DIANE ROBINS

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Androgen receptor gene polymorphisms and alterations in prostate cancer: of humanized mice and men
    Diane M Robins
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 5618, USA
    Mol Cell Endocrinol 352:26-33. 2012
  2. pmc Androgen receptor variants and prostate cancer in humanized AR mice
    Diane M Robins
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    J Steroid Biochem Mol Biol 108:230-6. 2008
  3. ncbi request reprint Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice
    Megan A Albertelli
    Department of Human Genetics, 4909 Buhl Bldg, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    Mol Endocrinol 20:1248-60. 2006
  4. pmc Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model
    Zhigang Yu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0605, USA
    J Clin Invest 116:2663-72. 2006
  5. ncbi request reprint Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice
    Megan A Albertelli
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    Hum Mol Genet 17:98-110. 2008
  6. pmc Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
    Zhigang Yu
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Dis Model Mech 2:500-7. 2009
  7. ncbi request reprint Adapter annealing to engineer restriction enzyme sites at cloning junctions
    Christopher J Krebs
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Anal Biochem 350:313-5. 2006
  8. pmc The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer
    Andrew P Lieberman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Alzheimers Dis 14:247-55. 2008
  9. pmc Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein
    Zhigang Yu
    Department of Pathology, University of Michigan Medical School, 1301 Catherine, 4233 Medical Science 1, Ann Arbor, Michigan 48109, USA
    Am J Pathol 168:195-204. 2006
  10. pmc Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer
    Orla A O'Mahony
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5618, USA
    Mol Cancer Res 6:1691-701. 2008

Collaborators

Detail Information

Publications18

  1. pmc Androgen receptor gene polymorphisms and alterations in prostate cancer: of humanized mice and men
    Diane M Robins
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 5618, USA
    Mol Cell Endocrinol 352:26-33. 2012
    ..Regardless of their frequency, these variants permute normal function to reveal novel means to target wild type AR and its key interacting partners...
  2. pmc Androgen receptor variants and prostate cancer in humanized AR mice
    Diane M Robins
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    J Steroid Biochem Mol Biol 108:230-6. 2008
    ..These mice provide a novel genetic paradigm in which to dissect opposing functions of AR in tumor suppression versus oncogenesis...
  3. ncbi request reprint Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice
    Megan A Albertelli
    Department of Human Genetics, 4909 Buhl Bldg, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    Mol Endocrinol 20:1248-60. 2006
    ..This h/mAR allelic series in a homogeneous mouse genetic background allows examination of numerous physiological traits for Q tract influences and provides an animal model to test novel drugs targeted specifically to human AR...
  4. pmc Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model
    Zhigang Yu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0605, USA
    J Clin Invest 116:2663-72. 2006
    ..These data define an important myopathic contribution to the Kennedy disease phenotype and suggest a role for muscle in non-cell autonomous toxicity of lower motor neurons...
  5. ncbi request reprint Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice
    Megan A Albertelli
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    Hum Mol Genet 17:98-110. 2008
    ....
  6. pmc Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
    Zhigang Yu
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Dis Model Mech 2:500-7. 2009
    ....
  7. ncbi request reprint Adapter annealing to engineer restriction enzyme sites at cloning junctions
    Christopher J Krebs
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Anal Biochem 350:313-5. 2006
  8. pmc The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer
    Andrew P Lieberman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Alzheimers Dis 14:247-55. 2008
    ..This series of mice with different Ar alleles has provided insights into the mechanisms by which variations in the CAG/glutamine tract length influence the occurrence of human disease...
  9. pmc Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein
    Zhigang Yu
    Department of Pathology, University of Michigan Medical School, 1301 Catherine, 4233 Medical Science 1, Ann Arbor, Michigan 48109, USA
    Am J Pathol 168:195-204. 2006
    ..Our data demonstrate that toxic effects of the mutant protein mediate aspects of the Kennedy disease phenotype previously attributed to a loss of AR function...
  10. pmc Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer
    Orla A O'Mahony
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5618, USA
    Mol Cancer Res 6:1691-701. 2008
    ..This suggests that alleles that are loss of function during development may still activate a subset of AR targets to become gain of function in tumorigenesis. Mutant ARs may thus use multiple mechanisms to evade cancer treatment...
  11. pmc Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy
    Mara P Steinkamp
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 5618, USA
    Cancer Res 69:4434-42. 2009
    ..Thus, treatment with antiandrogens selects for gain-of-function AR mutations with altered stability, promoter preference, or ligand specificity. These processes reveal multiple targets for effective therapies regardless of AR mutation...
  12. ncbi request reprint Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct
    M Ivelisse Gonzalez
    Department of Human Genetics, 4909 Buhl Bldg, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    Mol Cell Endocrinol 190:39-49. 2002
    ....
  13. ncbi request reprint Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
  14. ncbi request reprint The regulator of sex-limitation gene, rsl, enforces male-specific liver gene expression by negative regulation
    Kathryn M Tullis
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    Endocrinology 144:1854-60. 2003
    ..This characterization suggests Rsl functions to repress transcription of a set of genes that have in common their hormonal induction in male liver, and thus accentuates sexual dimorphism of liver gene expression...
  15. ncbi request reprint Multiple mechanisms of male-specific gene expression: lessons from the mouse sex-limited protein (Slp) gene
    Diane M Robins
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Prog Nucleic Acid Res Mol Biol 78:1-36. 2004
  16. ncbi request reprint Androgen receptor and molecular mechanisms of male-specific gene expression
    Diane M Robins
    Department of Human Genetics, 4909 Buhl Building, University of Michigan Medical School, Ann Arbor, MI 48109 0618, USA
    Novartis Found Symp 268:42-52; discussion 53-6, 96-9. 2005
    ..This sex-specific expression is further enforced by a novel class of KRAB zinc finger repressors. Their variation between species evidences diverging mechanisms of sexual differentiation, echoing AR's own recent origin...
  17. pmc A pair of mouse KRAB zinc finger proteins modulates multiple indicators of female reproduction
    Christopher J Krebs
    Department of Human Genetics, University of Michigan Medical School, 1241 E Catherine St, Ann Arbor, MI 48109 5618, USA
    Biol Reprod 82:662-8. 2010
    ..The large and rapidly diversifying KRAB-ZFP family may modulate biological processes, including reproduction, to confer individual differences that may isolate populations and ultimately lead to speciation...
  18. ncbi request reprint Androgens and prostate cancer: are the descriptors valid?
    Pradip Roy-Burman
    Cancer Biol Ther 4:4-5. 2005
    ..It is thus suggested that "androgen-independent (AI)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer...

Research Grants15

  1. RSL, A NOVEL REGULATOR OF SEXUALLY DIMORPHIC LIVER GENES
    DIANE ROBINS; Fiscal Year: 2007
    ..Our results will be broadly significant to mechanisms that establish and maintain gene silencing. ..
  2. MECHANISM OF STEROID SPECIFIC GENE ACTIVATION
    DIANE ROBINS; Fiscal Year: 2003
    ..For prostate cancer particularly, identification of cell-specific factors required for androgen action may have crucial value for future prognosis and therapies. ..
  3. RSL, A NOVEL REGULATOR OF SEXUALLY DIMORPHIC LIVER GENES
    DIANE ROBINS; Fiscal Year: 2002
    ..Establishing the basis of the Rsl pathway will enhance our understanding of basic mechanisms of gene expression. Further, Rsl control in mice may yield unique insights into regulation of liver genes in humans. ..
  4. Genetic Dissection of Context-Dependent and Opposing Roles of Androgen Receptor
    Diane M Robins; Fiscal Year: 2010
    ....