Lymphoma 47:2635-44. 2006
  10. ncbi request reprint Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncol Rep 14:1091-6. 2005

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The natural chemopreventive compound indole-3-carbinol: state of the science
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    In Vivo 20:221-8. 2006
    ..I3C has been found to be effective in treating some cases of recurrent respiratory papillomatosis, and it may have other clinical uses...
  2. ncbi request reprint Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha 68198 6805, USA
    Carcinogenesis 24:697-702. 2003
    ..The levels of 4-CE and quinone conjugates were highly significant predictors of breast cancer. These results suggest that some catechol estrogen metabolites and conjugates could serve as biomarkers to predict risk of breast cancer...
  3. doi request reprint NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 117:56-66. 2009
    ..Therefore, the inheritance of these NQO1 polymorphisms may favor the estrogen genotoxic mechanism of breast cancer...
  4. pmc Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 48:318-24. 2010
    ..Reaction of catechol quinones of natural and synthetic estrogens, benzene, naphthalene, and dopamine with DNA to form depurinating adducts is a common feature that may lead to initiation of cancer or neurodegenerative disease...
  5. pmc Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteine
    Divya Venugopal
    Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 109:22-30. 2008
    ..These results strongly implicate estrogen genotoxicity in mammary cell transformation. Since N-acetylcysteine is well tolerated in clinical studies, it may be a promising candidate for breast cancer prevention...
  6. pmc Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 45:136-45. 2008
    ..We conclude that Resv can protect breast cells from carcinogenic estrogen metabolites, suggesting that it could be used in breast cancer prevention...
  7. doi request reprint Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells
    Fang Lu
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Cancer Prev Res (Phila) 1:135-45. 2008
    ..Resveratrol also suppressed TCDD and/or estradiol-induced cell transformation. Thus, resveratrol can prevent breast cancer initiation by blocking multiple sites in the estrogen genotoxicity pathway...
  8. ncbi request reprint A unifying mechanism in the initiation of cancer and other diseases by catechol quinones
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Ann N Y Acad Sci 1028:247-57. 2004
    ..In summary, the apurinic sites produced in DNA from the loss of these depurinating adducts can be converted into mutations by error-prone repair, which may initiate cancer and other diseases...
  9. ncbi request reprint Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cells
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leuk Lymphoma 47:2635-44. 2006
    ..Thus, DNA damage induced by the ortho-quinones of benzene and estradiol may promote the growth of human blood mononuclear cells, including those that appear in large numbers in leukemia and lymphoma...
  10. ncbi request reprint Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma
    Seema Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncol Rep 14:1091-6. 2005
    ..These unbalances appear to be instrumental in causing excessive formation of catechol estrogen quinones that, by reacting with DNA, initiate the series of events leading to breast cancer...
  11. pmc N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cells
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 49:392-400. 2010
    ..This finding suggests that NAcCys, a common dietary supplement, could be used as a potential chemopreventive agent to block the initial step in the genotoxicity caused by catechol estrogen quinones...
  12. doi request reprint Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphoma
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biomarkers 14:502-12. 2009
    ..Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk...
  13. pmc Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 46:253-62. 2009
    ..Both UV and liquid chromatography-tandem mass spectrometry assays unequivocally corroborate the reduction of estrogen ortho-quinones by NQO2, indicating that it could be a novel target for prevention of breast cancer initiation...
  14. ncbi request reprint Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assay
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Mutat Res 588:158-65. 2005
    ..In summary, the inclusion of ARP in the DB[a,l]P-DNA adduct-forming reaction traps and protects the nascent abasic sites, allowing an improved quantification of abasic sites...
  15. pmc Novel biomarkers for risk of prostate cancer: results from a case-control study
    Li Yang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Prostate 69:41-8. 2009
    ..The goal of this case-control study was to detect and identify potential biomarkers of Pca...
  16. doi request reprint Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 50:78-85. 2011
    ..Their combined effects were additive. Therefore, these two antioxidants provide an excellent combination to protect catechol estrogens from oxidation to catechol quinones...
  17. ncbi request reprint Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo
    Kai Ming Li
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 25:289-97. 2004
    ..These adducts can generate the critical mutations that initiate cancer (Chakravarti et al., Oncogene, 2001, 20, 7945; Chakravarti et al., Proc. Am. Assoc. Cancer Res., 2003, 44, 180)...
  18. pmc The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin
    Dhrubajyoti Chakravarti
    Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198 6805, USA
    Mutat Res 649:161-78. 2008
    ..In conclusion, this study suggests that depurinating adducts play a major role in PAH mutagenesis...
  19. pmc Unbalanced estrogen metabolism in ovarian cancer
    Muhammad Zahid
    Department of Environmental Agricultural and Occupational Health College of Public Health, University of Nebraska Medical Center, Omaha, NE
    Int J Cancer 134:2414-23. 2014
    ..These findings indicate that estrogen metabolism is unbalanced in ovarian cancer and suggest that formation of estrogen-DNA adducts plays a critical role in the initiation of ovarian cancer. ..
  20. ncbi request reprint Identification and quantification of the depurinating DNA adducts formed in mouse skin treated with dibenzo[a,l]pyrene (DB[a,l]P) or its metabolites and in rat mammary gland treated with DB[a,l]P
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Chem Res Toxicol 18:976-83. 2005
    ..Only one depurinating diol epoxide adduct was formed. Tumorigenicity, mutations, and DNA adduct data suggest that depurinating Ade adducts play a major role in the initiation of tumors by DB[a,l]P...
  21. doi request reprint Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Future Oncol 6:75-91. 2010
    ..Two antioxidants, N-acetylcysteine and resveratrol, are prime candidates to prevent breast and other human cancers because in various M in vitro and in vivo experiments, they reduce the formation of estrogen-DNA adducts...
  22. pmc Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition
    Fang Lu
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    J Steroid Biochem Mol Biol 105:150-8. 2007
    ..We conclude that low COMT activity and increased formation of depurinating adducts can be critical factors leading to initiation of breast cancer...
  23. doi request reprint Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol
    Benjamin Hinrichs
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 127:276-81. 2011
    ..In this study, when MCF-10F cells were treated with a combination of resveratrol and DES, a dose-dependent reduction in the level of DES-DNA adducts was also observed...
  24. ncbi request reprint Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA
    Yan Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Metabolism 56:887-94. 2007
    ....
  25. doi request reprint Is bisphenol A a weak carcinogen like the natural estrogens and diethylstilbestrol?
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    IUBMB Life 62:746-51. 2010
    ..Knowledge of these mechanisms would allow us to begin to understand how BPA may act as a weak carcinogen and would be useful for regulating its use...
  26. ncbi request reprint Inhibition of depurinating estrogen-DNA adduct formation by natural compounds
    Muhammad Zahid
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Chem Res Toxicol 20:1947-53. 2007
    ..This approach is highly useful for identifying agents to prevent the initiation of human cancers, especially breast and prostate cancer...
  27. ncbi request reprint The molecular etiology of breast cancer: evidence from biomarkers of risk
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Int J Cancer 122:1949-57. 2008
    ..Thus, the depurinating estrogen-DNA adducts are possible biomarkers for early detection of breast cancer risk and response to preventive treatment...
  28. ncbi request reprint Estrogen metabolites, conjugates, and DNA adducts: possible biomarkers for risk of breast, prostate, and other human cancers
    Eleanor G Rogan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Adv Clin Chem 38:135-49. 2004
  29. pmc Unbalanced estrogen metabolism in thyroid cancer
    Muhammad Zahid
    Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE
    Int J Cancer 133:2642-9. 2013
    ..These findings indicate that estrogen metabolism is unbalanced in thyroid cancer and suggest that formation of estrogen-DNA adducts might play a role in the initiation of thyroid cancer. ..
  30. ncbi request reprint Prevalence of BER gene polymorphisms in sporadic breast cancer
    Mohamed F Ali
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncol Rep 19:1033-8. 2008
    ..Thus, the Gln allele was significantly more frequent in breast cancer cases (allele frequency, 0.52) than in controls (allele frequency, 0.35), suggesting that XRCC1 399Gln may enhance the risk of breast cancer...
  31. pmc Imbalanced estrogen metabolism in the brain: possible relevance to the etiology of Parkinson's disease
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, USA
    Biomarkers 16:434-44. 2011
    ..The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD...
  32. pmc Urine biomarkers of risk in the molecular etiology of breast cancer
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805
    Breast Cancer (Auckl) 3:1-8. 2009
    ..Therefore, relative levels of depurinating estrogen-DNA adducts could become biomarkers for early detection of breast cancer risk and aid in determining preventive strategies...
  33. doi request reprint Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
    J Steroid Biochem Mol Biol 125:169-80. 2011
    ..Specific antioxidants, such as N-acetylcysteine and resveratrol, can block the oxidation of catechol estrogens to their quinones and their reaction with DNA. As a result, the initiation of cancer can be prevented...
  34. pmc Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinones
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 43:1289-98. 2007
    ..Thus, clear evidence for the catalytic reduction of estrogen ortho-quinones by NQO1 has been obtained; its mechanism and implications are discussed...
  35. ncbi request reprint Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:1071-7. 2002
    ..These data suggest that there is a unifying molecular mechanism, namely, formation of specific depurinating DNA adducts at the N-7 of guanine and N-3 of adenine, that could initiate many cancers and neurodegenerative diseases...
  36. ncbi request reprint Repair of short oligodeoxyribonucleotides containing a stable adduct and an apurinic site by extracts of MCF-10A1 cells
    Kimberly A Chapman
    Eppley Institute for Research in Cancer and Allied Diseases and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Anticancer Res 24:117-21. 2004
    ..DNA with two sites of damage in close proximity might not be repaired as efficiently as DNA with a single damage site...
  37. ncbi request reprint Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer
    Ercole L Cavalieri
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Carcinogenesis 23:329-33. 2002
    ....
  38. ncbi request reprint Fluorobenzo[a]pyrenes as probes of the mechanism of cytochrome P450-catalyzed oxygen transfer in aromatic oxygenations
    Patrick P J Mulder
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Free Radic Biol Med 34:734-45. 2003
    ....
  39. ncbi request reprint Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    Howard F Tiano
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:3395-401. 2002
    ..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation...
  40. ncbi request reprint Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol
    Zhonglin Zhao
    New York University Dental School, New York, New York 10010, USA
    Chem Res Toxicol 19:475-9. 2006
    ..Thus, the results of this study support the proposal that estradiol can contribute to carcinogenesis via a genotoxic pathway...