Tamara I A Roach

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium
    Tamara I A Roach
    Alliance for Cellular Signaling, Northern California Institute for Research and Education, San Francisco, California 94121, USA
    J Biol Chem 283:17351-61. 2008
  2. pmc Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2
    Robert A Rebres
    Alliance for Cellular Signaling at Northern California Institute for Research and Education, VA Medical Center, San Francisco, California, USA
    J Leukoc Biol 87:1041-57. 2010
  3. pmc Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q
    Robert A Rebres
    Alliance for Cellular Signaling, Northern California Institute for Research and Education, University of California, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 286:942-51. 2011

Detail Information

Publications3

  1. pmc Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium
    Tamara I A Roach
    Alliance for Cellular Signaling, Northern California Institute for Research and Education, San Francisco, California 94121, USA
    J Biol Chem 283:17351-61. 2008
    ..PLCbeta3 may thus provide a selective target for inhibiting Ca(2+) responses to mediators of inflammation, including C5a, UDP, PAF, and LPA...
  2. pmc Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2
    Robert A Rebres
    Alliance for Cellular Signaling at Northern California Institute for Research and Education, VA Medical Center, San Francisco, California, USA
    J Leukoc Biol 87:1041-57. 2010
    ..In sum, ToxB has opposing, independently regulated effects on Ca(2+) signaling by different GPCR-linked PLCbeta isoforms in macrophages...
  3. pmc Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q
    Robert A Rebres
    Alliance for Cellular Signaling, Northern California Institute for Research and Education, University of California, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 286:942-51. 2011
    ..We conclude that Ca(2+) synergy between Gα(i)-coupled and Gα(q)-coupled receptors requires the direct action of both Gβγ and Gα(q) on PLCβ and is mediated primarily by PLCβ3, although PLCβ2 is also competent...