James L Roberts

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint LHRH-(1-5): a bioactive peptide regulating reproduction
    James L Roberts
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Trends Endocrinol Metab 18:386-92. 2007
  2. pmc Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
    Syed Z Imam
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 31:157-63. 2011
  3. pmc 17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo
    Matthew P Rowan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 335:190-6. 2010
  4. pmc Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease
    K C Biju
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Neurosci Lett 535:24-9. 2013
  5. ncbi request reprint Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells
    Nathaniel A Jeske
    Department of Pharmacology, University of Texas Health Science Center of San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 90:819-28. 2004
  6. ncbi request reprint Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia
    Nathaniel A Jeske
    Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    J Neurochem 97:13-21. 2006
  7. pmc Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta
    Rebecca L Cunningham
    Department of Pharmacology and the Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Endocrinology 150:5539-48. 2009
  8. pmc Insulin-like growth factor-I mediates neuroprotection in proteasome inhibition-induced cytotoxicity in SH-SY5Y cells
    Benxu Cheng
    Regional Academic Health Center Edinburg E RAHC, Medical Research Division, 1214 W Schunior St, Edinburg, TX 78541, USA
    Mol Cell Neurosci 47:181-90. 2011
  9. doi request reprint Effects of anabolic androgenic steroids and social subjugation on behavior and neurochemistry in male rats
    Krystle A Frahm
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Pharmacol Biochem Behav 97:416-22. 2011
  10. pmc Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease
    Kc Biju
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Ther 18:1536-44. 2010

Research Grants

Collaborators

Detail Information

Publications22

  1. ncbi request reprint LHRH-(1-5): a bioactive peptide regulating reproduction
    James L Roberts
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Trends Endocrinol Metab 18:386-92. 2007
    ..The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing...
  2. pmc Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease
    Syed Z Imam
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 31:157-63. 2011
    ..Moreover, inhibition of c-Abl offers new therapeutic opportunities for blocking PD progression...
  3. pmc 17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo
    Matthew P Rowan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 335:190-6. 2010
    ....
  4. pmc Bone marrow-derived microglia-based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson's disease
    K C Biju
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Neurosci Lett 535:24-9. 2013
    ..Thus, bone marrow-derived microglia can serve as cellular vehicles for sustained delivery of neurotrophic factors capable of mitigating dopaminergic injury...
  5. ncbi request reprint Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells
    Nathaniel A Jeske
    Department of Pharmacology, University of Texas Health Science Center of San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 90:819-28. 2004
    ..With these data, we conclude that EP24.15 association with lipid rafts on the extracellular surface precedes constitutive release of the peptidase into the extracellular milieu for its action on neuropeptides...
  6. ncbi request reprint Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia
    Nathaniel A Jeske
    Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    J Neurochem 97:13-21. 2006
    ..Taken together, these data demonstrate that EP24.15/16 modulate intracellular, peptidergic signaling cascades through B2R in a physiologically relevant nociceptive system...
  7. pmc Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta
    Rebecca L Cunningham
    Department of Pharmacology and the Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Endocrinology 150:5539-48. 2009
    ..These results support a neurotoxic consequence of testosterone on dopaminergic neurons and may provide insight into the gender bias found in PD...
  8. pmc Insulin-like growth factor-I mediates neuroprotection in proteasome inhibition-induced cytotoxicity in SH-SY5Y cells
    Benxu Cheng
    Regional Academic Health Center Edinburg E RAHC, Medical Research Division, 1214 W Schunior St, Edinburg, TX 78541, USA
    Mol Cell Neurosci 47:181-90. 2011
    ..Together these findings suggest that activation of PI3/AKT pathways by IGF-1 is involved in IGF-1 neuroprotection against apoptosis following proteasome inhibition...
  9. doi request reprint Effects of anabolic androgenic steroids and social subjugation on behavior and neurochemistry in male rats
    Krystle A Frahm
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Pharmacol Biochem Behav 97:416-22. 2011
    ..5HIAA was significantly increased in the prefrontal cortex of all experimental groups. We conclude that AAS and SS differentially affect behavior towards females as well as neurotransmitter levels...
  10. pmc Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease
    Kc Biju
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Ther 18:1536-44. 2010
    ..These results indicate that macrophage-mediated GDNF delivery is a promising strategy for developing a neuroprotective therapy for PD...
  11. ncbi request reprint Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon
    Mona Bains
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 703 Floyd Curl Drive MC 6205, San Antonio, TX 78229, USA
    Exp Neurol 204:767-76. 2007
    ..These data indicate that neuroprotection provided by estrogen against MPP(+) toxicity is mediated by ERalpha and involves an interplay among at least two cell types...
  12. pmc WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    David A Price
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA
    Eur J Neurosci 29:2177-86. 2009
    ....
  13. pmc Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesion
    Rebecca L Cunningham
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Horm Behav 60:617-24. 2011
    ..Collectively, the data support the hypothesis that androgens may underlie the gender bias observed in PD...
  14. ncbi request reprint Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity
    Qitao Ran
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Neurosci Res 84:202-8. 2006
    ..Our data demonstrate that overexpression of Gpx4 protects neurons against oxidative injury and beta-amyloid-induced cytotoxicity...
  15. ncbi request reprint EP24.15 is associated with lipid rafts
    Nathaniel A Jeske
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci Res 74:468-73. 2003
    ..With this exofacial localization, EP24.15 could have ample access to neuropeptides not only in the immediate microenvironment, but the ability to degrade or modify peptides bound for receptor interaction...
  16. ncbi request reprint Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
    Qian Gao
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Med 13:89-94. 2007
    ....
  17. ncbi request reprint Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice
    Tooru M Mizuno
    Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Diabetes 52:2675-83. 2003
    ....
  18. ncbi request reprint Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5)
    T J Wu
    Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Endocrinology 146:280-6. 2005
    ..The present study supports the hypothesis that the physiological metabolite of LHRH, LHRH-(1-5), is functionally capable of regulating the reproductive neuroendocrine system...
  19. ncbi request reprint Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity
    Vitor Oliveira
    Laboratorio de Neurociencias, Universidade da Cidade de São Paulo, Brazil
    FEBS J 272:2978-92. 2005
    ..15. Moreover, calcium was also observed to induce a major change in the EP24.15 cleavage site on distinctive fluorogenic substrates. These data suggest that calcium may be an important modulator of ep24.15 cell function...
  20. ncbi request reprint Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity
    Toni R Pak
    Department of Biomedical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, 80523, USA
    Endocrinology 147:1924-31. 2006
    ..Overall, our data suggest that ERbeta functions as a basic transcription factor in GnRH neurons and demonstrate a potential molecular mechanism for the negative feedback effects of E(2) on GnRH...
  21. ncbi request reprint Facilitation of lordosis in rats by a metabolite of luteinizing hormone releasing hormone
    T J Wu
    Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Endocrinology 147:2544-9. 2006
    ..Collectively, these results suggest a role for LHRH metabolites in the facilitation of female receptive behavior in rats...
  22. ncbi request reprint The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neurons
    I Wei Shu
    Fishberg Research Center for Neurobiology, New York, NY, USA
    Brain Res 985:1-12. 2003
    ..These results suggest that activation of hypothalamic POMC neurons may help to mediate some of the catabolic effects associated with feeding, cerulenin and leptin...

Research Grants11

  1. GROWTH FACTORS IN THE ADULT AND AGING BRAIN
    James Roberts; Fiscal Year: 2004
    ..Thus, we propose to establish whether new dopamine neurons are produced in response to injury or can be stimulated to differentiate by ectopically expressing cytokines, which are able to regulate neuronal. ..
  2. EXTRACELLULAR NEUROPEPTIDE PROCESSING ENDOPEPTIDASE
    James Roberts; Fiscal Year: 2002
    ..15? Aim 3b. Does phosphorylation alter the activity/partition of EP24.15 in the extracellular environment? Determine which form of EP24.15 and the residue on the EP24.15 protein for phosphorylation in vivo. ..
  3. ECM and the Differentiation/Plasticity of DA Neurons
    James Roberts; Fiscal Year: 2006
    ..Thus, we plan to culture embryonic dopamine neurons on striatal tissue slices collected from control and MPTP mice of different age groups. ..