Matthew R Roesch

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Neuronal activity related to anticipated reward in frontal cortex: does it represent value or reflect motivation?
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1121:431-46. 2007
  2. pmc Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, Maryland 21201, USA
    Nat Neurosci 10:1615-24. 2007
  3. pmc Should I stay or should I go? Transformation of time-discounted rewards in orbitofrontal cortex and associated brain circuits
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1104:21-34. 2007
  4. pmc Previous cocaine exposure makes rats hypersensitive to both delay and reward magnitude
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 27:245-50. 2007
  5. pmc Encoding of time-discounted rewards in orbitofrontal cortex is independent of value representation
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, 21201, USA
    Neuron 51:509-20. 2006
  6. pmc Associative encoding in anterior piriform cortex versus orbitofrontal cortex during odor discrimination and reversal learning
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cereb Cortex 17:643-52. 2007
  7. pmc Neural correlates of variations in event processing during learning in basolateral amygdala
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 30:2464-71. 2010
  8. ncbi request reprint Neuronal activity in primate orbitofrontal cortex reflects the value of time
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, University of Pittsburgh, Pennsylvania, USA
    J Neurophysiol 94:2457-71. 2005
  9. ncbi request reprint Neuronal activity dependent on anticipated and elapsed delay in macaque prefrontal cortex, frontal and supplementary eye fields, and premotor cortex
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurophysiol 94:1469-97. 2005
  10. pmc The orbitofrontal cortex and ventral tegmental area are necessary for learning from unexpected outcomes
    Yuji K Takahashi
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, MD 21201, USA
    Neuron 62:269-80. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Neuronal activity related to anticipated reward in frontal cortex: does it represent value or reflect motivation?
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1121:431-46. 2007
    ....
  2. pmc Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, Maryland 21201, USA
    Nat Neurosci 10:1615-24. 2007
    ..Moreover, when rats were given a choice between two differently valued outcomes, the activity of the neurons initially reflected the more valuable option, even when it was not subsequently selected...
  3. pmc Should I stay or should I go? Transformation of time-discounted rewards in orbitofrontal cortex and associated brain circuits
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1104:21-34. 2007
    ..We suggest a dual role for output from OFC in both discounting delayed reward, while at the same time supporting new learning for them...
  4. pmc Previous cocaine exposure makes rats hypersensitive to both delay and reward magnitude
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 27:245-50. 2007
    ..We conclude that previous exposure to cocaine makes choice behavior hypersensitive to differences in the time to and size of available rewards, consistent with a general effect of cocaine exposure on reward valuation mechanisms...
  5. pmc Encoding of time-discounted rewards in orbitofrontal cortex is independent of value representation
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, 21201, USA
    Neuron 51:509-20. 2006
    ....
  6. pmc Associative encoding in anterior piriform cortex versus orbitofrontal cortex during odor discrimination and reversal learning
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cereb Cortex 17:643-52. 2007
    ....
  7. pmc Neural correlates of variations in event processing during learning in basolateral amygdala
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 30:2464-71. 2010
    ..These results suggest that basolateral amygdala serves a critical function in attention for learning...
  8. ncbi request reprint Neuronal activity in primate orbitofrontal cortex reflects the value of time
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, University of Pittsburgh, Pennsylvania, USA
    J Neurophysiol 94:2457-71. 2005
    ..We conclude that neuronal activity in OF represents the time-discounted value of the expected reward...
  9. ncbi request reprint Neuronal activity dependent on anticipated and elapsed delay in macaque prefrontal cortex, frontal and supplementary eye fields, and premotor cortex
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurophysiol 94:1469-97. 2005
    ..We conclude that predicting a short delay, like predicting a large reward, induces an enhancement of neuronal activity related to motivational modulation of the monkey's preparatory state...
  10. pmc The orbitofrontal cortex and ventral tegmental area are necessary for learning from unexpected outcomes
    Yuji K Takahashi
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, MD 21201, USA
    Neuron 62:269-80. 2009
    ..Furthermore, bilateral inactivation of VTA or contralateral inactivation of VTA and OFC disrupted learning driven by unexpected outcomes...
  11. pmc Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala
    Thomas A Stalnaker
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, HSF 2 S251, Baltimore, Maryland 21201, USA
    Nat Neurosci 10:949-51. 2007
    ..Further, the presence of these neurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats...
  12. pmc Neural correlates of inflexible behavior in the orbitofrontal-amygdalar circuit after cocaine exposure
    Thomas A Stalnaker
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1121:598-609. 2007
    ..A similar mechanism of drug-induced orbitofrontal-amygdalar dysfunction may cause inflexible behavior when animals and addicts are exposed to drug-associated cues and contexts...
  13. pmc Attention-related Pearce-Kaye-Hall signals in basolateral amygdala require the midbrain dopaminergic system
    Guillem R Esber
    National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
    Biol Psychiatry 72:1012-9. 2012
    ..This requirement for prediction errors, coupled with projections from the midbrain dopamine system into basolateral amygdala, suggests that the PKH signal in amygdala may depend on dopaminergic input...
  14. pmc Ventral striatal neurons encode the value of the chosen action in rats deciding between differently delayed or sized rewards
    Matthew R Roesch
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 29:13365-76. 2009
    ..These results are consistent with the notion that VS serves to integrate information about the value of an expected reward with motor output during decision making...
  15. pmc Abnormal associative encoding in orbitofrontal neurons in cocaine-experienced rats during decision-making
    Thomas A Stalnaker
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, HSF 2 S251, Baltimore, MD 21201, USA
    Eur J Neurosci 24:2643-53. 2006
    ..These results provide direct neurophysiological evidence that exposure to cocaine can cause behaviorally relevant changes in the processing of associative information in a circuit that includes the orbitofrontal cortex...
  16. pmc Expectancy-related changes in firing of dopamine neurons depend on orbitofrontal cortex
    Yuji K Takahashi
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:1590-7. 2011
    ..These results are consistent with current conceptualizations of orbitofrontal cortex as supporting model-based behavior and suggest an unexpected role for this information in dopaminergic error signaling...
  17. ncbi request reprint Neuronal activity related to reward value and motivation in primate frontal cortex
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, Room 115, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Science 304:307-10. 2004
    ..Neuronal activity in orbitofrontal cortex represents the value of the expected reward, whereas neuronal activity in premotor cortex reflects the degree of motivation...
  18. pmc Associative encoding in posterior piriform cortex during odor discrimination and reversal learning
    Donna J Calu
    Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Cereb Cortex 17:1342-9. 2007
    ....
  19. pmc Reward prediction error signaling in posterior dorsomedial striatum is action specific
    Thomas A Stalnaker
    NIDA Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 32:10296-305. 2012
    ..This action-specific RPE-like signal could provide a mechanism for updating specific associative action representations in posterior dorsomedial striatum...
  20. pmc Neural correlates of variations in event processing during learning in central nucleus of amygdala
    Donna J Calu
    Program in Neuroscience, University of Maryland School of Medicine, 20 Penn St, HSF 2 S251, Baltimore, MD 21201, USA
    Neuron 68:991-1001. 2010
    ..These results indicate that CeA contributes to learning in response to reward omission due to a specific role in signaling actual omission rather than a more general involvement in signaling expectancies, errors, or reward value...
  21. pmc More is less: a disinhibited prefrontal cortex impairs cognitive flexibility
    Aaron J Gruber
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 30:17102-10. 2010
    ..02 mg/kg, i.p.) reduced the ability to switch only in control animals. We conclude that NVHL rats present PFC disinhibition, which affects neural information processing and the selection of appropriate behavioral responses...
  22. ncbi request reprint Impact of expected reward on neuronal activity in prefrontal cortex, frontal and supplementary eye fields and premotor cortex
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, Pittsburgh, Pennsylvania 15213 2683, USA
    J Neurophysiol 90:1766-89. 2003
    ....
  23. pmc A new perspective on the role of the orbitofrontal cortex in adaptive behaviour
    Geoffrey Schoenbaum
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Rev Neurosci 10:885-92. 2009
    ..We suggest that this function--signalling of expected outcomes--can also explain the crucial role of the OFC in changing behaviour in the face of unexpected outcomes...
  24. pmc Neural substrates of cognitive inflexibility after chronic cocaine exposure
    Thomas A Stalnaker
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 Room S251, Baltimore, MD 21201, USA
    Neuropharmacology 56:63-72. 2009
    ..These changes could explain cocaine-induced impairments to cognitive flexibility and may have theoretical importance in addiction...
  25. ncbi request reprint Neuronal activity in macaque SEF and ACC during performance of tasks involving conflict
    Kae Nakamura
    Center for the Neural Basis of Cognition, Mellon Institute, Pittsburgh, PA 15213 2683, USA
    J Neurophysiol 93:884-908. 2005
    ..In the ACC, there was no conflict-related enhancement. These results are incompatible with the idea that the SEF and ACC contain populations of neurons specialized for monitoring conflict...
  26. pmc Orbitofrontal cortex, decision-making and drug addiction
    Geoffrey Schoenbaum
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, HSF 2 S251, Baltimore, MD 21201, USA
    Trends Neurosci 29:116-24. 2006
    ....
  27. pmc Normal aging alters learning and attention-related teaching signals in basolateral amygdala
    Matthew R Roesch
    Department of Psychology, University of Maryland College Park, College Park, Maryland 20742, USA
    J Neurosci 32:13137-44. 2012
    ..These results indicate that normal aging alters teaching signals in the ABL. Changes in these teaching signals may contribute to a host of age-related cognitive changes...
  28. pmc Neural correlates of stimulus-response and response-outcome associations in dorsolateral versus dorsomedial striatum
    Thomas A Stalnaker
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA
    Front Integr Neurosci 4:12. 2010
    ..These results suggest that differences in information content in these two regions may not determine the differential roles they play in controlling behavior, demonstrated in previous studies...
  29. pmc Willingness to wait and altered encoding of time-discounted reward in the orbitofrontal cortex with normal aging
    Matthew R Roesch
    Department of Psychology, University of Maryland College Park, College Park, Maryland 20742, USA
    J Neurosci 32:5525-33. 2012
    ..These results suggest that natural aging results in altered representations of reward in orbitofrontal cortex. These changes may relate to the increased ability to delay gratification and reduced impulsivity associated with aging...