R Brooks Robey

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint pH-dependent fluorescence of a heterologously expressed Aequorea green fluorescent protein mutant: in situ spectral characteristics and applicability to intracellular pH estimation
    R B Robey
    Department of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine 60612, USA
    Biochemistry 37:9894-901. 1998
  2. ncbi request reprint Mitochondrial hexokinases: guardians of the mitochondria
    R Brooks Robey
    Department of Medicine, University of Illinois at Chicago, 60607 7170, USA
    Cell Cycle 4:654-8. 2005
  3. ncbi request reprint Caveat experimentor: reporting expression profiling data involving multiple, functionally redundant isoforms
    R Brooks Robey
    University of Illinois at Chicago College of Medicine and VA Chicago Health Care System, Chicago, Illinois 60612, USA
    J Leukoc Biol 74:307-8; author reply: 309-10. 2003
  4. ncbi request reprint Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
    R Brooks Robey
    Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:14370-8. 2002
  5. ncbi request reprint Regulation of mesangial cell hexokinase activity by PKC and the classic MAPK pathway
    R B Robey
    Department of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Am J Physiol 277:F742-9. 1999
  6. ncbi request reprint Thrombin is a novel regulator of hexokinase activity in mesangial cells
    R B Robey
    Department of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine and VA Chicago Health Care System, West Side Division, Chicago, Illinois 60612 7315, USA
    Kidney Int 57:2308-18. 2000
  7. ncbi request reprint LPA is a novel lipid regulator of mesangial cell hexokinase activity and HKII isoform expression
    Platina E Coy
    Section of Nephrology, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612 7315, USA
    Am J Physiol Renal Physiol 283:F271-9. 2002
  8. ncbi request reprint Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    Nathan Majewski
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell 16:819-30. 2004
  9. ncbi request reprint Proinflammatory interleukin-1 cytokines increase mesangial cell hexokinase activity and hexokinase II isoform abundance
    Navin Taneja
    Dept of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine, 820 South Wood Street, Rm 418W CSN M C 793, Chicago, IL 60612 7315, USA
    Am J Physiol Cell Physiol 287:C548-57. 2004
  10. ncbi request reprint Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death
    Jane M Bryson
    Department of Medicine, College of Medicine, University of Illinois, Chicago 60612, USA
    J Biol Chem 277:11392-400. 2002

Collaborators

  • Nissim Hay
  • Veronique Nogueira
  • J Ma
  • Markku Laakso
  • Qi Wang
  • William J Muller
  • Navdeep S Chandel
  • A A Bernardo
  • Krushna C Patra
  • Platina E Coy
  • Prashanth T Bhaskar
  • Nathan Majewski
  • Jane M Bryson
  • Navin Taneja
  • Robert E Carroll
  • Iris Lee
  • Kathrin Gottlob
  • Doris Joy D Espiritu
  • Michelle F Clasquin
  • Abhishek K Jha
  • Luke Miller
  • Eric L Allen
  • Will Wheaton
  • Zebin Wang
  • Gromoslaw A Smolen
  • Terry G Unterman
  • Steven M Swanson
  • Sang Min Jeon
  • Aleksandra J Poole
  • Angela L Tyner
  • Robert A Goodlad
  • Youngkyu Park
  • Prashanth Bhaskar
  • Jennifer E Skeen
  • Craig B Thompson
  • Claudie Hecquet
  • Jose A L Arruda

Detail Information

Publications15

  1. ncbi request reprint pH-dependent fluorescence of a heterologously expressed Aequorea green fluorescent protein mutant: in situ spectral characteristics and applicability to intracellular pH estimation
    R B Robey
    Department of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine 60612, USA
    Biochemistry 37:9894-901. 1998
    ....
  2. ncbi request reprint Mitochondrial hexokinases: guardians of the mitochondria
    R Brooks Robey
    Department of Medicine, University of Illinois at Chicago, 60607 7170, USA
    Cell Cycle 4:654-8. 2005
    ..We also propose that this "guardian" function of mtHK may be specifically exploited for therapeutic purposes...
  3. ncbi request reprint Caveat experimentor: reporting expression profiling data involving multiple, functionally redundant isoforms
    R Brooks Robey
    University of Illinois at Chicago College of Medicine and VA Chicago Health Care System, Chicago, Illinois 60612, USA
    J Leukoc Biol 74:307-8; author reply: 309-10. 2003
  4. ncbi request reprint Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
    R Brooks Robey
    Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:14370-8. 2002
    ..These findings suggest a novel mechanism whereby growth factors may couple metabolism to glomerular injury...
  5. ncbi request reprint Regulation of mesangial cell hexokinase activity by PKC and the classic MAPK pathway
    R B Robey
    Department of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Am J Physiol 277:F742-9. 1999
    ..Mesangial cell HK activity thus exhibits novel regulatory behavior involving both PKC and classic MAPK pathway activation, suggesting specific mechanisms whereby PKC activation may influence Glc metabolism...
  6. ncbi request reprint Thrombin is a novel regulator of hexokinase activity in mesangial cells
    R B Robey
    Department of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine and VA Chicago Health Care System, West Side Division, Chicago, Illinois 60612 7315, USA
    Kidney Int 57:2308-18. 2000
    ..Thrombin, a known activator of both PKC and ERK1/2, is increased in the settings of renal injury and diabetes. Thus, thrombin may contribute to the observed changes in HK activity in vivo...
  7. ncbi request reprint LPA is a novel lipid regulator of mesangial cell hexokinase activity and HKII isoform expression
    Platina E Coy
    Section of Nephrology, Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612 7315, USA
    Am J Physiol Renal Physiol 283:F271-9. 2002
    ..They also suggest a novel mechanism whereby metabolism may be coupled to cellular injury via extracellular lipid mediators...
  8. ncbi request reprint Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    Nathan Majewski
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell 16:819-30. 2004
    ....
  9. ncbi request reprint Proinflammatory interleukin-1 cytokines increase mesangial cell hexokinase activity and hexokinase II isoform abundance
    Navin Taneja
    Dept of Medicine, Section of Nephrology, University of Illinois at Chicago College of Medicine, 820 South Wood Street, Rm 418W CSN M C 793, Chicago, IL 60612 7315, USA
    Am J Physiol Cell Physiol 287:C548-57. 2004
    ..These findings suggest a novel, previously undescribed mechanism whereby metabolism may be coupled to inflammation and injury...
  10. ncbi request reprint Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death
    Jane M Bryson
    Department of Medicine, College of Medicine, University of Illinois, Chicago 60612, USA
    J Biol Chem 277:11392-400. 2002
    ..These findings also support the contention that HKs contribute to the protective effects of growth factors...
  11. pmc mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition
    Prashanth T Bhaskar
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Cell Biol 29:5136-47. 2009
    ..Consistently, the reduction of eIF4E levels abrogates the resistance of Tsc2(-/)(-) cells to serum deprivation-induced apoptosis...
  12. pmc Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
    Nathan Majewski
    Department of Biochemistry and Molecular Genetics M C 669, College of Medicine, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Mol Cell Biol 24:730-40. 2004
    ..These results suggest that Akt inhibits BID-mediated apoptosis downstream of BID cleavage via promotion of mitochondrial hexokinase association and antagonism of tBID-mediated BAX and BAK activation at the mitochondria...
  13. ncbi request reprint A central role for Pyk2-Src interaction in coupling diverse stimuli to increased epithelial NBC activity
    Doris Joy D Espiritu
    Section of Nephrology, Department of Medicine, University of Illinois at Chicago, 60612, USA
    Am J Physiol Renal Physiol 283:F663-70. 2002
    ..We conclude that Pyk2 plays a central role in coupling carbachol, ANG II, and CO(2) to increased NBC activity. This coupling is mediated by Pyk2 autophosphorylation and Pyk2-Src interaction...
  14. pmc Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
    Krushna C Patra
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    Cancer Cell 24:213-28. 2013
    ..Hk2 deletion in lung cancer cells suppressed glucose-derived ribonucleotides and impaired glutamine-derived carbon utilization in anaplerosis...
  15. pmc Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats
    Robert E Carroll
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Growth Horm IGF Res 19:447-56. 2009
    ....