Research Topics
Genomes and GenesSpecies | Eleanor G RoganSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
The natural chemopreventive compound indole-3-carbinol: state of the scienceEleanor G Rogan
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
In Vivo 20:221-8. 2006..I3C has been found to be effective in treating some cases of recurrent respiratory papillomatosis, and it may have other clinical uses...- Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancerEleanor G Rogan
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha 68198 6805, USA
Carcinogenesis 24:697-702. 2003..The levels of 4-CE and quinone conjugates were highly significant predictors of breast cancer. These results suggest that some catechol estrogen metabolites and conjugates could serve as biomarkers to predict risk of breast cancer... 
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cellsSeema Singh
Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
J Steroid Biochem Mol Biol 117:56-66. 2009..Therefore, the inheritance of these NQO1 polymorphisms may favor the estrogen genotoxic mechanism of breast cancer...
Reduction of estrogen-induced transformation of mouse mammary epithelial cells by N-acetylcysteineDivya Venugopal
Eppley Institute for Research in Cancer and Allied Diseases, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
J Steroid Biochem Mol Biol 109:22-30. 2008..These results strongly implicate estrogen genotoxicity in mammary cell transformation. Since N-acetylcysteine is well tolerated in clinical studies, it may be a promising candidate for breast cancer prevention...- Benzene and dopamine catechol quinones could initiate cancer or neurogenic diseaseMuhammad Zahid
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Free Radic Biol Med 48:318-24. 2010..Reaction of catechol quinones of natural and synthetic estrogens, benzene, naphthalene, and dopamine with DNA to form depurinating adducts is a common feature that may lead to initiation of cancer or neurodegenerative disease... - Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrolMuhammad Zahid
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Free Radic Biol Med 45:136-45. 2008..We conclude that Resv can protect breast cells from carcinogenic estrogen metabolites, suggesting that it could be used in breast cancer prevention... - Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cellsFang Lu
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Cancer Prev Res (Phila) 1:135-45. 2008..Resveratrol also suppressed TCDD and/or estradiol-induced cell transformation. Thus, resveratrol can prevent breast cancer initiation by blocking multiple sites in the estrogen genotoxicity pathway... - N-acetylcysteine blocks formation of cancer-initiating estrogen-DNA adducts in cellsMuhammad Zahid
Eppley Institute for Research in Cancer and Allied Diseases, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
Free Radic Biol Med 49:392-400. 2010..This finding suggests that NAcCys, a common dietary supplement, could be used as a potential chemopreventive agent to block the initial step in the genotoxicity caused by catechol estrogen quinones... - A unifying mechanism in the initiation of cancer and other diseases by catechol quinonesErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Ann N Y Acad Sci 1028:247-57. 2004..In summary, the apurinic sites produced in DNA from the loss of these depurinating adducts can be converted into mutations by error-prone repair, which may initiate cancer and other diseases... - Ortho-quinones of benzene and estrogens induce hyperproliferation of human peripheral blood mononuclear cellsDhrubajyoti Chakravarti
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
Leuk Lymphoma 47:2635-44. 2006..Thus, DNA damage induced by the ortho-quinones of benzene and estradiol may promote the growth of human blood mononuclear cells, including those that appear in large numbers in leukemia and lymphoma... - Relative imbalances in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinomaSeema Singh
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA
Oncol Rep 14:1091-6. 2005..These unbalances appear to be instrumental in causing excessive formation of catechol estrogen quinones that, by reacting with DNA, initiate the series of events leading to breast cancer... - Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinonesNilesh W Gaikwad
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Free Radic Biol Med 46:253-62. 2009..Both UV and liquid chromatography-tandem mass spectrometry assays unequivocally corroborate the reduction of estrogen ortho-quinones by NQO2, indicating that it could be a novel target for prevention of breast cancer initiation... - Urinary biomarkers suggest that estrogen-DNA adducts may play a role in the aetiology of non-Hodgkin lymphomaNilesh W Gaikwad
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Biomarkers 14:502-12. 2009..Thus, formation of estrogen-DNA adducts may play a critical role in the aetiology of NHL, and these adducts could be potential biomarkers of NHL risk... - Improved measurement of dibenzo[a,l]pyrene-induced abasic sites by the aldehyde-reactive probe assayDhrubajyoti Chakravarti
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Mutat Res 588:158-65. 2005..In summary, the inclusion of ARP in the DB[a,l]P-DNA adduct-forming reaction traps and protects the nascent abasic sites, allowing an improved quantification of abasic sites... - Novel biomarkers for risk of prostate cancer: results from a case-control studyLi Yang
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
Prostate 69:41-8. 2009..The goal of this case-control study was to detect and identify potential biomarkers of Pca... - Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cellsMuhammad Zahid
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
Free Radic Biol Med 50:78-85. 2011..Their combined effects were additive. Therefore, these two antioxidants provide an excellent combination to protect catechol estrogens from oxidation to catechol quinones... - The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skinDhrubajyoti Chakravarti
Eppley Institute for Research in Cancer and Allied Diseases, Omaha, NE 68198 6805, USA
Mutat Res 649:161-78. 2008..In conclusion, this study suggests that depurinating adducts play a major role in PAH mutagenesis... - Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivoKai-Ming Li
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA
Carcinogenesis 25:289-97. 2004..These adducts can generate the critical mutations that initiate cancer (Chakravarti et al., Oncogene, 2001, 20, 7945; Chakravarti et al., Proc. Am. Assoc. Cancer Res., 2003, 44, 180)... - Identification and quantification of the depurinating DNA adducts formed in mouse skin treated with dibenzo[a,l]pyrene (DB[a,l]P) or its metabolites and in rat mammary gland treated with DB[a,l]PErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Chem Res Toxicol 18:976-83. 2005..Only one depurinating diol epoxide adduct was formed. Tumorigenicity, mutations, and DNA adduct data suggest that depurinating Ade adducts play a major role in the initiation of tumors by DB[a,l]P... - Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibitionFang Lu
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
J Steroid Biochem Mol Biol 105:150-8. 2007..We conclude that low COMT activity and increased formation of depurinating adducts can be critical factors leading to initiation of breast cancer... - Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancersErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Future Oncol 6:75-91. 2010..Two antioxidants, N-acetylcysteine and resveratrol, are prime candidates to prevent breast and other human cancers because in various M in vitro and in vivo experiments, they reduce the formation of estrogen-DNA adducts... - Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrolBenjamin Hinrichs
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
J Steroid Biochem Mol Biol 127:276-81. 2011..In this study, when MCF-10F cells were treated with a combination of resveratrol and DES, a dose-dependent reduction in the level of DES-DNA adducts was also observed... - Is bisphenol A a weak carcinogen like the natural estrogens and diethylstilbestrol?Ercole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
IUBMB Life 62:746-51. 2010..Knowledge of these mechanisms would allow us to begin to understand how BPA may act as a weak carcinogen and would be useful for regulating its use... - Inhibition of depurinating estrogen-DNA adduct formation by natural compoundsMuhammad Zahid
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
Chem Res Toxicol 20:1947-53. 2007..This approach is highly useful for identifying agents to prevent the initiation of human cancers, especially breast and prostate cancer... - Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNAYan Zhang
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Metabolism 56:887-94. 2007.... - The molecular etiology of breast cancer: evidence from biomarkers of riskNilesh W Gaikwad
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Int J Cancer 122:1949-57. 2008..Thus, the depurinating estrogen-DNA adducts are possible biomarkers for early detection of breast cancer risk and response to preventive treatment... - Estrogen metabolites, conjugates, and DNA adducts: possible biomarkers for risk of breast, prostate, and other human cancersEleanor G Rogan
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Adv Clin Chem 38:135-49. 2004 - Prevalence of BER gene polymorphisms in sporadic breast cancerMohamed F Ali
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Oncol Rep 19:1033-8. 2008..Thus, the Gln allele was significantly more frequent in breast cancer cases (allele frequency, 0.52) than in controls (allele frequency, 0.35), suggesting that XRCC1 399Gln may enhance the risk of breast cancer... - Imbalanced estrogen metabolism in the brain: possible relevance to the etiology of Parkinson's diseaseNilesh W Gaikwad
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, USA
Biomarkers 16:434-44. 2011..The levels of adducts in cases versus controls (P < 0.005) suggest that unbalanced estrogen metabolism could play a causal role in the initiation of PD... - Urine biomarkers of risk in the molecular etiology of breast cancerNilesh W Gaikwad
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805
Breast Cancer (Auckl) 3:1-8. 2009..Therefore, relative levels of depurinating estrogen-DNA adducts could become biomarkers for early detection of breast cancer risk and aid in determining preventive strategies... - Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancerErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, United States
J Steroid Biochem Mol Biol 125:169-80. 2011..Specific antioxidants, such as N-acetylcysteine and resveratrol, can block the oxidation of catechol estrogens to their quinones and their reaction with DNA. As a result, the initiation of cancer can be prevented... - Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinonesNilesh W Gaikwad
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Free Radic Biol Med 43:1289-98. 2007..Thus, clear evidence for the catalytic reduction of estrogen ortho-quinones by NQO1 has been obtained; its mechanism and implications are discussed... - Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseasesErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Carcinogenesis 23:1071-7. 2002..These data suggest that there is a unifying molecular mechanism, namely, formation of specific depurinating DNA adducts at the N-7 of guanine and N-3 of adenine, that could initiate many cancers and neurodegenerative diseases... - Repair of short oligodeoxyribonucleotides containing a stable adduct and an apurinic site by extracts of MCF-10A1 cellsKimberly A Chapman
Eppley Institute for Research in Cancer and Allied Diseases and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA
Anticancer Res 24:117-21. 2004..CONCLUSION: The ability of human breast MCF-10A1 cells to repair DNA adducts and AP sites is affected by other near-by lesions... - Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancerErcole L Cavalieri
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Carcinogenesis 23:329-33. 2002.... - Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesisHoward F Tiano
Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Cancer Res 62:3395-401. 2002..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation... - Fluorobenzo[a]pyrenes as probes of the mechanism of cytochrome P450-catalyzed oxygen transfer in aromatic oxygenationsPatrick P J Mulder
Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
Free Radic Biol Med 34:734-45. 2003.... - Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiolZhonglin Zhao
New York University Dental School, New York, New York 10010, USA
Chem Res Toxicol 19:475-9. 2006..Thus, the results of this study support the proposal that estradiol can contribute to carcinogenesis via a genotoxic pathway...