JOHN MARSHALL ROBINSON

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Activation of striated muscle: nearest-neighbor regulatory-unit and cross-bridge influence on myofilament kinetics
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294 0005, USA
    J Mol Biol 322:1065-88. 2002
  2. pmc The cardiac Ca2+-sensitive regulatory switch, a system in dynamic equilibrium
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Biophys J 95:4772-89. 2008
  3. ncbi request reprint Switching of troponin I: Ca(2+) and myosin-induced activation of heart muscle
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 2041, USA
    J Mol Biol 340:295-305. 2004
  4. ncbi request reprint Can Förster resonance energy transfer measurements uniquely position troponin residues on the actin filament? A case study in multiple-acceptor FRET
    John M Robinson
    Department of Biochemistry and Molecular Genetics University of Alabama at Birmingham, 35294 2041, USA
    J Mol Biol 329:371-80. 2003
  5. ncbi request reprint Physical limits on computation by assemblies of allosteric proteins
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phys Rev Lett 101:178104. 2008
  6. ncbi request reprint Ca2+-induced conformational transition in the inhibitory and regulatory regions of cardiac troponin I
    Wen Ji Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham 35294 2041, USA
    J Biol Chem 278:8686-92. 2003
  7. ncbi request reprint Kinetics of conformational transitions in cardiac troponin induced by Ca2+ dissociation determined by Förster resonance energy transfer
    Wen Ji Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, AL 35294 0005, USA
    J Biol Chem 278:42394-402. 2003
  8. ncbi request reprint Ultrathin cryosections: an important tool for immunofluorescence and correlative microscopy
    Toshihiro Takizawa
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Histochem Cytochem 51:707-14. 2003
  9. pmc Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 425 Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Clin Immunol 122:146-55. 2007
  10. ncbi request reprint Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 136:2993-8. 2006

Research Grants

  1. Allosteric Regulation of Myocardial Contraction
    JOHN MARSHALL ROBINSON; Fiscal Year: 2011

Collaborators

  • Wen Ji Dong
  • Ying Wang
  • Jonghan Kim
  • Clark L Anderson
  • William L Hayton
  • Chaity Chaudhury
  • Toshihiro Takizawa
  • Tatiana M Oberyszyn
  • Samina Mehnaz
  • Sudhasri Mohanty
  • C L Bronson
  • Manzoor A Wani

Detail Information

Publications10

  1. ncbi request reprint Activation of striated muscle: nearest-neighbor regulatory-unit and cross-bridge influence on myofilament kinetics
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 35294 0005, USA
    J Mol Biol 322:1065-88. 2002
    ..The model is an initial attempt to construct a general theory of striated muscle activation-one that can be consistently used to interpret data from various types of muscle manipulation experiments...
  2. pmc The cardiac Ca2+-sensitive regulatory switch, a system in dynamic equilibrium
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Biophys J 95:4772-89. 2008
    ..110 kJ/mol/K), heat capacity change (DeltaC(p) = -7.6 kJ/mol/K), the enthalpy of activation (delta(double dagger) = 10.6 kJ/mol) and the effective barrier crossing attempt frequency (nu(adj) = 1.8 x 10(4) s(-1))...
  3. ncbi request reprint Switching of troponin I: Ca(2+) and myosin-induced activation of heart muscle
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 2041, USA
    J Mol Biol 340:295-305. 2004
    ..Strong cross-bridges eliminate cooperativity and re-sensitize the CRS to Ca(2+). We propose a kinetic scheme and a structural model to account for these findings...
  4. ncbi request reprint Can Förster resonance energy transfer measurements uniquely position troponin residues on the actin filament? A case study in multiple-acceptor FRET
    John M Robinson
    Department of Biochemistry and Molecular Genetics University of Alabama at Birmingham, 35294 2041, USA
    J Mol Biol 329:371-80. 2003
    ..3A, laterally along the actin surface toward actin subdomain 3 by 22.0A, and azimuthally toward the actin inner domain by 13.2A. This information is used to construct a low-resolution structural model of thin filament activation...
  5. ncbi request reprint Physical limits on computation by assemblies of allosteric proteins
    John M Robinson
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Phys Rev Lett 101:178104. 2008
    ..As a result, signaling fidelity and deactivation kinetics cannot be simultaneously optimized. This imposes an upper limit on the rate of information processing by assemblies of allosteric proteins that couple to a single ligand type...
  6. ncbi request reprint Ca2+-induced conformational transition in the inhibitory and regulatory regions of cardiac troponin I
    Wen Ji Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham 35294 2041, USA
    J Biol Chem 278:8686-92. 2003
    ..We have used the data to construct a structural model of the cTnI inhibitory and regulatory regions in the Mg(2+)- and Ca(2+)-saturated states...
  7. ncbi request reprint Kinetics of conformational transitions in cardiac troponin induced by Ca2+ dissociation determined by Förster resonance energy transfer
    Wen Ji Dong
    Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, AL 35294 0005, USA
    J Biol Chem 278:42394-402. 2003
    ..The kinetic results define the magnitudes of structural changes relevant in Ca2+ switching between activation and deactivation of cardiac muscle contraction...
  8. ncbi request reprint Ultrathin cryosections: an important tool for immunofluorescence and correlative microscopy
    Toshihiro Takizawa
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Histochem Cytochem 51:707-14. 2003
    ..Using a particle counting procedure and electron microscopy, we compared the labeling obtained with colloidal gold and FluoroNanogold and found a higher number of particles with silver-enhanced FluoroNanogold than with colloidal gold...
  9. pmc Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model
    Jonghan Kim
    Department of Internal Medicine, The Ohio State University, 425 Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Clin Immunol 122:146-55. 2007
    ..A simulation study demonstrates that the plasma concentrations of IgG and albumin could be dynamically controlled by both FcRn-related and -unrelated parameters...
  10. ncbi request reprint Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 136:2993-8. 2006
    ....

Research Grants1

  1. Allosteric Regulation of Myocardial Contraction
    JOHN MARSHALL ROBINSON; Fiscal Year: 2011
    ..The goal of this project is to establish mechanism of cooperative myofilament activation (Aim 1) and to establish the mechanism of altered myofilament sensitivity to Ca2+ (Aim II). ..