R P Robertson

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Transplanted intrahepatic islets: enigmatic absence of the alpha-cell response to hypoglycaemia
    R P Robertson
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Diabetes Nutr Metab 15:433-7. 2002
  2. ncbi request reprint Islet transplantation: travels up the learning curve
    R Paul Robertson
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Curr Diab Rep 2:365-70. 2002
  3. ncbi request reprint Glucagon, catecholamine, and symptom responses to hypoglycemia in living donors of pancreas segments
    R Paul Robertson
    Pacific Northwest Research Institute, University of Washington, Seattle 98122, USA
    Diabetes 52:1689-94. 2003
  4. ncbi request reprint Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    R Paul Robertson
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 53:S119-24. 2004
  5. ncbi request reprint Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Transplantation 73:736-41. 2002
  6. ncbi request reprint Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15
    C E Gleason
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Am J Physiol Endocrinol Metab 279:E997-1002. 2000
  7. ncbi request reprint Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis
    R P Robertson
    Pacific Northwest Research Institute and the University of Washington, Seattle 98122, USA
    Diabetes 50:47-50. 2001
  8. ncbi request reprint Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats
    J S Harmon
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 50:2481-6. 2001
  9. ncbi request reprint Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation
    R P Robertson
    Pacific Northwest Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98122, USA
    Diabetes 48:1737-40. 1999
  10. ncbi request reprint Restored hypoglycemic counterregulation is stable in successful pancreas transplant recipients for up to 19 years after transplantation
    B W Paty
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Transplantation 72:1103-7. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Transplanted intrahepatic islets: enigmatic absence of the alpha-cell response to hypoglycaemia
    R P Robertson
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Diabetes Nutr Metab 15:433-7. 2002
  2. ncbi request reprint Islet transplantation: travels up the learning curve
    R Paul Robertson
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Curr Diab Rep 2:365-70. 2002
    ....
  3. ncbi request reprint Glucagon, catecholamine, and symptom responses to hypoglycemia in living donors of pancreas segments
    R Paul Robertson
    Pacific Northwest Research Institute, University of Washington, Seattle 98122, USA
    Diabetes 52:1689-94. 2003
    ..We conclude that although glucagon response to arginine and insulin response to glucose and arginine are diminished after hemi-pancreatectomy, no deficiency in glucagon responses were detected during hypoglycemia...
  4. ncbi request reprint Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    R Paul Robertson
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 53:S119-24. 2004
    ....
  5. ncbi request reprint Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Transplantation 73:736-41. 2002
    ..e., the normal one of the donor and the unusual one of the ectopically transplanted recipient who is receiving immunosuppressant drugs that can diminish insulin secretion and cause insulin resistance...
  6. ncbi request reprint Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15
    C E Gleason
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Am J Physiol Endocrinol Metab 279:E997-1002. 2000
    ....
  7. ncbi request reprint Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis
    R P Robertson
    Pacific Northwest Research Institute and the University of Washington, Seattle 98122, USA
    Diabetes 50:47-50. 2001
    ..This usually overlooked procedure of intrahepatic islet transplantation designed to prevent diabetes in patients undergoing pancreatectomy for chronic pancreatitis should be considered more often...
  8. ncbi request reprint Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats
    J S Harmon
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 50:2481-6. 2001
    ..We conclude that antecedent elevated plasma glucose levels, not plasma lipid levels, are associated with elevated islet TAG content and decreased insulin mRNA levels in ZDF animals...
  9. ncbi request reprint Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation
    R P Robertson
    Pacific Northwest Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98122, USA
    Diabetes 48:1737-40. 1999
    ..Thus, concern about long-term deterioration, as distinct from rejection, should not be a major obstacle when deciding whether to recommend pancreas transplantation...
  10. ncbi request reprint Restored hypoglycemic counterregulation is stable in successful pancreas transplant recipients for up to 19 years after transplantation
    B W Paty
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Transplantation 72:1103-7. 2001
    ..CONCLUSION: These results indicate that the restoration of hypoglycemic counterregulation by pancreas transplantation remains stable in successful pancreas transplant recipients for up to 19 years after transplantation...
  11. ncbi request reprint In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression
    J S Harmon
    Pacific Northwest Research Institute, and Department of Medicine, University of Washington, Seattle 98122, USA
    Diabetes 48:1995-2000. 1999
    ..These findings provide the first in vivo evidence that prevention of progressive hyperglycemia in a model of type 2 diabetes preserves insulin and PDX-1 gene expression...
  12. ncbi request reprint Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and Wistar rat islets
    B W Paty
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Transplantation 73:353-7. 2002
    ..These findings support the use of low-dose immunosuppressive drug protocols in clinical islet transplantation...
  13. ncbi request reprint Pancreatic islet cell transplantation: likely impact on current therapeutics for type 1 diabetes mellitus
    R P Robertson
    Pacific Northwest Research Institute and the University of Washington, Seattle 98122, USA
    Drugs 61:2017-20. 2001
    ..These dramatic results have presented the research community with the challenges of replicating these results and, ultimately, with providing solutions to the serious supply and demand issues that will inevitably follow...
  14. doi request reprint A role for zinc in pancreatic islet β-cell cross-talk with the α-cell during hypoglycaemia
    R P Robertson
    Pacific Northwest Diabetes Research Institute and Division of Endocrinology and Metabolism, Department of Medicine and Pharmacology, University of Washington, Seattle, WA 98122, USA
    Diabetes Obes Metab 13:106-11. 2011
    ..It is now suggested that a switch-off signal provided by a sudden cessation of zinc secretion from β-cells during hypoglycaemia may play a critical role in stimulating glucagon secretion that is independent of the effect of insulin...
  15. ncbi request reprint Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets
    Wenjing Wang
    Islet and Cell Processing Laboratory, Puget Sound Blood Center Northwest Tissue Center, Seattle, Washington 98104, USA
    J Endocrinol 185:445-55. 2005
    ....
  16. ncbi request reprint Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets
    R Paul Robertson
    The Pacific Northwest Research Institute and the University of Washington, 720 Broadway, Seattle, WA 98122, USA
    Ann N Y Acad Sci 1043:513-20. 2005
    ..These observations suggest that enhancing antioxidant defense mechanisms in pancreatic islets may be a valuable pharmacologic approach to managing diabetes...
  17. ncbi request reprint Pancreas and islet transplantation in type 1 diabetes
    R Paul Robertson
    Diabetes Care 29:935. 2006
  18. ncbi request reprint Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells
    Jamie S Harmon
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 280:11107-13. 2005
    ..001). We conclude that the absence of MafA protein from beta cells via chronic oxidative stress contributes importantly to the loss of endogenous insulin gene expression as glucose toxicity develops...
  19. pmc Regulation of the insulin gene by glucose and fatty acids
    Vincent Poitout
    Department of Medicine, University of Montreal, Montreal, QC, Canada
    J Nutr 136:873-6. 2006
    ..Glucotoxicity and lipotoxicity have common targets, which makes their combination particularly harmful to insulin gene expression and beta-cell function in type 2 diabetes...
  20. ncbi request reprint Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell
    R Paul Robertson
    Department of Medicine and Department of Pharmacology, Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Free Radic Biol Med 41:177-84. 2006
    ..Translational research with humans is now under way to ascertain whether this protection can be provided to patients experiencing inadequate glycemic control...
  21. ncbi request reprint Oxidative stress and impaired insulin secretion in type 2 diabetes
    R Paul Robertson
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, 720 Broadway, Seattle, WA 98122, USA
    Curr Opin Pharmacol 6:615-9. 2006
    ..Co-incident with these changes are profound alterations in insulin gene expression, which involve greatly diminished levels of two transcription factors, MafA and Pdx-1...
  22. ncbi request reprint Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo
    Huarong Zhou
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 56:1107-12. 2007
    ..We conclude that zinc atoms, not the insulin molecule itself, provide the switch-off signal from the beta-cell to the alpha-cell to initiate glucagon secretion during hypoglycemia...
  23. ncbi request reprint Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats
    Huarong Zhou
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Endocrinology 148:2863-9. 2007
    ..We conclude that defective glucagon responses to hypoglycemia in BB rats can be corrected by restoring regulation of alpha-cell function by insulin...
  24. pmc Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase
    R Paul Robertson
    Pacific Northwest Research Institute, University of Washington, 720 Broadway, Seattle, WA 98122, United States
    FEBS Lett 581:3743-8. 2007
    ..This suggests that GPx mimetics may represent a valuable ancillary treatment that could add a novel layer of protection for the beta-cell...
  25. ncbi request reprint International trial of the Edmonton protocol for islet transplantation
    A M James Shapiro
    Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
    N Engl J Med 355:1318-30. 2006
    ..We conducted an international, multicenter trial to explore the feasibility and reproducibility of islet transplantation with the use of a single common protocol (the Edmonton protocol)...
  26. doi request reprint Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia
    Huarong Zhou
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Diabetes 57:1567-74. 2008
    ....
  27. ncbi request reprint Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress
    Phuong Oanh T Tran
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 279:53988-93. 2004
    ..These data provide the first report of GCLC expression in the islet and demonstrate that adenoviral overexpression of GCLC increases intracellular GSH levels and protects the beta cell from the adverse effects of IL-1 beta...
  28. ncbi request reprint Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 279:42351-4. 2004
  29. ncbi request reprint Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function
    Phuong Oanh T Tran
    Pacific Northwest Research Institute and Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Diabetes 51:1772-8. 2002
    ..These findings indicate that the sites of action through which sodium salicylate inhibits these negative effects of IL-1beta on beta-cell function include activation of NF-kappaB as well as generation of PGE(2) by COX-2...
  30. pmc A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
    Yoshito Tanaka
    Pacific Northwest Research Institute and the Department of Medicine, University of Washington, Seattle, WA, 98122, USA
    Proc Natl Acad Sci U S A 99:12363-8. 2002
    ..These observations support the hypothesis that oxidative stress is one mechanism for glucose toxicity in pancreatic islets...
  31. ncbi request reprint Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol
    Shinichi Matsumoto
    Islet and Cell Processing Laboratory ICPL at Puget Sound Blood Center and Northwest Tissue Center, Seattle, WA, USA
    Transplantation 74:1414-9. 2002
    ..In this study, we hypothesized that the two-layer method (TLM) could extend the acceptable preservation period of pancreata before islet isolation and increase islet yields...
  32. ncbi request reprint Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence
    Breay W Paty
    Clinical Islet Transplant Program, University of Alberta, 2000 College Plaza, 8215 112th Street, Edmonton, Alberta, Canada T6G 2C8
    Diabetes 51:3428-34. 2002
    ....
  33. ncbi request reprint Pancreas transplantation for patients with type 1 diabetes
    R Paul Robertson
    Diabetes Care 26:S120. 2003
  34. ncbi request reprint Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity
    Vincent Poitout
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Endocrinology 143:339-42. 2002
    ..We propose that chronic hyperglycemia, independent of hyperlipidemia, is toxic for beta-cell function, whereas chronic hyperlipidemia is deleterious only in the context of concomitant hyperglycemia...
  35. ncbi request reprint Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection
    R Paul Robertson
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 52:581-7. 2003
    ....
  36. ncbi request reprint Consequences on beta-cell function and reserve after long-term pancreas transplantation
    R Paul Robertson
    Pacific Northwest Research Institute, Seattle, Washington, USA
    Diabetes 53:633-44. 2004
    ....
  37. ncbi request reprint Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis
    Huarong Zhou
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 53:1482-7. 2004
    ..These data provide direct in vivo support for the beta-cell "switch-off" hypothesis and indicate that the alpha-cell is not intrinsically abnormal in insulin-dependent diabetes because of STZ-induced destruction of beta-cells...
  38. ncbi request reprint Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis
    Kristine M Hope
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 53:1488-95. 2004
    ..These results fully support the beta-cell switch-off hypothesis as a key mechanism for the alpha-cell response to hypoglycemia...
  39. ncbi request reprint AIRarg and AIRgluc as predictors of insulin secretory reserve
    R Paul Robertson
    Pacific Northwest Research Institute and the University of Washington, Seattle, 98122, USA
    Transplant Proc 36:1040-1. 2004
    ....
  40. doi request reprint Novel Nonimmunological Forms of {beta}-Cell Dysfunction: Diabetic Syndromes and Pathogenic Mechanisms
    R Paul Robertson
    Endocr Rev 29:253. 2008
  41. pmc Glucolipotoxicity: fuel excess and beta-cell dysfunction
    Vincent Poitout
    Montreal Diabetes Research Center, CR CHUM, Technopole Angus, 2901 Rachel Est, Montreal, Quebec, Canada H1W 4A4
    Endocr Rev 29:351-66. 2008
    ..Finally, we attempt to define the role of these phenomena in the natural history of beta-cell compensation, decompensation, and failure during the course of type 2 diabetes...
  42. ncbi request reprint D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways
    Hiroki Takahashi
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 279:37316-23. 2004
    ....
  43. ncbi request reprint Glutathione peroxidase protein expression and activity in human islets isolated for transplantation
    Naoko Tonooka
    Pacific Northwest Research Institute, University of Washington, WA 98122, USA
    Clin Transplant 21:767-72. 2007
    ..Overexpression of antioxidant enzymes has been reported to protect rodent beta cells from oxidative stress. However, very little is known about protein expression and activity of antioxidant enzymes in human islets...
  44. ncbi request reprint Intrahepatically transplanted islets--strangers in a strange land
    R Paul Robertson
    J Clin Endocrinol Metab 87:5416-7. 2002
  45. ncbi request reprint Improve islet yields and quality when clinical grade pancreata are preserved by the two-layer method
    Guangming Zhang
    Northwest Tissue Center at the Puget Sound Blood Center, Seattle, WA 98104, USA
    Cell Tissue Bank 7:195-201. 2006
    ..The goal of this study was to determine whether this would hold true for pancreata that meet selection criteria for clinical grade organs...
  46. ncbi request reprint Islet transplantation as a treatment for diabetes - a work in progress
    R Paul Robertson
    Pacific Northwest Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle 98122, USA
    N Engl J Med 350:694-705. 2004
  47. ncbi request reprint Estimation of beta-cell mass by metabolic tests: necessary, but how sufficient?
    R Paul Robertson
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 56:2420-4. 2007
    ....