ROBERT MICHAEL ROBERTS

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint Cdx2 gene expression and trophectoderm lineage specification in mouse embryos
    Kaushik Deb
    Department of Animal Sciences, Columbia, MO 65211, USA
    Science 311:992-6. 2006
  2. pmc Trophoblast stem cells
    R Michael Roberts
    Division of Animal Sciences, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Biol Reprod 84:412-21. 2011
  3. pmc Model systems for studying trophoblast differentiation from human pluripotent stem cells
    Toshihiko Ezashi
    Division of Animal Sciences and Bond Life Sciences Center, University of Missouri Columbia, 65211, USA
    Cell Tissue Res 349:809-24. 2012
  4. pmc Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and embryonic stem cells
    Rangan Gupta
    Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
    Mol Endocrinol 26:859-72. 2012
  5. pmc Nutritional skewing of conceptus sex in sheep: effects of a maternal diet enriched in rumen-protected polyunsaturated fatty acids (PUFA)
    Mark P Green
    Division of Animal Sciences, University of Missouri, Columbia MO 65211, USA
    Reprod Biol Endocrinol 6:21. 2008
  6. pmc Ets-2 and C/EBP-beta are important mediators of ovine trophoblast Kunitz domain protein-1 gene expression in trophoblast
    Anindita Chakrabarty
    Departments of Veterinary Pathobiology, University of Missouri Columbia, Columbia, MO 65211, USA
    BMC Mol Biol 8:14. 2007
  7. pmc Characterization of the bovine type I IFN locus: rearrangements, expansions, and novel subfamilies
    Angela M Walker
    Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
    BMC Genomics 10:187. 2009
  8. pmc The evolution of the Sin1 gene product, a little known protein implicated in stress responses and type I interferon signaling in vertebrates
    Shu Zong Wang
    Veterinary Pathobiology, University of Missouri, Columbia, USA
    BMC Evol Biol 5:13. 2005
  9. pmc Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy
    R Michael Roberts
    Department of Animal Sciences, University of Missouri Columbia, 240B CS Bond Life Sciences Center, 1201 Rollins Street, Columbia, MO 65211, United States
    Cytokine Growth Factor Rev 18:403-8. 2007
  10. pmc Interferons and the maternal-conceptus dialog in mammals
    R Michael Roberts
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Semin Cell Dev Biol 19:170-7. 2008

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Cdx2 gene expression and trophectoderm lineage specification in mouse embryos
    Kaushik Deb
    Department of Animal Sciences, Columbia, MO 65211, USA
    Science 311:992-6. 2006
    ..The asymmetrical distribution of Cdx2 gene products in the oocyte and embryo defines the lineage to trophectoderm...
  2. pmc Trophoblast stem cells
    R Michael Roberts
    Division of Animal Sciences, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Biol Reprod 84:412-21. 2011
    ..Recent derivation of TSC from blastocysts of the rhesus monkey suggests that isolation of the human equivalents may be possible and will reveal the extent to which mechanisms uncovered by using animal models are true in our own species...
  3. pmc Model systems for studying trophoblast differentiation from human pluripotent stem cells
    Toshihiko Ezashi
    Division of Animal Sciences and Bond Life Sciences Center, University of Missouri Columbia, 65211, USA
    Cell Tissue Res 349:809-24. 2012
    ....
  4. pmc Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and embryonic stem cells
    Rangan Gupta
    Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
    Mol Endocrinol 26:859-72. 2012
    ..Hence, a squelching mechanism underpins the transcriptional silencing of CGA by POU5F1 and could have general relevance to how pluripotency is maintained and how the trophoblast lineage emerges from pluripotent precursor cells...
  5. pmc Nutritional skewing of conceptus sex in sheep: effects of a maternal diet enriched in rumen-protected polyunsaturated fatty acids (PUFA)
    Mark P Green
    Division of Animal Sciences, University of Missouri, Columbia MO 65211, USA
    Reprod Biol Endocrinol 6:21. 2008
    ..Here, we examined whether maternal diet, specifically increased n-6 polyunsaturated fatty acid (PUFA) intake, of ewes with a constant body condition score around the time of conception influenced sex ratio...
  6. pmc Ets-2 and C/EBP-beta are important mediators of ovine trophoblast Kunitz domain protein-1 gene expression in trophoblast
    Anindita Chakrabarty
    Departments of Veterinary Pathobiology, University of Missouri Columbia, Columbia, MO 65211, USA
    BMC Mol Biol 8:14. 2007
    ..Our goal here has been to determine whether the ovine (ov) Tkdp-1 and IFNT genes possess a similar transcriptional code...
  7. pmc Characterization of the bovine type I IFN locus: rearrangements, expansions, and novel subfamilies
    Angela M Walker
    Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
    BMC Genomics 10:187. 2009
    ....
  8. pmc The evolution of the Sin1 gene product, a little known protein implicated in stress responses and type I interferon signaling in vertebrates
    Shu Zong Wang
    Veterinary Pathobiology, University of Missouri, Columbia, USA
    BMC Evol Biol 5:13. 2005
    ..Since SAPK pathways are ancient and the IFN system is confined to vertebrates, the organization of the Sin1 gene and the sequences of the Sin1 protein have been compared across a wide taxonomic range of species...
  9. pmc Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy
    R Michael Roberts
    Department of Animal Sciences, University of Missouri Columbia, 240B CS Bond Life Sciences Center, 1201 Rollins Street, Columbia, MO 65211, United States
    Cytokine Growth Factor Rev 18:403-8. 2007
    ..The IFNT provide an illustration of how a gene control region can be commandeered and then refined to provide a radically changed pattern of expression...
  10. pmc Interferons and the maternal-conceptus dialog in mammals
    R Michael Roberts
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Semin Cell Dev Biol 19:170-7. 2008
    ..Conceivably, disparate signaling mechanisms trigger common downstream events necessary to secure a successful pregnancy...
  11. pmc Trophoblast gene expression: transcription factors in the specification of early trophoblast
    R Michael Roberts
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Reprod Biol Endocrinol 2:47. 2004
    ....
  12. ncbi request reprint Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be important
    R Michael Roberts
    Division of Animal Sciences, University of Missouri, Columbia, MO, USA
    Cell Cycle 8:3078-81. 2009
    ....
  13. ncbi request reprint Evolution of the interferon tau genes and their promoters, and maternal-trophoblast interactions in control of their expression
    R M Roberts
    Department of Animal Science, University of Missouri Columbia, Columbia, MO 65211, USA
    Reprod Suppl 61:239-51. 2003
    ....
  14. pmc Transcript profiling of individual twin blastomeres derived by splitting two-cell stage murine embryos
    R Michael Roberts
    Division of Animal Sciences, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Biol Reprod 84:487-94. 2011
    ....
  15. ncbi request reprint The place of farm animal species in the new genomics world of reproductive biology
    R M Roberts
    Department of Animal Sciences and Biochemistry, University of Missouri, 158 ASRC, 920 East Campus Drive, Columbia, MO 65211, USA
    Biol Reprod 64:409-17. 2001
    ....
  16. ncbi request reprint The evolution of the type I interferons
    R M Roberts
    Department of Animal Sciences, University of Missouri, Columbia 65211 0001, USA
    J Interferon Cytokine Res 18:805-16. 1998
    ..These genes have also continued to duplicate to form an extensive family. Consequently, their involvement in early pregnancy is a feature of ruminants and not of other mammalian species...
  17. ncbi request reprint Rapid evolution of the trophoblast kunitz domain proteins (TKDPs)-a multigene family in ruminant ungulates
    Anindita Chakrabarty
    Department of Veterinary Pathobiology, University of Missouri Columbia, Columbia, Missouri 65211, USA
    J Mol Evol 63:274-82. 2006
    ....
  18. pmc Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line
    Padmalaya Das
    Christopher S Bond Life Sciences Center, University of Missouri Columbia, 1201 East Rollins Street, Columbia, MO 65211 7310, USA
    Mol Endocrinol 22:331-43. 2008
    ..The up-regulation of IFNT in the elongating bovine conceptus is likely due to the combinatorial effects of PKA, Ets2, and CBP/p300 and triggered via growth factors released from maternal endometrium...
  19. pmc Expression of bovine interferon-tau variants according to sex and age of conceptuses
    Angela M Walker
    Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
    Theriogenology 72:44-53. 2009
    ..001) among conceptuses of different age, although two, representing boIFN1a and boIFN3c, predominated throughout development. Notably, no alteration in overall IFNT variant diversity was detected in CT-1 cells over time (P=0.124)...
  20. ncbi request reprint Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, Missouri 65211 5300, USA
    Endocrinology 145:4452-60. 2004
    ..These data emphasize the importance of a complex Ets-2 enhancer for expression of IFNT and suggest a means whereby the mother can exert control over conceptus IFN-tau production...
  21. ncbi request reprint Effect of interferon-tau administration on endometrium of nonpregnant ewes: a comparison with pregnant ewes
    Yizhen Chen
    Department of Animal Sciences, University of Missouri, Columbia, 65211, USA
    Endocrinology 147:2127-37. 2006
    ..IFNT treatment mimics pregnancy, but relatively high doses of im-injected IFNT are required to elicit a full endometrial response...
  22. ncbi request reprint Family of Kunitz proteins from trophoblast: expression of the trophoblast Kunitz domain proteins (TKDP) in cattle and sheep
    James A Maclean
    Department of Animal Sciences, University of Missouri Columbia, 65211, USA
    Mol Reprod Dev 65:30-40. 2003
    ..It is possible that the TKDPs provide a broad range of specificities against maternal proteinases that might be damaging to the trophoblast during pregnancy...
  23. doi request reprint The promise of stem cell research in pigs and other ungulate species
    Bhanu Prakash V L Telugu
    Division of Animal Sciences, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA
    Stem Cell Rev 6:31-41. 2010
    ....
  24. ncbi request reprint Atypical Kunitz-type serine proteinase inhibitors produced by the ruminant placenta
    James A Maclean
    Department of Animal Sciences, University of Missouri Columbia, 920 E Campus Drive, Columbia, MO 65211, USA
    Biol Reprod 71:455-63. 2004
    ..It exhibited no inhibitory activity. These data suggest that the function of the TKDP, like certain Kunitz proteins found in snake venoms, may not be in proteinase inhibition...
  25. pmc Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells
    Suzanne D Westfall
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211 7310, USA
    Stem Cells Dev 17:869-81. 2008
    ..The data are consistent with the hypothesis that 4% O(2) favors the molecular mechanisms required for the maintenance of pluripotency...
  26. ncbi request reprint Maternal diet and other factors affecting offspring sex ratio: a review
    Cheryl S Rosenfeld
    University of Missouri Columbia, Columbia, MO 65211, USA
    Biol Reprod 71:1063-70. 2004
    ..A number of mechanisms, all of which are testable, are discussed to provide an explanation for the phenomenon. We conclude the review by discussing potential implications of these observations to human medicine and agriculture...
  27. ncbi request reprint The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 79:115-24. 2008
    ..Together, these results suggest that DLX3 has a central role in controlling IFNT gene expression by associating with ETS2 on the IFNT promoter...
  28. ncbi request reprint The establishment of an ELISA for the detection of pregnancy-associated glycoproteins (PAGs) in the serum of pregnant cows and heifers
    Jonathan A Green
    Department of Animal Sciences, University of Missouri Columbia, 163 ASRC, 920 East Campus Drive, Columbia, MS 65211, USA
    Theriogenology 63:1481-503. 2005
    ..In summary, a monoclonal-based assay has been established that is sensitive enough to detect PAG in maternal serum by the forth week of pregnancy, but does not suffer from carry-over of antigen from a previous pregnancy...
  29. doi request reprint Porcine induced pluripotent stem cells analogous to naïve and primed embryonic stem cells of the mouse
    Bhanu Prakash V L Telugu
    Division of Animal Sciences, University of Missouri, Columbia, MO, USA
    Int J Dev Biol 54:1703-11. 2010
    ..They exhibit high telomerase activity, a short cell cycle interval, and a normal karyotype, and are able to generate teratomas. Currently, the competence of these lines for contributing to germ-line chimeras is being tested...
  30. pmc Derivation of induced pluripotent stem cells from pig somatic cells
    Toshihiko Ezashi
    Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 106:10993-8. 2009
    ..Such cell lines derived from individual animals could provide a means for testing the safety and efficacy of stem cell-derived tissue grafts when returned to the same pigs at a later age...
  31. ncbi request reprint Sexual dimorphism in interferon-tau production by in vivo-derived bovine embryos
    Koji Kimura
    Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
    Mol Reprod Dev 67:193-9. 2004
    ..Thus, sexual dimorphism in IFN-tau production is observed in both IVP and in vivo-produced expanded blastocysts, but is lost by day 14 of in vivo development...
  32. ncbi request reprint Establishment of an ELISA for the detection of native bovine pregnancy-associated glycoproteins secreted by trophoblast binucleate cells
    Jonathan A Green
    Department of Animal Science, University of Missouri Columbia, USA
    Methods Mol Med 122:321-30. 2006
    ....
  33. ncbi request reprint A microarray analysis for genes regulated by interferon-tau in ovine luminal epithelial cells
    Yizhen Chen
    Division of Animal Sciences, University of Missouri Columbia, Missouri 65211, USA
    Reproduction 134:123-35. 2007
    ..IFNT targets a complex range of physiological processes during the establishment of pregnancy...
  34. pmc Effects of fgf2 and oxygen in the bmp4-driven differentiation of trophoblast from human embryonic stem cells
    Padmalaya Das
    Department of Animal Sciences, University of Missouri Columbia, Christopher S Bond Life Sciences Center, 65211, USA
    Stem Cell Res 1:61-74. 2007
    ..In conclusion, BMP4 induced conversion of hESC exclusively towards trophoblast; FGF2 slowed differentiation, while O(2) accelerated this process and promoted syncytiotrophoblast formation...
  35. ncbi request reprint Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus
    Cheryl S Rosenfeld
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 67:847-53. 2002
    ..These studies demonstrate the heavy concentration of IFNAR1 and IFNAR2 in cells of the LE and superficial GE, which appear to be the main targets for IFN-tau...
  36. pmc Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate
    Cheryl S Rosenfeld
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 100:4628-32. 2003
    ..The data show that the source of calories provided in a nutritionally complete diet to mature female mice can influence sex of offspring born...
  37. ncbi request reprint Interaction of stress-activated protein kinase-interacting protein-1 with the interferon receptor subunit IFNAR2 in uterine endometrium
    Shu Zong Wang
    Department of Veterinary Pathology, University of Missouri, Columbia, Missouri 65211, USA
    Endocrinology 145:5820-31. 2004
    ..Sin1 provides a possible link among type I IFN action, stress-activated signaling pathways, and control of prostaglandin production...
  38. ncbi request reprint Effects of D-glucose concentration, D-fructose, and inhibitors of enzymes of the pentose phosphate pathway on the development and sex ratio of bovine blastocysts
    Koji Kimura
    University of Missouri, Department of Animal Sciences, 105 Life Sciences Center, Columbia, MO 65211, USA
    Mol Reprod Dev 72:201-7. 2005
    ..In conclusion, glucose above 2.5 mM impairs bovine embryo development and increases sex ratio, most likely as a result of increased pentose-phosphate (PP) pathway activity in female embryos...
  39. pmc Low O2 tensions and the prevention of differentiation of hES cells
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 102:4783-8. 2005
    ..In addition, hES cell growth under hypoxia provided enhanced formation of embryoid bodies. Hypoxic culture would appear to be necessary to maintain full pluripotency of hES cells...
  40. pmc Development of monozygotic twin mouse embryos from the time of blastomere separation at the two-cell stage to blastocyst
    Mika Katayama
    Division of Animal Sciences, and Christopher S Bond Life Sciences Center, University of Missouri, 1201 E Rollins Street, Columbia, MO 65211, USA
    Biol Reprod 82:1237-47. 2010
    ..These data could explain the difficulty of creating monozygotic twins from two-cell stage embryos...
  41. ncbi request reprint A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene
    Debjani Ghosh
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211 5300, USA
    Mol Endocrinol 17:11-26. 2003
    ..The data are consistent with the hypothesis that Ets-2 has a general and possibly essential role in controlling the activity of genes associated with trophectoderm differentiation...
  42. pmc A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress
    Debjani Ghosh
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 105:11673-8. 2008
    ..We predict that SIN1 is a scaffold protein that organizes antiapoptotic responses in stressed cells, whereas PCBP2, its binding partner, provides for the selective expression of cell survival factors through posttranslational events...
  43. ncbi request reprint Effects of diets enriched in omega-3 and omega-6 polyunsaturated fatty acids on offspring sex-ratio and maternal behavior in mice
    Emily D Fountain
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Biol Reprod 78:211-7. 2008
    ..05). In conclusion, the N-3 diet had negative effects on murine fecundity and maternal behavior, whereas the N-6 diet favored birth of daughters...
  44. ncbi request reprint The contrasting effects of ad libitum and restricted feeding of a diet very high in saturated fats on sex ratio and metabolic hormones in mice
    Andrei P Alexenko
    Department of Animal Sciences, University of Missouri Columbia, Christopher S Bond Life Sciences Center, Columbia, Missouri 65211 7310, USA
    Biol Reprod 77:599-604. 2007
    ..Since males fed the VHF diet had neither more Y-sperm nor sired more sons than daughters, the dietary effects are manifested exclusively through the female...
  45. ncbi request reprint Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein
    Debjani Ghosh
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211 7310, USA
    Mol Endocrinol 19:1049-66. 2005
    ..We propose that regulation of hCGalpha by Ets-2 and CREB enables coordinated expression of hCGalpha with its partner hCGbeta subunit...
  46. doi request reprint The effect of superovulation on the contributions of individual blastomeres from 2-cell stage CF1 mouse embryos to the blastocyst
    Mika Katayama
    Division of Animal Sciences, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Int J Dev Biol 54:675-81. 2010
    ..In CF1 mice, superovulation has little effect on development to blastocyst, but enforces a greater degree of lineage restriction than natural breeding, most likely through constraints imposed by the zona pellucida...
  47. ncbi request reprint Aspartic proteinase phylogeny and the origin of pregnancy-associated glycoproteins
    Austin L Hughes
    Department of Biological Sciences, University of South Carolina, USA
    Mol Biol Evol 20:1940-5. 2003
    ..The conservation of this ancestral change suggests that it may be important to PAG function, particularly the fact that PAGs lack proteinase activity in spite of the conservation of active site residues in most PAGs...

Research Grants28

  1. Transcription Factors in Trophectoderm Differentiation
    R Roberts; Fiscal Year: 2006
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  2. Relationship between diet and sex of offspring.
    R Roberts; Fiscal Year: 2006
    ..abstract_text> ..
  3. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2006
    ..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
  4. Transcription Factors in Trophectoderm Differentiation
    R Roberts; Fiscal Year: 2005
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  5. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  6. Transcription Factors in Trophectoderm Differentiation
    R Roberts; Fiscal Year: 2006
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  7. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2007
    ..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
  8. Relationship between diet and sex of offspring
    Robert Roberts; Fiscal Year: 2007
    ..abstract_text> ..
  9. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    Robert Roberts; Fiscal Year: 2009
    ..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
  10. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2010
    ..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
  11. Relationship between diet and sex of offspring.
    R Roberts; Fiscal Year: 2005
    ..abstract_text> ..
  12. Transcription Factors in Trophectoderm Differentiation
    R Roberts; Fiscal Year: 2005
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  13. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2000
    ..Together these studies will provide information on roles for IFN in non- pathogenic processes and insight into how trophectoderm differentiates during early embryonic development. ..
  14. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2001
    ..Together these studies will provide information on roles for IFN in non- pathogenic processes and insight into how trophectoderm differentiates during early embryonic development. ..
  15. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2002
    ..Together these studies will provide information on roles for IFN in non- pathogenic processes and insight into how trophectoderm differentiates during early embryonic development. ..
  16. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2003
    ..Together these studies will provide information on roles for IFN in non- pathogenic processes and insight into how trophectoderm differentiates during early embryonic development. ..
  17. Transcription Factors in Trophectoderm Differentiation
    R Roberts; Fiscal Year: 2003
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  18. Transcription Factors in Trophectoderm Differentiation
    R Roberts; Fiscal Year: 2004
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  19. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    Robert Roberts; Fiscal Year: 2004
    ..Together these studies will provide information on roles for IFN in non- pathogenic processes and insight into how trophectoderm differentiates during early embryonic development. ..
  20. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    R Roberts; Fiscal Year: 2003
    ..Together these studies will provide information on roles for IFN in non- pathogenic processes and insight into how trophectoderm differentiates during early embryonic development. ..
  21. Relationship between diet and sex of offspring
    R Roberts; Fiscal Year: 2004
    ..abstract_text> ..
  22. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2011
    ..Also by generating such pluripotent cells from umbilical cords of babies born to mothers that developed pre-eclampsia, we hope to recreate the cell type that caused the disease in the first place. ..