Robert A Rissman
Affiliation: University of California
- Longitudinal plasma amyloid beta as a biomarker of Alzheimer's diseaseRobert A Rissman
Alzheimer s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92037 0624, USA
J Neural Transm 119:843-50. 2012..In this review, we discuss recent data on plasma β-amyloid (Aβ) and examine the issues that have arisen in establishing it as a reliable biomarker of AD...
- Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregationRobert A Rissman
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
Proc Natl Acad Sci U S A 109:6277-82. 2012....
- Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?Robert A Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037 0624, USA
J Alzheimers Dis 18:453-7. 2009..In this review, the question of whether stress-induced tau-P can be used as a model for examining the relationship between functional neuroplasticity and neuronal vulnerability will be discussed...
- Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's diseaseRobert A Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurochem 117:613-22. 2011..When developing AD therapeutics that modulate GABA it is important to consider how E/I balance impacts AD pathogenesis and the relationship between seizure activity and cognitive decline...
- Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptorsAllyson D Roe
Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA
Eur J Neurosci 34:448-56. 2011..CRFR mediation of stress-induced hippocampal tau-P may be limited to emotional stressors...
- Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylationRobert A Rissman
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
J Neurosci 27:6552-62. 2007....
- The role of caspase cleavage of tau in Alzheimer disease neuropathologyCarl W Cotman
Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA
J Neuropathol Exp Neurol 64:104-12. 2005..In addition, a model is presented whereby caspase cleavage of tau provides a mechanistic link between the development of amyloid and tangle pathologies...
- Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's diseaseDaniel A Nation
Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
J Alzheimers Dis 36:689-98. 2013..OBJECTIVe: To compare probable AD patients to mild cognitive impairment (MCI) and normal control (NC) participants on CVRi, the ratio of mean arterial pressure to rCBF...
- Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresisCheng Zhang
Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
Electrophoresis 34:2268-74. 2013..Collectively, our results indicate that this methodology offers great advantages, such as high separation efficiency, good selectivity, low limit of detection, simplicity and low cost of analysis. ..
- Interaction of age and APOE genotype on cerebral blood flow at restChristina E Wierenga
Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
J Alzheimers Dis 34:921-35. 2013..Findings may partially support suggestions that the gene exerts antagonistic pleiotropic effects...
- GABA(A) receptors in aging and Alzheimer's diseaseRobert A Rissman
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, USA
J Neurochem 103:1285-92. 2007..It is therefore crucial to understand the subunit composition of individual GABA(A) receptors in the diseased brain when developing therapeutics that act at these receptors...
- Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathologyRobert A Rissman
Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
J Clin Invest 114:121-30. 2004..These results suggest that therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline...