Ian F Robey

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Human monoclonal natural autoantibodies against the T-cell receptor inhibit interleukin-2 production in murine T cells
    Ian F Robey
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Immunology 105:419-29. 2002
  2. pmc Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    Ian F Robey
    Department of Biochemistry and Molecular Biophysics, University of Arizona Cancer Center, Tucson, AZ 85724, USA
    Neoplasia 7:324-30. 2005
  3. pmc Investigating mechanisms of alkalinization for reducing primary breast tumor invasion
    Ian F Robey
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    Biomed Res Int 2013:485196. 2013
  4. pmc Examining the relationship between diet-induced acidosis and cancer
    IAN FORREST ROBEY
    Arizona Respiratory Center, University of Arizona, 1501 N, Campbell Ave, Suite 2349, PO Box 245030, Tucson, Arizona 85724, USA
    Nutr Metab (Lond) 9:72. 2012
  5. pmc Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer
    Ian F Robey
    Arizona Respiratory Center, University of Arizona, Tucson, USA
    BMC Cancer 11:235. 2011
  6. pmc Regulation of the Warburg effect in early-passage breast cancer cells
    Ian F Robey
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 10:745-56. 2008
  7. pmc Bicarbonate increases tumor pH and inhibits spontaneous metastases
    Ian F Robey
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Cancer Res 69:2260-8. 2009
  8. ncbi request reprint Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo
    Benedicte F Jordan
    Department of Biochemistry and Molecular Biophysics, Arizona Cancer Center, Tucson, AZ 85724, USA
    NMR Biomed 18:430-9. 2005
  9. ncbi request reprint Natural and autoantibodies to human T-cell receptor Vbeta segments: potential roles in immunomodulation
    Miranda K Adelman
    Arizona Arthritis Center, University of Arizona, Tucson, AZ 85724, USA
    Crit Rev Immunol 27:221-32. 2007
  10. ncbi request reprint Specificity mapping of human anti-T cell receptor monoclonal natural antibodies: defining the properties of epitope recognition promiscuity
    Ian F Robey
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    FASEB J 16:642-52. 2002

Detail Information

Publications11

  1. pmc Human monoclonal natural autoantibodies against the T-cell receptor inhibit interleukin-2 production in murine T cells
    Ian F Robey
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Immunology 105:419-29. 2002
    ....
  2. pmc Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    Ian F Robey
    Department of Biochemistry and Molecular Biophysics, University of Arizona Cancer Center, Tucson, AZ 85724, USA
    Neoplasia 7:324-30. 2005
    ..This hypothesis was tested by renormalizing HIF-1alpha levels in renal carcinoma cells, leading to inhibition of aerobic glycolysis...
  3. pmc Investigating mechanisms of alkalinization for reducing primary breast tumor invasion
    Ian F Robey
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    Biomed Res Int 2013:485196. 2013
    ..003). Alkalinization, however, did not affect expression of carbonic anhydrase IX (CAIX). The findings suggest a possible mechanism in a live model system for breast cancer where systemic alkalinization slows the rate of invasion. ..
  4. pmc Examining the relationship between diet-induced acidosis and cancer
    IAN FORREST ROBEY
    Arizona Respiratory Center, University of Arizona, 1501 N, Campbell Ave, Suite 2349, PO Box 245030, Tucson, Arizona 85724, USA
    Nutr Metab (Lond) 9:72. 2012
    ..This review defines the relationship between dietary lifestyle and acid-base balance and discusses the potential consequences of diet-induced acidosis and cancer occurrence or progression...
  5. pmc Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer
    Ian F Robey
    Arizona Respiratory Center, University of Arizona, Tucson, USA
    BMC Cancer 11:235. 2011
    ..While these findings are compelling, recent assessments into the use of oral bicarbonate as a cancer intervention reveal limitations...
  6. pmc Regulation of the Warburg effect in early-passage breast cancer cells
    Ian F Robey
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 10:745-56. 2008
    ..Glycolysis was affected by pharmacological regulation of c-Myc and HIF-1alpha. These findings suggest that c-Myc and/or HIF-1alpha activities are both involved in the regulation of glycolysis in breast cancers...
  7. pmc Bicarbonate increases tumor pH and inhibits spontaneous metastases
    Ian F Robey
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Cancer Res 69:2260-8. 2009
    ..Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease...
  8. ncbi request reprint Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo
    Benedicte F Jordan
    Department of Biochemistry and Molecular Biophysics, Arizona Cancer Center, Tucson, AZ 85724, USA
    NMR Biomed 18:430-9. 2005
    ....
  9. ncbi request reprint Natural and autoantibodies to human T-cell receptor Vbeta segments: potential roles in immunomodulation
    Miranda K Adelman
    Arizona Arthritis Center, University of Arizona, Tucson, AZ 85724, USA
    Crit Rev Immunol 27:221-32. 2007
    ..10) to produce IL-2 in response to antigenic stimulation in vitro. These results support the hypothesis that autoantibodies against TCR Vbeta can shut down TH1-mediated inflammatory autodestructive reactions...
  10. ncbi request reprint Specificity mapping of human anti-T cell receptor monoclonal natural antibodies: defining the properties of epitope recognition promiscuity
    Ian F Robey
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    FASEB J 16:642-52. 2002
    ..Our results support the conclusion that epitope recognition promiscuity is a genuine feature of antibody and TCR recognition...
  11. ncbi request reprint Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice
    Ian F Robey
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:4624-9. 2004
    ..We suggest that the paucity of autoreactive specificities created in the N region-lacking repertoire, and the resultant protection afforded to the newborn, may be the reason that TdT expression is delayed in ontogeny...