E Robey

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Notch in vertebrates
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Curr Opin Genet Dev 7:551-7. 1997
  2. ncbi request reprint The alpha beta versus gamma delta T-cell lineage choice
    E Robey
    Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
    Curr Opin Immunol 10:181-7. 1998
  3. ncbi request reprint Regulation of T cell fate by Notch
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Annu Rev Immunol 17:283-95. 1999
  4. ncbi request reprint An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 87:483-92. 1996
  5. ncbi request reprint The role of CD8 alpha' in the CD4 versus CD8 lineage choice
    P Salmon
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    J Immunol 163:5312-8. 1999
  6. ncbi request reprint MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment
    D Chang
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 165:6710-5. 2000
  7. pmc Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii
    Marc Jan Gubbels
    Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California Berkeley, Berkeley, CA 94720, USA
    Infect Immun 73:703-11. 2005
  8. doi request reprint Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum
    Nicolas Blanchard
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Immunol 9:937-44. 2008
  9. pmc The ins and outs of CCR7 in the thymus
    Colleen M Witt
    Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California, Berkeley 94720, USA
    J Exp Med 200:405-9. 2004
  10. ncbi request reprint Notch signaling in lymphocyte development and function
    Ellen A Robey
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Curr Opin Immunol 16:360-6. 2004

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Notch in vertebrates
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Curr Opin Genet Dev 7:551-7. 1997
    ..Connections have also been discovered between alterations in Notch function and human disease...
  2. ncbi request reprint The alpha beta versus gamma delta T-cell lineage choice
    E Robey
    Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
    Curr Opin Immunol 10:181-7. 1998
    ..In addition, the transmembrane receptor Notch has recently been implicated as a new player in alpha beta versus gamma delta lineage determination...
  3. ncbi request reprint Regulation of T cell fate by Notch
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Annu Rev Immunol 17:283-95. 1999
    ..Possible models for the regulation of Notch by MHC recognition during CD4 versus CD8 lineage determination are discussed...
  4. ncbi request reprint An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
    E Robey
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 87:483-92. 1996
    ..However, activated Notch is not sufficient to promote CD8 cell development when both class I and class II MHC are absent. These results implicate Notch as a participant in the CD4 versus CD8 lineage decision...
  5. ncbi request reprint The role of CD8 alpha' in the CD4 versus CD8 lineage choice
    P Salmon
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    J Immunol 163:5312-8. 1999
    ..These results indicate that CD8 alpha' favors the development of CD8-lineage T cells, perhaps by reducing Lck activity upon class I MHC recognition in the thymus...
  6. ncbi request reprint MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment
    D Chang
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 165:6710-5. 2000
    ..These data indicate that survival and lineage commitment represent distinct, parallel pathways that occur as a consequence of MHC recognition, both of which are necessary for the development of mature CD8 lineage T cells...
  7. pmc Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii
    Marc Jan Gubbels
    Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California Berkeley, Berkeley, CA 94720, USA
    Infect Immun 73:703-11. 2005
    ....
  8. doi request reprint Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum
    Nicolas Blanchard
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Immunol 9:937-44. 2008
    ..gondii-infected ERAAP-deficient mice, which were more susceptible to toxoplasmosis. Thus, endoplasmic reticulum proteolysis is critical for eliciting protective immunity to a vacuolar parasite...
  9. pmc The ins and outs of CCR7 in the thymus
    Colleen M Witt
    Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California, Berkeley 94720, USA
    J Exp Med 200:405-9. 2004
    ..Together these papers provide a fascinating picture of the complex role of CCR7 in orchestrating thymocyte migration...
  10. ncbi request reprint Notch signaling in lymphocyte development and function
    Ellen A Robey
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Curr Opin Immunol 16:360-6. 2004
    ..Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells...
  11. pmc The impact of negative selection on thymocyte migration in the medulla
    Marie Le Borgne
    Department of Molecular and Cell Biology, University of California, Berkeley, USA
    Nat Immunol 10:823-30. 2009
    ..Our data suggest that many autoreactive thymocytes do not undergo immediate arrest and death after encountering a negative selecting ligand but instead adopt an altered migration program while remaining in the medullary microenvironment...
  12. ncbi request reprint Thymopoiesis in 4 dimensions
    Colleen M Witt
    Division of Immunology, Department of Molecular and Cell Biology, 479 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Semin Immunol 17:95-102. 2005
    ..We also discuss new imaging technologies and interdisciplinary approaches and discuss how the promise they offer to addressing these questions...
  13. ncbi request reprint The Notch regulator Numb links the Notch and TCR signaling pathways
    Ana C Anderson
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 174:890-7. 2005
    ..Together our data suggest that Notch and TCR signals may be integrated at the cell membrane, and that Numb may be an important adapter in this process...
  14. ncbi request reprint Thymocyte motility: mutants, movies and migration patterns
    Xinye Yin
    Division of Immunology, Department of Molecular and Cell Biology, 471 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Curr Opin Immunol 18:191-7. 2006
    ....
  15. pmc Dynamic repositioning of CD4 and CD8 genes during T cell development
    Stephanie Delaire
    Department of Molecular and Cell Biology, 475 Life Science Additions, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 200:1427-35. 2004
    ..We discuss our results in terms of our current knowledge of CD4 and CD8 gene regulation and CD4 versus CD8 lineage commitment...
  16. ncbi request reprint CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision
    Xinye Yin
    Department of Molecular and Cell Biology, Division of Immunology, University of California, Berkeley, CA 94720, USA
    J Immunol 179:7358-64. 2007
    ..These findings suggest that the timing of CCR7 expression relative to coreceptor down-regulation is regulated by lineage commitment signals...
  17. ncbi request reprint Thymocyte-dendritic cell interactions near sources of CCR7 ligands in the thymic cortex
    Ena Ladi
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 181:7014-23. 2008
    ..These observations identify a vasculature-associated microenvironment within the thymic cortex that promotes interactions between DCs and thymocytes that are receiving positive selection signals...
  18. pmc Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node
    Tatyana Chtanova
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Immunity 31:342-55. 2009
    ..Our results provide insight into cellular interactions during recall responses and suggest a mechanism of pathogen subversion of the immune response...
  19. ncbi request reprint Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1
    Jennifer O Manilay
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    J Immunol 174:6732-41. 2005
    ..Our data suggest that multiple Notch-dependent steps in early thymocyte development require Kuzbanian, but differ in the involvement of other Notch signaling components...
  20. pmc The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
    A Itano
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    J Exp Med 183:731-41. 1996
    ..We discuss these results in terms of current models for CD4 and CD8 lineage commitment...
  21. pmc Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis
    Stephanie L Osborn
    Cancer Research Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:13034-9. 2010
    ..We conclude that FADD constitutes a mechanism to keep TCR-induced programmed necrotic signaling in check during early phases of T-cell clonal expansion...
  22. ncbi request reprint Thymic microenvironments for T cell differentiation and selection
    Ena Ladi
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Immunol 7:338-43. 2006
    ..In addition, we discuss the diverse developmental signals provided by these microenvironments that contribute to the generation of divergent T cell lineages...
  23. ncbi request reprint Visualizing thymocyte motility using 2-photon microscopy
    Ellen A Robey
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Immunol Rev 195:51-7. 2003
    ..In this review, we discuss the implications of thymocyte motility for T-cell repertoire selection and for the mechanisms that determine the spatial organization of thymocyte subsets within the thymus...
  24. pmc Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals
    Yina H Huang
    Department of Molecular and Cell Biology, Division of Immunology and Cancer Research Laboratory, 475 LSA, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:4936-41. 2004
    ..These results help to identify TCR- and positive-selection-specific transcriptional events and help to clarify the relationship between positive selection and Notch...
  25. pmc Dynamics of neutrophil migration in lymph nodes during infection
    Tatyana Chtanova
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Immunity 29:487-96. 2008
    ..Our data provide insights into the cellular mechanisms underlying neutrophil swarming and suggest new roles for neutrophils in shaping immune responses...
  26. doi request reprint Dynamic imaging of host-pathogen interactions in vivo
    Janine L Coombes
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California 94720, USA
    Nat Rev Immunol 10:353-64. 2010
    ..Here we discuss how dynamic imaging of in vivo infection has revealed fascinating and unexpected details of host-pathogen interactions at a new level of spatial and temporal resolution...
  27. pmc Directed migration of positively selected thymocytes visualized in real time
    Colleen M Witt
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    PLoS Biol 3:e160. 2005
    ..These studies provide our first glimpse into the dynamics of developmentally programmed, long-range cell migration in the mammalian thymus...
  28. ncbi request reprint Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy
    Philippe Bousso
    Unité U277, Departement d Immunologie, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Immunity 21:349-55. 2004
    ..In this review we summarize what we have learned so far and point out areas for future investigation using this approach...
  29. pmc Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
    Liang Tung Yang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1737, USA
    Mol Biol Cell 16:927-42. 2005
    ....
  30. ncbi request reprint Immunology: guide for a cell-fate decision
    Ellen A Robey
    Nature 433:813-4. 2005
  31. ncbi request reprint A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development
    B J Fowlkes
    Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:1817-21. 2002
    ..We suggest that the discrepancies in previous reports of Notch1IC transgenic mice are due to differences in the propensity of the two different transgenic lines to develop tumors...