Robert A Rissman
Affiliation: University of California
- Longitudinal plasma amyloid beta as a biomarker of Alzheimer's diseaseRobert A Rissman
Alzheimer s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92037 0624, USA
J Neural Transm 119:843-50. 2012..In this review, we discuss recent data on plasma β-amyloid (Aβ) and examine the issues that have arisen in establishing it as a reliable biomarker of AD...
- Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregationRobert A Rissman
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
Proc Natl Acad Sci U S A 109:6277-82. 2012....
- Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?Robert A Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037 0624, USA
J Alzheimers Dis 18:453-7. 2009..In this review, the question of whether stress-induced tau-P can be used as a model for examining the relationship between functional neuroplasticity and neuronal vulnerability will be discussed...
- Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's diseaseRobert A Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurochem 117:613-22. 2011..When developing AD therapeutics that modulate GABA it is important to consider how E/I balance impacts AD pathogenesis and the relationship between seizure activity and cognitive decline...
- Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylationRobert A Rissman
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
J Neurosci 27:6552-62. 2007....
- Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptorsAllyson D Roe
Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA
Eur J Neurosci 34:448-56. 2011..CRFR mediation of stress-induced hippocampal tau-P may be limited to emotional stressors...
- The role of caspase cleavage of tau in Alzheimer disease neuropathologyCarl W Cotman
Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA
J Neuropathol Exp Neurol 64:104-12. 2005..In addition, a model is presented whereby caspase cleavage of tau provides a mechanistic link between the development of amyloid and tangle pathologies...
- Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's diseaseDaniel A Nation
Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
J Alzheimers Dis 36:689-98. 2013..By calculating the ratio of mean arterial pressure to rCBF, it is possible to estimate an index of regional cerebrovascular resistance (CVRi) that may be a sensitive measure of occult cerebrovascular disease...
- Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factorShannon N Campbell
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
J Alzheimers Dis 43:967-76. 2015..These data suggest critical roles for CRF and CRFR1 in tau-P and aggregation and may have implications for the development of AD cognitive decline...
- Characterization of ATP alternations in an Alzheimer's disease transgenic mouse modelCheng Zhang
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA Department of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA
J Alzheimers Dis 44:375-8. 2015..Overall, our results demonstrate that tissue ATP contents in Tg mice are significantly reduced, suggesting a decrease of tissue ATP production and mitochondrial dysfunction. ..
- Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresisCheng Zhang
Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
Electrophoresis 34:2268-74. 2013..Collectively, our results indicate that this methodology offers great advantages, such as high separation efficiency, good selectivity, low limit of detection, simplicity and low cost of analysis. ..
- Interaction of age and APOE genotype on cerebral blood flow at restChristina E Wierenga
Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
J Alzheimers Dis 34:921-35. 2013..Findings may partially support suggestions that the gene exerts antagonistic pleiotropic effects...
- GABA(A) receptors in aging and Alzheimer's diseaseRobert A Rissman
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, USA
J Neurochem 103:1285-92. 2007..It is therefore crucial to understand the subunit composition of individual GABA(A) receptors in the diseased brain when developing therapeutics that act at these receptors...
- Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathologyRobert A Rissman
Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
J Clin Invest 114:121-30. 2004..These results suggest that therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline...