Research Topics
Species | Terry RobinsonSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Modulation of the induction or expression of psychostimulant sensitization by the circumstances surrounding drug administrationT E Robinson
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor 48109 1109, USA
Neurosci Biobehav Rev 22:347-54. 1998....- Neuroscience. Addicted ratsTerry E Robinson
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Science 305:951-3. 2004 - Manipulations during the second, but not the first, week of life increase susceptibility to cocaine self-administration in female ratsShelly B Flagel
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 28:1741-51. 2003..We conclude that the second week of life in the rodent is a sensitive period during which manipulations result in a more vulnerable phenotype for the acquisition of cocaine SA... - Structural plasticity associated with exposure to drugs of abuseTerry E Robinson
Department of Psychology Biopsychology and Neuroscience Program, The University of Michigan, 525 E University East Hall, Ann Arbor, MI 48109, USA
Neuropharmacology 47:33-46. 2004.... 
Review. The incentive sensitization theory of addiction: some current issuesTerry E Robinson
Department of Psychology, Biopsychology Program, The University of Michigan, East Hall, 530 Church Street, Ann Arbor, MI 48109 1109, USA
Philos Trans R Soc Lond B Biol Sci 363:3137-46. 2008..the development of addiction-like behaviour in animals associated with sensitization? What is the best way to model addiction symptoms using animal models? And, finally, what are the roles of affective pleasure or withdrawal in addiction?..- Dissociating the predictive and incentive motivational properties of reward-related cues through the study of individual differencesTerry E Robinson
Biopsychology Program, Department of Psychology, University of Michigan, East Hall, 530 Church Street, Ann Arbor, MI 48109, USA
Biol Psychiatry 65:869-73. 2009..Thus, CSs can have both predictive and incentive properties. We ask here whether it is possible to dissociate the predictive versus incentive properties of a CS in rats by considering individual differences in the nature of the CR... - Widespread but regionally specific effects of experimenter- versus self-administered morphine on dendritic spines in the nucleus accumbens, hippocampus, and neocortex of adult ratsTerry E Robinson
Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, MI 48109, USA
Synapse 46:271-9. 2002.... - AddictionTerry E Robinson
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
Annu Rev Psychol 54:25-53. 2003.... - Morphine alters the structure of neurons in the nucleus accumbens and neocortex of ratsT E Robinson
Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA
Synapse 33:160-2. 1999..It is suggested that some of the long-term behavioral consequences of repeated exposure to morphine may be due to its ability to reorganize patterns of synaptic connectivity in the forebrain... - Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaineT E Robinson
Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
Eur J Neurosci 11:1598-604. 1999.... - Incentive-sensitization and addictionT E Robinson
Department of Psychology Biopsychology Program, University of Michigan, 525 E University East Hall, Ann Arbor, MI 48109, USA
Addiction 96:103-14. 2001.... - Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortexT E Robinson
Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor, Michigan 48109, USA
Synapse 39:257-66. 2001..Together, these two classes of drug-induced neuroadaptations may contribute to the development of addiction... - The psychology and neurobiology of addiction: an incentive-sensitization viewT E Robinson
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor 48109, USA
Addiction 95:S91-117. 2000.... - The rate of cocaine administration alters gene regulation and behavioral plasticity: implications for addictionAnne Noël Samaha
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
J Neurosci 24:6362-70. 2004..We propose that rapidly delivered cocaine may be more addictive, in part, because this more readily induces forms of neurobehavioral plasticity that lead to the compulsive pursuit of drugs... - Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaineLisa A Briand
Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
Neuropsychopharmacology 33:2969-80. 2008.... - The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbensYilin Li
Department of Psychology (Biopsychology) and Neuroscience Program, The University of Michigan, East Hall, 525 East University, Ann Arbor, MI 48109-1109, USA
Eur J Neurosci 20:1647-54. 2004.... - Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine useCarrie R Ferrario
Department of Psychology (Biopsychology) and Neuroscience Program, University of Michigan, Ann Arbor, MIichigan 48109-1109, USA
Biol Psychiatry 58:751-9. 2005..CONCLUSIONS: The transition from stable to escalated cocaine use, a hallmark of addiction, is associated with especially robust behavioral sensitization and synaptic reorganization in the core of the nucleus accumbens... - Cocaine self-administration produces a persistent increase in dopamine D2 High receptorsLisa A Briand
Neuroscience Program, The University of Michigan, United States
Eur Neuropsychopharmacol 18:551-6. 2008..This may also help explain why stimuli that increase dopamine neurotransmission, including drugs themselves, are so effective in producing relapse in individuals with a history of exposure to cocaine... - Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impactAnne Noël Samaha
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 57:351-60. 2005..We hypothesized, therefore, that varying the rate of nicotine administration may modulate its ability to elicit this form of plasticity... - The rate of intravenous cocaine or amphetamine delivery does not influence drug-taking and drug-seeking behavior in ratsHans S Crombag
Department of Psychology and Neuroscience Program, The University of Michigan, 530 Church Street, Ann Arbor, MI 48109 1109, USA
Pharmacol Biochem Behav 90:797-804. 2008.... - Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental contextSusan M Ferguson
Neuroscience Program, University of Michigan, Ann Arbor 48109, USA
J Neurochem 86:33-44. 2003..stress), the striatal cell population engaged (Dyn-SP+ vs. Enk+ cells), and environmental context (home vs. novel cage)... - A cocaine cue acts as an incentive stimulus in some but not others: implications for addictionBenjamin T Saunders
Department of Psychology, Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109, USA
Biol Psychiatry 67:730-6. 2010..We asked, therefore, whether rats that have a propensity to attribute incentive salience to a food cue are the same ones that attribute incentive value to a drug (cocaine) cue... - The rate of intravenous cocaine administration determines susceptibility to sensitizationAnne-Noel Samaha
Department of Psychology (Biopsychology Program, The University of Michigan, Ann Arbor, Michigan 48109-1109, USA
J Neurosci 22:3244-50. 2002..This suggests that the temporal dynamics of drug delivery to the brain is a critical factor in the ability of cocaine to induce forms of neuronal plasticity that may contribute to addiction... - Dissecting components of reward: 'liking', 'wanting', and learningKent C Berridge
Department of Psychology, University of Michigan, Ann Arbor, 48109 1043, USA
Curr Opin Pharmacol 9:65-73. 2009.... - Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticitySusan M Ferguson
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
Neuropsychopharmacology 31:2660-8. 2006..Our results suggest that enhanced ERK2 signaling following repeated drug exposure may facilitate the development of forms of cocaine-induced plasticity that contribute to addiction... - Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of ratsShelly B Flagel
Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI, 48109 0720, USA
Psychopharmacology (Berl) 191:599-607. 2007..The way an individual responds to cues associated with rewards may be a key determinant of vulnerability to compulsive behavioral disorders... - Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behaviorCarrie R Ferrario
Department of Psychology Biopsychology, The University of Michigan, 530 Church Street, Ann Arbor, MI 48109 1304, USA
Eur Neuropsychopharmacol 17:352-7. 2007..This suggests that the neural circuits that are altered as a consequence of repeated amphetamine treatment, and the induction of sensitization, may overlap with those responsible for the development of some addiction-like behaviors... - Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice - mediation by enhanced incentive motivation?Jason M Uslaner
Biopsychology and Neuroscience Programs, Department of Psychology, University of Michigan, East Hall, 525 E University Street, Ann Arbor, MI 48019 1109, USA
Eur J Neurosci 24:2345-54. 2006..These findings suggest that the STN may serve as a novel target for the treatment of psychological disorders characterized by deficits in behavioral control, such as drug addiction and attention deficit hyperactivity disorder... - Quantifying the psychomotor activating effects of cocaine in the ratShelly B Flagel
Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
Behav Pharmacol 18:297-302. 2007..We report that the combination of these measures provides an especially sensitive measure of the psychomotor activating effects of cocaine, and how behavior changes as a consequence of repeated drug treatment... - Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitizationShelly B Flagel
Molecular and Behavioral Neuroscience Institute, The University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Behav Brain Res 186:48-56. 2008.... - An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addictionShelly B Flagel
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Neuropsychopharmacology 35:388-400. 2010.... - Individual differences in the attribution of incentive salience to reward-related cues: Implications for addictionShelly B Flagel
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
Neuropharmacology 56:139-48. 2009..It will be important, therefore, to study how environmental, neurobiological and genetic interactions determine the extent to which individuals attribute incentive value to reward-predictive stimuli... - Effects of maternal separation on behavioural sensitization produced by repeated cocaine administration in adulthoodYilin Li
Department of Psychology and Program in Neuroscience, The University of Michigan, 525 East University, Ann Arbor, MI 48109-1109, USA
Brain Res 960:42-7. 2003..Therefore, early maternal separation decreased susceptibility to behavioural sensitization produced by cocaine in adulthood and the specific duration of maternal separation had no effect on this outcome... - Cocaine-induced psychomotor activity is associated with its ability to induce c-fos mRNA expression in the subthalamic nucleus: effects of dose and repeated treatmentJason M Uslaner
Biopsychology Program, Department of Psychology, The University of Michigan, East Hall, 525 E. University St, Ann Arbor, MI 48019-1109, USA
Eur J Neurosci 17:2180-6. 2003..These findings may have implications concerning the neurobiological mechanisms underlying the behavioural effects of psychostimulant drugs... - Parsing rewardKent C Berridge
Department of Psychology, Biopsychology Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
Trends Neurosci 26:507-13. 2003..The challenge is to identify how different brain circuits mediate different psychological components of reward, and how these components interact... - Biological basis of sex differences in the propensity to self-administer cocaineMing Hu
Psychology Department, University of Michigan, Ann Arbor, MI 48109-1109, USA
Neuropsychopharmacology 29:81-5. 2004..These data demonstrate that both intrinsic sex differences in brain organization and the actions of circulating estradiol contribute to increased vulnerability for cocaine use in female subjects... - Subthalamic nucleus lesions enhance the psychomotor-activating, incentive motivational, and neurobiological effects of cocaineJason M Uslaner
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48019 1109, USA
J Neurosci 25:8407-15. 2005..Thus, the STN may serve as a novel target for therapeutic interventions aimed at treating drug dependence... - Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional labilityQiang Wei
Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 101:11851-6. 2004..This finding suggests that natural variations in GR gene expression can contribute to the fine-tuning of emotional stability or lability and may play a role in bipolar disorder... - Opposite effects of amphetamine self-administration experience on dendritic spines in the medial and orbital prefrontal cortexHans S Crombag
Department of Psychology, The University of Michigan, Ann Arbor, MI, USA
Cereb Cortex 15:341-8. 2005.... - Cue-induced reinstatement of food seeking in rats that differ in their propensity to attribute incentive salience to food cuesLindsay M Yager
Department of Psychology Biopsychology Program, The University of Michigan, East Hall, 530 Church St, Ann Arbor, MI 48109, USA
Behav Brain Res 214:30-4. 2010.... - Memory processes governing amphetamine-induced psychomotor sensitizationStephan G Anagnostaras
Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI, USA
Neuropsychopharmacology 26:703-15. 2002.... - The attribution of incentive salience to a stimulus that signals an intravenous injection of cocaineJason M Uslaner
Biopsychology and Neuroscience Programs, Department of Psychology, The University of Michigan, Ann Arbor, MI 48019-1109, USA
Behav Brain Res 169:320-4. 2006..Delineating the neurobiological mechanisms responsible for this process will be important for understanding and treating drug addiction... - Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascadeSusan M Ferguson
Neuroscience Program, University of Michigan, Ann Arbor, Michigan, USA
J Neurochem 91:337-48. 2004..We speculate that this may be one mechanism by which environmental context facilitates some forms of drug experience-dependent plasticity, such as psychomotor sensitization... - The location of persistent amphetamine-induced changes in the density of dendritic spines on medium spiny neurons in the nucleus accumbens and caudate-putamenYilin Li
Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
Neuropsychopharmacology 28:1082-5. 2003.... - The ability of amphetamine to evoke arc (Arg 3.1) mRNA expression in the caudate, nucleus accumbens and neocortex is modulated by environmental contextJennifer E Klebaur
Biopsychology and Neuroscience Programs, Department of Psychology, East Hall, 525 East University Street, Ann Arbor, MI 48109-1109, USA
Brain Res 930:30-6. 2002..This could contribute to the ability of environmental context to modulate forms of drug experience-dependent neuroplasticity, including behavioral sensitization... - Rats markedly escalate their intake and show a persistent susceptibility to reinstatement only when cocaine is injected rapidlyKen T Wakabayashi
Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:11346-55. 2010.... - Transient changes in nucleus accumbens amino acid concentrations correlate with individual responsivity to the predator fox odor 2,5-dihydro-2,4,5-trimethylthiazolineB Jill Venton
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
J Neurochem 96:236-46. 2006..Cocaine (2 mg/kg, i.v.) increased locomotion but not amino acid levels. This work demonstrates that rapid and transient increases in amino acid neurotransmitters correlate with behavioral reactivity to salient stimuli... - Morphine-induced c-fos mRNA expression in striatofugal circuits: modulation by dose, environmental context, and drug historySusan M Ferguson
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109-1109, USA
Neuropsychopharmacology 29:1664-74. 2004..We suggest that alterations in c-fos expression patterns in striatofugal circuits following morphine administration may be involved in drug-experience-dependent plasticity... - Sex differences and hormonal influences on acquisition of cocaine self-administration in ratsLisa R Jackson
Department of Psychiatry, The University of Michigan, Ann Arbor, MI 48109-1109, USA
Neuropsychopharmacology 31:129-38. 2006.... - Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamineLisa A Briand
Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
Learn Mem 12:553-6. 2005..Prior treatment with amphetamine eliminated this effect. These results indicate that living in a complex environment facilitates conditional freezing to an auditory CS, and that this effect is abolished by pretreatment with amphetamine... - Why does the rapid delivery of drugs to the brain promote addiction?Anne Noël Samaha
Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
Trends Pharmacol Sci 26:82-7. 2005..We conclude that rapidly delivered drugs might promote addiction by promoting forms of neurobehavioural plasticity that contribute to the compulsive pursuit of drugs... - Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotypeJason M Uslaner
Biopsychology and Neuroscience Programs, Department of Psychology, The University of Michigan, Ann Arbor, Michigan 48019, USA
J Neurochem 85:105-14. 2003.... - Monitoring dopamine in vivo by microdialysis sampling and on-line CE-laser-induced fluorescenceMinshan Shou
Department of Chemistry, Neuroscience Program, Department of Psychology, and Department of Pharmacology, 930 North University Avenue, University of Michigan, Ann Arbor, Michigan 48109, USA
Anal Chem 78:6717-25. 2006..Over 60 additional peaks were detected in the electropherograms, suggesting the potential for monitoring many other substances in vivo by this method... - Methamphetamine-induced structural plasticity in the dorsal striatumJakub P Jedynak
Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA
Eur J Neurosci 25:847-53. 2007.... - Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fearB Jill Venton
Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI 48109 1055, USA
Eur J Neurosci 23:3391-8. 2006..These experiments demonstrate glutamate and GABA levels in the amygdala are differentially modulated during auditory and contextual fear learning, and are transiently increased during the expression of fear memories... - Environmental complexity has different effects on the structure of neurons in the prefrontal cortex versus the parietal cortex or nucleus accumbensBryan Kolb
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada
Synapse 48:149-53. 2003..The data further suggest that it is prudent to measure both dendritic length and spine density in studies of experience-dependent effects on synaptic plasticity... - Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbensBryan Kolb
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
Proc Natl Acad Sci U S A 100:10523-8. 2003.... - Locomotor sensitization to cocaine is associated with increased Fos expression in the accumbens, but not in the caudateHans S Crombag
Behavioral Neuroscience Branch, The National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Behav Brain Res 136:455-62. 2002..These results provide the first parametric evidence for sensitization of cocaine-induced Fos expression in the accumbens... - A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalisHeidi E W Day
Psychology Department, University of Colorado, Boulder, CO 80309 0345, USA
Brain Res 945:151-9. 2002.... - Phenotypic and genetic characterization of patients with features of "nonclassic" forms of cystic fibrosisJoshua D Groman
Cyctic Fibrosis Foundation Genotyping Center and McKusick Nathans Institute of Genetic Medicine, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21287, USA
J Pediatr 146:675-80. 2005.... - Plasticity and functions of the orbital frontal cortexBryan Kolb
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
Brain Cogn 55:104-15. 2004..It is proposed that both drug-induced and developmental abnormalities in the integrity of OFC neurons may lead to deficits in social behavior or other behavioral pathologies, possibly including depression...
Research Grants
- NEURAL BASIS OF BEHAVIORAL SENSITIZATIONTerry Robinson; Fiscal Year: 2001..In summary, these studies should provide new insights into how drug-environment interactions can so dramatically alter drug effects, including liability to forms of drug-induced plasticity that may contribute to addiction. ..
- Gordon Conference on Catecholamines (2003)Terry Robinson; Fiscal Year: 2003....
- Influence of drugs of abuse on neuronal morphologyTerry Robinson; Fiscal Year: 2005....
- NEURAL BASIS OF BEHAVIORAL SENSITIZATIONTerry Robinson; Fiscal Year: 2007..We believe this two-pronged approach will yield important new insights into the psychology and neurobiology of addiction. ..
- NIDA TRAINING PROGRAM IN NEUROSCIENCETerry Robinson; Fiscal Year: 2007..They may also serve as co-mentors to students supported on the NIDA Training Grant. The NIDA Training Program is administered by a Director and 2 Co-Directors, with the continuing advice of a three member Executive Committee. ..
- NEURAL BASIS OF BEHAVIORAL SENSITIZATIONTerry Robinson; Fiscal Year: 2000....
- NEURAL BASIS OF BEHAVIORAL SENSITIZATIONTerry Robinson; Fiscal Year: 1990....
- THE NEURAL BASIS OF BEHAVIORAL SENSITIZATIONTerry Robinson; Fiscal Year: 1993....