Aylin R Rodan
Affiliation: University of Texas Southwestern Medical Center
Rodan A, Huang C. Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens. 2009;18:350-5 pubmed publisher
..Analysis of human and animal model data can generate hypotheses for future experiments. ..
Neyra J, Rocha N, Bhargava R, Vaidya O, Hendricks A, Rodan A. Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed to denosumab and abiraterone: a case report. BMC Nephrol. 2015;16:118 pubmed publisher
..Nonetheless, our report is hypothesis-generating for further investigations on the effect of these drugs on muscle cells. ..
Schellinger J, Rodan A. Use of the Ramsay Assay to Measure Fluid Secretion and Ion Flux Rates in the Drosophila melanogaster Malpighian Tubule. J Vis Exp. 2015;: pubmed publisher
..In summary, this technique allows the molecular characterization of basic mechanisms of epithelial ion transport in the Drosophila tubule, as well as regulation of these transport mechanisms. ..
Rodan A, Baum M, Huang C. The Drosophila NKCC Ncc69 is required for normal renal tubule function. Am J Physiol Cell Physiol. 2012;303:C883-94 pubmed publisher
..Thus, Ncc69 plays an important role in transepithelial ion and fluid transport in the fly renal tubule and is a target for regulation in antidiuretic states. ..
Wu Y, Schellinger J, Huang C, Rodan A. Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. J Biol Chem. 2014;289:26131-42 pubmed publisher
Wu Y, Baum M, Huang C, Rodan A. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Am J Physiol Regul Integr Comp Physiol. 2015;309:R747-56 pubmed publisher
..In conclusion, Irk1 and Irk2 play redundant roles in transepithelial ion transport in the Drosophila melanogaster renal tubule and are additive to Na(+)/K(+)-ATPase-dependent pathways. ..
Rodan A. Potassium: friend or foe?. Pediatr Nephrol. 2017;32:1109-1121 pubmed publisher
..In some patient populations, however, potassium excess is deleterious. Risk factors for the development of hyperkalemia will be reviewed, as well as the risks and benefits of existing and emerging therapies for hyperkalemia. ..