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Genomes and Genes | Jacques RobertSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Antibody cross-linking of the thymocyte-specific cell surface molecule CTX causes abnormal mitosis and multinucleation of tumor cellsJ Robert
University of Rochester Medical Center, Rochester, New York 14642, USA
Exp Cell Res 235:227-37. 1997..Cells divide abnormally, accumulate in the G2/M phase of the cell cycle, and become multinucleated. This demonstrates, for the first time, that multinucleation can be induced by specifically cross-linking a cell surface molecule...- Ontogeny of CTX expression in xenopusJ Robert
Department of Microbiology, University of Rochester Medical Center, NY 14642, USA
Dev Comp Immunol 22:605-12. 1998..This pattern persists throughout larval and postmetamorphic life... - Evolution of immune surveillance and tumor immunity: studies in XenopusJ Robert
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York, USA
Immunol Rev 166:231-43. 1998.... - Cell surface expression of the endoplasmic reticular heat shock protein gp96 is phylogenetically conservedJ Robert
University of Rochester Medical Center, NY 14642, USA
J Immunol 163:4133-9. 1999..This selective surface expression of gp96 on some immune cells from different vertebrate classes is consistent with an ancestral immunological role of gp96 as danger-signaling molecule... - In vitro thymocyte differentiation in MHC class I-negative Xenopus larvaeJ Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
Dev Comp Immunol 25:323-36. 2001..This study also reveals that larval T-lymphoblasts are composed of two distinct subsets: CD5(high)CD8(-) and CD5 (high)CD8 (high)... - Xenopus as an experimental model for studying evolution of hsp--immune system interactionsJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Methods 32:42-53. 2004..Finally, techniques to study modalities of expression of the endoplasmic reticulum resident gp96 at the cell surface of tumor and normal lymphocytes are considered... - Evolution of heat shock protein and immunityJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672 601, Elmwood Avenue, Rochester, NY 14642, USA
Dev Comp Immunol 27:449-64. 2003..Data from studies with the frog Xenopus support this proposition... 
Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumorsAna Goyos
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Mol Immunol 46:1775-86. 2009..These data provide the first evidence of the expression of any class Ib genes in Xenopus larvae, and suggests evolutionary relationships between certain class Ib genes, malignancy and CD8 T cell ontogeny...- Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early developmentShauna Marr
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 179:6783-9. 2007..This study highlights the conserved involvement of XlAID during Ag-dependent B cell responses in Xenopus but also suggests another role in B cell differentiation earlier in ontogeny... - Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogsFrancisco De Jesús Andino
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Virology 432:435-43. 2012..Furthermore, greater proportions of larval than adult PLs were infected by FV3. Our study suggests that tadpole susceptibility to FV3 infection is partially due to poor virus-elicited innate immune responses... - Phylogenetic conservation of glycoprotein 96 ability to interact with CD91 and facilitate antigen cross-presentationJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 180:3176-82. 2008..The persistence of this biological process for >350 million years that separate mammals and amphibians from a common ancestor strongly supports the proposition that gp96 and CD91 are critically involved in immune surveillance... - Involvement of nonclassical MHC class Ib molecules in heat shock protein-mediated anti-tumor responsesAna Goyos
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Eur J Immunol 37:1494-501. 2007..This study provides in vitro and in vivo evidence of the evolutionary conservation of class Ib involvement in anti-tumor CD8+ T cell responses... - CD91 up-regulates upon immune stimulation in Xenopus adult but not larval peritoneal leukocytesShauna Marr
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, 14642, USA
Immunogenetics 56:735-42. 2005..These data are in agreement with a conserved role of CD91 in immunity... - Anti-tumor MHC class Ia-unrestricted CD8 T cell cytotoxicity elicited by the heat shock protein gp96Ana Goyos
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Eur J Immunol 34:2449-58. 2004.... - Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevisAsiya Seema Chida
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Comp Immunol 35:366-77. 2011.... - Remarkable conservation of distinct nonclassical MHC class I lineages in divergent amphibian speciesAna Goyos
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 186:372-81. 2011.... 
Xenopus, a unique comparative model to explore the role of certain heat shock proteins and non-classical MHC class Ib gene products in immune surveillanceJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
Immunol Res 45:114-22. 2009..In addition to a transplantable lymphoid tumor in genetically defined cloned Xenopus, we are generating transgenic frogs with inducible or knocked-down (RNAi) gene expression...- Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevisHeidi D Morales
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Virol 84:4912-22. 2010..This suggests that although PLs are actively involved in anti-FV3 immune responses, some of these cells can be permissive and harbor quiescent, asymptomatic FV3... - Comparative and developmental study of the immune system in XenopusJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
Dev Dyn 238:1249-70. 2009..laevis and S. tropicalis, as well as the whole Xenopus genus. Developmental Dynamics 238:1249-1270, 2009. (c) 2009 Wiley-Liss, Inc... - Identification and characterization of Xenopus CD8+ T cells expressing an NK cell-associated moleculeLaura Rau
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Eur J Immunol 32:1574-83. 2002..Taken together, these new data suggest that regulation of CD8+ T cell activity involving NK cell-associated molecules is a general and evolutionarily ancient phenomenon... - Minor histocompatibility antigen-specific MHC-restricted CD8 T cell responses elicited by heat shock proteinsJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 168:1697-703. 2002..e., gp96 purified from normal tissue also generates a significant antitumor response); this suggests a prominent contribution of an innate type of response in the absence of MHC class I Ags... - Adaptive immunity and histopathology in frog virus 3-infected XenopusJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Virology 332:667-75. 2005.... - Xenopus laevis: a possible vector of Ranavirus infection?Jacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Wildl Dis 43:645-52. 2007..These results suggest that FV3 can become quiescent in resistant species such as Xenopus, thereby making these species potential viral reservoirs... - Development and characterization of a model system to study amphibian immune responses to iridovirusesJennifer Gantress
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Virology 311:254-62. 2003.... - Antiviral immunity in amphibiansGuangchun Chen
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Viruses 3:2065-86. 2011.... - Structural phylogenetic analysis of activation-induced deaminase functionH Travis Ichikawa
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Immunol 177:355-61. 2006.... - The genus Xenopus as a multispecies model for evolutionary and comparative immunobiology of the 21st centuryJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, United States
Dev Comp Immunol 35:916-23. 2011..We also discuss the rich potential of the species with different degrees of polypoidy resulting from whole genome-wide duplication of the Xenopodinae subfamily as a model to study regulation at the genome level... - Bacterial stimulation upregulates the surface expression of the stress protein gp96 on B cells in the frog XenopusHeidi Morales
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Cell Stress Chaperones 8:265-71. 2003.... - Characterization of primary and memory CD8 T-cell responses against ranavirus (FV3) in Xenopus laevisHeidi D Morales
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Virol 81:2240-8. 2007..These results provide in vivo evidence of protective antigen-dependent CD8+ T-cell proliferation, recognition, and memory in fighting a natural pathogen in Xenopus... - Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogensLeon Grayfer
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Viruses 4:1075-92. 2012..This review focuses on the recent advances in the understanding of the RV immune evasion strategies with emphasis on the roles of the innate immune system in ranaviral infections... - Waterborne infectivity of the Ranavirus frog virus 3 in Xenopus laevisJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Virology 417:410-7. 2011..These data highlight the efficiency of FV3 infectivity by the water route and the ability of FV3 to adapt to its hosts... - Effects of thymectomy and tolerance induction on tumor immunity in adult Xenopus laevisJ Robert
Basel Institute for Immunology, Switzerland
Int J Cancer 70:330-4. 1997..Indeed, such grafts were rejected in accelerated fashion, suggesting that memory cells generated in the larvae persist through metamorphosis... - Evolution of the immunomodulatory role of the heat shock protein gp96J Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
Cell Mol Biol (Noisy-le-grand) 49:263-75. 2003.... - MHC-restricted and -unrestricted CD8 T cells: an evolutionary perspectiveL Rau
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Transplantation 72:1830-5. 2001..Our data also suggest that, at least in Xenopus, T cells that express a CD8 epitope may be effectors in MHC-unrestricted anti-tumor responses... - "Ranaviruses: an emerging threat to ectothermic vertebrates" report of the First International Symposium on Ranaviruses, Minneapolis MN July 8, 2011Jacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center Rochester, NY 14642, USA
Dev Comp Immunol 36:259-61. 2012.... - In vivo study of T-cell responses to skin alloantigens in Xenopus using a novel whole-mount immunohistology methodThaminda Ramanayake
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Transplantation 83:159-66. 2007..The African clawed frog, Xenopus, is a widely used comparative model for studying the immune response to transplantation antigens... - Improved knockout methodology reveals that frog virus 3 mutants lacking either the 18K immediate-early gene or the truncated vIF-2alpha gene are defective for replication and growth in vivoGuangchun Chen
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Virol 85:11131-8. 2011..In addition, our study describes a powerful methodology that lays the foundation for the discovery of potentially new ranaviral genes involved in virulence and immune escape... - Tumorigenesis and anti-tumor immune responses in XenopusAna Goyos
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Front Biosci 14:167-76. 2009.... - Phylogenetic conservation of the molecular and immunological properties of the chaperones gp96 and hsp70J Robert
University of Rochester Medical Center, Rochester, USA
Eur J Immunol 31:186-95. 2001..The remarkable conservation of these essential immunological properties of gp96 and hsp70 between amphibians and mammals suggests the importance of HSP in the evolution of the vertebrate immune system... - Optimized transgenesis in Xenopus laevis/gilli isogenetic clones for immunological studiesHristina Nedelkovska
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Genesis 50:300-6. 2012..Production of transgenic LG clones will allow us to modulate immune gene expression and further strengthen X. laevis as a biomedical model... - Effective RNAi-mediated β2-microglobulin loss of function by transgenesis in Xenopus laevisHristina Nedelkovska
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Biol Open 2:335-42. 2013..Additionally, b2m knockdown increased susceptibility to viral infection of F0 transgenic larvae. This loss of function strategy offers new avenues for studying ontogeny of immunity and other developmental processes in Xenopus... - Hsp72 mediates stronger antigen-dependent non-classical MHC class Ib anti-tumor responses than hsc73 in Xenopus laevisHristina Nedelkovska
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Cancer Immun 13:4. 2013..These results suggest that hsp72 can stimulate class Ib-mediated immune responses and represents a promising candidate for immunotherapy against malignancies with downregulated class Ia expression... - Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebratesJacques Robert
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, United States jacques
Dev Comp Immunol 34:915-25. 2010.... - Generation of a long-lasting, protective, and neutralizing antibody response to the ranavirus FV3 by the frog XenopusGregory D Maniero
Department of Biology, Stonehill College, Easton, MA 02356, USA
Dev Comp Immunol 30:649-57. 2006..These results with Xenopus suggest that other anuran amphibians are likely to develop effective long-lasting protective humoral immunity after an initial viral exposure... - Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stressMichelle M Appenheimer
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263 0001, USA
Eur J Immunol 37:2856-67. 2007.... - Ontogeny of Xenopus NK cells in the absence of MHC class I antigensTrudy L Horton
School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, UK
Dev Comp Immunol 27:715-26. 2003.... - Phylogenetic conservation of gp96-mediated antigen-specific cellular immunity: new evidence from adoptive cell transfer in xenopusGregory D Maniero
Department of Biology, Stonehill College, Easton, MA, USA
Transplantation 78:1415-21. 2004..We have developed an adoptive cell transfer protocol to further characterize these gp96-stimulated Xenopus effectors in vivo... - The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolutionSergey V Guselnikov
Institute of Cytology and Genetics, Novosibirsk, Russia
BMC Evol Biol 8:148. 2008..To better understand the evolutionary history of paired receptors, we extended the study of FcR-like genes in amphibian representatives Xenopus tropicalis and Xenopus laevis... - Quantification of the expression of multidrug resistance-related genes in human tumour cell lines grown with free doxorubicin or doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheresArmelle Laurand
, , and Institut Bergoni, 229 cours de l'Argonne, 33076 Bordeaux, France
Anticancer Res 24:3781-8. 2004..Our results show that several mechanisms may be involved in the acquisition of drug resistance and that drug encapsulation markedly alters or delays these processes... - Relationships between genetic polymorphisms and anticancer drug cytotoxicity vis-à-vis the NCI-60 panelValérie Le Morvan
Laboratoire de Pharmacologie des Agents Anticancéreux, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
Pharmacogenomics 7:843-52. 2006..We tested its potential interest for establishing relationships between the polymorphism of genes involved in drug metabolism and transport or in DNA repair, and drug cytotoxicity extracted from NCI databases... - Signaling FcRgamma and TCRzeta subunit homologs in the amphibian Xenopus laevisSergei V Guselnikov
Laboratory of Immunogenetics, Institute of Cytology and Genetics, Novosibirsk 30090, Russian Federation
Dev Comp Immunol 27:727-33. 2003..TCRzeta mRNA was predominantly expressed in the thymus and spleen. These data indicate that the amphibian immune system employs activating receptor complexes arranged in a mammalian-like way... - Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell linesValerie Pavillard
Universite Victor Segalen Bordeaux 2 and Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux, France
Cancer Chemother Pharmacol 49:329-35. 2002....