J M Roberts

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 22:109-27. 2003
  2. ncbi request reprint Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Graduate School of Public Health, University of Pittsburgh, and Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 41:437-45. 2003
  3. ncbi request reprint Preeclampsia: what we know and what we do not know
    J M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, PA 15213, USA
    Semin Perinatol 24:24-8. 2000
  4. ncbi request reprint Nutrient involvement in preeclampsia
    James M Roberts
    Magee Womens Research Institute and the Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Nutr 133:1684S-1692S. 2003
  5. ncbi request reprint Pre-eclampsia and cardiovascular disease in later life
    James M Roberts
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lancet 366:961-2. 2005
  6. ncbi request reprint Recent Insights into the pathogenesis of pre-eclampsia
    J M Roberts
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213 3180, USA
    Placenta 23:359-72. 2002
  7. ncbi request reprint Placental system A transporter mRNA is not different in preeclampsia, normal pregnancy, or pregnancies with small-for-gestational-age infants
    Amanda Malina
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Hypertens Pregnancy 24:65-74. 2005
  8. ncbi request reprint Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:4895-903. 2005
  9. pmc Uric acid inhibits placental system A amino acid uptake
    S A Bainbridge
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 30:195-200. 2009
  10. pmc Vitamins C and E to prevent complications of pregnancy-associated hypertension
    James M Roberts
    Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, USA
    N Engl J Med 362:1282-91. 2010

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 22:109-27. 2003
    ..Recommendations to increase participation in this research are also presented...
  2. ncbi request reprint Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Graduate School of Public Health, University of Pittsburgh, and Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 41:437-45. 2003
    ..Recommendations to increase participation in this research are also presented...
  3. ncbi request reprint Preeclampsia: what we know and what we do not know
    J M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, PA 15213, USA
    Semin Perinatol 24:24-8. 2000
    ..The author proposes that oxidative stress secondary to reduced placental perfusion leads to endothelial dysfunction, linking the 2 stages of the syndrome...
  4. ncbi request reprint Nutrient involvement in preeclampsia
    James M Roberts
    Magee Womens Research Institute and the Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Nutr 133:1684S-1692S. 2003
    ..Targets for nutritional investigation based on the current knowledge of pathophysiology are suggested...
  5. ncbi request reprint Pre-eclampsia and cardiovascular disease in later life
    James M Roberts
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Lancet 366:961-2. 2005
  6. ncbi request reprint Recent Insights into the pathogenesis of pre-eclampsia
    J M Roberts
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213 3180, USA
    Placenta 23:359-72. 2002
    ..Finally, the suggestion that some of the maternal alterations are due to fetal adaptive responses encourages careful choices of agents and meticulous infant follow up in well planned clinical trials...
  7. ncbi request reprint Placental system A transporter mRNA is not different in preeclampsia, normal pregnancy, or pregnancies with small-for-gestational-age infants
    Amanda Malina
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Hypertens Pregnancy 24:65-74. 2005
    ..We compared the expression of the system A transporters between preeclamptic and control and between small-for-gestational-age and controls pregnancies...
  8. ncbi request reprint Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:4895-903. 2005
    ..However, the latter condition occurs without maternal vascular disease...
  9. pmc Uric acid inhibits placental system A amino acid uptake
    S A Bainbridge
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 30:195-200. 2009
    ....
  10. pmc Vitamins C and E to prevent complications of pregnancy-associated hypertension
    James M Roberts
    Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, USA
    N Engl J Med 362:1282-91. 2010
    ..We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension...
  11. ncbi request reprint Maternal fetal/placental interactions and abnormal pregnancy outcomes
    James M Roberts
    Hypertension 49:15-6. 2007
  12. pmc Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor
    F von Versen-Höynck
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Placenta 30:434-42. 2009
    ..These data are consistent with the hypothesis that differences in placental adenosine receptors may contribute to alterations in placental function in preeclampsia...
  13. ncbi request reprint Mishandling of copper by albumin: role in redox-cycling and oxidative stress in preeclampsia plasma
    V E Kagan
    Department of Environmental and Occupational Health, and Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Hypertens Pregnancy 20:221-41. 2001
    ....
  14. pmc Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants
    Paul D Speer
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 198:112.e1-7. 2008
    ....
  15. ncbi request reprint The Trp64Arg polymorphism of the beta3-adrenergic receptor is not increased in women with preeclampsia
    Amanda N Malina
    Magee Womens Research Institute and Department of Obstetrics, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Obstet Gynecol 190:779-83. 2004
    ..The Trp64Arg polymorphism in the beta(3)-adrenergic receptor is associated with these metabolic changes. This study investigated whether the Trp64Arg polymorphism is more common in women with preeclampsia...
  16. ncbi request reprint Effect of smoking on uric acid and other metabolic markers throughout normal pregnancy
    Kristine Y Lain
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:5743-6. 2005
    ..We compared several metabolic markers of the metabolic syndrome in healthy primigravid smokers and nonsmokers over normal pregnancy to explore mechanisms for the reduced risk of preeclampsia in smokers...
  17. ncbi request reprint Homocysteine and folic acid are inversely related in black women with preeclampsia
    Thelma E Patrick
    Magee Womens Research Institute, Pittsburgh, PA, USA
    Hypertension 43:1279-82. 2004
    ..Racial differences in diet, adherence to folic acid supplementation, or interactions of nutritional and maternal factors warrant further study by race and pregnancy status...
  18. ncbi request reprint Maternal androgen and estrogen concentrations are not associated with blood pressure changes in uncomplicated pregnancies
    Rebecca Troisi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7246, USA
    Cancer Epidemiol Biomarkers Prev 15:2013-5. 2006
    ..These data are not consistent with the hypothesis that elevated androgen concentrations mediate the observed reduction in maternal breast cancer risk associated with increases in blood pressure over the pregnancy...
  19. pmc Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants
    E Shibata
    Magee Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Placenta 29:879-82. 2008
    ....
  20. ncbi request reprint Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy
    R W Powers
    Magee Womens Research Institute Department of Ob Gyn and Reproductive Sciences, Pittsburgh, Pennsylvania, USA
    Hypertens Pregnancy 20:69-77. 2001
    ....
  21. ncbi request reprint Low-density lipoprotein particle size decreases during normal pregnancy in association with triglyceride increases
    C A Hubel
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    J Soc Gynecol Investig 5:244-50. 1998
    ....
  22. ncbi request reprint Current concepts in preeclampsia
    T Patrick
    Department of Ob Gyn and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Women s Research Institute, Pennsylvania 15213, USA
    MCN Am J Matern Child Nurs 24:193-200; quiz 201. 1999
    ....
  23. ncbi request reprint Inflammation and triglycerides partially mediate the effect of prepregnancy body mass index on the risk of preeclampsia
    Lisa M Bodnar
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 162:1198-206. 2005
    ..Inflammation was a more important mediator than triglycerides. These findings suggest that approximately one third of the total effect of body mass index on preeclampsia risk is mediated through inflammation and triglyceride levels...
  24. ncbi request reprint Smoking during pregnancy is associated with alterations in markers of endothelial function
    Kristine Y Lain
    Magee Womens Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, Pittsburgh, PA, USA
    Am J Obstet Gynecol 189:1196-201. 2003
    ..Alterations in endothelial function may explain the reduced risk of preeclampsia that is associated with smoking. We hypothesized that markers of endothelial function increase over pregnancy but decrease with smoking...
  25. ncbi request reprint Inflammation and dyslipidemia related to risk of spontaneous preterm birth
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 166:1312-9. 2007
    ..The results indicate that some metabolic factors together with inflammation may be related to the risk of sPTB...
  26. ncbi request reprint Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk
    Patricia K Agatisa
    Department of Obstetics and Gynecology, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Heart Circ Physiol 286:H1389-93. 2004
    ..006). These data demonstrate that women with a history of preeclampsia exhibit impaired endothelial function up to 1 yr postpartum. This observation may explain their increased risk for hypertension and cardiovascular disease...
  27. ncbi request reprint Racial/ethnic differences in the monthly variation of preeclampsia incidence
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
    Am J Obstet Gynecol 196:324.e1-5. 2007
    ..The purpose of this study was to assess monthly patterns in preeclampsia risk separately by race/ethnicity...
  28. ncbi request reprint Association of periconceptional multivitamin use and risk of preterm or small-for-gestational-age births
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Epidemiol 166:296-303. 2007
    ..Study results indicate lower rates of severe preterm births and extreme SGA in women who report periconceptional vitamin use, although these should be considered cautiously until replicated...
  29. ncbi request reprint Maternal vitamin D deficiency increases the risk of preeclampsia
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, A742 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261, USA
    J Clin Endocrinol Metab 92:3517-22. 2007
    ..Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied...
  30. ncbi request reprint Association between infant birth weight and maternal cardiovascular risk factors in the health, aging, and body composition study
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Ann Epidemiol 17:36-43. 2007
    ....
  31. ncbi request reprint Changes in markers of vascular injury in response to transient hyperhomocysteinemia
    Robert W Powers
    Magee Womens Research Institute and the Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Metabolism 52:501-7. 2003
    ..These data suggest that very high homocysteine concentrations can promote endothelial injury; however, this effect is likely mediated by secondary effects that include a factor(s) present in plasma that affects endothelial cells...
  32. pmc Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women
    Lisa M Bodnar
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Nutr 140:999-1006. 2010
    ..One SNP in the VDR gene among white women and 3 SNP in black women were significantly associated with SGA. Our results suggest that vitamin D has a complex relation with fetal growth that may vary by race...
  33. ncbi request reprint Oxidative stress in preeclampsia
    James M Roberts
    Am J Obstet Gynecol 190:1177-8. 2004
  34. ncbi request reprint Seroprevalence of antibodies to Chlamydia pneumoniae in women with preeclampsia
    R Phillip Heine
    Duke University Medical Center, Durham, North Carolina, USA
    Obstet Gynecol 101:221-6. 2003
    ..We studied whether, like atherosclerosis, preeclampsia is related to seroprevalence of immunoglobulin (Ig) G antibodies to Chlamydia pneumoniae...
  35. pmc The two stage model of preeclampsia: variations on the theme
    J M Roberts
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Placenta 30:S32-7. 2009
    ..The modified Two Stage Model provides a useful guide towards investigating pathophysiology and guiding therapy...
  36. ncbi request reprint Increased umbilical cellular fibronectin concentrations are associated with a decreased prevalence of growth restriction in preeclampsia
    C H Gilmour
    Department of Pediatrics, University of Pittsburgh, Pennsylvania, USA
    J Soc Gynecol Investig 6:264-7. 1999
    ..We tested whether maternal or fetal cFN is related to fetal growth restriction in preeclampsia, in the context of gestational age at delivery...
  37. ncbi request reprint Distinct factors in plasma of preeclamptic women increase endothelial nitric oxide or prostacyclin
    S T Davidge
    Magee Womens Research Institute, University of Pittsburgh, PA, USA
    Hypertension 28:758-64. 1996
    ..Two distinct factors in the blood of preeclamptic women alter endothelial function in vitro. This information should guide the search for circulating factors contributing to the pathophysiology of preeclampsia...
  38. ncbi request reprint Human endothelial cell morphology and autacoid expression
    C J De Groot
    W M Keck Laboratory of Reproductive and Developmental Molecular Biology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California School of Medicine, San Francisco 94143, USA
    Am J Physiol 268:H1613-20. 1995
    ....
  39. ncbi request reprint Association of pre-eclampsia with common coding sequence variations in the lipoprotein lipase gene
    C A Hubel
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Clin Genet 56:289-96. 1999
    ..4% of population controls). The frequency of the S447X variant did not differ among groups. We conclude that carriers of N291S or combined D9N/ - 93T --> G mutations in the LPL gene are at substantially increased risk of pre-eclampsia...
  40. ncbi request reprint Elevated levels of S-nitrosoalbumin in preeclampsia plasma
    V A Tyurin
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15238, USA
    Circ Res 88:1210-5. 2001
    ..We conclude that S-nitrosoalbumin and total S-nitrosothiol concentrations are significantly increased in preeclampsia plasma and may reflect insufficient release of NO groups in this condition...
  41. pmc Effect of smoking on circulating angiogenic factors in high risk pregnancies
    Arun Jeyabalan
    Department of Obstetrics, Gynecology and Women s Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13270. 2010
    ..The objective of this study was to investigate whether smoking affects concentrations of angiogenic factors (sFlt1, PlGF, and sEng) in women at high risk for developing preeclampsia...
  42. ncbi request reprint Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia
    R W Powers
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 193:185-91. 2005
    ..We measured maternal serum soluble fms-like tyrosine kinase 1 concentrations across pregnancy and immediately postpartum in women who developed preeclampsia and normal pregnant women...
  43. doi request reprint Modification of angiogenic factors by regular and acute exercise during pregnancy
    Tracey L Weissgerber
    Department of Obstetrics, Gynecology and Reproductive Science, Magee Womens Research Institute, University of Pittsburgh, Rm A340, 204 Craft Ave, Pittsburgh, PA 15213, USA
    J Appl Physiol 108:1217-23. 2010
    ..012], but not in active nonpregnant women. Regular exercise during pregnancy is associated with higher serum PlGF and lower sFlt-1 and sEng concentrations in late gestation, a difference that is unlikely to have predated the pregnancy...
  44. ncbi request reprint Variability in cerebral oxygen delivery is reduced in premature neonates exposed to chorioamnionitis
    Toby D Yanowitz
    Department of Pediatrics, University of Pitttsburgh School of Medicine, PA 15217, USA
    Pediatr Res 59:299-304. 2006
    ..Further studies are needed to determine how these findings relate to cerebral blood flow autoregulation and oxygen utilization in premature infants...
  45. ncbi request reprint Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 194:160. 2006
    ..We investigated changes in serum uric acid across pregnancy in women with gestational hyperuricemia at delivery, with and without preeclampsia, compared with normal pregnant and women with preeclampsia without gestational hyperuricemia...
  46. ncbi request reprint Prepregnancy body mass index and the occurrence of severe hypertensive disorders of pregnancy
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Epidemiology 18:234-9. 2007
    ..Prepregnancy overweight is a risk factor for mild preeclampsia and mild transient hypertension of pregnancy. Its association with severe subtypes of these disorders has received less attention...
  47. ncbi request reprint Maternal leptin concentrations are similar in African Americans and Caucasians in normal pregnancy, preeclampsia and small-for-gestational-age infants
    Laura D Jenkins
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 26:101-9. 2007
    ..Differences in the frequency and severity of preeclampsia in African Americans cannot be explained by higher leptin concentrations...
  48. pmc Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes
    S Katherine Laughon
    Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 201:402.e1-5. 2009
    ..We sought to demonstrate that elevated first-trimester uric acid is associated with development of gestational diabetes mellitus (GDM)...
  49. ncbi request reprint Aspirin for pre-eclampsia: compelling data on benefit and risk
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Lancet 369:1765-6. 2007
  50. pmc Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women
    S Katherine Laughon
    Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Obstet Gynecol 201:582.e1-6. 2009
    ..We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth...
  51. pmc Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers
    Shannon A Bainbridge
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Cell Physiol 297:C440-50. 2009
    ....
  52. pmc Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia
    Arun Jeyabalan
    Magee Womens Research Institute and Foundation, Pittsburgh, Pennsylvania, USA
    Am J Hypertens 21:943-7. 2008
    ....
  53. pmc Evidence of endothelial dysfunction in preeclampsia and risk of adverse pregnancy outcome
    Robert W Powers
    Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Reprod Sci 15:374-81. 2008
    ..5-13.1) in women with preeclampsia, hyperuricemia, and elevated cFN compared with normotensive women. Elevated cFN is prevalent among women with preeclampsia and identifies women at increased risk of preterm delivery and SGA...
  54. ncbi request reprint Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertension
    James M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Hypertension 46:1263-9. 2005
    ..Hyperuricemia is at least as effective as proteinuria at identifying gestational hypertensive pregnancies at increased risk. Uric acid should be reexamined for clinical and research utility...
  55. ncbi request reprint Moderate hyperhomocysteinemia decreases endothelial-dependent vasorelaxation in pregnant but not nonpregnant mice
    Robert W Powers
    Magee Women s Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Hypertension 44:327-33. 2004
    ..This effect appears to result from a loss in NO-mediated relaxation that may be mediated by the oxidative inactivation of the NO synthase cofactor tetrahydrobiopterin...
  56. ncbi request reprint Plasma homocysteine and malondialdehyde are correlated in an age- and gender-specific manner
    Robert W Powers
    Magee Womens Research Institute and Department of Obstetrics Gynecology and Reproductive Sciences, University of Pittsburgh, PA 15213, USA
    Metabolism 51:1433-8. 2002
    ..Since oxidative stress correlates with basal homocysteine only in young men and does not increase with acutely increased homocysteine, it is unlikely to be the result of a direct effect of homocysteine...
  57. ncbi request reprint Evidence of increased oxidative stress, unexplained by lipid changes, is present in nulliparous black women from early gestation
    Thelma E Patrick
    Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 23:91-100. 2004
    ..We tested the hypothesis that race-specific lipid changes in pregnancy could predispose to oxidative stress and might increase the risk of preeclampsia for black women...
  58. ncbi request reprint A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium
    Judith L Balk
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh, Pennsylvania 15213, USA
    J Soc Gynecol Investig 9:238-42. 2002
    ....
  59. ncbi request reprint Nonglycosylated ferritin predominates in the circulation of women with preeclampsia but not intrauterine growth restriction
    Carl A Hubel
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Chem 50:948-51. 2004
  60. ncbi request reprint Contemporary concepts of the pathogenesis and management of preeclampsia
    Kristine Y Lain
    Magee Womens Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA
    JAMA 287:3183-6. 2002
  61. ncbi request reprint Antioxidant therapy to prevent preeclampsia
    James M Roberts
    Magee Women s Research Institute, Pittsburgh, PA 15213, USA
    Semin Nephrol 24:557-64. 2004
    ..These studies should definitively establish the efficacy and safety of this therapy for the mother and fetus...
  62. ncbi request reprint Maternal plasma homocysteine concentrations are not increased in twin pregnancies
    Robert W Powers
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 204 Craft Ave, Room 620, 15213, Pittsburgh, Pennsylvania 15213, USA
    Hypertens Pregnancy 24:49-58. 2005
    ..We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies without preeclampsia and normal singleton pregnancies...
  63. ncbi request reprint Interleukin-6 promoter -174 polymorphism and spontaneous preterm birth
    Hyagriv N Simhan
    University of Pittsburgh School of Medicine, Department of Obstetrics, Magee Womens Research Institute, Pittsburgh, PA, USA
    Am J Obstet Gynecol 189:915-8. 2003
    ..We assessed the relationship between interleukin-6 (IL-6) promoter -174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race...
  64. ncbi request reprint Second pregnancy outcomes following preeclampsia in a first pregnancy
    Kristine Y Lain
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Hypertens Pregnancy 24:159-69. 2005
    ..We compared second pregnancy outcomes among women with and without preeclampsia in their first pregnancies who all had second pregnancies without preeclampsia...
  65. ncbi request reprint The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy
    Robert W Powers
    Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Obstet Gynecol 101:762-6. 2003
    ....
  66. ncbi request reprint Preeclampsia: recent insights
    James M Roberts
    Magee Womens Research Institute, University of Pittsburgh, Pennsylvania, USA
    Hypertension 46:1243-9. 2005
    ..In the last decade such studies have provided valuable insights into pathophysiology that now guide ongoing clinical trials...
  67. ncbi request reprint Maternal leptin across pregnancy in women with small-for-gestational-age infants
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Am J Obstet Gynecol 196:558.e1-8. 2007
    ..We hypothesized that women with small-for-gestational-age (SGA) neonates would have lower concentrations of leptin compared to women with appropriately grown infants (AGA)...
  68. pmc Preeclampsia risk and angiotensinogen polymorphisms M235T and AGT -217 in African American and Caucasian women
    Laura D Jenkins
    Magee Women s Research Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Reprod Sci 15:696-701. 2008
    ..The authors investigated the frequency of M235T and AGT -217 in Caucasian and African American women with and without preeclampsia...
  69. ncbi request reprint Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia
    Carl A Hubel
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, PA, USA
    Hypertension 49:612-7. 2007
    ..The impact of AT1-AA after preeclampsia, especially in the context of cardiovascular risk, remains to be determined...
  70. ncbi request reprint The risk of preeclampsia rises with increasing prepregnancy body mass index
    Lisa M Bodnar
    Magee Womens Research Institute, Pittsburgh, PA, USA
    Ann Epidemiol 15:475-82. 2005
    ..To explore the dose-dependent relation between prepregnancy body mass index (BMI) and the risk of preeclampsia after adjusting for measured confounders...
  71. pmc Anxiety and optimism associated with gestational age at birth and fetal growth
    Janet M Catov
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA
    Matern Child Health J 14:758-64. 2010
    ..Trait anxiety was associated with a reduction in gestational age and increased risk for preterm birth among African American women. Interventions that reduce anxiety among African American pregnant women may improve pregnancy outcomes...
  72. ncbi request reprint Intracellular adhesion molecule concentrations in women who smoke during pregnancy
    Kristine Y Lain
    Magee Womens Research Institute and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obstet Gynecol 107:588-94. 2006
    ..Our objectives were to determine if smoking has an impact on endothelial function in pregnancy by comparing markers of endothelial function and to evaluate the contribution from different cellular sources...
  73. ncbi request reprint The Preterm Prediction Study: the value of serum alkaline phosphatase, alpha-fetoprotein, plasma corticotropin-releasing hormone, and other serum markers for the prediction of spontaneous preterm birth
    Atef H Moawad
    National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network, USA
    Am J Obstet Gynecol 186:990-6. 2002
    ..We investigated the relationship between 8 potential blood markers and subsequent spontaneous preterm birth in asymptomatic pregnant women...
  74. ncbi request reprint Pathogenesis and genetics of pre-eclampsia
    J M Roberts
    Magee-Womens Research Institute, Pittsburgh, PA, USA
    Lancet 357:53-6. 2001
    ..There are genetic components to susceptibility, but the relative contributions of maternal and fetal genotypes are still unclear. Whole-genome mapping could ultimately define the causative genes...
  75. pmc Uric acid as a pathogenic factor in preeclampsia
    S A Bainbridge
    Lab 336A, Magee Womens Research Institute, 204 Craft Ave, Pittsburgh, PA 15213, USA
    Placenta 29:S67-72. 2008
    ..Uric acid's ability to promote inflammation, oxidative stress and endothelial dysfunction will be highlighted with discussions of the potential impact on placental development and function and maternal vascular health...
  76. ncbi request reprint Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia
    J M Roberts
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143
    Am J Hypertens 4:700-8. 1991
    ..Preeclampsia is clearly more than "pregnancy induced hypertension."..
  77. ncbi request reprint Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia
    H Laivuori
    Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Hum Reprod 12:551-6. 2006
    ..This study suggests that despite similar failed placental bed vascular remodelling in pre-eclampsia and intrauterine growth restriction (IUGR), leptin gene expression is higher only in preterm pre-eclampsia...
  78. pmc Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Nutr 137:2437-42. 2007
    ..The rise in maternal obesity highlights that maternal and newborn vitamin D deficiency will continue to be a serious public health problem until steps are taken to identify and treat low 25(OH)D...
  79. pmc Prepregnancy lipids related to preterm birth risk: the coronary artery risk development in young adults study
    Janet M Catov
    Department of Obstetrics and Gynecology, University of Pittsburgh, 300 Halket Street, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 95:3711-8. 2010
    ..Preterm birth is associated with maternal cardiovascular risk, but mechanisms are unknown...
  80. ncbi request reprint Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activation
    Eiji Shibata
    Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Endocrinol Metab 291:E1009-16. 2006
    ..These data suggest that angiotensin II, via AT1-R signaling, decreases system A activity by suppressing Na(+)-K(+)-ATPase in human placental villi, consistent with possible adverse effects of enhanced placental RAS on fetal growth...
  81. pmc Maternal cereal consumption and adequacy of micronutrient intake in the periconceptional period
    Meredith Snook Parrott
    Magee Womens Research Institute, Pittsburgh, PA, USA
    Public Health Nutr 12:1276-83. 2009
    ..To assess the adequacy of periconceptional intake of key micronutrients for perinatal health in relation to regular cereal consumption of pregnant women...
  82. ncbi request reprint Family history of hypertension, heart disease, and stroke among women who develop hypertension in pregnancy
    Roberta B Ness
    University of Pittsburgh Graduate Scool of Public Health, and Magee Womens Research Institute, Pittsburgh, Pennsylvania 15261, USA
    Obstet Gynecol 102:1366-71. 2003
    ..To assess familial cardiovascular risk factors in women developing hypertension in pregnancy...
  83. pmc C-reactive protein is elevated 30 years after eclamptic pregnancy
    Carl A Hubel
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, PA, USA
    Hypertension 51:1499-505. 2008
    ..The triad of inflammation, low HDL, and insulin resistance may elevate risk for both preeclampsia/eclampsia and cardiovascular disease in later life...
  84. pmc A comparison of circulating TNF-alpha in obese and lean women with and without preeclampsia
    Sandra A Founds
    University of Pittsburgh School of Nursing, Pittsburgh, PA 15261, USA
    Hypertens Pregnancy 27:39-48. 2008
    ..We hypothesized that TNF-alpha would be higher in obese versus lean women with preeclampsia...
  85. ncbi request reprint Early pregnancy lipid concentrations and spontaneous preterm birth
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Obstet Gynecol 197:610.e1-7. 2007
    ..Women who deliver preterm infants may be at increased risk for cardiovascular disease, perhaps related to dyslipidemia...
  86. ncbi request reprint Preterm delivery and later maternal cardiovascular disease risk
    Janet M Catov
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Epidemiology 18:733-9. 2007
    ..Women who have delivered a preterm infant are at elevated risk for cardiovascular disease (CVD), but mechanisms for this association are not understood...
  87. ncbi request reprint Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia
    Yuping Wang
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shrevport, LA 71130, USA
    Am J Obstet Gynecol 186:214-20. 2002
    ..We hypothesized that increased endothelial monolayer permeability in preeclampsia reflects altered monolayer barrier properties produced by disorganization of endothelial cell junction proteins...
  88. ncbi request reprint Early occurrence of metabolic syndrome after hypertension in pregnancy
    Jean Claude Forest
    Center for the Development, Evaluation and Rational Implementation of New Medical Diagnostic, Hôpital St François d Assise du Centre Hospitalier Universitaire de Québec, Universite Laval, Quebec, Canada
    Obstet Gynecol 105:1373-80. 2005
    ..The objective of the present study was to evaluate the cardiovascular risk profile and the prevalence of metabolic syndrome among women with a history of pregnancy-induced hypertension (PIH)...
  89. ncbi request reprint Serum homocysteine levels after preterm premature rupture of the membranes
    Eric J Knudtson
    Am J Obstet Gynecol 191:537-41. 2004
    ..Elevated homocysteine levels have been shown to induce these same pathophysiologic changes. We tested the hypothesis that serum homocysteine levels would be higher in women with PPROM when compared with matched control women...
  90. ncbi request reprint Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance
    Myles Wolf
    Renal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:6239-43. 2004
    ..Women with a history of preeclampsia demonstrate altered expression of angiogenesis-related proteins and increased HOMA(IR) more than 1 yr postpartum. These factors may contribute to their risk of future CVD...
  91. ncbi request reprint The factor V leiden mutation and the risk of venous thromboembolism in gynecologic oncology patients1
    Amy J Ravin
    Grace Hill Neighborhood Health Centers Inc, St Louis, Missouri 63130, USA
    Obstet Gynecol 100:1285-9. 2002
    ..To measure the strength of the association between the factor V Leiden mutation and venous thromboembolism in gynecologic oncology patients...
  92. ncbi request reprint Preeclampsia more than 1 disease: or is it?
    James M Roberts
    Hypertension 51:989-90. 2008
  93. pmc A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy
    Dwight J Rouse
    University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 359:895-905. 2008
    ..Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy...
  94. ncbi request reprint Granulated metrial gland cells contain nitric oxide synthases during pregnancy in the rat
    S M Sladek
    Magee Womens Research Institute, Pittsburgh, PA 15213, USA
    Placenta 19:55-65. 1998
    ..Only a minority of uterine myocytes stained positively for inducible NOS and these were subjacent to the placental attachment site. Neuronal NOS immunostaining was not present in the decidua and the metrial gland...
  95. pmc Activation of the fibrinolytic cascade early in pregnancy among women with spontaneous preterm birth
    J M Catov
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA
    Obstet Gynecol 112:1116-22. 2008
    ..To evaluate the association of early pregnancy concentrations of thrombin-antithrombin III complex with subsequent spontaneous preterm birth...
  96. ncbi request reprint Rabbit alveolar beta-adrenergic receptors increase with gestational age
    V Lewis
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco
    Am J Obstet Gynecol 162:269-72. 1990
    ..This pattern is consistent with that previously observed after treatment of fetal rabbits in utero with corticosteroids...
  97. pmc How disturbed sleep may be a risk factor for adverse pregnancy outcomes
    Michele L Okun
    University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213, USA
    Obstet Gynecol Surv 64:273-80. 2009
    ....
  98. pmc Increased xanthine oxidase in the skin of preeclamptic women
    Shannon A Bainbridge
    Magee Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Craft Ave, Lab 336A, Pittsburgh, PA 15213, USA
    Reprod Sci 16:468-78. 2009
    ..The finding of increased xanthine oxidase in maternal tissue, most likely as the result of heightened maternal inflammation, suggests maternal xanthine oxidase as a source of free radical and uric acid generation in preeclampsia...
  99. ncbi request reprint Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies
    Rebecca Troisi
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7246, USA
    Int J Epidemiol 32:455-60. 2003
    ..Alterations in pregnancy hormone concentrations, particularly lower in utero exposure to oestrogen, are hypothesized to mediate this association...
  100. pmc Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer
    Inke Timmerbeul
    Department of Gastroenterology, Hepatology, and Endocrinology, Institute for Molecular Biology, Department of Hematology and Oncology, Institute for Pathology, Hannover Medical School, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 103:14009-14. 2006
    ..These studies may guide the choice of clinical settings in which pharmacologic inhibitors of the Skp2 pathway might be of therapeutic value...
  101. ncbi request reprint Preeclampsia--a pressing problem: an executive summary of a National Institute of Child Health and Human Development workshop
    John V Ilekis
    Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7510, USA
    Reprod Sci 14:508-23. 2007
    ..The research community needs to focus on these gaps to better understand the disease, with the ultimate goal of preventing the disorder...