Jesus Rivera-Nieves

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase
    J Rivera-Nieves
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:19525-31. 1999
  2. pmc Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:907-17. 2006
  3. ncbi request reprint L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 174:2343-52. 2005
  4. ncbi request reprint Intestinal ischemia and peripheral gangrene in a patient with chronic renal failure
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
    Gastroenterology 122:495-9. 2002
  5. ncbi request reprint Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    Gastroenterology 131:1518-29. 2006
  6. ncbi request reprint Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia, Charlottesville 22908, USA
    J Immunol 169:5308-14. 2002
  7. ncbi request reprint Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
    Gastroenterology 124:972-82. 2003
  8. ncbi request reprint Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 178:1809-18. 2007
  9. pmc TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
    Marco Marini
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 100:8366-71. 2003
  10. pmc A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis
    Johnson Ho
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 180:2573-80. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase
    J Rivera-Nieves
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:19525-31. 1999
    ..This thiol linkage was stable to HgCl2. Thus, linkage of GAPDH to NADH, in contrast to NAD, occurs in the presence of thiol, is independent of NO, and is mediated by superoxide...
  2. pmc Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:907-17. 2006
    ..Thus, the multiple roles of PSGL-1 may explain why targeting this single adhesion molecule results in attenuation of chronic murine ileitis, a disease previously resistant to antiadhesion molecule strategies...
  3. ncbi request reprint L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 174:2343-52. 2005
    ..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
  4. ncbi request reprint Intestinal ischemia and peripheral gangrene in a patient with chronic renal failure
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
    Gastroenterology 122:495-9. 2002
    ..Prompt diagnosis is crucial, as parathyroidectomy may result in clinical improvement in up to two thirds of patients who present with elevated parathyroid hormone levels...
  5. ncbi request reprint Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    Gastroenterology 131:1518-29. 2006
    ..Furthermore, although clinical trials to evaluate the efficacy of targeting the CCL25/CCR9 axis for the treatment of Crohn's disease are being conducted, preclinical data in animal models of IBD are lacking...
  6. ncbi request reprint Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia, Charlottesville 22908, USA
    J Immunol 169:5308-14. 2002
    ..In conclusion, antibiotic therapy significantly ameliorates the severity of ileitis in SAMP1/YitFc mice by a mechanism involving down-regulation of activated gut lymphocytes and inhibition of intestinal Th1 cytokine production...
  7. ncbi request reprint Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, Virginia 22908, USA
    Gastroenterology 124:972-82. 2003
    ..In this report, we describe the distinguishing features of the SAMP1/YitFc substrain at the University of Virginia, compared with the Japanese SAMP1/Yit parental strain...
  8. ncbi request reprint Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 178:1809-18. 2007
    ..All together, our results indicate that in SAMP1/YitFc mice, bacterial flora exacerbates intestinal inflammation, but is not essential for the generation of the chronic ileitis that is characteristic of these mice...
  9. pmc TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
    Marco Marini
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 100:8366-71. 2003
    ..These data demonstrate a novel mechanism of action of anti-TNF-alpha therapy that involves homeostatic regulation of mucosal cell apoptosis, which results in the net decrease of chronic inflammation typically found in CD...
  10. pmc A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis
    Johnson Ho
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 180:2573-80. 2008
    ..These inflammation-driven populations exert distinct roles during the development of chronic ileitis, and influence the balance of effector and regulatory functions in the chronically inflamed small intestine...
  11. ncbi request reprint Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis
    Sean L Barnes
    Digestive Health Center of Excellence, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 179:7012-20. 2007
    ..Our data suggest that RELMbeta is involved in the initiation of ileitis in SAMP1/Fc mice and may act through the induction of proinflammatory cytokines from resident immune cells within the mucosa...
  12. pmc Role of TL1A and its receptor DR3 in two models of chronic murine ileitis
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 103:8441-6. 2006
    ..Blockade of the TL1A/DR3 pathway may, therefore, offer therapeutic opportunities in Crohn's disease...
  13. ncbi request reprint Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease
    Masaru Odashima
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville 22908, USA
    Gastroenterology 129:26-33. 2005
    ..The aim of this study was to investigate the role of A 2A in mucosal inflammation by administering a selective A 2A agonist (ATL-146e) to experimental models of inflammatory bowel disease...
  14. pmc Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis
    Colm B Collins
    Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
    Gut 61:1154-62. 2012
    ..Objectives To analyse the effect of inflammation on the frequency of mononuclear phagocytes (MP) and the effect of altering their frequency by administration of Flt3-L in chronic ileitis...
  15. pmc Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease
    Jose L Tlaxca
    Department of Biomedical Engineering, School of Engineering and Applied Science, University of Virginia, Charlottesville, VA, United States
    J Control Release 165:216-25. 2013
    ....
  16. ncbi request reprint Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease
    Christopher Bachmann
    Division of Gastroenterology and Hepatology Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Gastroenterology 130:8-16. 2006
    ..The aim of the present study was to develop a noninvasive imaging modality to detect and evaluate ileitis in SAMP1/YitFc (SAMP) mice...
  17. ncbi request reprint Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
    Giorgos Bamias
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, PO Box 800708, Charlottesville, Virginia 22908, USA
    Gastroenterology 128:654-66. 2005
    ..In the present study we tested the hypothesis that TH2 cytokines also may participate in disease development in SAMP1/YitFc mice that spontaneously develop terminal ileitis with perianal manifestations...
  18. pmc The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice
    Joshua D Wermers
    Mucosal Inflammation Program, Department of Internal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA
    Gastroenterology 140:1526-35.e3. 2011
    ..We sought to determine whether interaction between the chemokine receptor 9 (CCR9) and its ligand, chemokine ligand 25 (CCL25), allows effectors or Tregs to localize to chronically inflamed small intestine...
  19. pmc T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo
    Emily Smith
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 183:5685-93. 2009
    ..Adoptively transferred Rag1(-/-) or WT thymocytes correct neutrophil counts in neutropenic nude mice. We conclude that the development of IL-17A-producing T-lineage cells requires an intact thymic epithelium, but not V(D)J recombination...
  20. pmc Leukocyte adhesion molecules in animal models of inflammatory bowel disease
    Jesus Rivera-Nieves
    Division of Gastroenterology, Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Inflamm Bowel Dis 14:1715-35. 2008
    ....