David Rodman

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Late diagnosis defines a unique population of long-term survivors of cystic fibrosis
    David M Rodman
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 171:621-6. 2005
  2. ncbi Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes
    David M Rodman
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circ Res 96:864-72. 2005
  3. ncbi Adenoviral gene transfer to the neonatal rat pulmonary circulation
    James West
    Center for Genetic Lung Disease, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Gene Med 6:734-9. 2004
  4. ncbi Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway
    Brian W Fouty
    Box C272, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 92:501-9. 2003
  5. ncbi Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    James West
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine and Department of Anesthesia, Denver, Colo 80262, USA
    Circ Res 94:1109-14. 2004
  6. ncbi Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic mice
    James West
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 128:553S. 2005
  7. ncbi Pseudomonas aeruginosa-human airway epithelial cell interaction: effects of iron on inflammation and apoptosis
    Milene Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:40S-41S. 2002
  8. ncbi Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
    Moira Hagen
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1473-9. 2007
  9. ncbi Chronic mucoid Pseudomonas aeruginosa cholangitis complicating ERCP in a CF patient
    Kristin Wallick
    University of Colorado Health Sciences Center, Denver, CO, USA
    J Cyst Fibros 1:99-101. 2002
  10. ncbi BMP signaling controls PASMC KV channel expression in vitro and in vivo
    Katharine A Young
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, Box B133, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L841-8. 2006

Research Grants

  1. HYPOXIA AND ET-1 EFFECT ON PA SMC EFFECT ON CHANNELS
    David Rodman; Fiscal Year: 2002
  2. NOS GENE TRANSFER IN PULMONARY HYPERTENSION
    David Rodman; Fiscal Year: 2002
  3. Effects of BMPRII Mutations in Pulmonary Hypertension
    David Rodman; Fiscal Year: 2004

Detail Information

Publications16

  1. ncbi Late diagnosis defines a unique population of long-term survivors of cystic fibrosis
    David M Rodman
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 171:621-6. 2005
    ..This is the largest cohort of older patients with CF described to date, and our findings indicate that patients diagnosed as adults differ distinctly from survivors of long-term CF diagnosed as children...
  2. ncbi Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes
    David M Rodman
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circ Res 96:864-72. 2005
    ..These studies establish that T-type voltage-operated Ca2+ channels are required for cell cycle progression and proliferation of human PA SMC...
  3. ncbi Adenoviral gene transfer to the neonatal rat pulmonary circulation
    James West
    Center for Genetic Lung Disease, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Gene Med 6:734-9. 2004
    ..CONCLUSIONS: We conclude that the neonatal pulmonary circulation can be effectively transduced using systemic adenoviral vector injection, has more sustained expression than liver, and may be a target for therapeutic gene delivery...
  4. ncbi Mevastatin can cause G1 arrest and induce apoptosis in pulmonary artery smooth muscle cells through a p27Kip1-independent pathway
    Brian W Fouty
    Box C272, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Circ Res 92:501-9. 2003
    ..These data suggest that HMG-CoA reductase inhibitors can both inhibit cell proliferation and induce apoptosis in PASMCs through p27Kip1-independent pathways and may be important therapeutic agents in pulmonary arterial hypertension...
  5. ncbi Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    James West
    University of Colorado Health Sciences Center, Division of Pulmonary Sciences and Critical Care Medicine and Department of Anesthesia, Denver, Colo 80262, USA
    Circ Res 94:1109-14. 2004
    ..Studies with SM22-tet-BMPRII(delx4+) mice support the hypothesis that loss of BMPRII signaling in smooth muscle is sufficient to produce the pulmonary hypertensive phenotype...
  6. ncbi Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic mice
    James West
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 128:553S. 2005
  7. ncbi Pseudomonas aeruginosa-human airway epithelial cell interaction: effects of iron on inflammation and apoptosis
    Milene Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:40S-41S. 2002
  8. ncbi Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle
    Moira Hagen
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1473-9. 2007
    ....
  9. ncbi Chronic mucoid Pseudomonas aeruginosa cholangitis complicating ERCP in a CF patient
    Kristin Wallick
    University of Colorado Health Sciences Center, Denver, CO, USA
    J Cyst Fibros 1:99-101. 2002
    ..The most likely mechanism of infection of the biliary tract was direct introduction of the upper respiratory tract pathogen during the diagnostic procedure...
  10. ncbi BMP signaling controls PASMC KV channel expression in vitro and in vivo
    Katharine A Young
    Center for Genetic Lung Disease, University of Colorado Health Sciences Center, Box B133, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L841-8. 2006
    ..These studies suggest that BMP regulates K(V) channel expression and that loss of this signaling pathway in PASMC through a mutation in BMPR2 is sufficient to cause pulmonary artery vasoconstriction...
  11. ncbi Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells
    Xiaojun Lu
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Pathol 165:1613-20. 2004
    ..These results suggest that TRAIL can induce apoptosis in premalignant cells and suggests a novel therapy for the treatment of premalignant lesions in vivo...
  12. ncbi Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease
    Milene T Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Am J Respir Crit Care Med 178:929-38. 2008
    ..Although the standard assessment of pulmonary treatment response is FEV(1), a measure of airflow limitation, the lack of systemic markers to reflect changes in lung inflammation critically limits the testing of proposed therapeutics...
  13. ncbi Manifestations of cystic fibrosis diagnosed in adulthood
    Jerry A Nick
    National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Curr Opin Pulm Med 11:513-8. 2005
    ..This review highlights the phenotypic features that lead to the diagnosis of cystic fibrosis in adults, and the prognosis of these patients...
  14. ncbi Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia
    Cynthia L Hartsfield
    Div of Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, 4200 East Ninth Ave, B 133, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 287:H2009-15. 2004
    ....
  15. ncbi Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop
    John H Newman
    Departments of Medicine, Nashville VA Medical Center (GRECC, and Vanderbilt University, Nashville, Tenn, USA
    Circulation 109:2947-52. 2004
  16. ncbi Nitric oxide and protein nitration in the cystic fibrosis airway
    Brian M Morrissey
    Division of Pulmonary and Critical Care Medicine, University of California, Davis and Department of Pulmonary Sciences and Critical Care Medicine, Sacramento, CA 95817, USA
    Arch Biochem Biophys 406:33-9. 2002
    ..The significance of altered NO metabolism and protein nitration in CF remains to be fully elucidated...

Research Grants12

  1. HYPOXIA AND ET-1 EFFECT ON PA SMC EFFECT ON CHANNELS
    David Rodman; Fiscal Year: 2002
    ....
  2. NOS GENE TRANSFER IN PULMONARY HYPERTENSION
    David Rodman; Fiscal Year: 2002
    ....
  3. Effects of BMPRII Mutations in Pulmonary Hypertension
    David Rodman; Fiscal Year: 2004
    ..We will have also tested the role of four pulmonary cell types, smooth muscle, endothelium, airway epithelium and macrophages in the link between BMPR2 and pulmonary hypertension. ..