Research Topics
Genomes and Genes | Ellen A RobeySummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Visualizing thymocyte motility using 2-photon microscopyEllen A Robey
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Immunol Rev 195:51-7. 2003..In this review, we discuss the implications of thymocyte motility for T-cell repertoire selection and for the mechanisms that determine the spatial organization of thymocyte subsets within the thymus...
Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph nodeTatyana Chtanova
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA
Immunity 31:342-55. 2009..Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response...- Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortexEna Ladi
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
J Immunol 181:7014-23. 2008..These observations identify a vasculature-associated microenvironment within the thymic cortex that promotes interactions between DCs and thymocytes that are receiving positive selection signals... - CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decisionXinye Yin
Department of Molecular and Cell Biology, Division of Immunology, University of California, Berkeley, CA 94720, USA
J Immunol 179:7358-64. 2007..These findings suggest that the timing of CCR7 expression relative to coreceptor down-regulation is regulated by lineage commitment signals... - Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondiiMarie Schaeffer
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
J Immunol 182:6379-93. 2009..Our data represent the first direct observation of the dynamics of T cell-parasite interactions within living tissue and provide a new perspective for understanding immune responses to persistent pathogens in the brain... 
The impact of negative selection on thymocyte migration in the medullaMarie Le Borgne
Department of Molecular and Cell Biology, University of California, Berkeley, USA
Nat Immunol 10:823-30. 2009..Our data suggest that many autoreactive thymocytes do not undergo immediate arrest and death after encountering a negative selecting ligand but instead adopt an altered migration program while remaining in the medullary microenvironment...- Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1Jennifer O Manilay
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
J Immunol 174:6732-41. 2005..Our data suggest that multiple Notch-dependent steps in early thymocyte development require Kuzbanian, but differ in the involvement of other Notch signaling components... - Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulumNicolas Blanchard
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nat Immunol 9:937-44. 2008..gondii-infected ERAAP-deficient mice, which were more susceptible to toxoplasmosis. Thus, endoplasmic reticulum proteolysis is critical for eliciting protective immunity to a vacuolar parasite... - Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissuesHeather J Melichar
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
Immunol Cell Biol 89:549-57. 2011..These approaches could be readily adapted to other fluorescent fusion proteins, tissues and biological questions... - The Toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burdenHarshita Satija Grover
Division of Immunology and Pathogenesis, Department of Molecular and Cellular Biology, University of California, Berkeley, California, USA
Infect Immun 80:3279-88. 2012.... - Thymic microenvironments for T cell differentiation and selectionEna Ladi
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nat Immunol 7:338-43. 2006..In addition, we discuss the diverse developmental signals provided by these microenvironments that contribute to the generation of divergent T cell lineages... - Directed migration of positively selected thymocytes visualized in real timeColleen M Witt
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
PLoS Biol 3:e160. 2005..These studies provide our first glimpse into the dynamics of developmentally programmed, long-range cell migration in the mammalian thymus... - Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosisStephanie L Osborn
Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 107:13034-9. 2010..We conclude that FADD constitutes a mechanism to keep TCR-induced programmed necrotic signaling in check during early phases of T-cell clonal expansion... - The Notch regulator Numb links the Notch and TCR signaling pathwaysAna C Anderson
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
J Immunol 174:890-7. 2005..Together our data suggest that Notch and TCR signals may be integrated at the cell membrane, and that Numb may be an important adapter in this process... - Thymopoiesis in 4 dimensionsColleen M Witt
Division of Immunology, Department of Molecular and Cell Biology, 479 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
Semin Immunol 17:95-102. 2005..We also discuss new imaging technologies and interdisciplinary approaches and discuss how the promise they offer to addressing these questions... - Two-photon imaging of the immune systemIvan L Dzhagalov
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
Curr Protoc Cytom . 2012..In this unit, we provide several protocols for preparation of various organs for imaging by two-photon microscopy that are intended to introduce the new user to some basic aspects of this method... - Dynamics of neutrophil migration in lymph nodes during infectionTatyana Chtanova
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA
Immunity 29:487-96. 2008..Our data provide insights into the cellular mechanisms underlying neutrophil swarming and suggest new roles for neutrophils in shaping immune responses... - Comparative study of hematopoietic differentiation between human embryonic stem cell linesHeather Melichar
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
PLoS ONE 6:e19854. 2011..These data underscore the difficulties in the current strategy of hESC forward differentiation and highlight distinct differences between CD34(+) hematopoietic precursors generated in vitro versus in vivo... - Thymocyte motility: mutants, movies and migration patternsXinye Yin
Division of Immunology, Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
Curr Opin Immunol 18:191-7. 2006.... - Dynamic repositioning of CD4 and CD8 genes during T cell developmentStephanie Delaire
Department of Molecular and Cell Biology, 475 Life Science Additions, University of California, Berkeley, Berkeley, CA 94720, USA
J Exp Med 200:1427-35. 2004..We discuss our results in terms of our current knowledge of CD4 and CD8 gene regulation and CD4 versus CD8 lineage commitment... - Dynamic imaging of host-pathogen interactions in vivoJanine L Coombes
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California 94720, USA
Nat Rev Immunol 10:353-64. 2010..Here we discuss how dynamic imaging of in vivo infection has revealed fascinating and unexpected details of host-pathogen interactions at a new level of spatial and temporal resolution... - Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinusJanine L Coombes
Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
Cell Rep 2:124-35. 2012..Our data reveal pathways through which NK cell migration and function are regulated after infection and identify an important accessory cell population for activation of NK cell responses in lymph nodes... - Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondiiMarc-Jan Gubbels
Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California-Berkeley, Berkeley, CA 94720, USA
Infect Immun 73:703-11. 2005.... - The ins and outs of CCR7 in the thymusColleen M Witt
Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California, Berkeley 94720, USA
J Exp Med 200:405-9. 2004..Together these papers provide a fascinating picture of the complex role of CCR7 in orchestrating thymocyte migration... - Notch signaling in lymphocyte development and functionEllen A Robey
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Curr Opin Immunol 16:360-6. 2004..Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells... - Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signalsYina H Huang
Department of Molecular and Cell Biology, Division of Immunology and Cancer Research Laboratory, 475 LSA, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 101:4936-41. 2004..These results help to identify TCR- and positive-selection-specific transcriptional events and help to clarify the relationship between positive selection and Notch... - 3D quantitative imaging of unprocessed live tissue reveals epithelial defense against bacterial adhesion and subsequent traversal requires MyD88Connie Tam
School of Optometry, University of California, Berkeley, California, United States of America
PLoS ONE 6:e24008. 2011.... - Immunology: guide for a cell-fate decisionEllen A Robey
Nature 433:813-4. 2005 - Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopyPhilippe Bousso
, , Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
Immunity 21:349-55. 2004..In this review we summarize what we have learned so far and point out areas for future investigation using this approach... - A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell developmentB J Fowlkes
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:1817-21. 2002..We suggest that the discrepancies in previous reports of Notch1IC transgenic mice are due to differences in the propensity of the two different transgenic lines to develop tumors...