Research Topics
Genomes and Genes | James L RobertsSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
LHRH-(1-5): a bioactive peptide regulating reproductionJames L Roberts
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Trends Endocrinol Metab 18:386-92. 2007..The involvement of LHRH-(1-5) in the control of aspects of reproduction might represent yet another level of regulatory complexity through neuropeptide processing...
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's diseaseSyed Z Imam
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
J Neurosci 31:157-63. 2011..Moreover, inhibition of c-Abl offers new therapeutic opportunities for blocking PD progression...- 17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivoMatthew P Rowan
Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
J Pharmacol Exp Ther 335:190-6. 2010.... - Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cellsNathaniel A Jeske
Department of Pharmacology, University of Texas Health Science Center of San Antonio, San Antonio, Texas 78229 3900, USA
J Neurochem 90:819-28. 2004..With these data, we conclude that EP24.15 association with lipid rafts on the extracellular surface precedes constitutive release of the peptidase into the extracellular milieu for its action on neuropeptides... - Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal gangliaNathaniel A Jeske
Department of Pharmacology, UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
J Neurochem 97:13-21. 2006..Taken together, these data demonstrate that EP24.15/16 modulate intracellular, peptidergic signaling cascades through B2R in a physiologically relevant nociceptive system... - Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase CdeltaRebecca L Cunningham
Department of Pharmacology and the Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78229, USA
Endocrinology 150:5539-48. 2009..These results support a neurotoxic consequence of testosterone on dopaminergic neurons and may provide insight into the gender bias found in PD... - Insulin-like growth factor-I mediates neuroprotection in proteasome inhibition-induced cytotoxicity in SH-SY5Y cellsBenxu Cheng
Regional Academic Health Center Edinburg E RAHC, Medical Research Division, 1214 W Schunior St, Edinburg, TX 78541, USA
Mol Cell Neurosci 47:181-90. 2011..Together these findings suggest that activation of PI3/AKT pathways by IGF-1 is involved in IGF-1 neuroprotection against apoptosis following proteasome inhibition... - Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalonMona Bains
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 703 Floyd Curl Drive MC 6205, San Antonio, TX 78229, USA
Exp Neurol 204:767-76. 2007..These data indicate that neuroprotection provided by estrogen against MPP(+) toxicity is mediated by ERalpha and involves an interplay among at least two cell types... 
Effects of anabolic androgenic steroids and social subjugation on behavior and neurochemistry in male ratsKrystle A Frahm
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Pharmacol Biochem Behav 97:416-22. 2011..5HIAA was significantly increased in the prefrontal cortex of all experimental groups. We conclude that AAS and SS differentially affect behavior towards females as well as neurotransmitter levels...- Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's diseaseKc Biju
Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Mol Ther 18:1536-44. 2010..These results indicate that macrophage-mediated GDNF delivery is a promising strategy for developing a neuroprotective therapy for PD... - Androgens exacerbate motor asymmetry in male rats with unilateral 6-hydroxydopamine lesionRebecca L Cunningham
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Horm Behav 60:617-24. 2011..Collectively, the data support the hypothesis that androgens may underlie the gender bias observed in PD... - WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's diseaseDavid A Price
Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA
Eur J Neurosci 29:2177-86. 2009.... - Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicityQitao Ran
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
J Neurosci Res 84:202-8. 2006..Our data demonstrate that overexpression of Gpx4 protects neurons against oxidative injury and beta-amyloid-induced cytotoxicity... - EP24.15 is associated with lipid raftsNathaniel A Jeske
Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
J Neurosci Res 74:468-73. 2003..With this exofacial localization, EP24.15 could have ample access to neuropeptides not only in the immediate microenvironment, but the ability to degrade or modify peptides bound for receptor interaction... - Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animalsQian Gao
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Med 13:89-94. 2007.... - Facilitation of lordosis in rats by a metabolite of luteinizing hormone releasing hormoneT J Wu
Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Endocrinology 147:2544-9. 2006..Collectively, these results suggest a role for LHRH metabolites in the facilitation of female receptive behavior in rats... - Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activityToni R Pak
Department of Biomedical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, 80523, USA
Endocrinology 147:1924-31. 2006..Overall, our data suggest that ERbeta functions as a basic transcription factor in GnRH neurons and demonstrate a potential molecular mechanism for the negative feedback effects of E(2) on GnRH... - Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificityVitor Oliveira
Laboratorio de Neurociencias, Universidade da Cidade de São Paulo, Brazil
FEBS J 272:2978-92. 2005..15. Moreover, calcium was also observed to induce a major change in the EP24.15 cleavage site on distinctive fluorogenic substrates. These data suggest that calcium may be an important modulator of ep24.15 cell function... - Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5)T J Wu
Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Endocrinology 146:280-6. 2005..The present study supports the hypothesis that the physiological metabolite of LHRH, LHRH-(1-5), is functionally capable of regulating the reproductive neuroendocrine system... - Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese miceTooru M Mizuno
Fishberg Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
Diabetes 52:2675-83. 2003.... - The fatty acid synthase inhibitor cerulenin and feeding, like leptin, activate hypothalamic pro-opiomelanocortin (POMC) neuronsI-Wei Shu
Fishberg Research Center for Neurobiology, New York, NY, USA
Brain Res 985:1-12. 2003..These results suggest that activation of hypothalamic POMC neurons may help to mediate some of the catabolic effects associated with feeding, cerulenin and leptin...
Research Grants
- GROWTH FACTORS IN THE ADULT AND AGING BRAINJames Roberts; Fiscal Year: 2004..Thus, we propose to establish whether new dopamine neurons are produced in response to injury or can be stimulated to differentiate by ectopically expressing cytokines, which are able to regulate neuronal. ..
- EXTRACELLULAR NEUROPEPTIDE PROCESSING ENDOPEPTIDASEJames Roberts; Fiscal Year: 2002..15? Aim 3b. Does phosphorylation alter the activity/partition of EP24.15 in the extracellular environment? Determine which form of EP24.15 and the residue on the EP24.15 protein for phosphorylation in vivo. ..
- ECM and the Differentiation/Plasticity of DA NeuronsJames Roberts; Fiscal Year: 2006..Thus, we plan to culture embryonic dopamine neurons on striatal tissue slices collected from control and MPTP mice of different age groups. ..