Research Topics
Genomes and Genes | Jesus Rivera-NievesSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenaseJ Rivera-Nieves
Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 274:19525-31. 1999..This thiol linkage was stable to HgCl2. Thus, linkage of GAPDH to NADH, in contrast to NAD, occurs in the presence of thiol, is independent of NO, and is mediated by superoxide...- Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitisJesus Rivera-Nieves
Digestive Health Center of Excellence, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
Gastroenterology 131:1518-29. 2006..Furthermore, although clinical trials to evaluate the efficacy of targeting the CCL25/CCR9 axis for the treatment of Crohn's disease are being conducted, preclinical data in animal models of IBD are lacking... 
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitisJesus Rivera-Nieves
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Exp Med 203:907-17. 2006..Thus, the multiple roles of PSGL-1 may explain why targeting this single adhesion molecule results in attenuation of chronic murine ileitis, a disease previously resistant to antiadhesion molecule strategies...- L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestineJesus Rivera-Nieves
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 174:2343-52. 2005..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine... - Intestinal ischemia and peripheral gangrene in a patient with chronic renal failureJesus Rivera-Nieves
Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
Gastroenterology 122:495-9. 2002..Prompt diagnosis is crucial, as parathyroidectomy may result in clinical improvement in up to two thirds of patients who present with elevated parathyroid hormone levels... - Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitisJesus Rivera-Nieves
Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
Gastroenterology 124:972-82. 2003..In this report, we describe the distinguishing features of the SAMP1/YitFc substrain at the University of Virginia, compared with the Japanese SAMP1/Yit parental strain... - Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitisGiorgos Bamias
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 178:1809-18. 2007..All together, our results indicate that in SAMP1/YitFc mice, bacterial flora exacerbates intestinal inflammation, but is not essential for the generation of the chronic ileitis that is characteristic of these mice... 
A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitisJohnson Ho
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 180:2573-80. 2008..These inflammation-driven populations exert distinct roles during the development of chronic ileitis, and influence the balance of effector and regulatory functions in the chronically inflamed small intestine...- Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitisSean L Barnes
Digestive Health Center of Excellence, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 179:7012-20. 2007..Our data suggest that RELMbeta is involved in the initiation of ileitis in SAMP1/Fc mice and may act through the induction of proinflammatory cytokines from resident immune cells within the mucosa... - Role of TL1A and its receptor DR3 in two models of chronic murine ileitisGiorgos Bamias
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Proc Natl Acad Sci U S A 103:8441-6. 2006..Blockade of the TL1A/DR3 pathway may, therefore, offer therapeutic opportunities in Crohn's disease... - Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel diseaseMasaru Odashima
Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville 22908, USA
Gastroenterology 129:26-33. 2005..The aim of this study was to investigate the role of A 2A in mucosal inflammation by administering a selective A 2A agonist (ATL-146e) to experimental models of inflammatory bowel disease... 
Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitisColm B Collins
Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
Gut 61:1154-62. 2012..Objectives To analyse the effect of inflammation on the frequency of mononuclear phagocytes (MP) and the effect of altering their frequency by administration of Flt3-L in chronic ileitis...- Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's diseaseChristopher Bachmann
Division of Gastroenterology and Hepatology/Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Gastroenterology 130:8-16. 2006.... - The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in miceJoshua D Wermers
Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
Gastroenterology 140:1526-35.e3. 2011..We sought to determine whether interaction between the chemokine receptor 9 (CCR9) and its ligand, chemokine ligand 25 (CCL25), allows effectors or Tregs to localize to chronically inflamed small intestine... - Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammationGiorgos Bamias
Digestive Health Center of Excellence, University of Virginia Health Sciences Center, PO Box 800708, Charlottesville, Virginia 22908, USA
Gastroenterology 128:654-66. 2005..CONCLUSIONS: Our results indicate that both TH1 and TH2 pathways mediate Crohn's-like ileitis and suggest that combined TH1/TH2 manipulation may offer a therapeutic advantage for the treatment of Crohn's disease... - T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivoEmily Smith
Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 183:5685-93. 2009..Adoptively transferred Rag1(-/-) or WT thymocytes correct neutrophil counts in neutropenic nude mice. We conclude that the development of IL-17A-producing T-lineage cells requires an intact thymic epithelium, but not V(D)J recombination... - Leukocyte adhesion molecules in animal models of inflammatory bowel diseaseJesus Rivera-Nieves
Division of Gastroenterology, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Inflamm Bowel Dis 14:1715-35. 2008.... - Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's diseaseJose L Tlaxca
Department of Biomedical Engineering, School of Engineering and Applied Science, University of Virginia, Charlottesville, VA, United States
J Control Release 165:216-25. 2013....