Robey R, Raval B, Ma J, Santos A. Thrombin is a novel regulator of hexokinase activity in mesangial cells. Kidney Int. 2000;57:2308-18 pubmed
..As such, thrombin is a novel regulator of HK activity in mesangial cells and may play a role in coupling renal injury to metabolism. ..
Robey R, Ma J, Santos A, Noboa O, Coy P, Bryson J. Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-ac. J Biol Chem. 2002;277:14370-8 pubmed
..These findings suggest a novel mechanism whereby growth factors may couple metabolism to glomerular injury. ..