Patrick J Roberts
Affiliation: University of North Carolina
- Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy?Patrick J Roberts
Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
J Clin Oncol 28:4769-77. 2010....
- KRAS mutation: should we test for it, and does it matter?Patrick J Roberts
Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
J Clin Oncol 31:1112-21. 2013..Here we review, in the context of NSCLC, the underlying biology of KRAS mutations, the predictive value of KRAS mutations for therapeutic intervention, and the integration of KRAS mutational testing into our current clinical paradigms...
- Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumorsAustin J Combest
University of North Carolina Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, 1013 Genetic Medicine Building, CB 7361, Chapel Hill, North Carolina 27599 7361, USA
Oncologist 17:1303-16. 2012..A critical factor influencing the predictability of rodent tumor models is drug PKs, but a comprehensive comparison of plasma and tumor PK parameters among xenograft models, OSTs, GEMMs, and human patients has not been performed...
- Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer modelsPatrick J Roberts
Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Clin Cancer Res 18:5290-303. 2012..Anticancer drug development is inefficient, but genetically engineered murine models (GEMM) and orthotopic, syngeneic transplants (OST) of cancer may offer advantages to in vitro and xenograft systems...
- Prediction of lung cancer histological types by RT-qPCR gene expression in FFPE specimensMatthew D Wilkerson
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Mol Diagn 15:485-97. 2013..The HEP also exhibited good performance in specimens with low tumor cellularity. Therefore, RT-qPCR gene expression from FFPE specimens can be effectively used to predict lung cancer histology. ..
- Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell typesMatthew D Wilkerson
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
Clin Cancer Res 16:4864-75. 2010..We sought to determine if SCC mRNA expression subtypes exist, are reproducible across multiple patient cohorts, and are clinically relevant...
- Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapyPatrick J Roberts
Department of Genetics, The University of North Carolina School of Medicine, Chapel Hill, NC, USA
J Natl Cancer Inst 104:476-87. 2012....